Homocysteine and diabetic retinopathy

Diabetes Care

Volumn 31, Issue 1, 2008, Pages 50-56

  Brazionis, Laima ^a   Rowley Sr , Kevin ^a   Itsiopoulos, Catherine ^a   Harper, Colin Alexander ^b   O'Dea, Kerin ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b CENTRE FOR EYE RESEARCH AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; HEMOGLOBIN A1C; HOMOCYSTEINE; BIOLOGICAL MARKER; GLYCOSYLATED HEMOGLOBIN;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; COMMUNITY CARE; CONTROLLED STUDY; DIABETIC RETINOPATHY; DISEASE DURATION; FEMALE; FLUORESCENCE POLARIZATION IMMUNOASSAY; HUMAN; INTERVIEW; KIDNEY DYSFUNCTION; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; QUESTIONNAIRE; SEX DIFFERENCE; SYSTOLIC BLOOD PRESSURE; BLOOD; BLOOD PRESSURE; CROSS-SECTIONAL STUDY; FLUORESCENCE ANGIOGRAPHY; MIDDLE AGED; RISK; RISK FACTOR;

ADULT; AGED; BIOLOGICAL MARKERS; BLOOD PRESSURE; CROSS-SECTIONAL STUDIES; DIABETIC RETINOPATHY; FEMALE; FLUORESCEIN ANGIOGRAPHY; FOLIC ACID; HEMOGLOBIN A, GLYCOSYLATED; HOMOCYSTEINE; HUMANS; LIFE STYLE; MALE; MIDDLE AGED; ODDS RATIO; RISK FACTORS;

EID: 38149042007     PISSN: 01495992     EISSN: 01495992     Source Type: Journal    
DOI: 10.2337/dc07-0632     Document Type: Article

References (36)

