Gene expression profiling of hypothalamic hamartomas: A search for genes associated with central precocious puberty

Hormone Research

Volumn 69, Issue 2, 2008, Pages 114-123

  Parent, Anne Simone ^a   Matagne, Valerie ^a   Westphal, Manfred ^b   Heger, Sabine ^a   Ojeda, Sergio ^a   Jung, Heike ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

DNA arrays; Gene expression; Hypothalamic hamartoma; Precocious puberty; Seizures

Indexed keywords

G PROTEIN COUPLED RECEPTOR 54; GONADORELIN; METABOTROPIC RECEPTOR 1; METASTIN; PROTEIN TSG 6; PROTEIN VILIP 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR IA 1; TRANSCRIPTION FACTOR MEF2A; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VISININ;

ADOLESCENT; ADULT; ARTICLE; CELL ADHESION; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE EXPRESSION; GENE IDENTIFICATION; HAMARTOMA; HUMAN; HYPOTHALAMIC HAMARTOMA; HYPOTHALAMUS; MALE; MONKEY; NONHUMAN; NUCLEOTIDE SEQUENCE; ONTOGENY; POLYMERASE CHAIN REACTION; PRECOCIOUS PUBERTY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEIZURE; SURGICAL TECHNIQUE; TRANSCRIPTION REGULATION;

ADOLESCENT; ADULT; ANIMALS; CELL ADHESION MOLECULES; CHILD; CHILD, PRESCHOOL; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION PROFILING; GONADOTROPIN-RELEASING HORMONE; HAMARTOMA; HUMANS; HYPOTHALAMIC DISEASES; MACACA MULATTA; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PUBERTY, PRECOCIOUS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, METABOTROPIC GLUTAMATE; REPRESSOR PROTEINS; SEXUAL MATURATION; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR SUPPRESSOR PROTEINS;

EID: 38349031319     PISSN: 03010163     EISSN: None     Source Type: Journal    
DOI: 10.1159/000111815     Document Type: Article

References (39)

