메뉴 건너뛰기




Volumn 9, Issue 26, 2007, Pages 5505-5508

Allocolchicines via intramolecular Nicholas reactions: The synthesis of NSC 51046

Author keywords

[No Author keywords available]

Indexed keywords

COLCHICINE;

EID: 38349093038     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol7024422     Document Type: Article
Times cited : (45)

References (43)
  • 31
    • 0043160327 scopus 로고    scopus 로고
    • For the corresponding ethers, see:, and references therein
    • (k) For the corresponding ethers, see: Baba, T.; Huang, G.; Isobe, M. Tetrahedron 2003, 59, 6851 and references therein.
    • (2003) Tetrahedron , vol.59 , pp. 6851
    • Baba, T.1    Huang, G.2    Isobe, M.3
  • 32
    • 33847393177 scopus 로고    scopus 로고
    • For recent reviews on the Nicholas reaction, see: a
    • For recent reviews on the Nicholas reaction, see: (a) Diaz, D. D.; Betancort, J. M.; Martin, V. S. Synlett 2007, 343.
    • (2007) Synlett , pp. 343
    • Diaz, D.D.1    Betancort, J.M.2    Martin, V.S.3
  • 36
    • 0033515799 scopus 로고    scopus 로고
    • In this case, the major product was 7-methoxynaphtho[2,1-b]-thiophene (50% yield), consistent with vinyl carbene insertion into the thiophene C(2)-H bond. For related chemistry, see: (a) Imamura, K.; Hirayama, D.; Yoshimura, H.; Takimiya, K.: Aso, Y.; Otsubo, T. Tetrahedron Lett. 1999, 40, 2789.
    • In this case, the major product was 7-methoxynaphtho[2,1-b]-thiophene (50% yield), consistent with vinyl carbene insertion into the thiophene C(2)-H bond. For related chemistry, see: (a) Imamura, K.; Hirayama, D.; Yoshimura, H.; Takimiya, K.: Aso, Y.; Otsubo, T. Tetrahedron Lett. 1999, 40, 2789.
  • 38
    • 38349168027 scopus 로고    scopus 로고
    • Acetates were chosen over alcohol leaving groups due to their superiority in benzocycloheptenyne complex syntheses; see ref 7a
    • Acetates were chosen over alcohol leaving groups due to their superiority in benzocycloheptenyne complex syntheses; see ref 7a.
  • 39
    • 38349146048 scopus 로고    scopus 로고
    • 1H NMR spectrum, reflecting biaryl restricted rotation.
    • 1H NMR spectrum, reflecting biaryl restricted rotation.
  • 41
    • 0033655836 scopus 로고    scopus 로고
    • Both 10 and 11 themselves also have significant tubulin assembly inhibitory activity. See refs 1b,c and: (a) Polański, J. Acta Biochim. Pol. 2000, 47, 37.
    • Both 10 and 11 themselves also have significant tubulin assembly inhibitory activity. See refs 1b,c and: (a) Polański, J. Acta Biochim. Pol. 2000, 47, 37.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.