Cholesterol depletion modulates basal L-type Ca2+ current and abolishes its β-adrenergic enhancement in ventricular myocytes

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 294, Issue 1, 2008, Pages

  Tsujikawa, Hiroto ^a   Song, Yumei ^a,c   Watanabe, Makino ^a   Masumiya, Haruko ^a,d   Gupte, Sachin A ^b   Ochi, Rikuo ^a,b   Okada, Takao ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NEW YORK MEDICAL COLLEGE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

Adenosine 3 ,5 cyclic monophosphate; Lipid raft; Phosphorylation; Protein kinase A

Indexed keywords

BUCLADESINE; CHOLESTEROL; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FORSKOLIN; ISOPRENALINE;

ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; MEMBRANE POTENTIAL; MONOCYTE; MUSCLE CELL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RABBIT; RAT;

3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ADENYLATE CYCLASE; ADRENERGIC BETA-AGONISTS; ANIMALS; BETA-CYCLODEXTRINS; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CHOLESTEROL; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC CMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATORS; FORSKOLIN; HEART VENTRICLES; ISOPROTERENOL; MEMBRANE MICRODOMAINS; MEMBRANE POTENTIALS; MYOCYTES, CARDIAC; RABBITS; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, BETA; TIME FACTORS;

EID: 38149126193     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00824.2007     Document Type: Article

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