1. Weir D, Scott J; Homocysteine as a risk factor for cardiovascular and related disease: nutritional implications. Nutr Res Rev 11:311-338, 1998
2. Coral K, Raman R, Rathi S, Rajesh M, Sulochana KN, Angayarkanni N, Paul PG, Ramakrishnan S: Plasma homocysteine and total thiol content in patients with exudative age-related macular degeneration. Eye 20:203-207, 2006
3. Jacques PF, Bostom AG, Wilson PW, Rich S, Rosenberg IH, Selhub J: Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am J Clin Nutr 73:613-621, 2001
4. Refsum H, Nurk E, Smith AD, Ueland PM, Gjesdal CG, Bjelland I, Tverdal A, Tell GS, Nygard O, Vollset SE: The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with disease. J Nutr 136:1731S-1740S, 2006
5. Chico A, Perez A, Cordoba A, Arcelus R, Carreras G, de Leiva A, Gonzalez-Sastre F, Blanco-Vaca F: Plasma homocysteine is related to albumin excretion rate in patients with diabetes mellitus: a new link between diabetic nephropathy and cardiovascular disease? Diabetologia 41:684-693, 1998
6. Hultberg B, Agardh E, Andersson A, Brattstrom L, Isaksson A, Israelsson B, Agardh CD: Increased levels of plasma homocysteine are associated with nephropathy, but not severe retinopathy in type 1 diabetes mellitus. Scand J Clin Lab Invest 51:277-282, 1991
7. Agardh CD, Agardh E, Andersson A, Hultberg B: Lack of association between plasma homocysteine levels and microangiopathy in type 1 diabetes mellitus. Scand J Clin Lab Invest 54:637-641, 1994
8. Neugebauer S, Baba T, Kurokawa K, Watanabe T: Defective homocysteine metabolism as a risk factor for diabetic retinopathy. Lancet 349:473-474, 1997
9. Smulders YM, Rakic M, Slaats EH, Treskes M, Sijbrands EJ, Odekerken DA, Stehouwer CD, Silberbusch J: Fasting and post-methionine homocysteine levels in NIDDM: determinants and correlations with retinopathy, albuminuria, and cardiovascular disease. Diabetes Care 22:125-132, 1999
10. Stabler SP, Estacio R, Jeffers BW, Cohen JA, Allen RH, Schrier RW: Total homocysteine is associated with nephropathy in non-insulin-dependent diabetes mellitus. Metabolism 48:1096-1101, 1999
11. Agardh E, Hultberg B, Agardh CD: Severe retinopathy in type 1 diabetic patients is not related to the level of plasma homocysteine. Scand J Clin Lab Invest 60:169-174, 2000
12. Chiarelli F, Pomilio M, Mohn A, Tumini S, Vanelli M, Morgese G, Spagnoli A, Verrotti A: Homocysteine levels during fasting and after methionine loading in adolescents with diabetic retinopathy and nephropathy. J Pediatr 137:386-392, 2000
13. Vaccaro O, Perna AF, Mancini FP, Iovine C, Cuomo V, Sacco M, Tufano A, Rivellese AA, Ingrosso D, Riccardi G: Plasma homocysteine and microvascular complications in type 1 diabetes. Nutr Metab Cardiovasc Dis 10:297-304, 2000
14. Hoogeveen EK, Kostense PJ, Eysink PE, Polak BC, Beks PJ, Jakobs C, Dekker JM, Nijpels G, Heine RJ, Bouter LM, Stehouwer CD: Hyperhomocysteinemia is associated with the presence of retinopathy in type 2 diabetes mellitus: the Hoorn Study. Arch Intern Med 160:2984-2990, 2000
15. Buysschaert M, Jamart J, Dramais AS, Wallemacq P, Hermans MP: Micro- and macrovascular complications and hyperhomocysteinaemia in type 1 diabetic patients. Diabetes Metab 27:655-659, 2001
16. Agullo-Ortuno MT, Albaladejo MD, Parra S, Rodriguez-Manotas M, Fenollar M, Ruiz-Espejo F, Tebar J, Martinez P: Plasmatic homocysteine concentration and its relationship with complications associated to diabetes mellitus. Clin Chim Acta 326:105-112, 2002
17. Abdella NA, Mojiminiyi OA, Akanji AO, Moussa MA: Associations of plasma homocysteine concentration in subjects with type 2 diabetes mellitus. Acta Diabetol 39:183-190, 2002
18. Matteucci E, Rossi L, Mariani S, Fagnani F, Quilici S, Cinapri V, Giampietro O: Blood levels of total homocysteine in patients with type 1 diabetes (with no complications, diabetic nephropathy and/or retinopathy) and in their non-diabetic relatives. Nutr Metab Cardiovasc Dis 12:184-189, 2002
19. Guo Q, Lu J, Pan C: [The abnormal reaction to post methionine loading test in type diabetes with or without retinopathy]. Zhonghua Yi Xue Za Zhi 82:725-728, 2002 [article in Chinese]
20. Yang G, Lu J, Pan C: [The impact of plasma homocysteine level on development of retinopathy in type 2 diabetes mellitus]. Zhonghua Nei Ke Za Zhi 41:34-38, 2002 [article in Chinese]
21. Looker HC, Fagot-Campagna A, Gunter EW, Pfeiffer CM, Narayan KM, Knowler WC, Hanson RL: Homocysteine as a risk factor for nephropathy and retinopathy in type 2 diabetes. Diabetologia 46:766-772, 2003
22. Sun J, Xu Y, Zhu Y, Lu H, Deng H, Fan Y, Sun S, Zhang Y: The relationship between MTHFR gene polymorphisms, plasma homocysteine levels and diabetic retinopathy in type 2 diabetes mellitus. Chin Med J (Engl) 116:145-147, 2003
23. Saeed BO, Nixon SJ, White AJ, Summer-field GP, Skillen AW, Weaver JU: Fasting homocysteine levels in adults with type 1 diabetes and retinopathy. Clin Chim Acta 341:27-32, 2004
24. Goldstein M, Leibovitch I, Yeffimov I, Gavendo S, Sela BA, Loewenstein A: Hyperhomocysteinemia in patients with diabetes mellitus with and without diabetic retinopathy. Eye 18:460-465, 2004
25. Yucel I, Yucel G, Muftuoglu F: Plasma homocysteine levels in noninsulin-dependent diabetes mellitus with retinopathy and neovascular glaucoma. Int Ophthalmol 25:201-205, 2004
26. Soedamah-Muthu SS, Chaturvedi N, Teerlink T, Idzior-Walus B, Fuller JH, Stehouwer CD: Plasma homocysteine and microvascular and macrovascular complications in type 1 diabetes: a cross-sectional nested case-control study. J Intern Med 258:450-459, 2005
27. de Luis DA, Fernandez N, Arranz ML, Aller R, Izaola O, Romero E: Total homocysteine levels relation with chronic complications of diabetes, body composition, and other cardiovascular risk factors in a population of patients with diabetes mellitus type 2. J Diabetes Complications 19:42-46, 2005
28. Huang EJ, Kuo WW, Chen YJ, Chen TH, Chang MH, Lu MC, Tzang BS, Hsu HH, Huang CY, Lee SD: Homocysteine and other biochemical parameters in type 2 diabetes mellitus with different diabetic duration or diabetic retinopathy. Clinica Chimica Acta 366:293-298, 2006
29. World Health Organization: Diabetes Mellitus: Report of a WHO Study Group. Geneva, World Health Org., 1999 (Tech. rep. ser. no. WHO/NCD/NCS/99.2.16)
30. Giles GG, English DR: The Melbourne Collaborative Cohort Study. IARC Sci Publ 156:69-70, 2002
31. Aldington SJ, Kohner EM, Meuer S, Klein R, Sjolie AK: Methodology for retinal photography and assessment of diabetic retinopathy: the EURODIAB IDDM complications study. Diabetologia 38:437-444, 1995
32. Refsum H, Smith AD, Ueland PM, Nexo E, Clarke R, McPartlin J, Johnston C, Engbaek F, Schneede J, McPartlin C, Scott JM: Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem 50:3-32, 2004
33. Brown RD, Jun R, Hughes W, Watman R, Arnold B, Kronenberg H: Red cell folate assays: some answers to current problems with radioassay variability. Pathology 22:82-87, 1990
34. Hankey GJ, Eikelboom JW, Ho WK, van Bockxmeer FM: Clinical usefulness of plasma homocysteine in vascular disease. Med J Aust 181:314-318, 2004
35. Rowley KG, Lee AJ, Yarmirr D, O'Dea K: Homocysteine concentrations lowered following dietary intervention in an aboriginal community. Asia Pac J Clin Nutr 12:92-95, 2003
36. Coca SG, Krumholz HM, Garg AX, Parikh CR: Underrepresentation of renal disease in randomized controlled trials of cardiovascular disease. Jama 296:1377-1384, 2006