-
1
-
-
0034034757
-
NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome
-
Boute N, Gribouval O, Roselli S, Benessy F, Lee H, Fuchshuber A, Dahan K, Gubler MC, Niaudet P, Antignac C. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat Genet 24: 349-354, 2000.
-
(2000)
Nat Genet
, vol.24
, pp. 349-354
-
-
Boute, N.1
Gribouval, O.2
Roselli, S.3
Benessy, F.4
Lee, H.5
Fuchshuber, A.6
Dahan, K.7
Gubler, M.C.8
Niaudet, P.9
Antignac, C.10
-
2
-
-
0027945787
-
Partial purification of a mitogen-activated protein kinase kinase activator from bovine brain. Identification as B-Raf or a B-Raf-associated activity
-
Catling AD, Reuter CW, Cox ME, Parsons SJ, Weber MJ. Partial purification of a mitogen-activated protein kinase kinase activator from bovine brain. Identification as B-Raf or a B-Raf-associated activity. J Biol Chem 269: 30014-30021, 1994.
-
(1994)
J Biol Chem
, vol.269
, pp. 30014-30021
-
-
Catling, A.D.1
Reuter, C.W.2
Cox, M.E.3
Parsons, S.J.4
Weber, M.J.5
-
3
-
-
0027304607
-
Extracellular signals and reversible protein phosphorylation: What to Mek of it all
-
Crews CM, Erikson RL. Extracellular signals and reversible protein phosphorylation: what to Mek of it all. Cell 74: 215-217, 1993.
-
(1993)
Cell
, vol.74
, pp. 215-217
-
-
Crews, C.M.1
Erikson, R.L.2
-
4
-
-
18444374405
-
-
Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR, Futreal PA. Mutations of the BRAF gene in human cancer. Nature 417: 949-954, 2002.
-
Davies H, Bignell GR, Cox C, Stephens P, Edkins S, Clegg S, Teague J, Woffendin H, Garnett MJ, Bottomley W, Davis N, Dicks E, Ewing R, Floyd Y, Gray K, Hall S, Hawes R, Hughes J, Kosmidou V, Menzies A, Mould C, Parker A, Stevens C, Watt S, Hooper S, Wilson R, Jayatilake H, Gusterson BA, Cooper C, Shipley J, Hargrave D, Pritchard-Jones K, Maitland N, Chenevix-Trench G, Riggins GJ, Bigner DD, Palmieri G, Cossu A, Flanagan A, Nicholson A, Ho JW, Leung SY, Yuen ST, Weber BL, Seigler HF, Darrow TL, Paterson H, Marais R, Marshall CJ, Wooster R, Stratton MR, Futreal PA. Mutations of the BRAF gene in human cancer. Nature 417: 949-954, 2002.
-
-
-
-
5
-
-
33846201272
-
New insight into BRAF mutations in cancer
-
Dhomen N, Marais R. New insight into BRAF mutations in cancer. Curr Opin Genet Dev 17: 31-39, 2007.
-
(2007)
Curr Opin Genet Dev
, vol.17
, pp. 31-39
-
-
Dhomen, N.1
Marais, R.2
-
6
-
-
0027201852
-
Nephrotic syndrome in the 1st year of life
-
Habib R. Nephrotic syndrome in the 1st year of life. Pediatr Nephrol 7: 347-353, 1993.
-
(1993)
Pediatr Nephrol
, vol.7
, pp. 347-353
-
-
Habib, R.1
-
7
-
-
0027342443
-
Diffuse mesangial sclerosis: A congenital glomerulopathy with nephrotic syndrome
-
Habib R, Gubler MC, Antignac C, Gagnadoux MF. Diffuse mesangial sclerosis: a congenital glomerulopathy with nephrotic syndrome. Adv Nephrol Necker Hosp 22: 43-57, 1993.
-
(1993)
Adv Nephrol Necker Hosp
, vol.22
, pp. 43-57
-
-
Habib, R.1
Gubler, M.C.2
Antignac, C.3
Gagnadoux, M.F.4
-
8
-
-
0022357227
-
The nephropathy associated with male pseudohermaphroditism and Wilms' tumor (Drash syndrome): A distinctive glomerular lesion - report of 10 cases
-
Habib R, Loirat C, Gubler MC, Niaudet P, Bensman A, Levy M, Broyer M. The nephropathy associated with male pseudohermaphroditism and Wilms' tumor (Drash syndrome): a distinctive glomerular lesion - report of 10 cases. Clin Nephrol 24: 269-278, 1985.
