Structural analysis of the carboxy terminal PH domain of pleckstrin bound to D-myo-inositol 1,2,3,5,6-pentakisphosphate

BMC Structural Biology

Volumn 7, Issue , 2007, Pages

  Jackson, Sean G ^a   Zhang, Yi ^a   Haslam, Richard J ^a   Junop, Murray S ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRO MYO INOSITOL 1,2,3,5,6 PENTAKISPHOSPHATE; INOSITOL PHOSPHATE; PLECKSTRIN; UNCLASSIFIED DRUG; INOSITOL PENTAKISPHOSPHATE; LIGAND; PHOSPHOPROTEIN; PLASMA PROTEIN; PLATELET PROTEIN P47;

ARTICLE; BINDING SITE; CHEMICAL INTERACTION; CRYSTAL STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PROTEIN BINDING; STRUCTURE ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM;

BLOOD PROTEINS; INOSITOL PHOSPHATES; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHOPROTEINS;

EID: 38349049373     PISSN: None     EISSN: 14726807     Source Type: Journal    
DOI: 10.1186/1472-6807-7-80     Document Type: Article

References (44)

1. Pleckstrin inhibits phosphoinositide hydrolysis initiated by G-protein-coupled and growth factor receptors. A role for pleckstrin's PH domains. CS Abrams H Wu W Zhao E Belmonte D White LF Brass, J Biol Chem 1995 270 24 14485 14492 10.1074/jbc.270.24.14485 7782310
2. Phosphopleckstrin inhibits gbetagamma-activable platelet phosphatidylinositol-4,5-bisphosphate 3-kinase. CS Abrams J Zhang CP Downes X Tang W Zhao SE Rittenhouse, J Biol Chem 1996 271 41 25192 25197 10.1074/jbc.271.41.25192 8810277
3. Phosphorylation of platelet pleckstrin activates inositol polyphosphate 5-phosphatase I. V Auethavekiat CS Abrams PW Majerus, J Biol Chem 1997 272 3 1786 1790 10.1074/jbc.272.3.1786 8999861
4. Pleckstrin associates with plasma membranes and induces the formation of membrane projections: requirements for phosphorylation and the NH2-terminal PH domain. AD Ma LF Brass CS Abrams, J Cell Biol 1997 136 5 1071 1079 10.1083/jcb.136.5.1071 9060471
5. Pleckstrin induces cytoskeletal reorganization via a Rac-dependent pathway. AD Ma CS Abrams, J Biol Chem 1999 274 40 28730 28735 10.1074/jbc.274.40.28730 10497244
6. Phosphorylated pleckstrin induces cell spreading via an integrin-dependent pathway. RL Roll EM Bauman JS Bennett CS Abrams, J Cell Biol 2000 150 6 1461 1466 10.1083/jcb.150.6.1461 10995449
7. Molecular cloning and expression of the major protein kinase C substrate of platelets. M Tyers RA Rachubinski MI Stewart AM Varrichio RG Shorr RJ Haslam CB Harley, Nature 1988 333 6172 470 473 10.1038/333470a0 2897630
8. Molecular analysis of pleckstrin: the major protein kinase C substrate of platelets. M Tyers RJ Haslam RA Rachubinski CB Harley, J Cell Biochem 1989 40 2 133 145 10.1002/jcb.240400202 2768345
9. Pleckstrin domain homology. RJ Haslam HB Koide BA Hemmings, Nature 1993 363 6427 309 310 10.1038/363309b0 8497315
10. A putative modular domain present in diverse signaling proteins. BJ Mayer R Ren KL Clark D Baltimore, Cell 1993 73 4 629 630 10.1016/0092-8674(93)90244-K 8500161
11. SMART 5: domains in the context of genomes and networks. I Letunic RR Copley B Pils S Pinkert J Schultz P Bork, Nucleic Acids Res 2006 34 Database D257 60 16381859 10.1093/nar/gkj079
12. Pleckstrin homology domains : not just for phosphoinositides. MA Lemmon, Biochem Soc Trans 2004 32 Pt 5 707 711 15493994
