메뉴 건너뛰기




Volumn 45, Issue SUPPL. 2, 2007, Pages

Lactose and lactase - Who is lactose intolerant and why?

Author keywords

Lactase phlorizin hydrolase; Phenotype; Single nucleotide polymor phism

Indexed keywords

GLYCOSYLCERAMIDASE; HYDROLASE; LACTASE; LACTASE PHLORIZIN HYDROLASE; LACTOSE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 38149108283     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/MPG.0b013e31812e68f6     Document Type: Conference Paper
Times cited : (29)

References (57)
  • 1
    • 0017294787 scopus 로고
    • Development of the human gastrointestinal tract. A review
    • Grand RJ, Watkins JB, Torti FM. Development of the human gastrointestinal tract. A review. Gastroenterology 1976;70:790-810.
    • (1976) Gastroenterology , vol.70 , pp. 790-810
    • Grand, R.J.1    Watkins, J.B.2    Torti, F.M.3
  • 2
    • 0033016823 scopus 로고    scopus 로고
    • Development of the human gastrointestinal tract: Twenty years of progress
    • Montgomery RK, Mulberg AE, et al. Development of the human gastrointestinal tract: twenty years of progress. Gastroenterology 1999;116:702-31.
    • (1999) Gastroenterology , vol.116 , pp. 702-731
    • Montgomery, R.K.1    Mulberg, A.E.2
  • 3
    • 19744379159 scopus 로고    scopus 로고
    • Adult-type hypolactasia and regulation of lactase expression
    • Troelsen JT. Adult-type hypolactasia and regulation of lactase expression. Biochim Biophys Acta 2005;1723:19-32.
    • (2005) Biochim Biophys Acta , vol.1723 , pp. 19-32
    • Troelsen, J.T.1
  • 4
    • 0029035072 scopus 로고
    • Intestinal brush border glycohydrolases: Structure, function, and development
    • Van Beers EH, Buller HA, Grand RJ, et al. Intestinal brush border glycohydrolases: structure, function, and development. Crit Rev Biochem Mol Biol 1995;30:197-262.
    • (1995) Crit Rev Biochem Mol Biol , vol.30 , pp. 197-262
    • Van Beers, E.H.1    Buller, H.A.2    Grand, R.J.3
  • 5
    • 0014667767 scopus 로고
    • What regulates lactose content in milk?
    • Palmiter RD. What regulates lactose content in milk? Nature 1969;221:912-4.
    • (1969) Nature , vol.221 , pp. 912-914
    • Palmiter, R.D.1
  • 6
    • 0025882118 scopus 로고
    • Structure of the chromosomal gene and cDNAs coding for lactase-phlorizin hydrolase in humans with adult-type hypolactasia or persistence of lactase
    • Boll W, Wagner P, Mantei N. Structure of the chromosomal gene and cDNAs coding for lactase-phlorizin hydrolase in humans with adult-type hypolactasia or persistence of lactase. Am J Hum Genet 1991;48:889-902.
    • (1991) Am J Hum Genet , vol.48 , pp. 889-902
    • Boll, W.1    Wagner, P.2    Mantei, N.3
  • 7
    • 0028211687 scopus 로고
    • Processing and transport of human small intestinal lactase-phlorizin hydrolase (LPH). Role of N-linked oligosaccharide modification
    • Naim HY. Processing and transport of human small intestinal lactase-phlorizin hydrolase (LPH). Role of N-linked oligosaccharide modification. FEBS Lett 1994;342:302-7.
    • (1994) FEBS Lett , vol.342 , pp. 302-307
    • Naim, H.Y.1
  • 8
    • 0029084617 scopus 로고
    • Verification of the lactase site of rat lactase-phlorizin hydrolase by site-directed mutagenesis
    • Neele AM, Einerhand AW, Dekker J, et al. Verification of the lactase site of rat lactase-phlorizin hydrolase by site-directed mutagenesis. Gastroenterology 1995;109:1234-40.
