A Double-Blind, Placebo-Controlled Trial of Donepezil for the Treatment of Menopause-Related Cognitive Loss

Gender Medicine

Volumn 4, Issue 4, 2007, Pages 352-358

  Devi, Gayatri ^a,b,c   Massimi, Steve ^a   Schultz, Sarah ^a   Khosrowshahi, Lynn ^a   Laakso, Ulla K ^b  

^a New York Memory and Healthy Aging Services   (United States)

^b LENOX HILL HOSPITAL   (United States)

^c NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cognitive loss; donepezil; menopause; randomized control trial

Indexed keywords

DONEPEZIL; PLACEBO;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; COGNITIVE DEFECT; COMMUNITY LIVING; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG TOLERABILITY; DRUG WITHDRAWAL; FEMALE; HUMAN; MEMORY DISORDER; MENOPAUSE; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; VIVID DREAM;

CHOLINESTERASE INHIBITORS; COGNITION DISORDERS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INDANS; MEMORY DISORDERS; MENOPAUSE; MIDDLE AGED; PIPERIDINES; TREATMENT OUTCOME;

EID: 38349070737     PISSN: 15508579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1550-8579(07)80064-7     Document Type: Article

References (34)

1. Hogervorst E., Williams J., Budge M., et al. The nature of the effect of female gonadal hormone replacement therapy on cognitive function in post-menopausal women: A meta-analysis. Neuroscience 101 (2000) 485-512
2. Henderson VW. The neurology of menopause. Neurologist 12 (2006) 149-159
3. LeBlanc E., Neiss M., Carello P., et al. Hot flashes and estrogen therapy do not influence cognition in early menopausal women. Menopause 14 (2007) 191-202
4. Sherwin B. Estrogen effects on cognition in menopausal women. Neurology 48 Suppl 7 (1997) S21-S26
5. Genazzani A., Pluchino N., Luisi S., and Luisi M. Estrogen, cognition, and female ageing. Hum Reprod Update 13 (2006) 175-187
6. Devi G., Hahn K., Massimi S., and Zhivotovskaya E. Prevalence of memory loss complaints and other symptoms associated with the menopause transition: A community survey. Gend Med 2 (2005) 255-264
7. Tang M., Jacobs D., Stern Y., et al. Effect of oestro- gen during menopause on risk and age at onset of Alzheimer's disease. Lancet 348 (1996) 429-432
8. Shumaker S., Legault C., Kuller L., et al., for the Women's Health Initiative Memory Study. Conjugated equine estrogens and incidence of probable dementia and mild cognitive impair- ment in postmenopausal women: Women's Health Initiative Memory Study. JAMA 291 (2004) 2947-2958
9. Yaffe K., Sawaya G., Lieberburg I., and Grady D. Estrogen therapy in postmenopausal women: Effects on cognitive function and dementia. JAMA 279 (1998) 688-695
10. Yaffe K., Lui L., Grady D., et al. Cognitive decline in women in relation to non-protein-bound oestradiol concentrations. Lancet 356 (2000) 708-712
11. Barrett-Connor E., and Goodman-Gruen D. Cognitive function and endogenous sex hormones in older women. J Am Geriatr Soc 47 (1999) 1289-1293
12. Elsabagh S., Hartley D., and File SE. Cognitive function in late versus early postmenopausal stage. Maturitas 56 (2007) 84-93
13. Sherwin B. The critical period hypothesis: Can it explain discrepancies in the oestrogen-cognition literature?. J Neuroendocrinol 19 (2007) 77-81
14. Guay M., Dragomir A., Pilon D., et al. Changes in pattern of use, clinical characteristics and persistence rate of hormone replacement therapy among postmenopausal women after the WHI publication. Pharmacoepidemiol Drug Saf 16 (2007) 17-27
15. Albertazzi P. Noradrenergic and serotonergic modulation to treat vasomotor symptoms. J Br Menopause Soc 12 (2006) 7-11
16. Clayden J., Bell J., and Pollard P. Menopausal flushing: Double-blind trial of a non-hormonal medication. Br Med J 1 (1974) 409-412
17. Wurtman R., and Zhdanova I. Improvement of sleep quality by melatonin. Lancet 346 (1995) 1491
18. McEwen B., Alves S., Bulloch K., and Weiland N. Ovarian steroids and the brain Implications for cognition and aging. Neurology 48 Suppl 7 (1997) S8-S15
19. Reisberg B., Schneck M., Ferris S., et al. The Brief Cognitive Rating Scale (BCRS): Findings in primary degenerative dementia. Psychopharmacol Bull 19 (1983) 47-50
20. Kaplan H., Sadock B., and Hamilton M. The Hamilton Depression Rating Scale. In: Kaplan H., and Sadock B. (Eds). Comprehensive Textbook of Psychiatry. 5th (1989), Baltimore, Md: Williams & Wilkins 541
21. Sherwin B. Cognitive assessment for post-menopausal women and general assessment of their mental health. Psychopharmacol Bull 34 (1998) 323-326
22. Black S., Doody R., Li H., et al. Donepezil preserves cognition and global function in patients with severe Alzheimer disease. Neurology 69 (2007) 459-469
23. Barnes L., Schneider J., Boyle P., et al. Memory complaints are related to Alzheimer disease pathology in older persons. Neurology 67 (2006) 1581-1585
24. Lam L., Lui V., Tam C., and Chiu H. Subjective memory complaints in Chinese subjects with mild cognitive impairment and early Alzheimer's disease. Int J Geriatr Psychiatry 20 (2005) 876-882
25. Hersh A., Stefanick M., and Stafford R. National use of postmenopausal hormone therapy: Annual trends and response to recent evidence. JAMA 291 (2004) 47-53
26. Rossouw J., Anderson G., Prentice R., et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial. JAMA 288 (2002) 321-333
27. Huang C., Hong C., and Huang IT. Hormone replacement therapy and cognitive function [in Chinese]. Acta Neurol Taiwan 15 (2006) 273-277
28. Whitlock Jr. J. Brain injury, cognitive impairment, and donepezil. J Head Trauma Rehabil 14 (1999) 424-427
29. Christodoulou C., Melville P., Scherl W., et al. Effects of donepezil on memory and cognition in multiple sclerosis. J Neurol Sci 245 (2006) 127-136
30. Yesavage J., Mumenthaler M., Taylor J., et al. Donepezil and flight simulator performance: Effects on retention of complex skills. Neurology 59 (2002) 123-125
31. Furey M., Pietrini P., Haxby J., et al. Cholinergic stimulation alters performance and task-specific regional cerebral blood flow during working memory. Proc Natl Acad Sci U S A 94 (1997) 6512-6516
32. Furey M., Pietrini P., Alexander G., et al. Cholinergic enhancement improves performance on working memory by modulating the functional activity in distinct brain regions: A positron emission tomography regional cerebral blood flow study in healthy humans. Brain Res Bull 51 (2000) 213-218
33. Furey M., Pietrini P., and Haxby JV. Cholinergic enhancement and increased selectivity of perceptual processing during working memory. Science 290 (2000) 2315-2319
34. Hutchison C., Nathan P., Mrazek L., and Stough C. Cholinergic modulation of speed of early information processing: The effect of donepezil on inspection time. Psychopharmacology (Berl) 155 (2001) 440-442