Effect of selective and non-selective β-blockers on body weight, insulin resistance and leptin concentration in chronic heart failure

Clinical Research in Cardiology

Volumn 97, Issue 1, 2008, Pages 24-31

  Kovačić, Dragan ^b   Marinšek, Matej ^b   Gobec, Lidija ^b   Lainščak, Mitja ^c   Podbregar, Matej ^a  

^a UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

^b General and Teaching Hospital Celje   (Slovenia)

^c General Hospital Murska Sobota   (Slovenia)

Author keywords

Bisoprolol; Carvedilol; Chronic heart failure; Insulin resistance; Leptin; Resistin

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BISOPROLOL; CARVEDILOL; GLUCOSE; INSULIN; LEPTIN; RESISTIN;

ADULT; AGED; ARTICLE; BODY WEIGHT; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DRUG EFFECT; FEMALE; GLUCOSE HOMEOSTASIS; HEART FAILURE; HUMAN; INSULIN RESISTANCE; MALE;

ADRENERGIC BETA-ANTAGONISTS; AGED; BISOPROLOL; BLOOD GLUCOSE; BODY WEIGHT; CARBAZOLES; CHRONIC DISEASE; FEMALE; HEART FAILURE; HOMEOSTASIS; HUMANS; INSULIN; INSULIN RESISTANCE; LEPTIN; MALE; MIDDLE AGED; PROPANOLAMINES; RESISTIN;

EID: 38149121622     PISSN: 18610684     EISSN: 18610692     Source Type: Journal    
DOI: 10.1007/s00392-007-0571-3     Document Type: Article

References (35)

