The neurobehavioural comorbidities of epilepsy: can a natural history be developed?

The Lancet Neurology

Volumn 7, Issue 2, 2008, Pages 151-160

  Hermann, Bruce ^a   Seidenberg, Michael ^b   Jones, Jana ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACADEMIC ACHIEVEMENT; ADOLESCENCE; AGING; AGORAPHOBIA; ALZHEIMER DISEASE; ANXIETY DISORDER; BEHAVIOR; BRAIN ATROPHY; BRAIN DEVELOPMENT; CHILDHOOD; COGNITION; COGNITIVE DEFECT; COMORBIDITY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE COURSE; DYSTHYMIA; EPILEPSY; HUMAN; INTRACTABLE EPILEPSY; LIFESPAN; MAJOR DEPRESSION; MENTAL DISEASE; MOOD DISORDER; ONSET AGE; PANIC; PREVALENCE; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; STIGMA; SUICIDAL IDEATION; TEMPORAL LOBE EPILEPSY;

ADULT; AGING; CHILD; CHILD BEHAVIOR DISORDERS; COMORBIDITY; DISEASE PROGRESSION; EPILEPSY; EPILEPSY, TEMPORAL LOBE; HUMANS; MENTAL DISORDERS;

EID: 38149000779     PISSN: 14744422     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1474-4422(08)70018-8     Document Type: Review

References (153)

1. World Health Organisation. Epilepsy: etiology, epidemiology and prognosis. Fact sheet 165 (2001), WHO, Geneva
2. Fox J. The response of epileptic children to mental and educational tests. British Journal of Medical Psychology 4 (1924) 235-248
3. Lennox W. Epilepsy and related disorders (1960), Little, Brown, and Co., Boston
4. Department of Health, Education, and Welfare. Plan for nationwide action on epilepsy. Washington, DC: Public Health Service, NIH.
5. Austin J., Carr D., and Hermann B. Living Well II: a review of progress since 2003. Epilepsy Behav 9 (2006) 386-393
6. Feinstein A. The pretherapeutic classification of comorbidity in chronic disease. J Chronic Dis 2 (1970) 455-468
7. Gaitatzis A., Carroll K., Majeed A., and Sander J. The epidemiology of the comorbidity of epilepsy in the general population. Epilepsia 45 (2004) 1613-1622
8. Stevens J. Interictal clinical manifestations of complex partial seizures. Adv Neurol 11 (1975) 85-112
9. Hermann B., and Whitman S. Behavioral and personality correlates of epilepsy: a review, methodological critique, and conceptual model. Psychol Bull 95 (1984) 451-497
10. Koponen A., Seppala U., Eriksson K., et al. Social functioning and psychological well-being of 347 young adults with epilepsy only-population-based, controlled study from Finland. Epilepsia 48 (2007) 907-912
11. Kokkonen J., Kokkonen E., Saukkonen A., and Pennanen P. Psychosocial outcome of young adults with epilepsy in childhood. J Neurol Neurosurg Psychiatry 62 (1997) 265-268
12. Camfield C., Camfield P., Smith B., Gordon K., and Dooley J. Biologic factors as predictors of social outcome of epilepsy in intellectually normal children: a population-based study. J Pediatr 122 (1993) 869-873
13. Wirrell E., Camfield C., Camfield P., Dooley J., Gordon K., and Smith B. Long-term psychosocial outcome in typical absence epilepsy. Sometimes a wolf in sheeps' clothing. Arch Pediatr Adolesc Med 151 (1997) 152-158
14. Tellez-Zenteno J., Patten S., Jette N., Williams J., and Wiebe S. Psychiatric comorbidity in epilepsy: a population-based analysis. Epilepsia 48 (2007) 2336-2344
15. Ettinger A., Reed M., and Cramer J. Depression and comorbidity in community-based patients with epilepsy or asthma. Neurology 63 (2004) 1008-1014
