The anti-inflammatory effect of low-dose radiation therapy involves a diminished CCL20 chemokine expression and granulocyte/endothelial cell adhesion

Strahlentherapie und Onkologie

Volumn 184, Issue 1, 2008, Pages 41-47

  Rödel, Franz ^a   Hofmann, Dorothée ^b   Auer, Judith ^b   Keilholz, Ludwig ^c   Röllinghoff, Martin ^b   Sauer, Rolf ^b   Beuscher, Horst Ulrich ^b  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c Clinical Center Bayreuth   (Germany)

Author keywords

Adhesion assay; CCL20; Low dose radiotherapy; Polymorphonuclear neutrophils

Indexed keywords

CYTOKINE; INTERCELLULAR ADHESION MOLECULE 1; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; NEUTRALIZING ANTIBODY; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CANCER RADIOTHERAPY; CELL ADHESION; CELL CULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; GRANULOCYTE; HUMAN; HUMAN CELL; IRRADIATION; LOW ENERGY RADIATION; NEUTROPHIL; RADIATION DOSE; UMBILICAL VEIN;

CELL ADHESION; CELL LINE; CHEMOKINE CCL20; CHEMOKINES; CHEMOKINES, CC; CHEMOTAXIS, LEUKOCYTE; DOSE FRACTIONATION; ENDOTHELIUM, VASCULAR; HUMANS; HYBRID CELLS; INTEGRINS; INTERLEUKIN-8; MACROPHAGE INFLAMMATORY PROTEINS; NEUTROPHIL INFILTRATION; NEUTROPHILS; RADIOTHERAPY DOSAGE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 38149070927     PISSN: 01797158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00066-008-1776-8     Document Type: Article

References (37)

