The relationship between MTHFR gene polymorphisms, plasma homocysteine levels and diabetic retinopathy in type 2 diabetes mellitus

Chinese Medical Journal

Volumn 116, Issue 1, 2003, Pages 145-147

  Sun, Jiazhong ^a   Xu, Yancheng ^a   Zhu, Yilian ^a   Lu, Hongyun ^a   Deng, Haohua ^a   Fan, Youyun ^a   Sun, Suxin ^a   Zhang, Ying ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Diabetic retinopathy; Homocysteine; Methylenetetrahydrofolate reductase gene

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); HOMOCYSTEINE;

ADULT; ALLELE; AMINO ACID BLOOD LEVEL; ARTICLE; CHINESE; CONTROLLED STUDY; DIABETIC MICROANGIOPATHY; DIABETIC RETINOPATHY; DISEASE COURSE; DNA POLYMORPHISM; ENZYME ACTIVITY; FEMALE; FLUORESCENCE ANALYSIS; GENE FREQUENCY; GENE MUTATION; GENETIC ANALYSIS; GENETIC PREDISPOSITION; GENETIC RISK; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK ASSESSMENT; RISK FACTOR;

AGED; DIABETES MELLITUS, TYPE 2; DIABETIC RETINOPATHY; FEMALE; GENOTYPE; HOMOCYSTEINE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; MUTATION; OXIDOREDUCTASES ACTING ON CH-NH GROUP DONORS; POLYMORPHISM, GENETIC;

EID: 0037256437     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Vaccaro O, Ingrosso D, Riveuese A, et al. Moderate hyperhomocysteinaemia and retinopathy in IDDM. Lancet 1997;349:1102-1103.
2. Symposium on hyperhomocysteinaemia and its related diseases in China. Natl Med J Chin 1999;79:406-410.
3. Gudnason V, Stansbie D, Scott J, et al. C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) : its frequency and impact on plasma homocysteine concentration in different European populations. Atherosclerosis 1998;136:347-354.
4. Hiroyuki M, Jun-ichi T, Hiroki K, et al. Genetic Polymorphism of 5, 10methy-lenetetrahydrofolate reductase as a risk factor for coronary artery disease. Circulation 1997;95:2032-2036.
5. Neugebaner S, Baba T, Kurokawa K, et al. Defective homocysteine metabolism as a risk factor for diabetic retinopathy. Lancet 1997;349:473-474.
6. Neugebaner S, Baba T, Watanabe T, et al. methylenetetrahydrofolate reductase gene polymorphism as a risk factor for diabetic nephropathy in NIDDM patients. Lancet 1998;352:454.
7. Kluijtmans LA, van den Heuval LP, Boers GH, et al. Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease. Am J Hum Genet 1996;58:35-41.