Mutational analysis of the nucleotide binding site of Escherichia coli dCTP deaminase

Archives of Biochemistry and Biophysics

Volumn 470, Issue 1, 2008, Pages 20-26

  Thymark, Majbritt ^a   Johansson, Eva ^a,b   Larsen, Sine ^a,b   Willemoës, Martin ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

Author keywords

Catalytic mechanism; Deamination; Deoxynucleotide metabolism; dUTP; Enzyme regulation

Indexed keywords

CARBOXYLIC ACID; DEAMINASE; DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE; METHYL GROUP; NUCLEOTIDE; PYRIMIDINE; PYROPHOSPHATE; THREONINE; THYMIDINE PHOSPHATE; UNCLASSIFIED DRUG; URIDINE PHOSPHATE;

ARTICLE; BINDING SITE; COMPLEX FORMATION; CRYSTAL STRUCTURE; DEAMINATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PURIFICATION; ENZYME REGULATION; ESCHERICHIA COLI; HYDROGEN BOND; HYDROLYSIS; MUTATION; NONHUMAN; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; STEREOSPECIFICITY; SYNTHESIS; WILD TYPE;

BINDING SITES; COMPUTER SIMULATION; ENZYME ACTIVATION; ESCHERICHIA COLI; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NUCLEOTIDE DEAMINASES; PROTEIN BINDING;

ESCHERICHIA COLI; SALMONELLA TYPHIMURIUM;

EID: 38149042542     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2007.10.013     Document Type: Article

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