Modulation of acute visceral nociception and bladder inflammation by plant triterpene, α, β-amyrin in a mouse model of cystitis: Role of tachykinin NK1-receptors, and K+ ATP channels

Inflammation Research

Volumn 56, Issue 12, 2007, Pages 487-494

  Lima Junior R C P ^a   Sousa, D I M ^a   Brito, G A C ^a   Cunha, G M ^a   Chaves, M H ^b   Rao, V S N ^a   Santos, F A ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b FEDERAL UNIVERSITY OF PIAUÍ   (Brazil)

Author keywords

, amyrin; Bladder inflammation; Cyclophosphamide cystitis; Mouse; Visceral nociception

Indexed keywords

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATASE (POTASSIUM); ALPHA, BETA AMYRIN; CAPSAICIN; CRISTALIA; CYCLOPHOSPHAMIDE; ENZYME; GENUXAL; GLIBENCLAMIDE; TACHYKININ; TRITERPENE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYSTITIS; DRUG EFFECT; DRUG MECHANISM; IMMUNOREACTIVITY; MALE; MOUSE; NOCICEPTION; NONHUMAN;

ACETYLCYSTEINE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CAPSAICIN; CYCLOPHOSPHAMIDE; CYSTITIS; EDEMA; GLYBURIDE; KATP CHANNELS; MALE; MICE; OLEANOLIC ACID; PAIN; RECEPTORS, NEUROKININ-1; TRPV CATION CHANNELS; URINARY BLADDER;

EID: 38349144952     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-007-7023-4     Document Type: Article

References (44)

