Evaluation of the topical anti-inflammatory activity of ginger dry extracts from solutions and plasters

Planta Medica

Volumn 73, Issue 15, 2007, Pages 1525-1530

  Minghetti, Paola ^a   Sosa, Silvio ^b   Cilurzo, Francesco ^a   Casiraghi, Antonella ^a   Alberti, Elisabetta ^a   Tubaro, Aurelia ^b   Della Loggia, Roberto ^b   Montanari, Luisa ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Adhesive plaster; Croton oil induced ear oedema; ex vivo skin permeation study; Gingerols; Topical anti inflammatory activity; Zingiber officinale; Zingiberaceae

Indexed keywords

6 GINGEROL; ACETONE; CHROMADEX; CROTON OIL; GINGER EXTRACT; GINGEROL; INDOMETACIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG PENETRATION; DRUG POTENCY; EAR; EDEMA; EPIDERMIS; EX VIVO STUDY; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PLASTER CAST; SKIN PENETRATION; TOPICAL TREATMENT;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CROTON OIL; DOSE-RESPONSE RELATIONSHIP, DRUG; EDEMA; FATTY ALCOHOLS; FEMALE; GINGER; HUMANS; MICE; MICE, INBRED HRS; PERMEABILITY; PHYTOTHERAPY; PLANT EXTRACTS; SKIN;

MUS; ZINGIBER OFFICINALE; ZINGIBERACEAE;

EID: 38149115436     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-993741     Document Type: Article

References (8)

1. Grzanna R, Lindmark L, Frondoza CG. Ginger - an herbal medicinal product with broad anti-inflammatory actions. J Med Food 2005; 8: 125-32.
2. Shen C-L, Hong K-J, Kim SW. Effect of ginger (Zingiber officinale Rosc.) on decreasing the production of inflammatory mediators in sow osteoarthritic cartilage explants. J Med Food 2003; 6: 323-8.
3. Shen C-L, Hong K-J, Kim SW. Comparative effects of ginger root (Zingiber officinale Rosc.) on the production of inflammatory mediators in normal and osteoarthrotic sow chondrocytes. J Med Food 2005; 8: 149-53.
4. Frondoza CG, Sohrabi A, Polotsky A, Phan PV, Hungerford DS, Lindmark L. An in vitro screening assay for inhibitors of proinflammatory mediators in herbal extracts using human synoviocyte cultures. In Vitro Cell Dev Biol Anim 2004; 40: 95-101.
5. Penna SC, Medeiros MV, Aimbire FSC, Faria-Neto HCC, Sertié JAA, Lopes-Martins RAB. Anti-inflammatory effect of the hydroalcoholic extract of Zingiber officinale rhizomes on rat paw and skin oedema. Phytomedicine 2003; 10: 381-5.
6. Park K-K, Chun K-S, Lee J-M, Lee SS, Surh Y-J. Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase and skin tumor promotion in ICR mice. Cancer Lett 1998; 129: 139-44.
7. Tubaro A, Dri P, Delbello G, Zilli C, Della Loggia R. The croton oil ear test revisited. Agents Actions 1985; 17: 347-9.
8. Casiraghi A, Ardovino P, Minghetti P, Botta C, Gattini A, Montanari L. Semisolid formulations containing dimethyl sulfoxide and α-tocopherol for the treatment of extravasation of antiblastic agents. Arch Dermatol Res 2007; 299: 201-7.