Mutations on the N-terminal region abolish differentially the enzymatic activity, membrane-damaging activity and cytotoxicity of Taiwan cobra phospholipase A2

Toxicon

Volumn 51, Issue 2, 2008, Pages 270-279

  Chiou, Yi Ling ^a   Cheng, Yun Ching ^a   Kao, Pei Hsiu ^a   Wang, Jeh Jeng ^b   Chang, Long Sen ^a  

^a NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Catalytic activity; Cytotoxicity; Membrane damaging activity; N terminal mutants; Phospholipase A2

Indexed keywords

PHOSPHOLIPASE A2; SNAKE VENOM;

ARTICLE; CALCIUM BINDING; CELL DEATH; CELL STRAIN U937; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MEMBRANE DAMAGE; MUTATION; NAJA NAJA ATRA; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SNAKE; WESTERN BLOTTING;

ANIMALS; COBRA; COBRA VENOMS; DNA, COMPLEMENTARY; MUTATION; PHOSPHOLIPASES A2; TAIWAN;

NAJA ATRA;

EID: 38149097819     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2007.10.001     Document Type: Article

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