-
(1985)
Clin Nephrol
, vol.24
, pp. 269-278
-
-
Habib, R.1
Loirat, C.2
Gubler, M.C.3
Niaudet, P.4
Bensman, A.5
Levy, M.6
Broyer, M.7
-
9
-
-
33751531864
-
-
Hinkes B, Wiggins RC, Gbadegesin R, Vlangos CN, Seelow D, Nurnberg G, Garg P, Verma R, Chaib H, Hoskins BE, Ashraf S, Becker C, Hennies HC, Goyal M, Wharram BL, Schachter AD, Mudumana S, Drummond I, Kerjaschki D, Waldherr R, Dietrich A, Ozaltin F, Bakkaloglu A, Cleper R, Basel-Vanagaite L, Pohl M, Griebel M, Tsygin AN, Soylu A, Muller D, Sorli CS, Bunney TD, Katan M, Liu J, Attanasio M, O'Toole JF, Hasselbacher K, Mucha B, Otto EA, Airik R, Kispert A, Kelley GG, Smrcka AV, Gudermann T, Holzman LB, Nurnberg P, Hildebrandt F. Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Nat Genet 38: 1397-1405, 2006.
-
Hinkes B, Wiggins RC, Gbadegesin R, Vlangos CN, Seelow D, Nurnberg G, Garg P, Verma R, Chaib H, Hoskins BE, Ashraf S, Becker C, Hennies HC, Goyal M, Wharram BL, Schachter AD, Mudumana S, Drummond I, Kerjaschki D, Waldherr R, Dietrich A, Ozaltin F, Bakkaloglu A, Cleper R, Basel-Vanagaite L, Pohl M, Griebel M, Tsygin AN, Soylu A, Muller D, Sorli CS, Bunney TD, Katan M, Liu J, Attanasio M, O'Toole JF, Hasselbacher K, Mucha B, Otto EA, Airik R, Kispert A, Kelley GG, Smrcka AV, Gudermann T, Holzman LB, Nurnberg P, Hildebrandt F. Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Nat Genet 38: 1397-1405, 2006.
-
-
-
-
10
-
-
0024026952
-
B-raf, a new member of the raf family, is activated by DNA rearrangement
-
Ikawa S, Fukui M, Ueyama Y, Tamaoki N, Yamamoto T, Toyoshima K. B-raf, a new member of the raf family, is activated by DNA rearrangement. Mol Cell Biol 8: 2651-2654, 1988.
-
(1988)
Mol Cell Biol
, vol.8
, pp. 2651-2654
-
-
Ikawa, S.1
Fukui, M.2
Ueyama, Y.3
Tamaoki, N.4
Yamamoto, T.5
Toyoshima, K.6
-
11
-
-
0028031527
-
The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras
-
Jaiswal RK, Moodie SA, Wolfman A, Landreth GE. The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras. Mol Cell Biol 14: 6944-6953, 1994.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 6944-6953
-
-
Jaiswal, R.K.1
Moodie, S.A.2
Wolfman, A.3
Landreth, G.E.4
-
12
-
-
0034051681
-
Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis
-
Kaplan JM, Kim SH, North KN, Rennke H, Correia LA, Tong HQ, Mathis BJ, Rodriguez-Perez JC, Allen PG, Beggs AH, Pollak MR. Mutations in ACTN4, encoding alpha-actinin-4, cause familial focal segmental glomerulosclerosis. Nat Genet 24: 251-256, 2000.
-
(2000)
Nat Genet
, vol.24
, pp. 251-256
-
-
Kaplan, J.M.1
Kim, S.H.2
North, K.N.3
Rennke, H.4
Correia, L.A.5
Tong, H.Q.6
Mathis, B.J.7
Rodriguez-Perez, J.C.8
Allen, P.G.9
Beggs, A.H.10
Pollak, M.R.11
-
13
-
-
0035865293
-
Phospholipase C(epsilon): A novel Ras effector
-
Kelley GG, Reks SE, Ondrako JM, Smrcka AV. Phospholipase C(epsilon): a novel Ras effector. EMBO J 20: 743-754, 2001.
-
(2001)
EMBO J
, vol.20
, pp. 743-754
-
-
Kelley, G.G.1
Reks, S.E.2
Ondrako, J.M.3
Smrcka, A.V.4
-
14
-
-
0021262325
-
Identification and characterization of podocalyxin-the major sialoprotein of the renal glomerular epithelial cell
-
Kerjaschki D, Sharkey DJ, Farquhar MG. Identification and characterization of podocalyxin-the major sialoprotein of the renal glomerular epithelial cell. J Cell Biol 98: 1591-1596, 1984.