16. Ettinger A., Reed M., Goldberg J., and Hirschfeld R. Prevalence of bipolar symptoms in epilepsy vs other chronic health disorders. Neurology 65 (2005) 535-540
17. Kobau R., Zahran H., Grant D., Thurman D., Price P., and Zack M. Prevalence of active epilepsy and health-related quality of life among adults with self-reported epilepsy in California: California Health Interview Survey, 2003. Epilepsia 48 (2007) 1904-1913
18. Strine T., Kobau R., Chapman D., Thurman D., Price P., and Balluz L. Psychological distress, comorbidities, and health behaviors among U.S. adults with seizures: results from the 2002 National Health Interview Survey. Epilepsia 46 (2005) 1133-1139
19. Kobau R., Gilliam F., and Thurman D. Prevalence of self-reported epilepsy or seizure disorder and its associations with self-reported depression and anxiety: results from the 2004 HealthStyles Survey. Epilepsia 47 (2006) 1915-1921
20. Kobau R., DiIorio C., Price P., et al. Prevalence of epilepsy and health status of adults with epilepsy in Georgia and Tennessee: Behavioral Risk Factor Surveillance System, 2002. Epilepsy Behav 5 (2004) 358-366
21. Semah F., Picot M., Adam C., et al. Is the underlying cause of epilepsy a major prognostic factor for recurrence?. Neurology 51 (1998) 1256-1262
22. Oyegbile T., Dow C., Jones J., et al. The nature and course of neuropsychological morbidity in chronic temporal lobe epilepsy. Neurology 62 (2004) 1736-1742
23. Marques C., Caboclo L., da Silva T., et al. Cognitive decline in temporal lobe epilepsy due to unilateral hippocampal sclerosis. Epileps Behav 10 (2007) 477-485
24. Matthews C., and Klove H. Instruction manual for the adult neuropsychology test battery (1964), University of Wisconsin Medical School, Madison, WI
25. Loring D., Marino S., and Meador K. Neuropsychological and behavioral effects of antiepilepsy drugs. Neuropsychol Rev 17 (2007) 413-425
26. Jokeit H., Daamen M., Zang H., Janszky J., and Ebner A. Seizures accelerate forgetting in patients with left-sided temporal lobe epilepsy. Neurology 57 (2001) 125-126
27. Dodrill C., and Wilensky A. Intellectual impairment as an outcome of status epilepticus. Neurology 40 suppl 2 (1990) 23-27
28. Dodrill C., and Wilkus R. Neuropsychological correlates of the electroencephalogram in epileptics: III. Generalized nonepileptiform abnormalities. Epilepsia 19 (1978) 453-462
29. Binnie C. Cognitive impairment during epileptiform discharges: is it ever justifiable to treat the EEG?. Lancet Neurol 2 (2003) 725-730
30. Aldenkamp A., and Arends J. The relative influence of epileptic EEG discharges, short nonconvulsive seizures, and type of epilepsy on cognitive function. Epilepsia 45 (2004) 54-63
31. Elger C., Helmstaedter C., and Kurthen M. Chronic epilepsy and cognition. Lancet Neurol 3 (2004) 663-672
32. Henry T., Mazziotta J., and Engel Jr. J. Interictal metabolic anatomy of mesial temporal lobe epilepsy. Arch Neurol 50 (1993) 582-589
33. Rauch S., Dougherty D., Cosgrove G., et al. Cerebral metabolic correlates as potential predictors of response to anterior cingulotomy for obsessive compulsive disorder. Biol Psychiatry 50 (2001) 659-667
34. Jokeit H., Seitz R., Markowitsch H., Neumann N., Witte O., and Ebner A. Prefrontal asymmetric interictal glucose hypometabolism and cognitive impairment in patients with temporal lobe epilepsy. Brain 120 (1997) 2283-2294