13. Membrane targeting by pleckstrin homology domains. GE Cozier J Carlton D Bouyoucef PJ Cullen, Curr Top Microbiol Immunol 2004 282 49 88 14594214
14. Crystal structure of Rac1 bound to its effector phospholipase C-beta2. MR Jezyk JT Snyder S Gershberg DK Worthylake TK Harden J Sondek, Nat Struct Mol Biol 2006 13 12 1135 1140 10.1038/nsmb1175 17115053
15. Crystal structure of the DH/PH fragment of Dbs without bound GTPase. DK Worthylake KL Rossman J Sondek, Structure 2004 12 6 1078 1086 10.1016/j.str.2004.03.021 15274927
16. PH domain of ELMO functions in trans to regulate Rac activation via Dock180. M Lu JM Kinchen KL Rossman C Grimsley C deBakker E Brugnera AC Tosello-Trampont LB Haney D Klingele J Sondek MO Hengartner KS Ravichandran, Nat Struct Mol Biol 2004 11 8 756 762 10.1038/nsmb800 15247908
17. Multiple roles of pleckstrin homology domains in phospholipase Cbeta function. F Philip Y Guo S Scarlata, FEBS Lett 2002 531 1 28 32 10.1016/S0014-5793(02)03411-7 12401198
18. Structure and phosphatidylinositol-(3,4)-bisphosphate binding of the C-terminal PH domain of human pleckstrin. C Edlich G Stier B Simon M Sattler C Muhle-Goll, Structure 2005 13 2 277 286 10.1016/j.str.2004.11.012 15698571
19. Studies of the functions of pleckstrin in blood platelets : interactions of pleckstrin with phospholipids and soluble platelet proteins. Y Zhang, PhD Thesis McMaster University, Department of Medical Sciences 2005
20. Structure of the carboxy-terminal PH domain of pleckstrin at 2.1 Angstroms. SG Jackson Y Zhang X Bao K Zhang R Summerfield RJ Haslam MS Junop, Acta Crystallogr D Biol Crystallogr 2006 62 Pt 3 324 330 10.1107/ S0907444905043179 16510979
21. Structural analysis of the binding of myo-inositol pentakisphosphates by the C-terminal PH domain of pleckstrin. SG Jackson Y Zhang K Zhang X Bao C Schultz R Haslam M Junop, FASEB J 2007 21 5 A629-a
22. Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. KM Ferguson JM Kavran VG Sankaran E Fournier SJ Isakoff EY Skolnik MA Lemmon, Mol Cell 2000 6 2 373 384 10.1016/S1097-2765(00)00037-X 10983984
23. X-linked agammaglobulinemia and other immunoglobulin deficiencies. CI Smith KB Islam I Vorechovsky O Olerup E Wallin H Rabbani B Baskin L Hammarstrom, Immunol Rev 1994 138 159 183 10.1111/j.1600-065X.1994.tb00851.x 8070814
24. Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate. E Baraldi KD Carugo M Hyvonen PL Surdo AM Riley BV Potter R O'Brien JE Ladbury M Saraste, Structure 1999 7 4 449 460 10.1016/S0969-2126(99)80057-4 10196129
25. Inositol trisphosphate and calcium signalling. MJ Berridge, Nature 1993 361 6410 315 325 10.1038/361315a0 8381210
26. An expanded view of inositol signaling. JD York S Guo AR Odom BD Spiegelberg LE Stolz, Adv Enzyme Regul 2001 41 57 71 10.1016/S0065-2571(00) 00025-X 11384737
27. Back in the water: the return of the inositol phosphates. RF Irvine MJ Schell, Nat Rev Mol Cell Biol 2001 2 5 327 338 10.1038/35073015 11331907
28. A novel metal-dye detection system permits picomolar-range h.p.l.c. analysis of inositol polyphosphates from non-radioactively labelled cell or tissue specimens. GW Mayr, Biochem J 1988 254 2 585 591 3178774