    • (1995) Gastroenterology , vol.109 , pp. 1234-1240
    • Neele, A.M.1    Einerhand, A.W.2    Dekker, J.3
  • 9
    • 0029964611 scopus 로고    scopus 로고
    • Maturation of human intestinal lactase-phlorizin hydrolase: Generation of the brush border form of the enzyme involves at least two proteolytic cleavage steps
    • Jacob R, Radebach I, Wuthrich M, et al. Maturation of human intestinal lactase-phlorizin hydrolase: generation of the brush border form of the enzyme involves at least two proteolytic cleavage steps. Eur J Biochem 1996;236:789-95.
    • (1996) Eur J Biochem , vol.236 , pp. 789-795
    • Jacob, R.1    Radebach, I.2    Wuthrich, M.3
  • 10
    • 0023657227 scopus 로고
    • Biosynthesis, glycosylation, and intracellular transport of intestinal lactase-phlorizin hydrolase in rat
    • Buller HA, Montgomery RK, Sasak WV, et al. Biosynthesis, glycosylation, and intracellular transport of intestinal lactase-phlorizin hydrolase in rat. J Biol Chem 1987;262:17206-11.
    • (1987) J Biol Chem , vol.262 , pp. 17206-17211
    • Buller, H.A.1    Montgomery, R.K.2    Sasak, W.V.3
  • 11
    • 0035070246 scopus 로고    scopus 로고
    • Molecular and cellular aspects and regulation of intestinal lactase-phlorizin hydrolase
    • Naim HY. Molecular and cellular aspects and regulation of intestinal lactase-phlorizin hydrolase. Histol Histopathol 2001;16:553-61.
    • (2001) Histol Histopathol , vol.16 , pp. 553-561
    • Naim, H.Y.1
  • 12
    • 0031930993 scopus 로고    scopus 로고
    • Asymmetrical localization of mRNAs in enterocytes of human jejunum
    • Barth JA, Li W, Krasinski SD, et al. Asymmetrical localization of mRNAs in enterocytes of human jejunum. J Histochem Cytochem 1998;46:335-43.
    • (1998) J Histochem Cytochem , vol.46 , pp. 335-343
    • Barth, J.A.1    Li, W.2    Krasinski, S.D.3
  • 13
    • 0345549529 scopus 로고    scopus 로고
    • mRNA localization in polarized intestinal epithelial cells
    • Houle VM, Li W, Montgomery RK, et al. mRNA localization in polarized intestinal epithelial cells. Am J Physiol 2003;284:G722-7.
    • (2003) Am J Physiol , vol.284
    • Houle, V.M.1    Li, W.2    Montgomery, R.K.3
  • 14
    • 0031749893 scopus 로고    scopus 로고
    • Three distinct mRNA distribution patterns in human jejunal enterocytes
    • Li W, Krasinski SD, Verhave M, et al. Three distinct mRNA distribution patterns in human jejunal enterocytes. Gastroenterology 1998;115:86-92.
    • (1998) Gastroenterology , vol.115 , pp. 86-92
    • Li, W.1    Krasinski, S.D.2    Verhave, M.3
  • 15
    • 0026556365 scopus 로고
    • Messenger RNA sorting in enterocytes. Co-localization with encoded proteins
    • Rings EH, Buller HA, de Boer PA, et al. Messenger RNA sorting in enterocytes. Co-localization with encoded proteins. FEBS Lett 1992;300:183-7.
    • (1992) FEBS Lett , vol.300 , pp. 183-187
    • Rings, E.H.1    Buller, H.A.2    de Boer, P.A.3
  • 16
    • 0024463439 scopus 로고
    • New insights into lactase and glycosylceramidase activities of rat lactase-phlorizin hydrolase
    • Buller HA, VanWassenaer AG, Raghavan S, et al. New insights into lactase and glycosylceramidase activities of rat lactase-phlorizin hydrolase. Am J Physiol 1989;257:G616-23.
    • (1989) Am J Physiol , vol.257
    • Buller, H.A.1    VanWassenaer, A.G.2    Raghavan, S.3
  • 17
    • 0021894443 scopus 로고
    • Ontogeny of enzymes in the small intestine
    • Henning SJ. Ontogeny of enzymes in the small intestine. Ann Rev Physiol 1985;47:231-45.