1. Olivar T, Laird JM. Cyclophosphamide cystitis in mice: behavioural characterisation and correlation with bladder inflammation. Eur J Pain 1999; 3: 141-9.
2. Laird JM, Martinez-Caro L, Garcia-Nicas E, Cervero F. A new model of visceral pain and referred hyperalgesia in the mouse. Pain 2001; 92: 335-42.
3. Giamberardino, MA. Recent and forgotten aspects of visceral pain. Eur J Pain 1999; 3: 77-92.
4. Cox PJ. Cyclophosphamide cystitis: identification of acrolein as the causative agent. Biochem Pharmacol 1979; 28: 2045-9.
5. Laird JM, Olivar T, Roza C, De Felipe C, Hunt SP, Cervero F. Deficits in visceral pain and hyperalgesia of mice with a disruption of the tachykinin NK1 receptor gene. Neuroscience 2000; 98: 345-52.
6. Bon K, Lichtensteiger CA, Wilson SG, Mogil JS. Characterization of cyclophosphamide cystitis, a model of visceral and referred pain, in the mouse: species and strain differences. J Urol 2003; 170: 1008-12.
7. Chow YC, Yang S, Huang CJ, Tzen CY, Huang PL, Su YH et al. Epinephrine promotes hemostasis in rats with cyclophosphamide-induced hemorrhagic cystitis. Urology 2006; 67(3): 636-41.
8. Oter S, Korkmaz A, Oztas E, Yildirim I, Topal T, Bilgic H. Inducible nitric oxide synthase inhibition in cyclophosphamide induced hemorrhagic cystitis in rats. Urol Res 2004; 32: 185-9.
9. Korkmaz A, Oter S, Sadir S, Coskun O, Topal T, Ozler M et al. Peroxynitrite may be involved in bladder damage caused by cyclophosphamide in rats. J Urol 2005; 173: 1793-6.
10. Nishii H, Nomura M, Fujimoto N, Matsumoto T. Up-regulation of interleukin-6 gene expression in cyclophosphamide-induced cystitis in mice: An in situ hybridization histochemical study. Int J Urol 2006; 13: 1339-43.
11. LaBerge J, Malley SE, Zvarova K, Vizzard MA. Expression of corticotropin-releasing factor and CRF receptors in micturition pathways after cyclophosphamide-induced cystitis. Am J Physiol Regul Integr Comp Physiol. 2006; 291: R692-703.
12. Meen M, Coudore-Civiale MA, Parry L, Eschalier A, Boucher M. Involvement of N-methyl-D-aspartate receptors in nociception in the cyclophosphamide-induced vesical pain model in the conscious rat. Eur J Pain 2002; 6: 307-14.
13. Dattilio A, Vizzard MA. Up-regulation of protease activated receptors in bladder after cyclophosphamide induced cystitis and colocalization with capsaicin receptor (VR1) in bladder nerve fibers. J Urol 2005; 173: 635-9.
14. Meen M, Coudore-Civiale MA, Parry L, Eschalier A, Boucher M. Involvement of hypogastric and pelvic nerves for conveying cystitis induced nociception in conscious rats. J Urol. 2001; 166: 318-22.
15. Guerios SD, Wang ZY, Bjorling DE. Nerve growth factor mediates peripheral mechanical hypersensitivity that accompanies experimental cystitis in mice. Neurosci Lett 2006; 392: 193-7.
16. Kanat O, Kurt E, Yalcinkaya, U., Evrensel T, Manavoglu, O. Comparison of uroprotective efficacy of mesna and amifostine in cyclophosphamide-induced haemorrhagic cystitis in rats. Indian J Cancer 2006; 43: 12-5.
17. Sadir S, Deveci S, Korkmaz A, Oter S. Alpha-tocopherol, beta-carotene and melatonin administration protects cyclophosphamide-induced oxidative damage to bladder tissue in rats. Cell Biochem Funct 2006; [Epub ahead of print].
18. Khaw SL, Downie PA, Waters KD, Ashley DM, Heath JA. Adverse hypersensitivity reactions to mesna as adjunctive therapy for cyclophosphamide. Pediatr Blood Cancer 2005; [Epub ahead of print].
19. Andre E, Campi B, Trevisani M, Ferreira J, Malheiros A, Yunes RA et al. Pharmacological characterisation of the plant sesquiterpenes polygodial and drimanial as vanilloid receptor agonists. Biochem Pharmacol. 2006; 71(8): 1248-54.
20. Ozcan A, Korkmaz A, Oter S, Coskun O. Contribution of flavonoid antioxidants to the preventive effect of mesna in cyclophosphamide-induced cystitis in rats. Arch Toxicol. 2005; 79(8): 461-5.
21. Siani AC, Ramos MFS, de Lima MO, Santos R, Ferreira FE, Soares EC et al. Evaluation of anti-inflammatory-related activity of essential oils from the leaves and resin of species of Protium. J Ethnopharmacol 1999; 66: 57-69.
22. Oliveira FA, Lima-Júnior RC; Cordeiro WM, Vieira-Junior GM, Chaves MH, Almeida FRC et al. Pentacyclic triterpenoids, alpha, beta-amyrins, suppress the scratching behavior in a mouse model of pruritus. Pharmacol Biochem Behav 2004a; 78: 719-25.
