Antidiabetic drug miglitol inhibits myocardial apoptosis involving decreaed hydroxyl radical production and Bax expression in an ischaemia/reperfusion rabbit heart

British Journal of Pharmacology

Volumn 142, Issue 6, 2004, Pages 983-990

  Wang, Ningyuan ^a   Minatoguchi, Shinya ^a   Chen, Xuehal ^a   Uno, Yoshihiro ^a   Arai, Masazumi ^a   Lu, ChuanJiang ^a   Takemera, Genzou ^a   Fujiwara, Takako ^b   Fujiwara, Hisayoshi ^a  

^a GIFU UNIVERSITY   (Japan)

^b KYOTO WOMEN'S UNIVERSITY   (Japan)

Author keywords

glucosidase inhibitor; Apoptosis; Hydroxyl radicals; Ischaemia; Miglitol; Myocardial infarction

Indexed keywords

2,5 DIHYDROBENZOIC ACID; ANTIDIABETIC AGENT; APOPTOSIS INHIBITOR; BENZOIC ACID DERIVATIVE; DNA FRAGMENT; HYDROXYL RADICAL; MIGLITOL; PROTEIN BAX; PROTEIN BCL XL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; HEART HEMODYNAMICS; HEART INFARCTION SIZE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; IMMUNOHISTOCHEMISTRY; MALE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; UPREGULATION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; BLOOD PRESSURE; BLOTTING, WESTERN; DNA FRAGMENTATION; ELECTROPHORESIS, AGAR GEL; GENTISATES; GLUCOSAMINE; HEART RATE; HEMODYNAMIC PHENOMENA; HYDROXYL RADICAL; HYPOGLYCEMIC AGENTS; IMINO PYRANOSES; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; MYOCYTES, CARDIAC; PROTO-ONCOGENE PROTEINS C-BCL-2; RABBITS; TIME FACTORS;

EID: 3843134181     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0705863     Document Type: Article

References (30)