    • (1985) Ann Rev Physiol , vol.47 , pp. 231-245
    • Henning, S.J.1
  • 18
    • 0027954745 scopus 로고
    • Transcriptional regulation of intestinal hydrolase biosynthesis during postnatal development in rats
    • Krasinski SD, Estrada G, Yeh KY, et al. Transcriptional regulation of intestinal hydrolase biosynthesis during postnatal development in rats. Am J Physiol 1994;267:G584-94.
    • (1994) Am J Physiol , vol.267
    • Krasinski, S.D.1    Estrada, G.2    Yeh, K.Y.3
  • 19
    • 0026704988 scopus 로고
    • Lactase gene expression during early development of rat small intestine
    • Rings EH, de Boer PA, Moorman AF, et al. Lactase gene expression during early development of rat small intestine. Gastroenterology 1992;103:1154-61.
    • (1992) Gastroenterology , vol.103 , pp. 1154-1161
    • Rings, E.H.1    de Boer, P.A.2    Moorman, A.F.3
  • 20
    • 0028217322 scopus 로고
    • Restriction of lactase gene expression along the proximal-to-distal axis of rat small intestine occurs during postnatal development
    • Rings EH, Krasinski SD, van Beers EH, et al. Restriction of lactase gene expression along the proximal-to-distal axis of rat small intestine occurs during postnatal development. Gastroenterology 1994;106:1223-32.
    • (1994) Gastroenterology , vol.106 , pp. 1223-1232
    • Rings, E.H.1    Krasinski, S.D.2    van Beers, E.H.3
  • 21
    • 0017686603 scopus 로고
    • Developmental pattern of small intestinal enterokinase and disaccharidase activities in the human fetus
    • Antonowicz I, Lebenthal E. Developmental pattern of small intestinal enterokinase and disaccharidase activities in the human fetus. Gastroenterology 1977;72:1299-303.
    • (1977) Gastroenterology , vol.72 , pp. 1299-1303
    • Antonowicz, I.1    Lebenthal, E.2
  • 22
    • 0017607971 scopus 로고
    • Disaccharidase and lysosomal enzyme activities in amniotic fluid, intestinal mucosa, and meconium. Correlation between morphology and disaccharidase activities in human fetal small intestine
    • Antonowicz I, Milunsky A, Lebenthal E, et al. Disaccharidase and lysosomal enzyme activities in amniotic fluid, intestinal mucosa, and meconium. Correlation between morphology and disaccharidase activities in human fetal small intestine. Biol Neonate 1977;32:280-9.
    • (1977) Biol Neonate , vol.32 , pp. 280-289
    • Antonowicz, I.1    Milunsky, A.2    Lebenthal, E.3
  • 23
    • 0014169921 scopus 로고
    • Disaccharidase activity in the small intestine: Prevalence of lactase deficiency in 100 healthy subjects
    • Newcomer AD, McGill DB. Disaccharidase activity in the small intestine: prevalence of lactase deficiency in 100 healthy subjects. Gastroenterology 1967;53:881-9.
    • (1967) Gastroenterology , vol.53 , pp. 881-889
    • Newcomer, A.D.1    McGill, D.B.2
  • 24
    • 0013963615 scopus 로고
    • Distribution of disaccharidase activity in the small bowel of normal and lactase-deficient subjects
    • Newcomer AD, McGill DB. Distribution of disaccharidase activity in the small bowel of normal and lactase-deficient subjects. Gastroenterology 1966;51:481-8.
    • (1966) Gastroenterology , vol.51 , pp. 481-488
    • Newcomer, A.D.1    McGill, D.B.2
  • 25
    • 0024094598 scopus 로고
    • The acceptability of milk and milk products in populations with a high prevalence of lactose intolerance
    • Scrimshaw NS, Murray EB. The acceptability of milk and milk products in populations with a high prevalence of lactose intolerance. Am J Clin Nutr 1988;48:1079-159.
