Transcriptional regulation of pig lactase-phlorizin hydrolase: Involvement of HNF-1 and FREACs

Gastroenterology

Volumn 116, Issue 4, 1999, Pages 842-854

  Spodsberg, N ^a   Troelsen, J T ^a   Carlsson, P ^a   Enerback, S ^a   Sjostrom, H ^a   Noren, O ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSYLCERAMIDASE; NUCLEAR FACTOR I; TRANSCRIPTION FACTOR;

ARTICLE; DIGESTION; ENHANCER REGION; GENE SEQUENCE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SWINE; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE; WEANING;

EID: 0032999058     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(99)70067-3     Document Type: Article

References (68)

1. RG Doell N Kretchmer Studies of small intestine development. I. Distribution and activity of β-galactosidase Biochem Biophys Acta 62 1962 353 362
2. TA Kruse L Bolund KH Grzeschik HH Ropers H Sjöström O Norén N Mantei G Semenza The human lactase-phlorizin hydrolase gene is located on chromosome 2 FEBS Lett 240 1988 123 126
3. CB Harvey MF Fox PA Jeggo N Mantei S Povey DM Swallow Regional localization of the lactase-phlorizin hydrolase gene, LCT, to chromosome 2q21 Ann Hum Genet 57 1993 179 185
4. PD Thomsen M Johansson JT Troelsen L Andersson The lactase phlorizin hydrolase (LCT) gene maps to pig chromosome 15q13 Anim Genet 26 1995 49 52
5. I Duluc R Boukamel N Mantei G Semenza F Raul JN Freund Sequence of the precursor of intestinal lactase-phlorizin hydrolase from fetal rat Gene 103 1991 275 276
6. I Duluc B Jost JN Freund Multiple levels of control of the stage-and region-specific expression of rat intestinal lactase J Cell Biol 123 1993 1577 1586
7. O Norén H Sjöström EM Danielsen GM Cowell H Skovberg The enzyme of the enterocyte plasma membrane P Desnuelle H Sjöström O Norén Molecular and cellular basis of digestion 1986 Elsevier Science New York 335 365
8. G Semenza S Auricchio Small intestinal disaccharidases CR Scriver AL Beaudet SS Sly D Valle The metabolic basis of inherited disease. II 1989 McGraw-Hill New York 2975 2997
9. TC Freeman Parallel patterns of cell-specific gene expression during enterocyte differentiation and maturation in the small intestine of the rabbit Differentiation 59 1995 179 192
10. P Keller E Zwicker N Mantei G Semenza The levels of lactase and of sucrase-isomaltase along the rabbit small intestine are regulated both at the mRNA level and post-translationally FEBS Lett 313 1992 265 269
11. N Torp M Rossi JT Troelsen J Olsen EM Danielsen Lactasephlorizin hydrolase and aminopeptidase N are differentially regulated in the small intestine of the pig Biochem J 295 1993 177 182
12. Y Wang C Harvey M Rousset DM Swallow Expression of human intestinal mRNA transcripts during development: analysis by a semiquantitative RNA polymerase chain reaction method Pediatr Res 36 1994 514 521
13. V Lorenzsonn M Lloyd WA Olsen Immunocytochemical heterogeneity of lactase-phlorizin hydrolase in adult lactase deficiency Gastroenterology 105 1993 51 59
14. RA Hodin SM Chamberlain S Meng Pattern of rat intestinal brush-border enzyme gene expression changes with epithelial growth state Am J Physiol 269 1995 C385 C391
15. G Flatz The genetic polymorphism of intestinal lactase activity in adult humans CR Scriver AL Beaudet WS Sly D Valle The metabolic basis of inherited disease. II 1989 McGraw-Hill New York 2999 3006
16. JT Troelsen J Olsen O Norén H Sjöström A novel intestinal trans-factor (NF-LPH1) interacts with the lactase-phlorizin hydrolase promoter and co-varies with the enzymatic activity J Biol Chem 267 1992 20407 20411
17. SW Lacey HY Naim RR Magness MJ Gething JF Sambrook Expression of lactase-phlorizin hydrolase in sheep is regulated at the RNA level Biochem J 302 1994 929 935
18. O Fajardo HY Naim SW Lacey The polymorphic expression of lactase in adults is regulated at the messenger RNA level Gastroenterology 106 1994 1233 1241
19. JT Troelsen A Mehlum J Olsen N Spodsberg GH Hansen H Prydz O Norén H Sjöström 1 kb of the lactase-phlorizin hydrolase promoter directs post-weaning decline and small intestinal-specific expression in transgenic mice FEBS Lett 342 1994 291 296
20. R Quan NA Santiago KK Tsuboi GM Gray Intestinal lactase. Shift in intracellular processing to altered inactive species in the adult rat J Biol Chem 265 1990 15882 15888
