Common variation in the C-terminal region of the fibrinogen β-chain: Effects on fibrin structure, fibrinolysis and clot rigidity

Blood

Volumn 111, Issue 2, 2008, Pages 643-650

  Ajjan, Ramzi ^a   Lim, Bernard C B ^b   Standeven, Kristina F ^a   Harrand, Robert ^c   Dolling, Sarah ^a   Phoenix, Fladia ^a   Greaves, Richard ^d   Abou Saleh, Radwa H ^c   Connell, Simon ^c   Smith, D Alastair M ^c   Weisel, John W ^b   Grant, Peter J ^a,c   Ariëns, Robert A S ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c UNIVERSITY OF LEEDS   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FIBRIN; FIBRINOGEN; FIBRINOGEN BETA CHAIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BLOOD CLOTTING; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; FEMALE; FIBRINOLYSIS; GENETIC VARIABILITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; PROTEIN STRUCTURE; SCANNING ELECTRON MICROSCOPY; TURBIDITY;

EID: 38349134548     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2007-05-091231     Document Type: Article

References (41)

1. Baumann RE, Henschen AH. Human fibrinogen polymorphic site analysis by restriction endonuclease digestion and allele-specific polymerase chain reaction amplification: identification of polymorphisms at positions A alpha 312 and B beta 448. Blood. 1993;82:2117-2124.
2. Carter AM, Catto AJ, Bamford JM, Grant PJ. Gender-specific associations of the fibrinogen B beta 448 polymorphism, fibrinogen levels, and acute cerebrovascular disease. Arterioscler Thromb Vasc Biol. 1997;17:589-594.
3. Behague I, Poirier O, Nicaud V, et al. Beta fibrinogen gene polymorphisms are associated with plasma fibrinogen and coronary artery disease in patients with myocardial infarction: the ECTIM Study. Etude Cas-Temoins sur l'Infarctus du Myocarde. Circulation. 1996;93:440-449.
4. Dunn EJ, Ariëns RA, de Lange M, et al. Genetics of fibrin clot structure: a twin study. Blood. 2004;103:1735-1740.
5. Fatah K, Silveira A, Tornvall P, et al. Proneness to formation of tight and rigid fibrin gel structures in men with myocardial infarction at a young age. Thromb Haemost. 1996;76:535-540.
6. Shats EA, Nair CH, Dhall DP. Interaction of endothelial cells and fibroblasts with modified fibrin networks: role in atherosclerosis. Atherosclerosis. 1997;129:9-15.
7. Kaijzel EL, Koolwijk P, van Erck MG, van Hinsbergh VW, de Maat MP. Molecular weight fibrinogen variants determine angiogenesis rate in a fibrin matrix in vitro and in vivo. J Thromb Haemost. 2006;4:1975-1981.
8. Weisel JW. Fibrinogen and fibrin. Adv Protein Chem. 2005;70:247-299.
9. Litvinov RI, Gorkun OV, Galanakis DK, et al. Polymerization of fibrin: direct observation and quantification of individual B:b knob-hole interactions. Blood. 2007;109:130-138.
10. Lim BC, Ariëns RA, Carter AM, Weisel JW, Grant PJ. Genetic regulation of fibrin structure and function: complex gene-environment interactions may modulate vascular risk. Lancet. 2003;361:1424-1431.
11. Maghzal GJ, Brennan SO, George PM. Fibrinogen B beta polymorphisms do not directly contribute to an altered in vitro clot structure in humans. Thromb Haemost. 2003;90:1021-1028.
12. Henschen-Edman AH. Fibrinogen non-inherited heterogeneity and its relationship to function in health and disease. Ann N Y Acad Sci. 2001;936:580-593.
13. Standeven KF, Grant PJ, Carter AM, et al. Functional analysis of the fibrinogen Aalpha Thr312Ala polymorphism: effects on fibrin structure and function. Circulation. 2003;107:2326-2330.
14. Gorkun OV, Veklich YI, Weisel JW, Lord ST. The conversion of fibrinogen to fibrin: recombinant fibrinogen typifies plasma fibrinogen. Blood. 1997;89:4407-4414.
15. Chung DW, Que BG, Rixon MW, Mace M Jr, Davie EW. Characterization of complementary deoxyribonucleic acid and genomic deoxyribonucleic acid for the beta chain of human fibrinogen. Biochemistry. 1983;22:3244-3250.
16. Mullin JL, Gorkun OV, Lord ST. Decreased lateral aggregation of a variant recombinant fibrinogen provides insight into the polymerization mechanism. Biochemistry. 2000;39:9843-9849.
17. Takebe M, Soe G, Kohno I, Sugo T, Matsuda M. Calcium ion-dependent monoclonal antibody against human fibrinogen: preparation, characterization, and application to fibrinogen purification. Thromb Haemost. 1995;73:662-667.