    • (1988) Am J Clin Nutr , vol.48 , pp. 1079-1159
    • Scrimshaw, N.S.1    Murray, E.B.2
  • 26
    • 0031750479 scopus 로고    scopus 로고
    • The genetically programmed down-regulation of lactase in children
    • Wang Y, Harvey CB, Hollox EJ, et al. The genetically programmed down-regulation of lactase in children. Gastroenterology 1998;114:1230-6.
    • (1998) Gastroenterology , vol.114 , pp. 1230-1236
    • Wang, Y.1    Harvey, C.B.2    Hollox, E.J.3
  • 27
    • 2442677652 scopus 로고    scopus 로고
    • Genetic signatures of strong recent positive selection at the lactase gene
    • Bersaglieri T, Sabeti PC, Patterson N, et al. Genetic signatures of strong recent positive selection at the lactase gene. Am J Hum Genet 2004;74:1111-20.
    • (2004) Am J Hum Genet , vol.74 , pp. 1111-1120
    • Bersaglieri, T.1    Sabeti, P.C.2    Patterson, N.3
  • 28
    • 0014632032 scopus 로고
    • Primary adult lactose intolerance and the milking habit: A problem in biological and cultural interrelations. I. Review of the medical research
    • Simoons FJ. Primary adult lactose intolerance and the milking habit: a problem in biological and cultural interrelations. I. Review of the medical research. Am J Dig Dis 1969;14:819-36.
    • (1969) Am J Dig Dis , vol.14 , pp. 819-836
    • Simoons, F.J.1
  • 29
    • 0026555758 scopus 로고
    • Regulation of intestinal lactase in adult hypolactasia
    • Lloyd M, Mevissen G, Fischer M, et al. Regulation of intestinal lactase in adult hypolactasia. J Clin Invest 1992;89:524-9.
    • (1992) J Clin Invest , vol.89 , pp. 524-529
    • Lloyd, M.1    Mevissen, G.2    Fischer, M.3
  • 30
    • 0028319212 scopus 로고
    • Mosaic regulation of lactase in human adult-type hypolactasia
    • Maiuri L, Rossi M, Raia V, et al. Mosaic regulation of lactase in human adult-type hypolactasia. Gastroenterology 1994;107:54-60.
    • (1994) Gastroenterology , vol.107 , pp. 54-60
    • Maiuri, L.1    Rossi, M.2    Raia, V.3
  • 31
    • 0025066272 scopus 로고
    • Biogenesis of intestinal lactase-phlorizin hydrolase in adults with lactose intolerance
    • Sterchi EE, Mills PR, Fransen JA, et al. Biogenesis of intestinal lactase-phlorizin hydrolase in adults with lactose intolerance. J Clin Invest 1990;86:1329-37.
    • (1990) J Clin Invest , vol.86 , pp. 1329-1337
    • Sterchi, E.E.1    Mills, P.R.2    Fransen, J.A.3
  • 33
    • 0028327817 scopus 로고
    • The polymorphic expression of lactase in adults is regulated at the messenger RNA level
    • Fajardo O, Naim HY, Lacey SW. The polymorphic expression of lactase in adults is regulated at the messenger RNA level. Gastroenterology 1994;106:1233-41.
    • (1994) Gastroenterology , vol.106 , pp. 1233-1241
    • Fajardo, O.1    Naim, H.Y.2    Lacey, S.W.3
  • 34
    • 0028969249 scopus 로고    scopus 로고
    • Wang Y, Harvey CB, Pratt W, et al. The lactase persistence/nonpersistence polymorphism is controlled by a cis-acting element. Hum Mol Genet 1995;4:657-62.
    • Wang Y, Harvey CB, Pratt W, et al. The lactase persistence/nonpersistence polymorphism is controlled by a cis-acting element. Hum Mol Genet 1995;4:657-62.
  • 35
    • 0037200071 scopus 로고    scopus 로고
    • Hepatocyte nuclear factor-1alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription
    • Boudreau F, Rings EHHM, van Wering HM, et al. Hepatocyte nuclear factor-1alpha, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. J Biol Chem 2002;277:31909-17.