35. Bromfield E., Altshuler L., Leiderman D., et al. Cerebral metabolism and depression in patients with complex partial seizures. Arch Neurol 49 (1992) 617-623
36. Salzberg M., Taher T., Davie M., et al. Depression in temporal lobe epilepsy surgery patients: an FDG-PET study. Epilepsia 47 (2006) 2125-2130
37. Lencz T., McCarthy G., Bronen R., et al. Quantitative magnetic resonance imaging in temporal lobe epilepsy: relationship to neuropathology and neuropsychological function. Ann Neurol 31 (1992) 629-637
38. Cendes F., Andermann F., Gloor P., et al. MRI volumetric measurement of amygdala and hippocampus in temporal lobe epilepsy. Neurology 43 (1993) 719-725
39. Salmenpera T., Kalviainen R., Partanen K., and Pitkanen A. Hippocampal and amygdaloid damage in partial epilepsy: a cross-sectional MRI study of 241 patients. Epilepsy Res 46 (2001) 69-82
40. Bernasconi N., Bernasconi A., Caramanos Z., Antel S., Andermann F., and Arnold D. Mesial temporal damage in temporal lobe epilepsy: a volumetric MRI study of the hippocampus, amygdala and parahippocampal region. Brain 126 (2003) 462-469
41. Bernasconi N., Bernasconi A., Andermann F., Dubeau F., Feindel W., and Reutens D. Entorhinal cortex in temporal lobe epilepsy: a quantitative MRI study. Neurology 52 (1999) 1870-1876
42. Bonilha L., Rorden C., Halford J., et al. Asymmetrical extra-hippocampal grey matter loss related to hippocampal atrophy in patients with medial temporal lobe epilepsy. J Neurol Neurosurg Psychiatry 78 (2007) 286-294
43. Kuzniecky R., Bilir E., Gilliam F., Faught E., Martin R., and Hugg J. Quantitative MRI in temporal lobe epilepsy: evidence for fornix atrophy. Neurology 53 (1999) 496-501
44. DeCarli C., Hatta J., Fazilat S., Fazilat S., Gaillard W., and Theodore W. Extratemporal atrophy in patients with complex partial seizures of left temporal origin. Ann Neurol 43 (1998) 41-45
45. Dreifuss S., Vingerhoets F., Lazeyras F., et al. Volumetric measurements of subcortical nuclei in patients with temporal lobe epilepsy. Neurology 57 (2001) 1636-1641
46. Natsume J., Bernasconi N., Andermann F., and Bernasconi A. MRI volumetry of the thalamus in temporal, extratemporal, and idiopathic generalized epilepsy. Neurology 60 (2003) 1296-1300
47. Szabo C., Lancaster J., Lee S., et al. MR imaging volumetry of subcortical structures and cerebellar hemispheres in temporal lobe epilepsy. AJNR Am J Neuroradiol 27 (2006) 2155-2160
48. Marsh L., Morrell M., Shear P., et al. Cortical and hippocampal volume deficits in temporal lobe epilepsy. Epilepsia 38 (1997) 576-587
49. Lee J., Andermann F., Dubeau F., et al. Morphometric analysis of the temporal lobe in temporal lobe epilepsy. Epilepsia 39 (1998) 727-736
50. Jutila L., Ylinen A., Partanen K., et al. MR volumetry of the entorhinal, perirhinal, and temporopolar cortices in drug-refractory temporal lobe epilepsy. AJNR Am J Neuroradiol 22 (2001) 1490-1501
51. Moran N., Lemieux L., Kitchen N., Fish D., and Shorvon S. Extrahippocampal temporal lobe atrophy in temporal lobe epilepsy and mesial temporal sclerosis. Brain 124 (2001) 167-175
52. Hermann B., Seidenberg M., Bell B., et al. The neurodevelopmental impact of childhood-onset temporal lobe epilepsy on brain structure and function. Epilepsia 43 (2002) 1062-1071
53. Sandok E., O'Brien T., Jack C., and So E. Significance of cerebellar atrophy in intractable temporal lobe epilepsy: a quantitative MRI study. Epilepsia 41 (2000) 1315-1320