1. Auer J, Blaess M, Schulze-Koops H, et al. Expression and regulation of CCL18 in synovial fluid neutrophils of patients with rheumatoid arthritis. Arthritis Res Ther 2007;9:R94.
2. Bazzoni F, Cassatella MA, Rossi F, et al. Phagocytosing neutrophils produce and release high amounts of the neutrophil-activating peptide 1/interleukin 8. J Exp Med 1991;173:771-4.
3. Cho ML, Min SY, Chang SH, et al. Transforming growth factor beta 1 (TGF-beta1) down-regulates TNF alpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression. Immunol Lett 2006;105:159-66.
4. Hanyuda M, Kasama T, Isozaki T, et al. Activated leucocytes express and secrete macrophage inflammatory protein-1alpha upon interaction with synovial fibroblasts of rheumatoid arthritis via a beta2-integrin/ICAM-1 mechanism. Rheumatology (Oxf) 2003;42:1390-7.
5. Hart PH, Spencer LK, Nulsen MF, et al. Neutrophil activity in abscess-bearing mice: comparative studies with neutrophils isolated from peripheral blood, elicited peritoneal exudates, and abscesses. Infect Immun 1986;51:936-41.
6. Heyd R, Tselis N, Ackermann H, et al. Functional outcome after megavoltage irradiation for heel spurs. Strahlenther Onkol 2006;182:733-9.
7. Heyd R, Tselis N, Ackermann H, et al. Radiation therapy for painful heel spurs. Results of a prospective randomized study. Strahlenther Onkol 2007;183:3-9.
8. Hieshima K, Imai T, Opdenakker G, et al. Molecular cloning of a novel human CC chemokine liver and activation-regulated chemokine (LARC) expressed in liver. Chemotactic activity for lymphocytes and gene localization on chromosome 2. J Biol Chem 1997;272:5846-53.
9. Hildebrandt G, Loppnow G, Jahns J, et al. Inhibition of the iNOS pathway in inflammatory macrophages by low-dose X-irradiation in vitro. Is there a time dependence? Strahlenther Onkol 2003;179:158-66.
10. Hildebrandt G, Maggiorella L, Rödel F, et al. Mononuclear cell adhesion and cell adhesion molecule liberation after X-irradiation of activated endothelial cells in vitro. Int J Radiat Biol 2002;78:315-25.
11. Hildebrandt G, Seed MP, Freemantle CN, et al. Mechanisms of the anti-inflammatory activity of low-dose radiation therapy. Int J Radiat Biol 1998;74:367-78.
12. Homey B, Dieu-Nosjean MC, Wiesenborn A, et al. Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis. J Immunol 2000;164:6621-32.
13. Issa R, Xie S, Lee KY, et al. GRO-alpha regulation in airway smooth muscle by IL-1beta and TNF-alpha: role of NF-kappaB and MAP kinases. Am J Physiol Lung Cell Mol Physiol 2006;291:L66-74.
14. Kasama T, Strieter RM, Standiford TJ, et al. Expression and regulation of human neutrophil-derived macrophage inflammatory protein 1 alpha. J Exp Med 1993;178:63-72.
15. Kern PM, Keilholz L, Forster C, et al. Low-dose radiotherapy selectively reduces adhesion of peripheral blood mononuclear cells to endothelium in vitro. Radiother Oncol 2000;54:273-82.
16. Kobayashi SD, Voyich JM, Burlak C, et al. Neutrophils in the innate immune response. Arch Immunol Ther Exp (Warsz) 2005;53:505-17.
17. Mayer R, Sminia P, McBride WH, et al. Lymphatic fistulas: obliteration by low-dose radiotherapy. Strahlenther Onkol 2005;181:660-4.
18. Micke O, Haidenberger A, Auer T, et al. Irradiation causes biphasic neutrophilic granulocyte phagocytic function. Strahlenther Onkol 2005;181:313-8.
19. Okada M, Suzuki K, Takada K, et al. Detection of up-regulated genes in thrombin-stimulated human umbilical vein endothelial cells. Thromb Res 2006;118:715-21.
20. Rödel F, Franz S, Sheriff A, et al. The CFSE distribution assay is a powerful technique for the analysis of radiation-induced cell death and survival on a single-cell level. Strahlenther Onkol 2005;181:456-62.
21. Rödel F, Keilholz L, Herrmann M, et al. Radiobiological mechanisms in inflammatory diseases of low-dose radiation therapy. Int J Radiat Biol 2007;83:357-66.
22. Rödel F, Kley N, Beuscher HU, et al. Anti-inflammatory effect of low-dose X-irradiation and the involvement of a TGF-beta1-induced down-regulation of leukocyte/endothelial cell adhesion. Int J Radiat Biol 2002;78:711-9.
23. Rödel F, Schaller U, Schultze-Mosgau S, et al. The induction of TGF-beta1 and NF-kappaB parallels a biphasic time course of leukocyte/ endothelial cell adhesion following low-dose X-irradiation. Strahlenther Onkol 2004;180:194-200.
24. Sampson AP. The role of eosinophils and neutrophils in inflammation. Clin Exp Allergy 2000;30:Suppl 1:22-7.
25. Scapini P, Lapinet-Vera JA, Gasperini S, et al. The neutrophil as a cellular source of chemokines. Immunol Rev 2000;177:195-203.
26. Scapini P, Laudanna C, Pinardi C, et al. Neutrophils produce biologically active macrophage inflammatory protein-3alpha (MIP-3alpha)/CCL20 and MIP-3beta/CCL19. Eur J Immunol 2001;31:1981-8.
27. Schaue D, Marples B, Trott KR. The effects of low-dose X-irradiation on the oxidative burst in stimulated macrophages. Int J Radiat Biol 2002;78:567-76.
28. Schultze J, Eilf K. Perspectives of radiation therapy in benign diseases. Strahlenther Onkol 2006;182:259-62.
29. Schutyser E, Struyf S, Menten P, et al. Regulated production and molecular diversity of human liver and activation-regulated chemokine/macrophage inflammatory protein-3 alpha from normal and transformed cells. J Immunol 2000;165:4470-7.
30. Seegenschmiedt MH, Katalinic A, Makoski H, et al. Radiation therapy for benign diseases: patterns of care study in Germany. Int J Radiat Oncol Biol Phys 2000;47:195-202.
31. Seegenschmiedt MH, Micke O, Willich N. Radiation therapy for nonmalignant diseases in Germany. Current concepts and future perspectives. Strahlenther Onkol 2004;180:718-30.
32. Smith WB, Noack L, Khew-Goodall Y, et al. Transforming growth factor-beta 1 inhibits the production of IL-8 and the transmigration of neutrophils through activated endothelium. J Immunol 1996;157:360-8.
33. Trott KR. Therapeutic effects of low radiation doses. Strahlenther Onkol 1994;170:1-12.
34. Trott KR, Kamprad F. Radiobiological mechanisms of anti-inflammatory radiotherapy. Radiother Oncol 1999;51:197-203.
35. Trott KR, Kamprad F. Estimation of cancer risks from radiotherapy of benign diseases. Strahlenther Onkol 2006;182:431-6.
36. Witko-Sarsat V, Rieu P, Descamps-Latscha B, et al. Neutrophils: molecules, functions and pathophysiological aspects. Lab Invest 2000;80:617-53.
37. Zweiman B. Neutrophils. Clin Allergy Immunol 2002;16:77-95.