21. KK Tsuboi LK Kwong P Sunshine RO Castillo Mechanism of maturational decline of rat intestinal lactase-phlorizin hydrolase Biochem J 282 1992 107 113
22. M Lloyd G Mevissen M Fischer W Olsen D Goodspeed M Genini W Boll G Semenza N Mantei Regulation of intestinal lactase in adult hypolactasia J Clin Invest 89 1992 524 529
23. EE Sterchi PR Mills JA Fransen HP Hauri MJ Lentze HY Naim L Ginsel J Bond Biogenesis of intestinal lactase-phlorizin hydrolase in adults with lactose intolerance. Evidence for reduced biosynthesis and slowed-down maturation in enterocytes J Clin Invest 86 1990 1329 1337
24. CB Harvey Y Wang LA Hughes DM Swallow WP Thurrell VR Sams R Barton S Lanzon-Miller M Sarner Studies on the expression of intestinal lactase in different individuals Gut 36 1995 28 33
25. HA Büller MJ Kothe DA Goldman SA Grubman WV Sasak PT Matsudaira RK Montgomery RJ Grand Coordinate expression of lactase-phlorizin hydrolase mRNA and enzyme levels in rat intestine during development J Biol Chem 265 1990 6978 6983
26. SD Krasinski G Estrada KY Yeh M Yeh PG Traber EH Rings HA Büller M Verhave RK Montgomery RJ Grand Transcriptional regulation of intestinal hydrolase biosynthesis during postnatal development in rats Am J Physiol 267 1994 G584 G594
27. RP Green SM Cohn JC Sacchettini KE Jackson JI Gordon The mouse intestinal fatty acid binding protein gene: nucleotide sequence, pattern of developmental and regional expression, and proposed structure of its protein product DNA Cell Biol 11 1992 31 41
28. PT Sangild PD Cranwell H Sørensen K Mortensen O Norén L Wetterberg H Sjötröm Development of intestinal dissacharidases, intestinal peptidases and pancreatic proteases in suckling pigs. The effects of age and ACTH treatment Proceedings of the 5th International Symposium on Digestive Physiology in Pigs 1991 73 78
29. M Pinto S Robine-Leon MD Appay M Kedinger N Triadou E Dussaulx B Lacroix P Simon-Assmann K Haffen J Fogh A Zweibaum Enterocyte-like diffentiation and polarization of the human colon carcinoma cell line Caco-2 in culture Biol Cell 47 1983 323 330
30. EH van Beers RH Al EH Rings AW Einerhand J Dekker HA Büller Lactase and sucrase-isomaltase gene expression during Caco-2 cell dif ferentiation Biochem J 308 1995 769 775
31. G Westin T Gerster MM Muller G Schaffner W Schaffner OVEC, a versatile system to study transcription in mammalian cells and cell-free extracts Nucleic Acids Res 15 1987 6787 6798
32. F Sanger S Nicklen AR Coulson DNA sequencing with chain-terminating inhibitors Proc Natl Acad Sci USA 74 1977 5463 5467
33. W Boll P Wagner N Mantei Structure of the chromosomal gene and cDNAs coding for lactase-phlorizin hydrolase in humans with adult-type hypolactasia or persistence of lactase Am J Hum Genet 48 1991 889 902
34. C Gorman LF Moffat BH Howard Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells Mol Cell Biol 2 1982 1044 1051
35. I Bach M Yaniv More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing EMBO J 12 1993 4229 4242
36. L Samuelsson K Stromberg K Vikman G Bjursell S Enerback The CCAAT/enhancer binding protein and its role in adipocyte differentiation: evidence for direct involvement in terminal adipocyte development EMBO J 10 1991 3787 3793
37. PH Vachon JF Beaulieu Transient mosaic patterns of morphological and functional differentiation in the Caco-2 cell line Gastroenterology 103 1992 414 423
38. P Chomczynski N Sacchi Single-step method of RNA isolation by acid guanidinium thiocyanate- phenol-chloroform extraction Anal Biochem 162 1987 156 159
39. J Olsen L Laustsen U Kärnström H Sjöström O Norén Tissue-specific interactions between nuclear proteins and the aminopeptidase N promoter J Biol Chem 266 1991 18089 18096
40. K Gorski M Carneiro U Schibler Tissue-specific in vitro transcription from mouse albumin promoter Cell 47 1986 767 776
41. TF Osborne G Gil MS Brown RC Kowal JL Goldstein Identification of promoter elements required for in vitro transcription of hamster 3-hydroxy-methylglutaryl coenzyme A reductase gene Proc Natl Acad Sci USA 84 1987 3614 3618
42. MM Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of proteindye binding Anal Biochem 72 1976 248 254
43. S Pierrou M Hellqvist L Samuelsson S Enerbäck P Carlsson Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending EMBO J 13 1994 5002 5012
