Different measures of molecular mobility: Comparison between calorimetric and thermally stimulated current relaxation times below Tg and correlation with dielectric relaxation times above Tg

Journal of Pharmaceutical Sciences

Volumn 97, Issue 10, 2008, Pages 4498-4515

  Bhugra, Chandan ^a,b   Shmeis, Rama ^b,c   Krill, Steven L ^b   Pikal, Michael J ^a  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

^c SANOFI   (France)

Author keywords

Amorphous pharmaceuticals; Calorimetry (DSC); Dielectric relaxation; Enthalpy relaxation; Heat capacity; Isothermal microcalorimetry (TAM) transition; Molecular mobility; Thermally stimulated depolarization current spectroscopy (TSDC)

Indexed keywords

FELODIPINE; FLOPROPIONE; INDOMETACIN; KETOCONAZOLE; NIFEDIPINE;

AMORPHOUS STATE; ARTICLE; CALORIMETRY; CORRELATION ANALYSIS; DIELECTRIC CONSTANT; DIELECTRIC SPECTROSCOPY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG STABILITY; ENTHALPY; GLASS TRANSITION TEMPERATURE; ISOTHERMAL MICROCALORIMETRY; MICROCALORIMETRY; PHYSICAL STATE; SPECTROSCOPY; TEMPERATURE SENSITIVITY; THERMAL STIMULATION; THERMALLY STIMULATED DEPOLARIZATION CURRENT SPECTROSCOPY;

EID: 55849136563     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21324     Document Type: Article

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