Cholinergic enhancement improves performance on working memory by modulating the functional activity in distinct brain regions: A positron emission tomography regional cerebral blood flow study in healthy humans

Brain Research Bulletin

Volumn 51, Issue 3, 2000, Pages 213-218

  Furey, Maura L ^a   Pietrini, Pietro ^a,b   Alexander, Gene E ^a   Schapiro, Mark B ^a   Horwitz, Barry ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF PISA   (Italy)

Author keywords

Cognition; PET; Physostigmine; rCBF; Working memory

Indexed keywords

PHYSOSTIGMINE;

ADULT; ARTICLE; BRAIN BLOOD FLOW; BRAIN REGION; CHOLINERGIC ACTIVITY; CLINICAL TRIAL; COGNITION; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; TASK PERFORMANCE; WORKING MEMORY;

ADULT; AGED; BRAIN; BRAIN MAPPING; CEREBROVASCULAR CIRCULATION; CHOLINESTERASE INHIBITORS; FEMALE; HUMANS; MALE; MEMORY; MIDDLE AGED; PHYSOSTIGMINE; REACTION TIME; REFERENCE VALUES; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0033963841     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0361-9230(99)00219-1     Document Type: Article

References (35)

1. Asthana S., Greig N.H., Hegedus L., Holloway H.H., Raffaele K.C., Schapiro M.B., Soncrant T.T. Clinical pharmacokinetics of physostigmine in patients with Alzheimer's disease. Clin. Pharm. Ther. 58:(3):1995;299-309.
2. Baddeley A., Logie R., Bressi S., Della Sala S., Spinnler H. Dementia and working memory. Q. J. Exp. Psychol. 38A:1986;603-618.
3. Baddeley A.D., Bressi S., Della Sala S., Logie R., Spinnler H. The decline of working memory in Alzheimer's disease. Brain. 114:1991;2521-2542.
4. Buzsaki G., Ponomareff G.L., Bayardo F., Ruiz R., Gage F.H. Neuronal activity in the subcortically denervated hippocampus A chronic model for epilepsy . Neuroscience. 28:1989;527-538.
5. Carson R.E., Berg G.W., Finn R.D., Patlak C.S., Daube-Witherspoon M.E., Stein S.D., Simpson N.R., Green M.V., Larson S.M. Tomographic measurement of LCBF with high-resolution PET and H215O Comparison of methods . J. Cereb. Blood Flow Metab. 7:1987;S578.
6. Courtney S.M., Ungerleider L.G., Keil K., Haxby J.V. Object and spatial visual working memory activate separate neural systems in human cortex. Cereb. Cortex. 6:(1):1996;39-49.
7. Courtney S.M., Ungerleider L.G., Keil K., Haxby J.V. Transient and sustained activity in a distributed neural system for human working memory. Nature. 386:1997;608-611.
8. Everitt B.J., Robbins T.W. Central cholinergic systems and cognition. Annu. Rev. Psychol. 48:1997;649-684.
9. Friston K.J., Holmes A.P., Worsley K.J., Poline J.-B., Frith C.D., Frackowiak R.S.J. Statistical parametric maps in functional imaging A general linear approach . Hum. Brain Mapp. 2:1995;189-210.
10. Furey M.L., Pietrini P., Haxby J.V., Alexander G.E., Lee H.C., VanMeter J., Grady C.L., Shetty U., Rapoport S.I., Schapiro M.B., Freo U. Cholinergic stimulation alters performance and task-specific regional cerebral blood flow during working memory. Proc. Nat. Acad. Sci. U.S.A. 94:1997;6512-6516.
11. Furey M.L., Pietrini P., VanMeter J., Lee H.C., Alexander G.E., Grady C.L., Dani A., Rapoport S.I., Schapiro M.B., Freo U. Pharmacokinetic and pharmacodynamic effects of physostigmine Implications for brain imaging studies . Soc. Neurosci. Abstr. 21:1995;275.
12. Geaney D.P., Soper N., Shepstone B.J., Cowen P.J. Effect of central cholinergic stimulation on regional cerebral blood flow in Alzheimer disease. Lancet. 335:1990;1484-1487.
13. Glasky A.J., Melchior C.L., Pirzadeh B., Heydari N., Ritsmann R.F. Effect of AIT-082, a purine analog, on working memory in normal and aged mice. Pharmacol. Biochem. Behav. 47:(2):1994;325-329.
14. Haxby J.V., Ungerleider L.G., Horwitz B., Rapoport S.I., Grady C.L. Hemispheric differences in neural systems for face working memory A PET rCBF study . Hum. Brain Mapp. 3:1995;68-82.