44. J Olsen I Classen-Linke H Sjöström O Norén Pseudopregnancy induces the expression of hepatocyte nuclear factor-1 beta and its target gene aminopeptidase N in rabbit endometrium via the epithelial promoter Biochem J 312 1995 31 37
45. JT Troelsen C Mitchelmore N Spodsberg AM Jensen O Norén H Sjöström Regulation of lactase-phlorizin hydrolase gene expression by the caudal-related homeodomain protein Cdx-2 Biochem J 322 1997 833 838
46. F Tronche M Yaniv HNF1, a homeoprotein member of the hepatic transcription regulatory network Bioessays 14 1992 579 587
47. RJ Christy KH Kaestner DE Geiman MD Lane CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes Proc Natl Acad Sci USA 88 1991 2593 2597
48. M Serfas AL Tyner HNF-1α and HNF-1β expression in mouse intestinal crypts Am J Physiol 265 1993 G506 G513
49. N Miura K Iwai I Miyamoto Immunological characterization of hepatocyte nuclear factor 1 protein: appearance of hepatocyte nuclear factor 1 protein in developing mouse embryos Eur J Cell Biol 60 1993 376 382
50. E Sibley NA Santiago PG Traber Lactase regulation associated with differential interaction between its promoter and at least two nuclear proteins (abstr) Gastroenterology 110 1996 A839
51. C Mitchelmore JT Troelsen H Sjöström O Norén The HOXC11 homeodomain protein interacts with the lactase-phlorizin hydrolase promoter and stimulates HNF1α-dependent transcription J Biol Chem 273 1998 13297 13306
52. E Suh PG Traber An intestine-specific homeobox gene regulates proliferation and differentiation Mol Cell Biol 16 1996 619 625
53. WA Olsen M Lloyd H Korsmo YZ He Regulation of sucrase and lactase in Caco-2 cells: relationship to nuclear factors SIF-1 and NF-LPH-1 Am J Physiol 271 1996 G707 G713
54. DB Mendel PA Khavari PB Conley MK Graves LP Hansen A Admon GR Crabtree Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein Science 254 1991 1762 1767
55. H Ye TF Kelly U Samadani L Lim S Rubio DG Overdier KA Roebuck RH Costa Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues Mol Cell Biol 17 1997 1626 1641
56. RK Montgomery EH Rings JF Thompson CC Schuijt KM Aras VJ Wielenga MJ Kothe HA Buller RJ Grand Increased C/EBP in fetal rat small intestine precedes initiation of dif ferentiation marker mRNA synthesis Am J Physiol 272 1997 G534 G544
57. RM Umek AD Friedman SL McKnight CCAAT-enhancer binding protein: a component of a differentiation switch Science 251 1991 288 292
58. M Verhave SD Krasinski SM Maas FJ Smiers K Mishra NG Breeuwsma HY Naim RJ Grand Further characterization of the 5'-flanking region of the rat lactase-phlorizin hydrolase gene Biochem Biophys Res Commun 209 1995 989 995
59. TJ Osterreicher LL Leeper GJ Darlington SJ Henning Mice lacking C/EBPα show normal perinatal expression of various intestinal mRNAs (abstr) Gastroenterology 110 1997 A826
60. Y Wang CB Harvey WS Pratt VR Sams M Sarner M Rossi S Auricchio DM Swallow The lactase persistence/non-persistence polymorphism is controlled by a cis-acting element Hum Mol Genet 4 1995 657 662
61. Y Wang CB Harvey EJ Hollox AD Phillips M Poulter P Clay JA Walker-Smith DM Swallow The genetically programmed down-regulation of lactase in children Gastroenterology 114 1998 1230 1236
62. E Suh L Chen J Taylor PG Traber A homeodomain protein related to caudal regulates intestine-specific gene transcription Mol Cell Biol 14 1994 7340 7351
63. SY Lee BP Nagy AR Brooks DM Wang B Paulweber B Levy-Wilson Members of the caudal family of homeodomain proteins repress transcription from the human apolipoprote in B promoter in intestinal cells J Biol Chem 271 1996 707 718
64. J Olsen L Laustsen JT Troelsen HNF1α activates the aminopeptidase N promoter in intestinal (Caco-2) cells FEBS Lett 342 1994 325 328
65. F Drummond J Sowden K Morrison YH Edwards The caudal-type homeobox protein Cdx-2 binds to the colon promoter of the carbonic anhydrase 1 gene Eur J Biochem 236 1996 670 681
66. M Lambert S Colnot E Suh F L'Horset C Blin ME Calliot M Raymondjean M Thomasset PG Traber C Perret Cis-acting elements and transcription factors involved in the intestinal specific expression of the rat calbindin-D9K gene: binding of the intestine-specific transcription factor Cdx-2 to the TATA box Eur J Biochem 236 1996 778 788
67. T Jin DJ Drucker Activation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2/3 Mol Cell Biol 16 1996 19 28
68. PG Traber DG Silberg Intestine-specific gene transcription Annu Rev Physiol 58 1996 275 297