-
(1984)
J Cell Biol
, vol.98
, pp. 1591-1596
-
-
Kerjaschki, D.1
Sharkey, D.J.2
Farquhar, M.G.3
-
15
-
-
0028871915
-
Molecular cloning, expression, and characterization of podocalyxin-like protein 1 from rabbit as a transmembrane protein of glomerular podocytes and vascular endothelium
-
Kershaw DB, Thomas PE, Wharram BL, Goyal M, Wiggins JE, Whiteside CI, Wiggins RC. Molecular cloning, expression, and characterization of podocalyxin-like protein 1 from rabbit as a transmembrane protein of glomerular podocytes and vascular endothelium. J Biol Chem 270: 29439-29446, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 29439-29446
-
-
Kershaw, D.B.1
Thomas, P.E.2
Wharram, B.L.3
Goyal, M.4
Wiggins, J.E.5
Whiteside, C.I.6
Wiggins, R.C.7
-
16
-
-
0032015551
-
Positionally cloned gene for a novel glomerular protein-nephrin-is mutated in congenital nephrotic syndrome
-
Kestila M, Lenkkeri U, Mannikko M, Lamerdin J, McCready P, Putaala H, Ruotsalainen V, Morita T, Nissinen M, Herva R, Kashtan CE, Peltonen L, Holmberg C, Olsen A, Tryggvason K. Positionally cloned gene for a novel glomerular protein-nephrin-is mutated in congenital nephrotic syndrome. Mol Cell 1: 575-582, 1998.
-
(1998)
Mol Cell
, vol.1
, pp. 575-582
-
-
Kestila, M.1
Lenkkeri, U.2
Mannikko, M.3
Lamerdin, J.4
McCready, P.5
Putaala, H.6
Ruotsalainen, V.7
Morita, T.8
Nissinen, M.9
Herva, R.10
Kashtan, C.E.11
Peltonen, L.12
Holmberg, C.13
Olsen, A.14
Tryggvason, K.15
-
17
-
-
22244466451
-
Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex
-
Lehtonen S, Ryan JJ, Kudlicka K, Iino N, Zhou H, Farquhar MG. Cell junction-associated proteins IQGAP1, MAGI-2, CASK, spectrins, and alpha-actinin are components of the nephrin multiprotein complex. Proc Natl Acad Sci USA 102: 9814-9819, 2005.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 9814-9819
-
-
Lehtonen, S.1
Ryan, J.J.2
Kudlicka, K.3
Iino, N.4
Zhou, H.5
Farquhar, M.G.6
-
18
-
-
19944427728
-
Characterization of the interactions of the nephrin intracellular domain
-
Liu XL, Kilpelainen P, Hellman U, Sun Y, Wartiovaara J, Morgunova E, Pikkarainen T, Yan K, Jonsson AP, Tryggvason K. Characterization of the interactions of the nephrin intracellular domain. FEBS J 272: 228-243, 2005.
-
(2005)
FEBS J
, vol.272
, pp. 228-243
-
-
Liu, X.L.1
Kilpelainen, P.2
Hellman, U.3
Sun, Y.4
Wartiovaara, J.5
Morgunova, E.6
Pikkarainen, T.7
Yan, K.8
Jonsson, A.P.9
Tryggvason, K.10
-
19
-
-
0028172146
-
Association of MEK1 with p21ras. GMPPNP is dependent on B-Raf
-
Moodie SA, Paris MJ, Kolch W, Wolfman A. Association of MEK1 with p21ras. GMPPNP is dependent on B-Raf. Mol Cell Biol 14: 7153-7162, 1994.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 7153-7162
-
-
Moodie, S.A.1
Paris, M.J.2
Kolch, W.3
Wolfman, A.4
-
20
-
-
33646682170
-
Mutations in the Wilms' tumor 1 gene cause isolated steroid resistant nephrotic syndrome and occur in exons 8 and 9
-
Mucha B, Ozaltin F, Hinkes BG, Hasselbacher K, Ruf RG, Schultheiss M, Hangan D, Hoskins BE, Everding AS, Bogdanovic R, Seeman T, Hoppe B, Hildebrandt F. Mutations in the Wilms' tumor 1 gene cause isolated steroid resistant nephrotic syndrome and occur in exons 8 and 9. Pediatr Res 59: 325-331, 2006.
