Aging dilates atrium and pulmonary veins: Implications for the genesis of atrial fibrillation

Chest

Volumn 133, Issue 1, 2008, Pages 190-196

  Pan, Nan Hung ^a   Tsao, Hsuan Ming ^b   Chang, Nen ^a   Chen, Yi Jen ^a,d   Chen, Shih Ann ^c  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Atrial fibrillation; Multidetector CT; Pulmonary vein

Indexed keywords

ADULT; AGE DISTRIBUTION; AGED; AGING; ARTICLE; CORRELATION ANALYSIS; FEMALE; HEART ATRIUM FIBRILLATION; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIDETECTOR COMPUTED TOMOGRAPHY; PATHOGENESIS; PRIORITY JOURNAL; PULMONARY VEIN; VEIN DIAMETER;

EID: 38349059865     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.07-1769     Document Type: Article

References (31)

1. Krahn AD, Manfreda J, Tate RB, et al. The natural history of atrial fibrillation: incidence, risk factors, and prognosis in the Manitoba Follow-up Study. Am J Med 1995; 98:476-484
2. Psaty BM, Manolio TA, Kuller LH, et al. Incidence of and risk factors for atrial fibrillation in older adults. Circulation 1997; 96:2455-2461
3. Furberg CD, Psaty BM, Manolio TA, et al. Prevalence of atrial fibrillation in elderly subjects (the Cardiovascular Health Study). Am J Cardiol 1994; 74:236-241
4. Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stoke: the Framingham Study. Stroke 1991; 22:983-988
5. Chen CH, Nakayama M, Nevo E, et al. Coupled systolic-ventricular and vascular stiffening with age: implications for pressure regulation and cardiac reserve in the elderly. J Am Coll Cardiol 1998; 32:1221-1227
6. Terman A, Brunk UT. The aging myocardium: roles of mitochondrial damage and lysosomal degradation. Heart Lung Circ 2005; 14:107-114
7. Brunk UT, Terman A. Lipofuscin: mechanisms of age-related accumulation and influence on cell functions. Free Radic Biol Med 2002; 33:611-619
8. Wongcharoen W, Chen YC, Chen YJ, et al. Effects of aging and ouabain on left atrial arrhythmogenicity. J Cardiovasc Electrophysiol 2007; 18:526-531
9. Chen SA, Hsieh MH, Tai CT, et al. Initiation of atrial fibrillation by ectopic beats originating from the pulmonary veins: electrophysiological characteristics, pharmacological responses, and effects of radiofrequeney ablation. Circulation 1999; 100:1879-1886
10. Tsao HM, Wu MH, Huang BH, et al. Morphologic remodeling of pulmonary veins and left atrium after catheter ablation of atrial fibrillation: insight from long-term follow-up of three-dimensional magnetic resonance imaging. J Cardiovasc Electrophvsiol 2005; 16:7-12
11. Nieman K, Cademartiri F, Lemos PA, et al. Reliable noninvasive coronary angiography with fast submillimeter multislice spiral computed tomography. Circulation 2002; 106:2051-2054
12. Mollet NR, Cademartiri F, Nieman K, et al. Multislice spiral computed tomography coronary angiography in patients with stable angina pectoris. J Am Coll Cardiol 2004; 43:2265-2270
13. Mollet NR, Cademartiri F, Nieman K, et al. Noninvasive assessment of coronary plaque burden using multislice computed tomography. Am J Cardiol 2005; 95:1165-1169
14. Ropers D, Baum U, Pohle K, et al. Detection of coronary artery stenoses with thin-slice multi-detector row spiral computed tomography and multiplanar reconstruction. Circulation 2003; 107:664-666
15. Schwartzman D, Lacomis J, Wigginton WG. Characterization of left atrium and distal pulmonary vein morphology using multidimensional computed tomography. J Am Coll Cardiol 2003; 41:1349-1357
16. Huonker M, Schmidt-Trucksass A, Heiss HW, et al. Effects of physical training and age-induced structural and functional changes in cardiovascular system and skeletal muscles. Z Gerontol Geriatr 2002; 35:151-156
17. Gardin JM, Henry WL, Savage DD, et al. Echocardiographic measurements in normal subjects: evaluation of an adult population without clinically apparent heart disease. J Clin Ultrasound 1979; 7:439-447
18. Feinberg WM, Blackshear JL, Laupacis A, et al. Prevalence, age distribution, and gender of patients with atrial fibrillation: analysis and implications. Arch Intern Med 1995; 155:469-473
19. Lloyd-Jones DM, Wang TJ, Leip EP, et al. Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation 2004; 110:1042-1046
20. Wongcharoen W, Chen YC, Chen YJ, et al. Aging increases pulmonary veins arrhythmogenesis and susceptibility to calcium regulation agents. Heart Rhythm 2007; 4:1338-1349
21. Gardin JM, Arnold A, Gottdiener JS, et al. Left ventricular mass in the elderly: the Cardiovascular Health Study. Hypertension 1997; 29:1095-1103
22. Hundley WG, Kitzman DW, Morgan TM, et al. Cardiac cycle-dependent changes in aortic area and distensibility are reduced in older patients with isolated diastolic heart failure and correlate with exercise intolerance. J Am Coll Cardiol 2001; 38:796-802
23. Vaziri SM, Larson MG, Lauer MS, et al. Influence of blood pressure on left atrial size: the Framingham Heart Study. Hypertension 1995; 25:1155-1160
24. Chae CU, Pfeffer MA, Glynn RJ, et al. Increased pulse pressure and risk of heart failure in the elderly. JAMA 1999; 281:634-639
25. Vasan RS, Larson MG, Benjamin EJ, et al. Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction: prevalence and mortality in a population-based cohort. J Am Coll Cardiol 1999; 33:1948-1955
26. Kitzman DW. Diastolic dysfunction in the elderly: genesis and diagnostic and therapeutic implications. Cardiol Clin 2000; 18:597-617
27. Tsang TS, Gersh BJ, Appleton CP, et al. Left ventricular diastolic dysfunction as a predictor of the first diagnosed nonvalvular atrial fibrillation in 840 elderly men and women. J Am Coll Cardiol 2002; 40:1636-1644
28. Festa A, D'Agostino R Jr, Howard G, et al. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 2000; 102:42-47
29. Najjar SS, Scuteri A, Lakatta EG. Arterial aging: is it an immutable cardiovascular risk factor? Hypertension 2005; 46:454-462
30. Huang JL, Tai CT, Lin YJ, et al. The mechanisms of an increased dominant frequency in the left atrial posterior wall during atrial fibrillation in acute atrial dilatation. J Cardiovasc Electrophysiol 2006; 17:178-188
31. Kalifa J, Tanaka K, Zaitsev AV, et al. Mechanisms of wave fractionation at boundaries of high-frequency excitation in the posterior left atrium of the isolated sheep heart during atrial fibrillation. Circulation 2006; 113:626-633