Heterogeneity of genomic breakpoints in MSN-ALK translocations in anaplastic large cell lymphoma

Human Pathology

Volumn 35, Issue 8, 2004, Pages 1038-1041

  Tort, Frederic ^a   Campo, Elias ^a,c   Pohlman, Brad ^b   Hsi, Eric ^b  

^a HOSPITAL CLÍNIC   (Spain)

^b LERNER RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF BARCELONA   (Spain)

Author keywords

ALCL; ALK; anaplastic large cell lymphoma; anaplastic lymphoma kinase; breakpoint; moesin; MSN; PCR; polymerase chain reaction; translocation

Indexed keywords

ANAPLASTIC LYMPHOMA KINASE; ANTIBIOTIC AGENT; CARBOPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; ETOPOSIDE; IFOSFAMIDE; MOESIN; PREDNISONE; VINCRISTINE;

ADULT; ANAPLASTIC CARCINOMA; ANAPLASTIC LARGE CELL LYMPHOMA; ARTICLE; BASE PAIRING; CANCER STAGING; CASE REPORT; CAT SCRATCH DISEASE; CELL MEMBRANE; CHROMOSOME 2; DRUG MEGADOSE; EXON; FUSION GENE; GENE DELETION; GENE SEQUENCE; GENE TRANSLOCATION; GENETIC HETEROGENEITY; GENOMICS; HUMAN; IMMUNOHISTOCHEMISTRY; INTRON; LARGE CELL LYMPHOMA; LYMPHADENOPATHY; MALE; MOLECULAR MECHANICS; STEM CELL TRANSPLANTATION;

ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BASE SEQUENCE; DNA, NEOPLASM; FATAL OUTCOME; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOPHENOTYPING; LYMPHOMA, LARGE-CELL; MALE; MICROFILAMENT PROTEINS; MOLECULAR SEQUENCE DATA; NEOPLASM STAGING; POLYMERASE CHAIN REACTION; PROTEIN-TYROSINE KINASES; RNA, MESSENGER; TRANSLOCATION, GENETIC; TUMOR MARKERS, BIOLOGICAL;

EID: 3843071050     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2004.05.006     Document Type: Article

References (15)

1. Morris S.W., Kirstein M.N., Valentine M.B., et al. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science. 263:1984;1281-1284
2. Falini B., Mason D.Y. Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia Clinical value of their detection by immunocytochemistry. Blood. 99:2002;409-426
3. Stein H., Foss H.D., Durkop H., et al. CD30(+) anaplastic large cell lymphoma A review of its histopathologic, genetic, and clinical features. Blood. 96:2000;3681-3695
4. Tort F., Pinyol M., Pulford K., et al. Molecular characterization of a new ALK translocation involving moesin (MSN-ALK) in anaplastic large cell lymphoma. Lab Invest. 81:2001;419-426
5. Chiarle R., Gong J.Z., Guasparri I., et al. NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors. Blood. 101:2003;1919-1927
6. Nieborowska-Skorska M., Slupianek A., Xue L., et al. Role of signal transducer and activator of transcription 5 in nucleophosmin/anaplastic lymphoma kinase-mediated malignant transformation of lymphoid cells. Cancer Res. 61:2001;6517-6523
7. Zhang Q., Raghunath P.N., Xue L., et al. Multilevel dysregulation of STAT3 activation in anaplastic lymphoma kinase-positive T/null-cell lymphoma. J Immunol. 168:2002;466-474
8. Slupianek A., Nieborowska-Skorska M., Hoser G., et al. Role of phosphatidylinositol 3-kinase-Akt pathway in nucleophosmin/anaplastic lymphoma kinase-mediated lymphomagenesis. Cancer Res. 61:2001;2194-2199
9. Bai R.Y., Dieter P., Peschel C., et al. Nucleophosmin-anaplastic lymphoma kinase of large-cell anaplastic lymphoma is a constitutively active tyrosine kinase that utilizes phospholipase C-gamma to mediate its mitogenicity. Mol Cell Biol. 18:1998;6951-6961
10. Lamant L., Gascoyne R.D., Duplantier M.M., et al. Non-muscle myosin heavy chain (MYH9) A new partner fused to ALK in anaplastic large cell lymphoma. Genes Chromosomes Cancer. 37:2003;427-432
11. Cools J., Wlodarska I., Somers R., et al. Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor. Genes Chromosomes Cancer. 34:2002;354-362
12. Hernandez L., Bea S., Bellosillo B., et al. Diversity of genomic breakpoints in TFG-ALK translocations in anaplastic large cell lymphomas Identification of a new TFG-ALK(XL) chimeric gene with transforming activity. Am J Pathol. 160:2002;1487-1494
13. Lamant L., Dastugue N., Pulford K., et al. A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2)(q25;p23) translocation. Blood. 93:1999;3088-3095
14. Zucman-Rossi J., Legoix P., Victor J.M., et al. Chromosome translocation based on illegitimate recombination in human tumors. Proc Natl Acad Sci U S A. 95:1998;11786-11791
15. Falini B., Pulford K., Pucciarini A., et al. Lymphomas expressing ALK fusion protein(s) other than NPM-ALK. Blood. 94:1999;3509-3515