-
(2006)
Pediatr Res
, vol.59
, pp. 325-331
-
-
Mucha, B.1
Ozaltin, F.2
Hinkes, B.G.3
Hasselbacher, K.4
Ruf, R.G.5
Schultheiss, M.6
Hangan, D.7
Hoskins, B.E.8
Everding, A.S.9
Bogdanovic, R.10
Seeman, T.11
Hoppe, B.12
Hildebrandt, F.13
-
21
-
-
0029919472
-
Post-translational modification of H-Ras is required for activation of, but not for association with, B-Raf
-
Okada T, Masuda T, Shinkai M, Kariya K, Kataoka T. Post-translational modification of H-Ras is required for activation of, but not for association with, B-Raf. J Biol Chem 271: 4671-4678, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 4671-4678
-
-
Okada, T.1
Masuda, T.2
Shinkai, M.3
Kariya, K.4
Kataoka, T.5
-
22
-
-
33751540445
-
A new piece in the nephrotic puzzle
-
Quaggin SE. A new piece in the nephrotic puzzle. Nat Genet 38: 1360-1361, 2006.
-
(2006)
Nat Genet
, vol.38
, pp. 1360-1361
-
-
Quaggin, S.E.1
-
23
-
-
22844436647
-
TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function
-
Reiser J, Polu KR, Moller CC, Kenlan P, Altintas MM, Wei C, Faul C, Herbert S, Villegas I, Avila-Casado C, McGee M, Sugimoto H, Brown D, Kalluri R, Mundel P, Smith PL, Clapham DE, Pollak MR. TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function. Nat Genet 37: 739-744, 2005.
-
(2005)
Nat Genet
, vol.37
, pp. 739-744
-
-
Reiser, J.1
Polu, K.R.2
Moller, C.C.3
Kenlan, P.4
Altintas, M.M.5
Wei, C.6
Faul, C.7
Herbert, S.8
Villegas, I.9
Avila-Casado, C.10
McGee, M.11
Sugimoto, H.12
Brown, D.13
Kalluri, R.14
Mundel, P.15
Smith, P.L.16
Clapham, D.E.17
Pollak, M.R.18
-
25
-
-
0027117408
-
Cell biology: A signal chain of events
-
Roberts TM. Cell biology: a signal chain of events. Nature 360: 534-535, 1992.
-
(1992)
Nature
, vol.360
, pp. 534-535
-
-
Roberts, T.M.1
-
26
-
-
2342424547
-
IQGAP1 binds ERK2 and modulates its activity
-
Roy M, Li Z, Sacks DB. IQGAP1 binds ERK2 and modulates its activity. J Biol Chem 279: 17329-17337, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 17329-17337
-
-
Roy, M.1
Li, Z.2
Sacks, D.B.3
-
27
-
-
24344491858
-
IQGAP1 is a scaffold for mitogen-activated protein kinase signaling
-
Roy M, Li Z, Sacks DB. IQGAP1 is a scaffold for mitogen-activated protein kinase signaling. Mol Cell Biol 25: 7940-7952, 2005.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 7940-7952
-
-
Roy, M.1
Li, Z.2
Sacks, D.B.3
-
28
-
-
0024573781
-
Biogenesis of podocalyxin-the major glomerular sialoglycoprotein-in the newborn rat kidney
-
Schnabel E, Dekan G, Miettinen A, Farquhar MG. Biogenesis of podocalyxin-the major glomerular sialoglycoprotein-in the newborn rat kidney. Eur J Cell Biol 48: 313-326, 1989.
-
(1989)
Eur J Cell Biol
, vol.48
, pp. 313-326
-
-
Schnabel, E.1
Dekan, G.2
Miettinen, A.3
Farquhar, M.G.4
-
29
-
-
0032513127
-
Identification of PLC210, a Caenorhabditis elegans phospholipase C, as a putative effector of Ras
-
Shibatohge M, Kariya K, Liao Y, Hu CD, Watari Y, Goshima M, Shima F, Kataoka T. Identification of PLC210, a Caenorhabditis elegans phospholipase C, as a putative effector of Ras. J Biol Chem 273: 6218-6222, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 6218-6222
-
-
Shibatohge, M.1
Kariya, K.2
Liao, Y.3
Hu, C.D.4
Watari, Y.5
Goshima, M.6
Shima, F.7
Kataoka, T.8
-
30
-
-
33645403170
-
Hereditary proteinuria syndromes and mechanisms of proteinuria
-
Tryggvason K, Patrakka J, Wartiovaara J. Hereditary proteinuria syndromes and mechanisms of proteinuria. N Engl J Med 354: 1387-1401, 2006.