1. Berry C, Clark AL (2000) Catabolism in chronic heart failure. Eur Heart J 21:521-532
2. Bischoff B, Silber S, Richartz BM, Pieper L, Klotsche J, Wittchen HU; DETECT Study-Group (2006) Inadequate medical treatment of patients with coronary artery disease by primary care physicians in Germany. Clin Res Cardiol 95(8):405-412
3. Bonora E, Targger G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, Monauni T, Muggeo M (2000) Homeostasis model assesment closely mirrors the glucose clamp technique in the assesment of insulin sensitivity: studies in subjects with various degree of glucose tolerance and insulin sensitivity. Diabetes Care 23:57-63
4. Coats AJ, Anker SD, Roecker EB (2001) Prevention and reversal of cardiac cachexia in patients with severe heart failure by carvedilol: results of the COPERNICUS study (abstract). American Heart Association Scientific Sessions
5. Davos CH, Doehner W, Rauchhaus M, Cicoira M, Francis DP, Coats AJ, Clark AL, Anker SD (2003) Body mass and survival in patients with chronic heart failure without cachexia: the importance of obesity. J Card Fail 9:29-35
6. Doehner W, Pflaum CD, Rauchhaus M, Godsland IF, Egerer K, Cicoira M, Florea VG, Sharma R, Bolger AP, Coats AJS, Anker SD, Strasburger CJ (2001) Leptin, insulin sensitivity and growth hormone binding protein in chronic heart failure with and without cardiac cachexia. Eur J Endocrionology 145:727-735
7. Doehner W, Rauchhaus M, Ponikowski P, Godsland IF, von Haehling S, Okonko DO, Leyva F, Proudler AJ, Coats AJ, Anker SD (2005) Impaired insulin sensitivity as an independent risk factor for mortality in patients with stable chronic heart failure. J Am Coll Cardiol 46:1019-1026
8. Donahoo WT, Jensen DR, Yost TJ, Eckel RH (1997) Isoproterenol and somatostatin decrease plasma leptin in humans: a novel mechanism regulating leptin secretion. J Clin Endocrinol Metab 82:4139-4143
9. Ghali JK, Wilson AC (1996) Diabetes mellitus, a predictor of morbidity and mortality in the Studies Of Left Ventricular Dysfunction (SOLVD) trials trials and registry. Am J Cardiol 77:1017-1020
10. Herndon DN, Hart DW, Wolf SE, Chinkes DL, Wolfe RR (2001) Reversal of catabolism by beta-blockade after severe burns. N Engl J Med 345:1223-1229
11. Hoppe CU (2007) Treatment of heart failure with ACE inhibitors and beta blockers. What is next? AT1-receptor antagonists? Clin Res Cardiol 96(4): 196-198
12. Hryniewicz K, Androne SA, Hudaihed A, Katz DS (2003) Partial reversal of cachexia by _-adrenergic receptor blocker therapy in patients with chronic heart failure. J Card Failure 9(6):464-468
13. Jacob S, Rett K, Henriksen EJ (1989) Antihypertensive therapy and insulin sensitivity: do we have to redefine the role of beta blocking agents? Am J Hypertens 1:1258-1265
14. Jacob S, Rett K, Wicklmayr M (1999) Differential effect of chronic treatment with two beta-blocking agents on insulin sensitivity: the carvedilolmetoprolol study. J Hypert 14:489-494
15. Lainscak M, Keber I, Anker SD (2006) Body composition changes in patients with systolic heart failure treated with beta blockers: A pilot study. Int J Cardiol 106:319-322
16. Leichmann JG, Lavis VR, Aguilar D, Wilsonund C, Taegtmeyer H (2006) The metabolic syndrome and the heart-insulinresistenz des Herzens. Clin Res Cardiol 95(1):i134-i141
17. Leyva F, Anker SD, Egerer K, Stevenson JC, Kox WJ, Coats AJ (1998) Hyperleptinaemia in chronic heart failure. Relationships with insulin. Eur Heart J 19:1547-1155
18. Leyva F, Anker SD, Egerer K, Stevenson JC, Kox WJ, Coats AJ (1998) Hyperleptinaemia in chronic heart failure: relationship with insulin. Eur Heart J 19:1547-1551
19. Malminiemi K for Celiprolol Multicenter Study Group (2000) Long-term celiprolol therapy lowers fasting plasma leptin values. Cardiovasc Drugs Ther 14(1):67-75
20. Murdoch DR, Rooney E, Dargie HJ, Shapiro D, Morton JJ, McMurray JJ (1999) Inappropriately low plasma leptin concentration in the cachexia associated with chronic heart failure. Heart 82:352-356
21. Owada A, Suda S, Hata T, Miyake S (2001) The effects of bisoprolol, a selective beta1-blocker, on glucose metabolism by long-term administration in essential hypertension. Clin Exp Hypertens 23(4):305-316
22. Packer M, Bristow MR, Cohn JN, Colucci WS, Fowler MB, Gilbert EM, Shusterman NH (1996) The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. US Carvedilol Heart Failure Study Group. N Engl J Med 334:1349-1355
23. Paolisso G, De Riu S, Marrazzo G, Verza M, Varrichio M, D'Onofrio F (1991) Insulin resistence and hyperinsulinemia in patients with chronic congestive heart failure. Metabolism 40(9):972-977
24. Podbregar M, Voga G (2002) Effect of selective and nonselective beta-blockers on resting energy production rate and total body substrate utilization in chronic heart failure. J Card Fail 8:369-378
25. Poehlman ET, Scheffers J, Gottlieb SS, Fisher ML, Vaitekevicius P (1994) Increased resting metabolic rate in patients with congestive heart failure. Ann Intern Med 121:860-862
26. Regitz-Zagrosek V, Lehmkuhl E, Weickert MO (2006) Gender differences in the metabolic syndrome and their role for cardiovascular disease. Clin Res Cardiol 95(3):147
27. Rosenbaum M, Leibel RL (1999) The role of leptin in human physiology. N Engl J Med 341:913-915
28. Schulze CP, Kratzsch J, Linke A, Schoene N, Adams V, Gielen S, Erbs S, Moebius-Winkler S, Schuler G (2003) Elevated serum levels of leptin and soluble leptin receptor in patients with advanced chronic heart failure. Eur J Heart Fail 5:33-40
29. Sharma AM, Pischon T, Hardt S, Kunz I, Luft FC (2001) Hypothesis: Beta-adrenergic receptor blockers and weight gain: a systematic analysis. Hypertension 37:250-254
30. Shindler DM, Kostis JB, Yusuf S, Quinones MA, Pitt B, Stewart D, Pinkett T, Ghali JK, Wilson AC (1996) Diabetes mellitus, a predictor of morbidity and mortal. Am J Cardiol 77(11):1017-1020
31. Swan JW, Anker SD, Walton C, Godsland IF, Clark AL, Leyva F, Stevenson JC, Coats AJ (1997) Insulin resistance in chronic heart failure: relation to severity and etiology of heart failure. J Am Coll Cardiol 30:527-532
32. Toth MJ, Gottlieb SS, Fisher ML, Ryan AS, Nicklas BJ, Poehlman ET (1997) Plasma leptin concentrations and energy expenditure in heart failure patients. Metabolism 46:450-453
33. Van der Horst ICC, Voorsund AA, Van Veldhuisen DJ (2007) Treatment of heart failure with ACE inhibitors and beta blockers. What is next? Aldosterone receptor antagonists? Clin Res Cardiol 96(4):193-195
34. Weilund J, Schunkert H (2006) Pathophysiologie der chronischen Herzinsuffizienz. Clin Res Cardiol 95(4):1-17
35. Witte KK, Clark AL (2002) Nutritional abnormalities contributing to cachexia in chronic illness. Int J Cardiol 85:23-31