    • (2002) J Biol Chem , vol.277 , pp. 31909-31917
    • Boudreau, F.1    Rings, E.H.H.M.2    van Wering, H.M.3
  • 36
    • 0034804228 scopus 로고    scopus 로고
    • Differential activation of intestinal gene promoters: Functional interactions between GATA-5 and HNF-1 alpha
    • Krasinski SD, Van Wering HM, Tannemaat MR, et al. Differential activation of intestinal gene promoters: functional interactions between GATA-5 and HNF-1 alpha. Am J Physiol 2001;281:G69-84.
    • (2001) Am J Physiol , vol.281
    • Krasinski, S.D.1    Van Wering, H.M.2    Tannemaat, M.R.3
  • 37
    • 4644290609 scopus 로고    scopus 로고
    • Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4
    • van Wering HM, Bosse T, Musters A, et al. Complex regulation of the lactase-phlorizin hydrolase promoter by GATA-4. Am J Physiol 2004;287:G899-909.
    • (2004) Am J Physiol , vol.287
    • van Wering, H.M.1    Bosse, T.2    Musters, A.3
  • 38
    • 0037008768 scopus 로고    scopus 로고
    • Physical interaction between GATA-5 and hepatocyte nuclear factor-1alpha results in synergistic activation of the human lactase-phlorizin hydrolase promoter
    • van Wering HM, Huibregtse IL, van der Zwan SM, et al. Physical interaction between GATA-5 and hepatocyte nuclear factor-1alpha results in synergistic activation of the human lactase-phlorizin hydrolase promoter. J Biol Chem 2002;277:27659-67.
    • (2002) J Biol Chem , vol.277 , pp. 27659-27667
    • van Wering, H.M.1    Huibregtse, I.L.2    van der Zwan, S.M.3
  • 39
    • 0034804228 scopus 로고    scopus 로고
    • Differential activation of intestinal gene promoters by GATA-4, -5, and -6, HNF1alpha and beta, and Cdx-2: Demonstration of functional and physical interactions between GATA-5 and HNF-1alpha
    • van Wering HM, Tannemaat MR, Grand RJ, et al. Differential activation of intestinal gene promoters by GATA-4, -5, and -6, HNF1alpha and beta, and Cdx-2: demonstration of functional and physical interactions between GATA-5 and HNF-1alpha. Am J Physiol 2001;281:G69-84.
    • (2001) Am J Physiol , vol.281
    • van Wering, H.M.1    Tannemaat, M.R.2    Grand, R.J.3
  • 40
    • 0032557437 scopus 로고    scopus 로고
    • Mitchelmore C, Troelsen JT, Sjostrom H, et al. The HOXC11 homeodomain protein interacts with the lactase-phlorizin hydrolase promoter and stimulates HNF1alpha-dependent transcription. J Biol Chem 1998;273:13297-306.
    • Mitchelmore C, Troelsen JT, Sjostrom H, et al. The HOXC11 homeodomain protein interacts with the lactase-phlorizin hydrolase promoter and stimulates HNF1alpha-dependent transcription. J Biol Chem 1998;273:13297-306.
  • 41
    • 0034163801 scopus 로고    scopus 로고
    • Interaction between the homeodomain proteins Cdx2 and HNF1alpha mediates expression of the lactase-phlorizin hydrolase gene
    • Mitchelmore C, Troelsen JT, Spodsberg N, et al. Interaction between the homeodomain proteins Cdx2 and HNF1alpha mediates expression of the lactase-phlorizin hydrolase gene. Biochem J 2000;346:529-35.
    • (2000) Biochem J , vol.346 , pp. 529-535
    • Mitchelmore, C.1    Troelsen, J.T.2    Spodsberg, N.3
  • 42
    • 0032999058 scopus 로고    scopus 로고
    • Transcriptional regulation of pig lactase-phlorizin hydrolase: Involvement of HNF-1 and FREACs
    • Spodsberg N, Troelsen JT, Carlsson P, et al. Transcriptional regulation of pig lactase-phlorizin hydrolase: involvement of HNF-1 and FREACs. Gastroenterology 1999;116:842-54.