1. Ojeda SR, Terasawa E: Neuroendocrine regulation of puberty;in Pfaff D, Arnold A, Etgen A, Fahrbach S, Moss R, Rubin R (eds): Hormones, Brain and Behavior. New York, Elsevier, 2002, vol 4, pp 589-659.
2. Dungan HM, Clifton DK, Steiner RA: Minireview: kisspeptin neurons as central processors in the regulation of gonadotropin-releasing hormone secretion. Endocrinology 2006;147:1154-1158.
3. de Roux N, Genin E, Carel J-C, Matsuda F, Chaussain J-L, Milgrom E: Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci USA 2003;100:10972-10976.
4. Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno JS Jr, Shagoury JK, Bo-Abbas Y, Kuohung W, Schwinof KM, Hendrick AG, Zahn D, Dixon J, Kaiser UB, Slaugenhaupt SA, Gusella JF, O'Rahilly S, Carlton MB, Crowley WF Jr, Aparicio SA, Colledge WH: The GPR54 gene as a regulator of puberty. N Engl J Med 2003;349:1614-1627.
5. Jung H, Parent AS, Ojeda SR: Hypothalamic hamartoma: a paradigm/model for studying the onset of puberty; in Delemarre-van de Waal HA (ed): Abnormalities in Puberty. Scientific and Clinical Advances. Endocr Dev. Basel, Karger, 2005, pp 81-93.
6. Zuniga OF, Tanner SM, Wild WO, Mosier HD Jr: Hamartoma of CNS associated with precocious puberty. Am J Dis Child 1983;137:127-133.
7. Dammann O, Commentz JC, Valdueza JM, Christante L, Bentele KH: Gelastic epilepsy and precocious puberty in hamartoma of the hypothalamus. Klin Pädiatr 1991;203:439-447.
8. Watanabe G, Terasawa E: In vivo release of luteinizing hormone releasing hormone increases with puberty in the female rhesus monkey. Endocrinology 1989;125:92-99.
9. Hussein D, Taylor SS: Farnesylation of Cenp-F is required for G2/M progression and degradation after mitosis. J Cell Sci 2002;115:3403-3414.
10. Korkolopoulou P, Patsouris E, Konstantinidou AE, Christodoulou P, Thomas-Tsagli E, Kouzelis K, Angelidakis D, Rologis D, Davaris P: Mitosin and DNA topoisomerase IIalpha: two novel proliferation markers in the prognostication of diffuse astrocytoma patient survival. Appl Immunohistochem Mol Morphol 2001;9:207-214.
11. Breslin MB, Zhu M, Lan MS: NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system. J Biol Chem 2003;278:38991-38997.
12. Heidenreich KA, Linseman DA: Myocyte enhancer factor-2 transcription factors in neuronal differentiation and survival. Mol Neurobiol 2004;29:155-166.
13. Bortolotto ZA, Fitzjohn SM, Collingridge GL: Roles of metabotropic glutamate receptors in LTP and LTD in the hippocampus. Curr Opin Neurobiol 1999;9:299-304.
14. Braunewell K-H, Gundelfinger ED: Intracellular neuronal calcium sensor proteins: a family of EF-hand calcium-binding proteins in search of a function. Cell Tissue Res 1999;295:1-12.
15. Wisniewski HG, Vilcek J: Cytokine-induced gene expression at the crossroads of innate immunity, inflammation and fertility: TSG-6 and PTX3/TSG-14. Cytokine Growth Factor Rev 2004;15:129-146.
16. Culler FL, James HE, Simon ML, Jones KL: Identification of gonadotropin-releasing hormone in neurons of a hypothalamic hamartoma in a boy with precocious puberty. Neurosurgery 1985;17:408-412.
17. Jung H, Carmel P, Schwartz MS, Witkin JW, Bentele KHP, Westphal M, Piatt JH, Costa ME, Cornea A, Ma YJ, Ojeda SR: Some hypothalamic hamartomas contain transforming growth factor alpha, a puberty-inducing growth factor, but not luteinizing hormone-releasing hormone neurons. J Clin Endocrinol Metab 1999;84:4695-4701.
18. Plant TM, Witchel SF: Puberty in nonhuman primates and humans; in Neill JD (ed): The Physiology of Reproduction, ed 3. San Diego, Academic Press/Elsevier, 2006, pp 2177-2230.
19. Rowe JD, Nieves E, Listowsky I: Subunit diversity and tissue distribution of human glutathione S-transferases: interpretations based on electrospray ionization-MS and peptide sequence-specific antisera. Biochem J 1997;325:481-486.
20. Mungenast AE, Parent A, Chen SS, Goodlett D, Aebersold R, Corfas G, Ojeda SR: The synaptic adhesion molecule SynCAM is associated with ERBB4 dysregulation in the hypothalamus of mice with a delayed onset of puberty. Program No 281 20, 2003 Abstract Viewer. Washington, Society for Neuroscience, 2003 Online.
21. Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M: Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature 2001;411:613-617.
22. Flavell SW, Cowan CW, Kim TK, Greer PL, Lin Y, Paradis S, Griffith EC, Hu LS, Chen C, Greenberg ME: Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number. Science 2006;311:1008-1012.
23. Mahloogi H, Gonzáles-Guerrico AM, Lopez De Cicco R, Bassi ED, Goodrow T, Braunewell K-H, Klein-Szanto JP: Overexpression of the calcium sensor visinin-like protein-1 leads to a cAMP-mediated decrease of in vivo and in vitro growth and invasiveness of squamous cell carcinoma cells. Cancer Res 2003;63:4997-5004.
24. Katoh M, Katoh M: FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products. Int J Oncol 2003;22:1375-1381.
25. Seidita G, Polizzi D, Costanzo G, Costa S, Di Leonardo A: Differential gene expression in p53-mediated G1 arrest of human fibroblasts after γ-irradiation or N-phosphoacetyl-L-aspartate treatment. Carcinogenesis 2000;21:2203-2210.
26. Kubota K, Kim JY, Sawada A, Tokimasa S, Fujisaki H, Matsuda-Hashii Y, Ozono K, Hara J: LRRC8 involved in B cell development belongs to a novel family of leucinerich repeat proteins. FEBS Lett 2004;564:147-152.
27. Harry JB, Kobrinsky E, Abernethy DR, Soldatov NM: New short splice variants of the human cardiac Cavbeta2 subunit: redefining the major functional motifs implemented in modulation of the Cav1.2 channel. J Biol Chem 2004;279:46367-46372.
28. Pushkin A, Abuladze N, Lee I, Newman D, Hwang J, Kurtz I: Cloning, tissue distribution, genomic organization, and functional characterization of NBC3, a new member of the sodium bicarbonate cotransporter family. J Biol Chem 1999;274:16569-16575.
29. Takahashi SX, Mittman S, Colecraft HM: Distinctive modulatory effects of five human auxiliary beta2 subunit splice variants on Ltype calcium channel gating. Biophys J 2003;84:3007-3021.
30. Bok D, Galbraith G, Lopez I, Woodruff M, Nusinowitz S, BeltrandelRio H, Huang W, Zhao S, Geske R, Montgomery C, Van Sligtenhorst I, Friddle C, Platt K, Sparks MJ, Pushkin A, Abuladze N, Ishiyama A, Dukkipati R, Liu W, Kurtz I: Blindness and auditory impairment caused by loss of the sodium bicarbonate cotransporter NBC3. Nat Genet 2003;34:313-319.
31. Gierl MS, Karoulias N, Wende H, Strehle M, Birchmeier C: The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells. Genes Dev 2006;20:2465-2478.
32. 2+ sensor protein visinin-like protein-1 is expressed in pancreatic islets and regulates insulin secretion. J Biol Chem 2006;281:21942-21953.
33. Goto Y, De Silva MG, Toscani A, Prabhakar BS, Notkins AL, Lan MS: A novel human insulinoma-associated cDNA, IA-1, encodes a protein with 'zinc-finger' DNA-binding motifs. J Biol Chem 1992;267:15252-15257.
34. Braunewell KH, Brackmann M, Manahan-Vaughan D: Group I mGlu receptors regulate the expression of the neuronal calcium sensor protein VILIP-1 in vitro and in vivo: implications for mGlu receptor-dependent hippocampal plasticity? Neuropharmacology 2003;44:707-715.
35. Schutte WP, Knight PJ: Precocious puberty because of a pancreatic neuroectodermal tumor. J Pediatr Surg 2006;41:1916-1918.
36. Freeman JL: The anatomy and embryology of the hypothalamus in relation to hypothalamic hamartomas. Epileptic Disord 2003;5:177-186.
37. Jung H, Probst EN, Hauffa BP, Partsch C-J, Dammann O: Association of morphological characteristics with precocious puberty and/ or gelastic seizures in hypothalamic hamartoma. J Clin Endocrinol Metab 2003;88:4590-4595.
38. Bernstein HG, Baumann B, Danos P, Diekmann S, Bogerts B, Gundelfinger ED, Braunewell KH: Regional and cellular distribution of neural visinin-like protein immunoreactivities (VILIP-1 and VILIP-3) in human brain. J Neurocytol 1999;28:655-662.
39. Milner CM, Day AJ: TSG-6: a multifunctional protein associated with inflammation. J Cell Sci 2003;116:1863-1873.