54. Theodore W., DeCarli C., and Gaillard W. Total cerebral volume is reduced in patients with localization-related epilepsy and a history of complex febrile seizures. Arch Neurol 60 (2003) 250-252
55. Weber B., Luders E., Faber J., et al. Distinct regional atrophy in the corpus callosum of patients with temporal lobe epilepsy. Brain 130 (2007) 3149-3154
56. Oyegbile T., Hansen R., Magnotta V., et al. Quantitative measurement of cortical surface features in localization-related temporal lobe epilepsy. Neuropsychology 18 (2004) 729-737
57. Ronan L., Murphy K., Delanty N., et al. Cerebral cortical gyrification: a preliminary investigation in temporal lobe epilepsy. Epilepsia 48 (2007) 211-219
58. Arfanakis K., Hermann B., Rogers B., Carew J., Seidenberg M., and Meyerand M. Diffusion tensor MRI in temporal lobe epilepsy. Mag Res Imag 20 (2002) 511-519
59. Hermann B., Hansen R., Seidenberg M., Magnotta V., and O'Leary D. Neurodevelopmental vulnerability of the corpus callosum to childhood onset localization-related epilepsy. Neuroimage 18 (2003) 284-292
60. Seidenberg M., Kelly K., Parrish J., et al. Ipsilateral and contralateral MRI volumetric abnormalities in chronic unilateral temporal lobe epilepsy and their clinical correlates. Epilepsia 46 (2005) 420-430
61. Gross D., Concha L., and Beaulieu C. Extratemporal white matter abnormalities in mesial temporal lobe epilepsy demonstrated with diffusion tensor imaging. Epilepsia 47 (2006) 1360-1363
62. Concha L., Beaulieu C., Wheatley B., and Gross D. Bilateral white matter diffusion changes persist after epilepsy surgery. Epilepsia 48 (2007) 931-940
63. Yu A., Li K., Li L., Shan B., Wang Y., and Xue S. Whole-brain voxel-based morphometry of white matter in medial temporal lobe epilepsy. Eur J Radiol (2007). published online June 5. DOI:10.1016/j.ejrad.2007.04.011
64. Jutila L., Ylinen A., Partanen K., et al. MR volumetry of the entorhinal, perirhinal, and temporal cortices in drug-refractory temporal lobe epilepsy. AJNR Am J Neuroradiol 22 (2001) 1490-1501
65. Pulsipher D., Seidenberg M., and Hermann B. Relative degree of atrophy across neural regions ipsilateral and contralateral to side of temporal lobe seizure onset. Epilepsy and Behavior 11 (2007) 442-449
66. Lin J., Salamon N., Lee A., et al. Reduced neocortical thickness and complexity mapped in mesial temporal lobe epilepsy with hippocampal sclerosis. Cereb Cortex 17 (2007) 2007-2018
67. Dow C., Seidenberg M., and Hermann B. Relationship between information processing speed in temporal lobe epilepsy and white matter volume. Epilepsy Behav 5 (2004) 919-925
68. Hermann B., Seidenberg M., Sears L., et al. Cerebellar atrophy in temporal lobe epilepsy affects procedural memory. Neurology 63 (2004) 2129-2131
69. Trenerry M., Jack Jr. C., Ivnik R., et al. MRI hippocampal volumes and memory function before and after temporal lobectomy. Neurology 43 (1993) 1800-1805
70. Seidenberg M., Geary E., and Hermann B. Investigating temporal lobe contribution to confrontation naming using MRI quantitative volumetrics. J Int Neuropsychol Soc 11 (2005) 358-366
71. Swinkels W., Kuyk J., van Dyck R., and Spinhoven P. Psychiatric comorbidity in epilepsy. Epilepsy Behav 7 (2005) 37-50
