The Interplay of Familial Depression Liability and Adverse Events in Predicting the First Onset of Depression During a 10-Year Follow-up

Biological Psychiatry

Volumn 63, Issue 4, 2008, Pages 406-414

  Zimmermann, Petra ^a   Brückl, Tanja ^a   Lieb, Roselind ^a,c   Nocon, Agnes ^a   Ising, Marcus ^a   Beesdo, Katja ^b   Wittchen, Hans Ulrich ^a,b  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Biological synergism; depression; depression liability; gene environment interaction; trauma; vulnerability

Indexed keywords

ADOLESCENT; ADULT; ALGORITHM; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DEPRESSION; DISEASE ASSOCIATION; FAMILIAL DISEASE; FOLLOW UP; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; PREDICTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; PSYCHOTRAUMA; SEPARATION ANXIETY;

ADOLESCENT; ADULT; AGE OF ONSET; ANXIETY, SEPARATION; DEPRESSIVE DISORDER, MAJOR; ENVIRONMENT; FEMALE; FOLLOW-UP STUDIES; GENOTYPE; HUMANS; LIFE CHANGE EVENTS; LONGITUDINAL STUDIES; MALE; PROSPECTIVE STUDIES; QUESTIONNAIRES; RISK FACTORS; STRESS DISORDERS, POST-TRAUMATIC;

EID: 38349103678     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2007.05.020     Document Type: Article

References (58)

1. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., et al. Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science 301 (2003) 386-389
2. Gillespie N.A., Whitfield J.B., Williams B., Heath A.C., and Martin N.G. The relationship between stressful life events, the serotonin transporter (5-HTTLPR) genotype and major depression. Psychol Med 35 (2005) 101-111
3. Surtees P.G., Wainwright N.W., Willis-Owen S.A., Luben R., Day N.E., and Flint J. Social adversity, the serotonin transporter (5-HTTLPR) polymorphism and major depressive disorder. Biol Psychiatry 59 (2006) 224-229
4. Plomin R., Defries J.C., and Loehlin J.C. Genotype-environment interaction and correlation in analysis of human-behavior. Psychol Bull 84 (1977) 309-322
5. Rutter M., and Silberg J. Gene-environment interplay in relation to emotional and behavioral disturbance. Annu Rev Psychol 53 (2002) 463-490
6. Eaves L., Silberg J., and Erkanli A. Resolving multiple epigenetic pathways to adolescent depression. J Child Psychol Psychiatry 44 (2003) 1006-1014
7. Silberg J., Rutter M., Neale M., and Eaves L. Genetic moderation of environmental risk for depression and anxiety in adolescent girls. Br J Psychiatry 179 (2001) 116-121
8. Rice F., Harold G.T., Shelton K.H., and Thapar A. Family conflict interacts with genetic liability in predicting childhood and adolescent depression. J Am Acad Child Adolesc Psychiatry 45 (2006) 841-848
9. Kendler K.S., Kessler R.C., Neale M.C., Heath A.C., and Eaves L.J. The prediction of major depression in women: Toward an integrated etiologic model. Am J Psychiatry 150 (1993) 1139-1148
10. Kendler K.S., Kessler R.C., Walters E.E., Maclean C., Neale M.C., Heath A.C., et al. Stressful life events, genetic liability, and onset of an episode of major depression in women. Am J Psychiatry 152 (1995) 833-842
11. Foley D.L., Neale M.C., and Kendler K.S. A longitudinal study of stressful life events assessed at interview with an epidemiological sample of adult twins: The basis of individual variation in event exposure. Psychol Med 26 (1996) 1239-1252
12. Kendler K.S., and Karkowski-Shuman L. Stressful life events and genetic liability to major depression: Genetic control of exposure to the environment. Psychol Med 27 (1997) 539-547
13. Lyons M.J., Goldberg J., Eisen S.A., True W., Tsuang M.T., Meyer J.M., et al. Do genes influence exposure to trauma?. A twin study of combat. Am J Med Genet 48 (1993) 22-27
14. Plomin R., Pedersen N.L., Lichtenstein P., Mcclearn G.E., and Nesselroade J.R. Genetic influence on life events during the last half of the life-span. Psychol Aging 5 (1990) 25-30
15. Thapar A., and McGuffin P. Genetic influences on life events in childhood. Psychol Med 26 (1996) 813-820
16. Drieling T., van Calker D., and Hecht H. Stress, personality and depressive symptoms in a 6.5 year follow-up of subjects at familial risk for affective disorders and controls. J Affect Disord 91 (2006) 195-203
17. Hillegers M.H., Burger H., Wals M., Reichart C.G., Verhulst F.C., Nolen W.A., et al. Impact of stressful life events, familial loading and their interaction on the onset of mood disorders: Study in a high-risk cohort of adolescent offspring of parents with bipolar disorder. Br J Psychiatry 185 (2004) 97-101
18. McGuffin P., Katz R., and Bebbington P. The Camberwell Collaborative Depression Study. III. Depression and adversity in the relatives of depressed probands. Br J Psychiatry 152 (1988) 775-782
19. Pollit J. The relationship between genetic and precipitating factors in depressive illness. Br J Psychiatry 121 (1972) 67-70
20. Wals M., Hillegers M.H.J., Reichart C.G., Verhulst F.C., Nolen W.A., and Ormel J. Stressful life events and onset of mood disorders in children of bipolar parents during 14-month follow-up. J Affect Disord 87 (2005) 253-263
21. Farmer A., Harris T., Redman K., Sadler S., Mahmood A., and McGuffin P. Cardiff depression study. A sib-pair study of life events and familiality in major depression. Br J Psychiatry 176 (2000) 150-155
22. Farmer A.E., and McGuffin P. Humiliation, loss and other types of life events and difficulties: A comparison of depressed subjects, healthy controls and their siblings. Psychol Med 33 (2003) 1169-1175
23. Perris H., Vonknorring L., and Perris C. Genetic vulnerability for depression and life events. Neuropsychobiology 8 (1982) 241-247
24. Eley T.C., Liang H.L., Plomin R., Sham P., Sterne A., Williamson R., et al. Parental familial vulnerability, family environment, and their interactions as predictors of depressive symptoms in adolescents. J Am Acad Child Adolesc Psychiatry 43 (2004) 298-306
25. Fendrich M., Warner V., and Weissman M.M. Family risk-factors, parental depression, and psychopathology in offspring. Dev Psychol 26 (1990) 40-50
26. Hammen C., Shih J., Altman T., and Brennan P.A. Interpersonal impairment and the prediction of depressive symptoms in adolescent children of depressed and nondepressed mothers. J Am Acad Child Adolesc Psychiatry 42 (2003) 571-577
27. Hoffmann J.P., Baldwin S.A., and Cerbone F.G. Onset of major depressive disorder among adolescents. J Am Acad Child Adolesc Psychiatry 42 (2003) 217-224
28. Moffitt T.E., Caspi A., and Rutter M. Strategy for investigating interactions between measured genes and measured environments. Arch Gen Psychiatry 62 (2003) 473-481
