Quantitative trait locus analysis of carotid atherosclerosis in an intercross between C57BL/6 and C3H apolipoprotein E-deficient mice

Stroke

Volumn 39, Issue 1, 2008, Pages 166-173

  Li, Qiongzhen ^a   Li, Yuhua ^a   Zhang, Zhimin ^a   Gilbert, Timothy R ^a   Matsumoto, Alan H ^a   Dobrin, Seth E ^b   Shi, Weibin ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b MARSHFIELD CLINIC   (United States)

Author keywords

Carotid atherosclerosis; Hyperlipidemia; Quantitative trait locus; Stroke

Indexed keywords

APOLIPOPROTEIN E; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CAROTID ARTERY; CHOLESTEROL BLOOD LEVEL; CHROMOSOME 1; CHROMOSOME 11; CHROMOSOME 12; CHROMOSOME 4; CHROMOSOME 5; CHROMOSOME 6; CONTROLLED STUDY; FEMALE; GENETIC MARKER; GENETIC VARIABILITY; GENOME; LIPID BLOOD LEVEL; MOUSE; MOUSE STRAIN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BLOOD; C3H MOUSE; C57BL MOUSE; CAROTID ARTERY DISEASE; DISEASE MODEL; DISEASE PREDISPOSITION; GENETICS; GENOTYPE; MALE; MOUSE MUTANT; PATHOLOGY;

ANIMALS; APOLIPOPROTEINS E; CAROTID ARTERY DISEASES; CHOLESTEROL, HDL; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; FEMALE; GENOTYPE; LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL; MALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, KNOCKOUT; PHENOTYPE; QUANTITATIVE TRAIT LOCI; TRIGLYCERIDES;

EID: 38149032631     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.107.492165     Document Type: Article

References (38)