72. Swinkels W., van Emde Boas W., Kuyk J., van Dyck R., and Spinhoven P. Interictal depression, anxiety, personality traits, and psychological dissociation in patients with temporal lobe epilepsy (TLE) and extra-TLE. Epilepsia 47 (2006) 2092-2103
73. Sturm V., Rosen H., Allison S., Miller B., and Levenson R. Self-conscious emotion deficits in frontotemporal lobar degeneration. Brain 129 (2006) 2508-2516
74. Rosen H., Allison S., Schauer G., Gorno-Tempini M., Weiner M., and Miller B. Neuroanatomical correlates of behavioural disorders in dementia. Brain 128 (2005) 2612-2625
75. Rosen H., Wilson M., Schauer G., et al. Neuroanatomical correlates of impaired recognition of emotion in dementia. Neuropsychologia 44 (2006) 365-373
76. Schacher M., Winkler R., Grunwald T., et al. Mesial temporal lobe epilepsy impairs advanced social cognition. Epilepsia 47 (2006) 2141-2146
77. Meletti S., Benuzzi F., Rubboli G., et al. Impaired facial emotion recognition in early-onset right mesial temporal lobe epilepsy. Neurology 60 (2003) 426-431
78. Benuzzi F., Meletti S., Zamboni G., et al. Impaired fear processing in right mesial temporal sclerosis: a fMRI study. Brain Res Bull 63 (2004) 269-281
79. Kanner A. Depression in epilepsy: prevalence, clinical semiology, pathogenic mechanisms, and treatment. Biol Psychiatry 54 (2003) 388-398
80. Christensen J., Vestergaard M., Mortensen P., Sidenius P., and Agerbo E. Epilepsy and risk of suicide: a population-based case-control study. Lancet Neurol 6 8 (2007) 693-698
81. Hesdorffer D., Hauser W., Annegers J., and Cascino G. Major depression is a risk factor for seizures in older adults. Ann Neurol 47 (2000) 246-249
82. Hesdorffer D., Hauser W., Olafsson E., Ludvigsson P., and Kjartansson O. Depression and suicide attempt as risk factors for incident unprovoked seizures. Ann Neurol 59 (2006) 35-41
83. Alper K., Schwartz K., Kolts R., and Khan A. Seizure incidence in psychopharmacological clinical trials: an analysis of Food and Drug Administration (FDA) summary basis of approval reports. Biol Psychiatry 62 (2007) 345-354
84. Thapar A., Roland M., and Harold G. Do depression symptoms predict seizure frequency-or vice versa?. J Psychosom Res 59 (2005) 269-274
85. Trinka E., Kienpointner G., Unterberger I., et al. Psychiatric comorbidity in juvenile myoclonic epilepsy. Epilepsia 47 (2006) 2086-2091
86. Devinsky O., Gershengorn J., Brown E., Perrine K., Vazquez B., and Luciano D. Frontal functions in juvenile myoclonic epilepsy. Neuropsychiatry Neuropsychol Behav Neurol 10 (1997) 243-246
87. Sonmez F., Atakli D., Sari H., Atay T., and Arpaci B. Cognitive function in juvenile myoclonic epilepsy. Epilepsy Behav 5 (2004) 329-336
88. Jokeit H., and Ebner A. Long-term effects of refractory temporal lobe epilepsy on cognitive abilities: a cross sectional study. J Neurol Neurosurg Psychiatry 67 (1999) 44-50
89. Helmstaedter C., and Elger C. The phantom of progressive dementia in epilepsy. Lancet 354 (1999) 2133-2134
90. Helmstaedter C. Effects of chronic epilepsy on declarative memory sytems. Prog Brain Res 135 (2002) 439-453
91. Dodrill C. Neuropsychological effects of seizures. Epilepsy Behav 5 suppl 1 (2004) S21-S24
92. Seidenberg M., Pulsipher D., and Hermann B. Cognitive progression in epilepsy. Neuropsychol Rev 17 (2007) 445-454
93. Dodrill CB. Progressive cognitive decline in adolescents and adults with epilepsy. In: Sutula T, Pitkanen A, eds. Do seizures damage the brain? Prog Brain Res 2002 135: 399-407