18. Ariëns RA, Philippou H, Nagaswami C, et al. The factor XIII V34L polymorphism accelerates thrombin activation of factor XIII and affects cross-linked fibrin structure. Blood. 2000;96:988-995.
19. Woodhead JL, Nagaswami C, Matsuda M, Arocha-Pinango CL, Weisel JW. The ultrastructure of fibrinogen Caracas II molecules, fibers, and clots. J Biol Chem. 1996;271:4946-4953.
20. Uhde J, Ter Oganessian N, Pink DA, Sackmann E, Boulbitch A. Viscoelasticity of entangled actin networks studied by long-pulse magnetic bead microrheometry. Phys Rev E Stat Nonlin Soft Matter Phys. 2005;72:61916-61921.
21. Huang H, Dong CY, Kwon HS, et al. Three-dimensional cellular deformation analysis with a two-photon magnetic manipulator workstation. Biophys J. 2002;82:2211-2223.
22. Collet JP, Park D, Lesty C, et al. Influence of fibrin network conformation and fibrin fiber diameter on fibrinolysis speed: dynamic and structural approaches by confocal microscopy. Arterioscler Thromb Vasc Biol. 2000;20:1354-1361.
23. Berman HM, Westbrook J, Feng Z, et al. The Protein Data Bank. Nucleic Acids Res. 2000;28:235-242.
24. Doolittle RF, Yang Z, Mochalkin I. Crystal structure studies on fibrinogen and fibrin. Ann N Y Acad Sci. 2001;936:31-43.
25. Brooks BR, Bruccoleri RE, Olafson BD, et al. CHARMM: A program for macromolecular energy, minimization, and dynamics calculations. J Comput Chem. 1983;4:187-217.
26. Mouawad L, Perahia D. Diagonalization in a mixed basis: a method to compute low-frequency normal-modes for large macromolecules. Biopolymers. 1993;33:599-611.
27. Van Gunsteren WF, Berendsen HJC. Algorithms for macromolecular dynamics and constraint dynamics. Mol Phys. 1977;34:1311-1327.
28. Oldfield TJ. SQUID: a program for the analysis and display of data from crystallography and molecular dynamics. J Mol Graph. 1992;10:247-252.
29. Matthew JB, Gurd FRN, Garciamoreno EB, et al. Ph-dependent processes in proteins. CRC Crit Rev Biochem. 1985;18:91-197.
30. Ikeura Y, Shimono K, Iwamoto M, Sudo Y, Kamo N. Arg-72 of pharaonis phoborhodopsin (sensory rhodopsin II) is important for the maintenance of the protein structure in the solubilized states. Photochem Photobiol. 2003;77:96-100.
31. Litvinov RI, Gorkun OV, Galanakis DK, et al. Polymerization of fibrin: direct observation and quantification of individual B:b knob-hole interactions. Blood. 2007;109:130-138.
32. Yakovlev S, Makogonenko E, Kurochkina N, et al. Conversion of fibrinogen to fibrin: mechanism of exposure of tPA- and plasminogen-binding sites. Biochemistry. 2000;39:15730-15741.
33. Collet JP, Moen JL, Veklich YI, et al. The alphaC domains of fibrinogen affect the structure of the fibrin clot, its physical properties, and its susceptibility to fibrinolysis. Blood. 2005;106:3824-3830.
34. Kostelansky MS, Bolliger-Stucki B, Betts L, Gorkun OV, Lord ST. B beta Glu397 and B beta Asp398 but not B beta Asp432 are required for "B:b" interactions. Biochemistry. 2004;43:2465-2474.
35. Collet JP, Woodhead JL, Soria J, et al. Fibrinogen Dusart: electron microscopy of molecules, fibers and clots, and viscoelastic properties of clots. Biophys J. 1996;70:500-510.
36. Koopman J, Haverkate F, Grimbergen J, et al. Molecular basis for fibrinogen Dusart (A alpha 554 Arg->Cys) and its association with abnormal fibrin polymerization and thrombophilia. J Clin Invest. 1993;91:1637-1643.
37. Ryan EA, Mockros LF, Weisel JW, Lorand L. Structural origins of fibrin clot rheology. Biophys J. 1999;77:2813-2826.
38. Weisel JW. The mechanical properties of fibrin for basic scientists and clinicians. Biophys Chem. 2004;112:267-276.
39. Marchi R, Mirshahi SS, Soria C, et al. Thrombotic dysfibrinogenemia: fibrinogen "Caracas V" relation between very tight fibrin network and defective clot degradability. Thromb Res. 2000;99:187-193.
40. Collet JP, Allali Y, Lesty C, et al. Altered fibrin architecture is associated with hypofibrinolysis and premature coronary atherothrombosis. Arterioscler Thromb Vasc Biol. 2006;26:2567-2573.
41. Scrutton MC, Ross-Murphy SB, Bennett GM, Stirling Y, Meade TW. Changes in clot deformability: a possible explanation for the epidemiological association between plasma fibrinogen concentration and myocardial infarction. Blood Coagul Fibrinolysis. 1994;5:719-723.