1. Bonita R. Epidemiology of stroke. Lancet. 1992;339:342-344.
2. Humphries SE, Morgan L. Genetic risk factors for stroke and carotid atherosclerosis: insights into pathophysiology from candidate gene approaches. Lancet Neurol. 2004;3:227-236.
3. Paigen B, Morrow A, Brandon C, Mitchell D, Holmes P. Variation in susceptibility to atherosclerosis among inbred strains of mice. Atherosclerosis. 1985;57:65-73.
4. Qiao JH, Xie PZ, Fishbein MC, Kreuzer J, Drake TA. Pathology of atheromatous lesions in inbred and genetically engineered mice. Genetic determination of arterial calcification. Arterioscler Thromb. 1994;14:1480-1497.
5. Plump AS, Smith JD, Hayek Y, Aalto-Setala K, Walsh A, Verstuyft JG, Rubin EM, Vreslow JL. Severe hyper-cholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 1992;71:343-353.
6. Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science. 1992;258:468-471.
7. Nakashima Y, Plupm AS, Raines EW, Breslow JL, Ross R. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb. 1994;14:133-140.
8. Rosenfeld ME, Polinsky P, Virmani R, Kauser K, Rubanyi G, Schwartz SM. Advanced atherosclerotic lesions in the innominate artery of the apoE knockout mouse. Arterioscler Thromb Vasc Biol. 2000;20:2587-2592.
9. Dansky HM, Charlton SA, Sikes JL, Heath SC, Simantov R, Levin LF, Shu P, Moore KJ, Breslow JL, Smith JD. Genetic background determines the extent of atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol. 1999;19:1960-1968.
10. Shi W, Wang NJ, Shih DM, Sun VZ, Wang X, Lusis AJ. Determinants of atherosclerosis susceptibility in the C3H and C57BL/6 mouse model: evidence for involvement of endothelial cells but not blood cells or cholesterol metabolism. Circ Res. 2000;86:1078-1084.
11. Tian J, Pei H, James JC, Li Y, Matsumoto AH, Helm GA, Shi W. Circulating adhesion molecules in apoE-deficient mouse strains with different atherosclerosis susceptibility. Biochem Biophys Res Commun. 2005;329:1102-1107.
12. von der Thusen JH, van Berkel TJ, Biessen EA. Induction of rapid atherogenesis by perivascular carotid collar placement in apolipoprotein E-deficient and low-density lipoprotein receptor-deficient mice. Circulation. 2001;103:1164-1170.
13. Su Z, Li Y, James JC, McDuffie M, Matsumoto AH, Helm GA, Weber JL, Lusis AJ, Shi W. Quantitative trait locus analysis of atherosclerosis in an intercross between C57BL/6 and C3H mice carrying the mutant apolipoprotein E gene. Genetics. 2006;172:1799-1807.
14. Colinayo VV, Qiao JH, Wang X, Krass KL, Schadt E, Lusis AJ, Drake TA. Genetic loci for diet-induced atherosclerosis lesions and plasma lipids in mice. Mamm Genome. 2003;14:464-471.
15. Sehayek E, Duncan EM, Yu HJ, Petukhova L, Breslow JL. Loci controlling plasma non-HDL and HDL cholesterol levels in a C57BL/6JX CASA/Rk intercross. J Lipid Res. 2003;44:1744-1750.
16. Purcell-Huynh DA, Weinreb A, Castellani LW, Mehrabian M, Doolittle MH, Lusis AJ. Genetic factors in lipoprotein metabolism. Analysis of a genetic cross between inbred mouse strains NZB/BINJ and SM/J using a complete linkage map approach. J Clin Invest. 1995;96:1845-1858.
17. Ishimori N, Li R, Kelmenson PM, Korstanje R, Walsh KA, Churchill GA, Forsman-Semb K, Paigen B. Quantitative trait loci analysis for plasma HDL-cholesterol concentrations and atherosclerosis susceptibility between inbred mouse strains C57BL/6J and 129S1/SvImJ. Arterioscler Thromb Vasc Biol. 2004;24:161-166.
18. Mehrabian M, Castellani LW, Wen P, Wong J, Rithaporn T, Hama SY, Hough GP, Johnson D, Albers JJ, Mottino GA, Frank JS, Navab M, Fogelman AM, Lusis AJ. Genetic control of HDL levels and composition in an interspecific mouse cross (CAST/EiC57BL/6J). J Lipid Res. 2000;41:1936-1946.
19. Wittenburg H, Lyons MA, Li R, Kurtz U, Wang X, Mossner J, Churchill GA, Carey MC, Paigen B. QTL mapping for genetic determinants of lipoprotein cholesterol levels in combined crosses of inbred mouse strains. J Lipid Res. 2006;47:1780-1790.
20. Suto J, Sekikawa K. Quantitative trait locus analysis of plasma cholesterol and triglyceride levels in KKRR F2 mice. Biochem Genet. 2003;41:325-341.
21. Witting PK, Pettersson K, Letters J, Stocker R. Site-specific antiatherogenic effect of probucol in apolipoprotein E deficient mice. Arterioscler Thromb Vasc Biol. 2000;20:e26-e33.
22. Reardon CA, Blachowicz L, White T, Cabana V, Wang Y, Lukens J, Bluestone J, Getz GS. Effect of immune deficiency on lipoproteins and atherosclerosis in male apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2001;21:1011-1016.
23. Markus H, Cullinane M. Severely impaired cerebrovascular reactivity predicts stroke and TIA risk in patients with carotid artery stenosis and occlusion. Brain. 2001;124:457-467.
24. Matteis M, Vernieri F, Caltagirone C, Troisi E, Rossini PM, Silvestrini M. Patterns of cerebrovascular reactivity in patients with carotid artery occlusion and severe contralateral stenosis. J Neurol Sci. 1999;168:47-51.
25. Bots ML, Hofman A, Grobbee DE. Increased common carotid intima-media thickness. Adaptive response or a reflection of atherosclerosis? Findings from the Rotterdam Study. Stroke. 1997;28:2442-2447.
26. Mathiesen EB, Bonaa KH, Joakimsen O. Echolucent plaques are associated with high risk of ischemic cerebrovascular events in carotid stenosis: the Tromsø study. Circulation. 2001;103:2171-2175.
27. O'Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson SK Jr. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. N Engl J Med. 1999;340:14-22.
28. Touboul PJ, Elbaz A, Koller C, Lucas C, Adrai V, Chedru F, Amarenco P. Common carotid artery intima-media thickness and brain infarction: the Etude du Profil Genetique de l'Infarctus Cerebral (GENIC) case-control study. The GENIC Investigators. Circulation. 2000;102:313-318.
29. Grobbee DE, Bots ML. Carotid intima-media thickness as an indicator of generalized atherosclerosis. J Intern Med. 1994;236:567-573.
30. Kiechl S, Willeit J, Bonora E, Schwarz S, Xu Q. No association between dehydroepiandrosterone sulfate and development of atherosclerosis in a prospective population study (Bruneck Study). Arterioscler Thromb Vasc Biol. 2000;20:1094-1100.
31. Mehrabian M, Wong J, Wang X, Jiang Z, Shi W, Folglman AM, Lusis AJ. Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia. Circ Res. 2001;89:125-130.
32. Welch CL, Bretschger S, Latib N, Bezouevski M, Guo Y, Pleskac N, Liang CP, Barlow C, Dansky H, Breslow JL, Tall AR. Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model. Proc Natl Acad Sci U S A. 2001;98:7946-7951.
33. Dansky HM, Shu P, Donavan M, Montagno J, Nagle DL, Smutko JS, Roy N, Whiteing S, Barrios J, McBride TJ, Smith JD, Duyk G, Breslow JL, Moore KJ. A phenotype-sensitizing APOE-deficient genetic background reveals novel atherosclerosis predisposition loci in the mouse. Genetics. 2002;160:1599-1608.
34. Shi W, Haberland ME, Jien ML, Shih DM, Lusis AJ. Endothelial responses to oxidized lipoproteins determine genetic susceptibility to atherosclerosis in mice. Circulation. 2000;102:75-81.
35. Pei H, Wang Y, Miyoshi T, Zhang Z, Matsumoto AH, Helm GA, Tellides G, Shi W. Direct evidence for a crucial role of the arterial wall in control of atherosclerosis susceptibility. Circulation. 2006;114:2382-2389.
36. Peters LL, Robledo RF, Bult CJ, Churchill GA, Paigen BJ, Svenson KL. The mouse as a model for human biology: a resource guide for complex trait analysis. Nat Rev Genet. 2007;8:58-69.
37. Wang X, Ishimori N, Korstanje R, Rollins J, Paigen B. Identifying novel genes for atherosclerosis through mouse-human comparative genetics. Am J Hum Genet. 2005;77:1-15.
38. Vivancos-Mora J, Gil-Nunez AC. Lipids and stroke: the opportunity of lipid-lowering treatment. Cerebrovasc Dis. 2005;20(suppl 2):53-67.