94. Andersson-Roswall L., Engman E., Samuelsson H., Sjoberg-Larsson C., and Malmgren K. Verbal memory decline and adverse effects on cognition in adult patients with pharmacoresistant partial epilepsy: a longitudinal controlled study of 36 patients. Epilepsy Behav 5 (2004) 677-686
95. Piazzini A., Canevini M., Turner K., Chifari R., Canger R., and Canevini M. Elderly people and epilepsy: cognitive function. Epilepsia 47 (2006) 82-84
96. Hermann B., Seidenberg M., Dow C., et al. Cognitive prognosis in chronic temporal lobe epilepsy. Ann Neurol 60 (2006) 80-87
97. Griffith H., Martin R., Bambara J., Faught E., Vogtle L., and Marson D. Cognitive functioning over 3 years in community dwelling older adults with chronic partial epilepsy. Epilepsy Res 74 (2007) 91-96
98. Jones J., Bell B., Fine J., Rutecki P., Seidenberg M., and Hermann B. A controlled prospective investigation of psychiatric comorbidity in temporal lobe epilepsy. Epilepsia 48 (2007) 2357-2360
99. Martin R., Griffith H., Faught E., Gilliam F., Mackey M., and Vogtle L. Cognitive functioning in community dwelling older adults with chronic partial epilepsy. Epilepsia 46 (2005) 298-303
100. Griffith H., Martin R., Bambara J., Marson D., and Faught E. Older adults with epilepsy demonstrate cognitive impairments compared with patients with amnestic mild cognitive impairment. Epilepsy Behav 8 (2006) 161-168
101. Tellez-Zenteno J., Matijevic S., and Wiebe S. Somatic comorbidity of epilepsy in the general population in Canada. Epilepsia 46 (2005) 1955-1962
102. Romanelli M., Morris J., Ashkin K., and Coben L. Advanced Alzheimer's disease is a risk factor for late-onset seizures. Arch Neurol 47 (1990) 847-850
103. Hauser W., Morris M., Heston L., and Anderson V. Seizures and myoclonus in patients with Alzheimer's disease. Neurology 36 (1986) 1226-1230
104. Amatniek J., Hauser W., DelCastillo-Castaneda C., et al. Incidence and predictors of seizures in patients with Alzheimer's disease. Epilepsia 47 (2006) 867-872
105. Hesdorffer D., Hauser W., Annegers J., Kokmen E., and Rocca W. Dementia and adult-onset unprovoked seizures. Neurology 46 (1996) 727-730
106. Breteler M., van Duijn C., Chandra V., et al. Medical history and the risk of Alzheimer's disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group. Int J Epidemiol 20 suppl 2 (1991) S36-S42
107. Breteler M., de Groot R., van Romunde L., and Hofman A. Risk of dementia in patients with Parkinson's disease, epilepsy, and severe head trauma: a register-based follow-up study. Am J Epidemiol 142 (1995) 1300-1305
108. Hermann B., Seidenberg M., Sager M., et al. Growing old with epilepsy: the neglected issue of cognitive and brain health in aging persons with chronic epilepsy. Epilepsia. published online November 21. DOI:10.1111/j.1528-1167.2007.01435.x
109. Dikmen S., Matthews C., and Harley J. The effect of early versus late onset of major motor epilepsy upon cognitive-intellectual performance. Epilepsia 16 (1975) 73-81
110. Dikmen S., Matthews C., and Harley J. Effect of early versus late onset of major motor epilepsy on cognitive-intellectual performance: further considerations. Epilepsia 18 (1977) 31-36
111. Dodrill C., and Matthews C. The role of neuropsychology in the assessment and treatment of persons with epilepsy. Am Psychol 47 (1992) 1139-1142