23. Oliveira FA, Vieira-Júnior GM, Chaves MH, Almeida FRC, Santos KA, Martins FS et al. Gastroprotective effect of the mixture of alpha- and beta-amyrin from Protium heptaphyllum: role of capsaicin-sensitive primary afferent neurons. Planta Med. 2004b; 70: 780-2.
24. Oliveira FA, Chaves MH, Almeida FR, Lima RC Jr, Silva RM, Maia JL, Briti GA, Santos FA, Rao VS.Protective effect of alpha- and beta-amyrin, a triterpene mixture from Protium heptaphyllum (Aubl.) March. Trunk wood resin, against acetaminophen-induced liver injury in mice. J Ethnopharmacol 2005; 98: 103-8.
25. Lima-Júnior RCP, Oliveira FA, Gurgel LA, Cavalcante IJM, Santos KA, Campos DA, et al. Attenuation of visceral nociception by alpha-and beta-amyrin, a triterpenoid mixture isolated from the resin of Protium heptaphyllum, in mice. Planta Med 2006; 72: 34-9.
26. Burnstock G. Purine-mediated signalling in pain and visceral perception. Trends Pharmacol Sci. 2001; 22: 182-8.
27. Birder LA, de Groat WC. Mechanism of disease: Involvement of the urothelium in bladder dysfunction. Nat Cli Pract Urol 2007; 4: 46-54.
28. Alfieri AB; Gardner CJ (1997) The NKI antagonist, GR203040, inhibits cyclophosphamide-induced damage in the rat and ferret bladder. Gen Pharmacol 1997; 29: 245-50.
29. Maggi CA, Santicioli P, Abelli L, Parlani M, Capasso M, Conte B et al. (1987) Regional differences in the effects of capsaicin and tachykinins on motor activity and vascular permeability of the rat lower urinary tract. Naunyn-Schmiedeberg's Arch Pharmacol 1987; 335: 636-45.
30. Chahl LA. Antidromic vasodilatation and neurogenic inflammation. Pharmacol Ther 1988; 37: 275-300.
31. Vieira-Junior GM, Souza CML, Chaves MH. Resina de Protium heptaphyllum: isolamento, caracterização estrutural e avaliação das propriedades térmicas. Química Nova, 2005; 28: 183-7.
32. 13C NMR. Química Nova 1990; 13: 278-81.
33. Mahato SB, Sen S. Advances in triterpenoid research. 1990-1994. Phytochestry 1997; 44: 1165-236.
34. Saria A, Lundberg JM. Evans blue fluorescence: quantitative and morphological evaluation of vascular permeability in animal tissue. J Neurosci Methods 1983; 8: 41-9.
35. Maggi CA, Geppetti P, Santicioli P, Frilli S, Giuliani S, Furio M et al. Tachykinin-like immunoreactivity in the mammalian urinary bladder: correlation with the fractions of the capsaicin-sensitive sensory nerves. Neuroscience 1988; 26: 233-42.
36. Palma PC, Villaca Júnior CJ, Netto Júnior NR. N-acetylcysteine in the prevention of cyclophosphamide induced haemorrhagic cystitis. Int Surg 1986; 71: 36-7.
37. Gerhauser C, Klimo K, Heiss E, Neumann I, Gamal-Eldeen A, Knauft J et al. Mechanism-based in vitro screening of potential cancer chemopreventive agents. Mutat Res 2003; 523-524: 163-72.
38. Shishodia S, Majumdar S, Banerjee S, Aggarwal BB. Ursolic acid inhibits nuclear facto-kappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down-regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1.Cancer Res 2003; 63: 4375-83.
39. Otuki MF, Ferreira J, Vieira-Lima F, Meyre-Silva C, Malheiros A, Mull LA et al. Antinociceptive properties of mixture of alpha-amyrin and beta-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways. J Pharmacol Exp Ther. 2005; 313: 310-8.
40. de Groat, W.C. Integrative control of the lower urinary tract: pre-clinical perspective. Br J Pharmacol 2006; 147: S25-S40.
41. Gamboa-Esteves FO, McWilliam PN, Batten TF. Substance P (NK1) and somatostatin (sst2A) receptor immunoreactivity in NTS-projecting rat dorsal horn neurons activated by nociceptive afferent input. J Chem Neuroanatomy 2004; 27: 251-66.
42. Maggi CA, Geppetti P, Santicioli P, Frilli S, Giuliani S, Furio M et al. Tachykinin-like immunoreactivity in the mammalian urinary bladder: correlation with the functions of the capsaicin-sensitive sensory nerves. Neuroscience 1988; 26: 233-42.
43. Alfieri AB, Cubeddu LX. Nitric oxide and NK(1)-tachykinin receptors in cyclophosphamide-induced cystitis, in rats. J Pharmacol Exp Ther 2000; 295: 824-9.
44. Steers WD, Tuttle JB. Mechanisms of disease: the role of nerve growth factor in the pathophysiology of bladder disorders. Nat Clin Pract Urol 2006; 3: 101-10.