29. Heim C., Plotsky P.M., and Nemeroff C.B. Importance of studying the contributions of early adverse experience to neurobiological findings in depression. Neuropsychopharmacology 29 (2004) 641-648
30. Kendler K.S., Kuhn J.W., and Prescott C.A. Childhood sexual abuse, stressful life events and risk for major depression in women. Psychol Med 34 (2004) 1475-1482
31. Lieb R., Isensee B., Sydow von K., and Wittchen H.U. The Early Developmental Stages of Psychopathology Study (EDSP): A methodological update. Eur Addict Res 6 (2000) 170-182
32. Wittchen H.U., Perkonigg A., Lachner G., and Nelson C.B. Early Developmental Stages of Psychopathology Study (EDSP): Objectives and design. Eur Addict Res 4 (1998) 18-27
33. Lachner G., and Wittchen H.U. Münchner Composite International Diagnostic Interview, M-CIDI (familiengenetische Version). Elternbefragung, Version 2.0 (1997), Max-Planck-Institut für Psychiatrie/Eigendruck, Munich
34. Lieb R., Isensee B., Hofler M., Pfister H., and Wittchen H.U. Parental major depression and the risk of depression and other mental disorders in offspring: A prospective-longitudinal community study. Arch Gen Psychiatry 59 (2002) 365-374
35. Wittchen H.U., and Pfister H. DIAXInterviews: Manual für ScreeningVerfahren und Interview; Interviewheft Längsschnittuntersuchung (DIAXLifetime); Ergänzungsheft (DIAXLifetime); Interviewheft Querschnittuntersuchung (DIAX12 Monate); Ergänzungsheft (DIAX12Monate); PCProgramm zur Durchführung des Interviews (Längs und Querschnittuntersuchung); Auswertungsprogramm (1997), Swets & Zeitlinger, Frankfurt, Germany
36. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. (1994), American Psychiatric Association, Washington, DC
37. Lachner G., Wittchen H.U., Perkonigg A., Holly A., Schuster P., Wunderlich U., et al. Structure, content and reliability of the Munich Composite International Diagnostic Interview (M-CIDI) substance use sections. Eur Addict Res 4 (1998) 28-41
38. Reed V., Gander F., Pfister H., Steiger A., Sonntag H., Trenkwalder C., et al. To what degree the Composite International Diagnostic Interview (CIDI) correctly identifies DSM-IV disorders?. Testing validity issues in a clinical sample. Int J Methods Psychiatr Res 7 (1998) 142-155
39. Wittchen H.U., Lachner G., Wunderlich U., and Pfister H. Test-retest reliability of the computerized DSM-IV version of the Munich Composite International Diagnostic Interview (M-CIDI). Soc Psychiatry Psychiatr Epidemiol 33 (1998) 568-578
40. Merikangas K.R., Stevens D.E., Fenton B., Stolar M., O'Malley S., Woods S.W., et al. Co-morbidity and familial aggregation of alcoholism and anxiety disorders. Psychol Med 28 (1998) 773-788
41. Darroch J. Biologic synergism and parallelism. Am J Epidemiol 145 (1997) 661-668
42. Henquet C., Krabbendam L., Spauwen J., Lieb R., Wittchen H.U., and van Os J. Biological synergism between cannabis use and psychosis liability in young people. Acta Psychiatr Scand 110 (2004) 53-54
43. van Os J., Pederson C.B., and Mortensen P.B. Confirmation of synergy between urbanicity and familial liability in the causation of psychosis. Am J Psychiatry 161 (2004) 2312-2314
44. Greenland S. Basic problems in interaction assessment. Environ Health Perspect 101 suppl 4 (1993) 59-66
45. Höfler M. Causal inference based on counterfactuals. BMC Med Res Methodol 5 (2005) 28
46. Rothman K.J., and Greenland S. Modern Epidemiology. 2nd ed. (1998), Lippincott Williams & Wilkins, Philadelphia
47. Joffe M.M., and Greenland S. Standardized estimates from categorical regression-models. Stat Med 14 (1995) 2131-2141
48. Thernau T.M., and Grambsch P.M. Modeling Survival Data: Extending the Cox Model (Statistics for Biology and Health) (2000), Springer, New York
49. StataCorp LP. Stata/SE 9.2 for Windows. [computer program] (2006), StataCorp, College Station, TX
50. Royall S. Model robust confidence intervals using maximum likelihood estimators. Int Stat Rev 54 (1993) 142-155
51. Kessler R.C. The effects of stressful life events on depression. Annu Rev Psychol 48 (1997) 191-214
52. Sullivan P.F., Neale M.C., and Kendler K.S. Genetic epidemiology of major depression: Review and meta-analysis. Am J Psychiatry 157 (2000) 1552-1562
53. Wachs T.D., and Plomin R. Conceptualization and Measurement of Organism-Environment Interaction (1991), American Psychological Association, Washington, DC
54. Kendler K.S., Karkowski L., and Prescott C.A. The assessment of dependence in the study of stressful life events: Validation using a twin design. Psychol Med 29 (1999) 1455-1460
55. Heim C., and Nemeroff C.B. The role of childhood trauma in the neurobiology of mood and anxiety disorders: Preclinical and clinical studies. Biol Psychiatry 49 (2001) 1023-1039
56. Heim C., and Nemeroff C.B. The impact of early adverse experiences on brain systems involved in the pathophysiology of anxiety and affective disorders. Biol Psychiatry 46 (1999) 1509-1522
57. Jacobs N., Kenis G., Peeters F., Derom C., Vlietinck R., and van Os J. Stress-related negative affectivity and genetically altered serotonin transporter function: Evidence of synergism in shaping risk of depression. Arch Gen Psychiatry 63 (2006) 989-996
58. Kendler K.S., Kuhn J.W., Vittum J., Prescott C.A., and Riley B. The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: A replication. Arch Gen Psychiatry 62 (2005) 529-535