112. O'Leary D., Seidenberg M., Berent S., and Boll T. Effects of age of onset of tonic-clonic seizures on neuropsychological performance in children. Epilepsia 22 (1981) 197-204
113. Schoenfeld J., Seidenberg M., Woodard A., et al. Neuropsychological and behavioral status of children with complex partial seizures. Dev Med Child Neurol 41 (1999) 724-731
114. Harrison R., and Taylor D. Childhood seizures: a 25-year follow up. Social and medical prognosis. Lancet 1 (1976) 948-951
115. Jalava M., Sillanpaa M., Camfield C., and Camfield P. Social adjustment and competence 35 years after onset of childhood epilepsy: a prospective controlled study. Epilepsia 38 (1997) 708-715
116. Britten N., Morgan K., Fenwick P., and Britten H. Epilepsy and handicap from birth to age 36. Dev Med Child Neurol 28 (1986) 719-728
117. Shackleton D., Trenite D.K.-N., de Craen A., Vandenbroucke J., and Westendorp R. Living with epilepsy: long-term prognosis and psychosocial outcomes. Neurology 61 (2003) 64-70
118. Lindsay J., Ounsted C., and Richards P. Long-term outcome in children with temporal lobe seizures. I: Social outcome and childhood factors. Dev Med Child Neurol 21 3 (1979) 285-298
119. Lindsay J., Ounsted C., and Richards P. Long-term outcome in children with temporal lobe seizures. III: Psychiatric aspects in childhood and adult life. Dev Med Child Neurol 21 (1979) 630-636
120. Sillanpaa M., Jalava M., Kaleva O., and Shinnar S. Long-term prognosis of seizures with onset in childhood. N Engl J Med 338 (1998) 1715-1722
121. Rutter M., Graham P., and Yule W. A neuropsychiatric study in childhood (1970), SIMP/William Heineman Medical Books, London
122. Davies S., Heyman I., and Goodman R. A population survey of mental health problems in children with epilepsy. Dev Med Child Neurol 45 (2003) 292-295
123. Nolan M., Redoblado M., Lah S., et al. Intelligence in childhood epilepsy syndromes. Epilepsy Res 53 (2003) 139-150
124. Farwell J., Dodrill C., and Batzel L. Neuropsychological abilities of children with epilepsy. Epilepsia 26 (1985) 395-400
125. Germano E., Gagliano A., Magazu A., et al. Benign childhood epilepsy with occipital paroxysms: neuropsychological findings. Epilepsy Res 64 (2005) 137-150
126. Roeschl-Heils A., Bledowski C., Elger C., Heils A., and Helmstaedter C. Neuropsychological functioning among 32 patients with temporal lobe epilepsy and their discordant siblings. Epilepsia 43 (2002) 185
127. Smith M., Elliott I., and Lach L. Cognitive skills in children with intractable epilepsy: comparison of surgical and nonsurgical candidates. Epilepsia 43 (2002) 631-637
128. Fedio P., and Mirsky A. Selective intellectual deficits inchildren with temporal lobe or centrencephalic epilepsy. Neuropsychologia 7 (1969) 287-300
129. Camfield P., Gates R., Ronen G., Camfield C., Ferguson A., and MacDonald G. Comparison of cognitive ability, personality profile, and school success in epileptic children with pure right versus left temporal lobe EEG foci. Ann Neurol 15 (1984) 122-126
130. Gleissner U., Sassen R., Lendt M., Clusmann H., Elger C., and Helmstaedter C. Pre- and postoperative verbal memory in pediatric patients with temporal lobe epilepsy. Epilepsy Res 51 (2002) 287-296
131. Nolan M., Redoblado M., Lah S., et al. Memory function in childhood epilepsy syndromes. J Paediatr Child Health 40 (2004) 20-27