1. AMBROSIO, G., ZWEIER, J.L. & BECKER, L.C. (1998). Apoptosis is prevented by administration of superoxide dismutase in dogs with reperfused myocardial infarction. Basic Res. Cardiol., 93, 94-96.
2. BOLLI, R. (1988). Oxygen-derived free radicals and postischemic myocardial dysfunction ('stunned myocardium'). J. Am. Coll. Cardiol., 12, 239-249.
3. BOLLEN, M. & STALMANS, W. (1989). The antiglycogenolytic action of 1-deoxynojirimycin results from a specific inhibition of the α-1,6-glucosidase activity of the debranching enzyme. Eur. J. Biochem., 181, 775-780.
4. BOLLI, R. (1991). Oxygen-derived free radicals and myocardial reperfusion injury: an overview. Cardiovasc. Drug Ther., 5, 249-268.
5. CHAO, D.T. & KORSMEYER, S.J. (1998). BCL-2 family: regulation of cell death. Annu. Rev. Immunol., 16, 395-419.
6. CHEN, X., MINATOGUCHI, S., WANG, N., ARAI, M., LU, C., UNO, Y., MISAO, YU., TAKEMURA, G. & FUJIWARA, H. (2003). Quinaprilat reduces myocardial infarct size involving nitric oxide production and mitochondrial KATP channel in rabbits. J. Cardiovasc. Pharmacol., 41, 938-945.
7. COOK, S.A., SUGDEN, P.H. & CLERK, A. (1999). Regulation of bcl-2 family proteins during development and in response to oxidative stress in cardiac myocytes: association with changes in mitochondrial membrane potential. Circ. Res., 85, 940-949.
8. FERRARI, R., CECONI, C, CURELLO, S., ALFIERI, O. & VISIOLI, O. (1993). Myocardial damage during ischaemia and reperfusion. Eur. Heart J., 14 (Suppl G), 25-30.
9. FREEMAN, B.A. & CRAPO, J.D. (1982). Biology of disease. Free radicals and tissue injury. Lab. Invest., 47, 412-426.
10. FUJIWARA, H., FUJIWARA, T., TANAKA, M., ONODERA, T., MIYAZAKI, S., WU, D.J., MATSUDA, M., SASAYAMA, S. & KAWAI, C. (1988). Detection of early myocardial infarction in formalin-fixed, paraffin-embedded tissue. Am. J. Cardiovasc. Pathol., 2, 57-61.
11. GOLSTEIN, P. (1997). Controlling cell death. Science, 275, 1081-1082.
12. GROOTVELT, M. & HALLIWELL, B. (1986). Aromatic hydroxylation as a hydroxyl-radical formation in vivo. Biochem. J., 237, 499-504.
13. HARE, J.M. (2001). Oxidative stress and apoptosis in heart failure progression. Circ. Res., 89, 198-200.
14. HASHIMOTO, K., MINATOGUCHI, S., HASHIMOTO, Y., WANG, N., QIU, X., YAMASHITA, K., UNO, Y., ARAI, M., NISHIDA, Y., TAKEMURA, G., SUZUKI, T. & FUJIWARA, H. (2001). Role of protein kinase C, KATP channels and DNA fragmentation in the infarct size-reducing effects of the free radical scavenger T-0970. Clin. Exp. Pharmacol. Physiol., 28, 193-199.
15. HORWITZ, L.D., FENNESSEY, P.V., SHIKES, R.H. & KONG, Y. (1994). Marked reduction in myocardial infarct size due to prolonged infusion of an antioxidant during reperfusion. Circulation, 89, 1792-1801.
16. JENNINGS, R.B., MURRY, C.E. & REIMER, K.A. (1991). Energy metabolism in preconditioned and control myocardium: effect of total ischaemia. J. Mol. Cell. Cardiol., 23, 1449-1458.
17. KIDA, M., FUJIWARA, H., ISHIDA, M., KAWAI, C., OHURA, M., MIURA, I. & YABUUCHI, Y. (1991). Ischemic preconditioning preserves creatine phosphate and intracellular pH. Circulation, 84, 2495-2503.
18. MCCORD, J.M. (1988). Free radicals and myocardial ischaemia: overview and outlook. Free Radic. Biol. Med., 4, 9-14.
19. MINATOGUCHI, S., ARAI, M., UNO, Y., KARIYA, T., NISHIDA, Y., HASHIMOTO, K., KAWASAKI, M., TAKEMURA, G., FUJIWARA, T. & FUJIWARA, H. (1999). A novel anti-diabetic drug, miglitol, markedly reduces myocardial infarct size in rabbits. Br. J. Pharmacol., 128, 1667-1672.
20. MURRY, C.E., JENNINGS, R.B. & REIMER, K.A. (1986). Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation, 74, 1124-1136.
21. NAKAMURA, M., WANG, N.P., ZHAO, Z.Q., WILCOX, J.N., THOURANI, V., GUYTON, R.A. & VINTEN-JOHANSEN, J. (2000). Preconditioning decreases Bax expression, PMN accumulation and apoptosis in reperfused rat heart. Cardiovasc. Res., 45, 661-670.
22. PORTZ, S.J., LESNEFSKY, E.J., VANBENTHUYSEN, K.M., MCMURTRY, I.M. & HOROWITZ, L.D. (1989). Dimethylthiourea, but not dimethylsulfoxide, reduces canine infarct size. Free Radic. Biol. Med., 7, 53-58.
23. SABBAH, H.N. (2000). Apoptotic cell death in heart failure. Cardiovasc. Res., 45, 704-712.
24. SCHMITZ, G.G., WALTER, T., SEIBL, R. & KESSELER, C. (1991). Nonradioactive labeling of oligonucleotides in vitro with the hapten digoxigenin by tailing with terminal transferase. Anal. Biochem., 192, 222-231.
25. STANLEY, W.C., LOPASCHUK, G.D., HALL, J.L. & McCORMACK, J.G. (1997). Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions - potential for pharmacological interventions. Cardiovasc. Res., 33, 243-257.
26. TAKEMURA, G., ONODERA, T. & ASHRAF, M. (1992). Quantification of hydroxyl radical and its lack of relevance to myocardial injury during early reperfusion after graded ischemia in rat hearts. Circ. Res., 71, 96-105.
27. YAMAMURA, T., OTANI, H., NAKAO, Y., HATTORI, R., OSAKO, M. & IMAMURA, H. (2001). IGF-1 differentially regulates Bcl-xL and Bax and confers myocardial protection in the rat heart. Am. J. Physiol. Heart. Circ. Physiol., 280, H1191-H1200.
28. YANG, J.J., KETTRITZ, R., FALK, R.J., JENNETTE, J.C. & GAIDO, M.L. (1996). Apoptosis of endothelial cells induced by the neutrophil serine proteases proteinase 3 and elastase. Am. J. Pathol., 149, 1617-1623.
29. ZHAO, Z.Q., NAKAMURA, M., WANG, N.P., WILCOX, J.N., SHEARER, S., RONSON, R.S., GUYTON, R.A. & VINTEN-JOHANSEN, J. (2000). Reperfusion induces myocardial apoptotic cell death. Cardiovasc. Res., 45, 651-660.
30. ZHAO, Z.Q., VELEZ DA WANG, N.P., HEWAN-LOWE, K.O., NAKAMURA, M., GUYTON, R.A. & VINTEN-JOHANSEN, J. (2001). Progressively developed myocardial apoptotic cell death during late phase of reperfusion. Apoptosis, 6, 279-290.