29. myo-inositol pentakisphosphates. Structure, biological occurrence and phosphorylation to myo-inositol hexakisphosphate. LR Stephens PT Hawkins AF Stanley T Moore DR Poyner PJ Morris MR Hanley RR Kay RF Irvine, Biochem J 1991 275 Pt 2 485 499 1850990
30. Metabolism of inositol phosphates. SB Shears, Adv Second Messenger Phosphoprotein Res 1992 26 63 92 1329895
31. Multiple isomers of inositol pentakisphosphate in Epstein-Barr-virus- transformed (T5-1) B-lymphocytes. Identification of inositol 1,3,4,5,6-pentakisphosphate, D-inositol 1,2,4,5,6-pentakisphosphate and L-inositol 1,2,4,5,6-pentakisphosphate. FM McConnell LR Stephens SB Shears, Biochem J 1991 280 Pt 2 323 329 1660712
32. Modulation of ATP-dependent chromatin-remodeling complexes by inositol polyphosphates. X Shen H Xiao R Ranallo WH Wu C Wu, Science 2003 299 5603 112 114 10.1126/science.1078068 12434013
33. Regulation of chromatin remodeling by inositol polyphosphates. DJ Steger ES Haswell AL Miller SR Wente EK O'Shea, Science 2003 299 5603 114 116 12434012 10.1126/science.1078062
34. A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host cell actin cytoskeleton rearrangements and bacterial internalization. D Zhou LM Chen L Hernandez SB Shears JE Galan, Mol Microbiol 2001 39 2 248 259 10.1046/j.1365-2958.2001.02230.x 11136447
35. Pathogenicity of Salmonella: SopE-mediated membrane ruffling is independent of inositol phosphate signals. S Deleu K Choi JM Reece SB Shears, FEBS Lett 2006 580 7 1709 1715 16500648 10.1016/j.febslet.2006.02.019
36. Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway. E Piccolo S Vignati T Maffucci PF Innominato AM Riley BV Potter PP Pandolfi M Broggini S Iacobelli P Innocenti M Falasca, Oncogene 2004 23 9 1754 1765 10.1038/sj.onc.1207296 14755253
37. Inhibition of the phosphatidylinositol 3-kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects. T Maffucci E Piccolo A Cumashi M Iezzi AM Riley A Saiardi HY Godage C Rossi M Broggini S Iacobelli BV Potter P Innocenti M Falasca, Cancer Res 2005 65 18 8339 8349 10.1158/0008-5472.CAN-05-0121 16166311
38. Inositol pyrophosphates mediate chemotaxis in Dictyostelium via pleckstrin homology domain-PtdIns(3,4,5)P3 interactions. HR Luo YE Huang JC Chen A Saiardi M Iijima K Ye Y Huang E Nagata P Devreotes SH Snyder, Cell 2003 114 5 559 572 10.1016/S0092-8674(03)00640-8 13678580
39. Processing of X-ray Diffraction Data Collected in Oscillation Mode. Z Otwinowski W Minor, Methods in Enzymology 1997 276 Macromolecular Crystallography, part A 307 326
40. MOLREP: an automated program for molecular replacement. A Vagin A Teplyakov, J Appl Cryst 1997 30 1022 1025 10.1107/S0021889897006766
41. Coot: model-building tools for molecular graphics. P Emsley K Cowtan, Acta Crystallogr D Biol Crystallogr 2004 60 Pt 12 Pt 1 2126 2132 10.1107/S0907444904019158 15572765
42. The CCP4 suite : programs for protein crystallography. Collaborative Computational Project, Number 4, Acta Crystallogr D Biol Crystallogr 1994 50 Pt 5 760 763 10.1107/S0907444994003112 15299374
43. Refinement of macromolecular structures by the maximum-likelihood method. GN Murshudov AA Vagin EJ Dodson, Acta Crystallogr D Biol Crystallogr 1997 53 Pt 3 240 255 10.1107/S0907444996012255 15299926
44. The PyMOL Molecular Graphics System. http://www.pymol.org