    • (1999) Gastroenterology , vol.116 , pp. 842-854
    • Spodsberg, N.1    Troelsen, J.T.2    Carlsson, P.3
  • 43
    • 16644366716 scopus 로고    scopus 로고
    • Regulatory regions in the rat lactase-phlorizin hydrolase gene that control cell-specific expression
    • Verhave M, Krasinski SD, Christian SI, et al. Regulatory regions in the rat lactase-phlorizin hydrolase gene that control cell-specific expression. J Pediatr Gastroenterol Nutr 2004;39:275-85.
    • (2004) J Pediatr Gastroenterol Nutr , vol.39 , pp. 275-285
    • Verhave, M.1    Krasinski, S.D.2    Christian, S.I.3
  • 44
    • 4143107904 scopus 로고    scopus 로고
    • Transcriptional regulation of the lactase-phlorizin hydrolase promoter by PDX-1
    • Wang Z, Fang R, Olds LC, et al. Transcriptional regulation of the lactase-phlorizin hydrolase promoter by PDX-1. Am J Physiol 2004;287:G555-61.
    • (2004) Am J Physiol , vol.287
    • Wang, Z.1    Fang, R.2    Olds, L.C.3
  • 45
    • 0030752589 scopus 로고    scopus 로고
    • Rat lactase-phlorizin hydrolase/human growth hormone transgene is expressed on small intestinal villi in transgenic mice
    • Krasinski SD, Upchurch BH, Irons SJ, et al. Rat lactase-phlorizin hydrolase/human growth hormone transgene is expressed on small intestinal villi in transgenic mice. Gastroenterology 1997;113:844-55.
    • (1997) Gastroenterology , vol.113 , pp. 844-855
    • Krasinski, S.D.1    Upchurch, B.H.2    Irons, S.J.3
  • 46
    • 0037066758 scopus 로고    scopus 로고
    • Regulation of intestine-specific spatiotemporal expression by the rat lactase promoter
    • Lee SY, Wang Z, Lin C-K, et al. Regulation of intestine-specific spatiotemporal expression by the rat lactase promoter. J Biol Chem 2002;277:13099-105.
    • (2002) J Biol Chem , vol.277 , pp. 13099-13105
    • Lee, S.Y.1    Wang, Z.2    Lin, C.-K.3
  • 47
    • 0028350976 scopus 로고
    • 1 kb of the lactase-phlorizin hydrolase promoter directs post-weaning decline and small intestinal-specific expression in transgenic mice
    • Troelsen JT, Mehlum A, Olsen J, et al. 1 kb of the lactase-phlorizin hydrolase promoter directs post-weaning decline and small intestinal-specific expression in transgenic mice. FEBS Lett 1994;342:291-6.
    • (1994) FEBS Lett , vol.342 , pp. 291-296
    • Troelsen, J.T.1    Mehlum, A.2    Olsen, J.3
  • 48
    • 0030566803 scopus 로고    scopus 로고
    • Characterisation of a human homologue of a yeast cell division cycle gene, MCM6, located adjacent to the 5′ end of the lactase gene on chromosome 2q21
    • Harvey CB, Wang Y, Darmoul D, et al. Characterisation of a human homologue of a yeast cell division cycle gene, MCM6, located adjacent to the 5′ end of the lactase gene on chromosome 2q21. FEBS Lett 1996;398:135-40.
    • (1996) FEBS Lett , vol.398 , pp. 135-140
    • Harvey, C.B.1    Wang, Y.2    Darmoul, D.3
  • 49
    • 0036479030 scopus 로고    scopus 로고
    • Identification of a variant associated with adult-type hypolactasia
    • Enattah NS, Sahi T, Savilahti E, et al. Identification of a variant associated with adult-type hypolactasia. Nat Genet 2002;30:233-7.
    • (2002) Nat Genet , vol.30 , pp. 233-237
    • Enattah, N.S.1    Sahi, T.2    Savilahti, E.3
  • 50
    • 0032722506 scopus 로고    scopus 로고
    • Common polymorphism in a highly variable region upstream of the human lactase gene affects DNA-protein interactions
    • Hollox EJ, Poulter M, Wang Y, et al. Common polymorphism in a highly variable region upstream of the human lactase gene affects DNA-protein interactions. Eur J Hum Genet 1999;7:791-800.
