Pharmacokinetics of PC-SOD, a lecithinized recombinant superoxide dismutase, after single- and multiple-dose administration to healthy Japanese and Caucasian volunteers

Journal of Clinical Pharmacology

Volumn 48, Issue 2, 2008, Pages 184-192

  Suzuki, Jun ^a,d   Broeyer, Freerk ^b   Cohen, Adam ^b   Takebe, Masato ^c   Burggraaf, Jacobus ^b   Mizushima, Yutaka ^a,d  

^a LTT Bio Pharma Co Ltd   (Japan)

^b CENTRE FOR HUMAN DRUG RESEARCH   (Netherlands)

^c Association for Promoting Drug Development   (Japan)

^d JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Free radicals; Oxidative stress; PC SOD; Pharmacokinetics; Superoxide dismutase

Indexed keywords

FREE RADICAL; RECOMBINANT SUPEROXIDE DISMUTASE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ADULT; AREA UNDER THE CURVE; ARTICLE; BODY MASS; CAUCASIAN; CLINICAL TRIAL; COMPARTMENT MODEL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEMOGRAPHY; DIARRHEA; DISEASE COURSE; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE ESCALATION; DRUG DOSE INCREASE; DRUG HALF LIFE; DRUG SAFETY; FATIGUE; FEMALE; FOLLOW UP; HEADACHE; HUMAN; INFLUENZA; JAPANESE; MALE; MAXIMUM PLASMA CONCENTRATION; MYALGIA; NORMAL HUMAN; OUTCOME ASSESSMENT; OXIDATIVE STRESS; PAIN;

AREA UNDER CURVE; ASIAN CONTINENTAL ANCESTRY GROUP; COHORT STUDIES; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ENZYME-LINKED IMMUNOSORBENT ASSAY; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; HALF-LIFE; HUMANS; INJECTIONS, INTRAVENOUS; MALE; PHOSPHATIDYLCHOLINES; SINGLE-BLIND METHOD; SUPEROXIDE DISMUTASE; TIME FACTORS;

EID: 38349084809     PISSN: 00912700     EISSN: 15524604     Source Type: Journal    
DOI: 10.1177/0091270007309705     Document Type: Article

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