15. Horwitz B. Data analysis paradigms for metabolic-flow data Combining neural modeling and functional neuroimaging . Hum. Brain Mapp. 2:1994;112-122.
16. Ingles J.L., Beninger R.J., Jhamandas K., Boegman R.J. Scopolamine injected into the rat amygdala impairs working memory in the double Y-maze. Brain Res. Bull. 32:(4):1993;339-344.
17. Kitajima I., Yamamoto T., Ohno M., Ueki S. Working and reference memory in rats in the three-panel runway task following dorsal hippocampal lesions. Jpn. J. Pharmacol. 58:(2):1992;175-183.
18. Levy A., Brandeis R., Treves T.A., Meshulam Y., Mawassi F., Feiler D., Wengier A., Glikfeld P., Grunwald J., Dachir S. Transdermal physostigmine in the treatment of Alzheimer's disease. Alzheimer Dis. Assoc. Disord. 8:(1):1994;15-21.
19. Li Y.J., Simon J.R., Low W.C. Intrahippocampal grafts of cholinergic-rich striatal tissue ameliorate spatial memory deficits in rats with fornix lesions. Brain Res. Bull. 29:(2):1992;147-155.
20. Mallet P.E., Beninger R.J., Flesher S.N., Jhamandas B., Boegman R.J. Nucleus basalis lesions Implications of basoanygdaloid cholinergic pathways in memory . Brain Res. Bull. 36:1995;51-56.
21. McIntosh A.R., Grady C.L., Haxby J.V., Ungerleider L.G., Horwitz B. Changes in limbic and prefrontal functional interactions in a working memory task for faces. Cereb. Cortex. 6:1996;571-584.
22. Mirakhur R.K., Dundee J.W., Clarke R.S. Glycopyrrolate-neostigmine mixture for antagonism of neuromuscular block Comparison with atropine-neostigmine mixture . Br. J. Anaesth. 49:1977;825-829.
23. Muir J.L., Dunnett S.B., Robbins T.W., Everitt B.J. Attentional functions of the forebrain cholinergic systems Effects of intraventricular hemicholinium, physostigmine, basal forebrain lesions and intracortical grafts on a multiple-choice serial reaction time task . Exp. Brain Res. 89:1992;611-622.
24. Muir J.L., Everitt B.J., Robbins T.W. AMPA-induced excitotoxic lesions of the basal forebrain A significant role for the cortical cholinergic system in attentional function . J. Neurosci. 14:1994;2313-2326.
25. Muir J.L., Everitt B.J., Robbins T.W. Reversal of visual attentional dysfunction following lesions of the cholinergic basal forebrain by physostigmine and nicotine but not by the 5-HT3 receptor antagonist, ondansetron. Psychopharmacology. 118:1995;82-92.
26. Odouro K.A. Glycopyrrolate methobromide 2. Comparison with atropine sulphate in anaesthesia . Can. Anaesth. Soc. J. 22:1975;466-473.
27. Olton D.S., Becker J.T., Handelmann J.E. Hippocampus, space and memory. Behav. Brain Sci. 2:1979;313-365.
28. Pang K., Williams M.J., Egeth H., Olton D.S. Nucleus basalis magnocellularis and attention Effects of muscimol infusions . Behav. Neurosci. 107:1993;1031-1038.
29. Raffaele K.C., Olton D.S. Hippocampal and amygdaloid involvement in working memory for nonspatial stimuli. Behav. Neurosci. 102:(3):1988;349-355.
30. Rawlins J.N.P., Olton D.S. The septohippocampal system and cognitive mapping. Behav. Brain Res. 5:1982;331-358.
31. Rothblat L.A., Kromer L.F. Object recognition memory in the rat The role of the hippocampus . Behav. Brain Res. 42:1991;25-32.
32. Rusted J.M. Dissociative effects of scopolamine on working memory in healthy young volunteers. Psychopharmacology. 96:(4):1988;487-492.
33. Sano M., Bell K., Marder K., Stricks L., Stern Y., Mayeux R. Safety and efficacy of oral physostigmine in the treatment of Alzheimer disease. Clin. Neuropharmacol. 16:(1):1993;61-69.
34. Talairach J., Tournoux P. Co-planar stereotaxic atlas of the human brain. 1988;Thieme, New York.
35. Terry A.V., Jackson W.J., Buccafusco J.J. Effects of concomitant cholinergic and adrenergic stimulation on learning and memory performance by young and aged monkeys. Cereb. Cortex. 3:(4):1993;304-312.