    • (1999) Eur J Hum Genet , vol.7 , pp. 791-800
    • Hollox, E.J.1    Poulter, M.2    Wang, Y.3
  • 51
    • 0038476614 scopus 로고    scopus 로고
    • Transcriptional regulation of the lactase-phlorizin hydrolase gene by polymorphisms associated with adult-type hypolactasia
    • Kuokkanen M, Enattah NS, Oksanen A, et al. Transcriptional regulation of the lactase-phlorizin hydrolase gene by polymorphisms associated with adult-type hypolactasia. Gut 2003;52:647-52.
    • (2003) Gut , vol.52 , pp. 647-652
    • Kuokkanen, M.1    Enattah, N.S.2    Oksanen, A.3
  • 52
    • 7244255746 scopus 로고    scopus 로고
    • A genetic test which can be used to diagnose adult-type hypolactasia in children
    • Rasinpera H, Savilahti E, Enattah NS, et al. A genetic test which can be used to diagnose adult-type hypolactasia in children. Gut 2004;53:1571-6.
    • (2004) Gut , vol.53 , pp. 1571-1576
    • Rasinpera, H.1    Savilahti, E.2    Enattah, N.S.3
  • 53
    • 0344375110 scopus 로고    scopus 로고
    • The causal element for the lactase persistence/non-persistence polymorphism is located in a 1Mb region of linkage disequilibrium in Europeans
    • Poulter M, Hollox E, Harvey CB, et al. The causal element for the lactase persistence/non-persistence polymorphism is located in a 1Mb region of linkage disequilibrium in Europeans. Ann Hum Genet 2003;67:298-311.
    • (2003) Ann Hum Genet , vol.67 , pp. 298-311
    • Poulter, M.1    Hollox, E.2    Harvey, C.B.3
  • 54
    • 2442673931 scopus 로고    scopus 로고
    • The T allele of a singlenucleotide polymorphism 13.9 kb upstream of the lactase gene (LCT) (C-13.9kbT) does not predict or cause the lactase-persistence phenotype in Africans
    • Mulcare CA, Weale ME, Jones AL, et al. The T allele of a singlenucleotide polymorphism 13.9 kb upstream of the lactase gene (LCT) (C-13.9kbT) does not predict or cause the lactase-persistence phenotype in Africans. Am J Hum Genet 2004;74:1102-10.
    • (2004) Am J Hum Genet , vol.74 , pp. 1102-1110
    • Mulcare, C.A.1    Weale, M.E.2    Jones, A.L.3
  • 55
    • 0345059399 scopus 로고    scopus 로고
    • An upstream polymorphism associated with lactase persistence has increased enhancer activity
    • Troelsen JT, Olsen J, Moller J, et al. An upstream polymorphism associated with lactase persistence has increased enhancer activity. Gastroenterology 2003;125:1686-94.
    • (2003) Gastroenterology , vol.125 , pp. 1686-1694
    • Troelsen, J.T.1    Olsen, J.2    Moller, J.3
  • 56
    • 0141702274 scopus 로고    scopus 로고
    • Lactase persistence DNA variant enhances lactase promoter activity in vitro: Functional role as a cis regulatory element
    • Olds LC, Sibley E. Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element. Hum Mol Genet 2003;12:2333-40.
    • (2003) Hum Mol Genet , vol.12 , pp. 2333-2340
    • Olds, L.C.1    Sibley, E.2
  • 57
    • 0345257771 scopus 로고    scopus 로고
    • Gene-culture coevolution between cattle milk protein genes and human lactase genes
    • Beja-Pereira A, Luikart G, England PR, et al. Gene-culture coevolution between cattle milk protein genes and human lactase genes. Nat Genet 2003;35:311-3.
    • (2003) Nat Genet , vol.35 , pp. 311-313
    • Beja-Pereira, A.1    Luikart, G.2    England, P.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.