-
(2006)
N Engl J Med
, vol.354
, pp. 1387-1401
-
-
Tryggvason, K.1
Patrakka, J.2
Wartiovaara, J.3
-
31
-
-
0028111836
-
B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP
-
Vaillancourt RR, Gardner AM, Johnson GL. B-Raf-dependent regulation of the MEK-1/mitogen-activated protein kinase pathway in PC12 cells and regulation by cyclic AMP. Mol Cell Biol 14: 6522-6530, 1994.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 6522-6530
-
-
Vaillancourt, R.R.1
Gardner, A.M.2
Johnson, G.L.3
-
32
-
-
29144490392
-
Podocyte depletion causes glomerulosclerosis: Diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene
-
Wharram BL, Goyal M, Wiggins JE, Sanden SK, Hussain S, Filipiak WE, Saunders TL, Dysko RC, Kohno K, Holzman LB, Wiggins RC. Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. J Am Soc Nephrol 16: 2941-2952, 2005.
-
(2005)
J Am Soc Nephrol
, vol.16
, pp. 2941-2952
-
-
Wharram, B.L.1
Goyal, M.2
Wiggins, J.E.3
Sanden, S.K.4
Hussain, S.5
Filipiak, W.E.6
Saunders, T.L.7
Dysko, R.C.8
Kohno, K.9
Holzman, L.B.10
Wiggins, R.C.11
-
33
-
-
2342514426
-
PLC-epsilon: A shared effector protein in Ras-, Rho-, and G alpha beta gamma-mediated signaling
-
Wing MR, Bourdon DM, Harden TK. PLC-epsilon: a shared effector protein in Ras-, Rho-, and G alpha beta gamma-mediated signaling. Mol Interv 3: 273-280, 2003.
-
(2003)
Mol Interv
, vol.3
, pp. 273-280
-
-
Wing, M.R.1
Bourdon, D.M.2
Harden, T.K.3
-
34
-
-
20844461826
-
A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis
-
Winn MP, Conlon PJ, Lynn KL, Farrington MK, Creazzo T, Hawkins AF, Daskalakis N, Kwan SY, Ebersviller S, Burchette JL, Pericak-Vance MA, Howell DN, Vance JM, Rosenberg PB. A mutation in the TRPC6 cation channel causes familial focal segmental glomerulosclerosis. Science 308: 1801-1804, 2005.
-
(2005)
Science
, vol.308
, pp. 1801-1804
-
-
Winn, M.P.1
Conlon, P.J.2
Lynn, K.L.3
Farrington, M.K.4
Creazzo, T.5
Hawkins, A.F.6
Daskalakis, N.7
Kwan, S.Y.8
Ebersviller, S.9
Burchette, J.L.10
Pericak-Vance, M.A.11
Howell, D.N.12
Vance, J.M.13
Rosenberg, P.B.14
-
35
-
-
8444221929
-
Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities
-
Zenker M, Aigner T, Wendler O, Tralau T, Muntefering H, Fenski R, Pitz S, Schumacher V, Royer-Pokora B, Wuhl E, Cochat P, Bouvier R, Kraus C, Mark K, Madlon H, Dotsch J, Rascher W, Maruniak-Chudek I, Lennert T, Neumann LM, Reis A. Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities. Hum Mol Genet 13: 2625-2632, 2004.
-
(2004)
Hum Mol Genet
, vol.13
, pp. 2625-2632
-
-
Zenker, M.1
Aigner, T.2
Wendler, O.3
Tralau, T.4
Muntefering, H.5
Fenski, R.6
Pitz, S.7
Schumacher, V.8
Royer-Pokora, B.9
Wuhl, E.10
Cochat, P.11
Bouvier, R.12
Kraus, C.13
Mark, K.14
Madlon, H.15
Dotsch, J.16
Rascher, W.17
Maruniak-Chudek, I.18
Lennert, T.19
Neumann, L.M.20
Reis, A.21
more..
-
36
-
-
33644864549
-
Genome-wide prediction of C. elegans genetic interactions
-
Zhong W, Sternberg PW. Genome-wide prediction of C. elegans genetic interactions. Science 311: 1481-1484, 2006.
-
(2006)
Science
, vol.311
, pp. 1481-1484
-
-
Zhong, W.1
Sternberg, P.W.2
|