132. Guimaraes C., Li L., Rzezak P., et al. Temporal lobe epilepsy in childhood: comprehensive neuropsychological assessment. J Child Neurol 22 (2007) 836-840
133. Guimaraes C., Bonilha L., Franzon R., Li L., Cendes F., and Guerreiro M. Distribution of regional gray matter abnormalities in a pediatric population with temporal lobe epilepsy and correlation with neuropsychological performance. Epilepsy Behav 11 (2007) 558-566
134. Igarashi K., Oguni H., Osawa M., et al. Wisconsin card sorting test in children with temporal lobe epilepsy. Brain Dev 24 (2002) 174-178
135. Cormack F., Cross J., Isaacs E., et al. The development of intellectual abilities in pediatric temporal lobe epilepsy. Epilepsia 48 (2007) 201-204
136. Cormack F., Gadian D., Vargha-Khadem F., Cross J., Connelly A., and Baldeweg T. Extra-hippocampal grey matter density abnormalities in paediatric mesial temporal sclerosis. Neuroimage 27 (2005) 635-643
137. Bourgeois B., Prensky A., Palkes H., Talent B., and Busch S. Intelligence in epilepsy: a prospective study in children. Ann Neurol 14 (1983) 438-444
138. Kolk A., Beilmann A., Tomberg T., Napa A., and Talvik T. Neurocognitive development of children with congenital unilateral brain lesion and epilepsy. Brain Dev 23 (2001) 88-96
139. Williams J., Bates S., Griebel M., et al. Does short-term antiepileptic drug treatment in children result in cognitive or behavioral changes?. Epilepsia 39 (1998) 1064-1069
140. Stores G., Williams P., Styles E., and Zaiwalla Z. Psychological effects of sodium valproate and carbamazepine in epilepsy. Arch Dis Child 67 (1992) 1330-1337
141. Bailet L., and Turk W. The impact of childhood epilepsy on neurocognitive and behavioral performance: a prospective longitudinal study. Epilepsia 41 (2000) 426-431
142. Oostrom K., Smeets-Schouten A., Kruitwagen C., Peters A., and Jennekens-Schinkel A. Not only a matter of epilepsy: early problems of cognition and behavior in children with "epilepsy only"-a prospective, longitudinal, controlled study starting at diagnosis. Pediatrics 112 (2003) 1338-1344
143. Hermann B., Jones J., Sheth R., Dow C., Koehn M., and Seidenberg M. Children with new-onset epilepsy: neuropsychological status and brain structure. Brain 129 (2006) 2609-2619
144. Austin J., Harezlak J., Dunn D., Huster G., Rose D., and Ambrosius W. Behavior problems in children before first recognized seizures. Pediatrics 107 (2001) 115-122
145. Dunn D., Harezlak J., Ambrosius W., Austin J., and Hale B. Teacher assessment of behaviour in children with new-onset seizures. Seizure 11 (2002) 169-175
146. Hesdorffer D., Ludvigsson P., Olafsson E., Gudmundsson G., Kjartansson O., and Hauser W. ADHD as a risk factor for incident unprovoked seizures and epilepsy in children. Arch Gen Psychiatry 61 (2004) 731-736
147. Jones J., Watson R., Sheth R., et al. Psychiatric comorbidity in children with new onset epilepsy. Dev Med Child Neurol 49 (2007) 493-497
148. Berg A., Smith S., Frobish D., et al. Special education needs of children with newly diagnosed epilepsy. Dev Med Child Neurol 47 (2005) 749-753
149. McNelis A., Johnson C., Huberty T., and Austin J. Factors associated with academic achievement in children with recent-onset seizures. Seizure 14 (2005) 331-339
150. Dennis M. Developmental plasticity in children: the role of biological risk, development, time, and reserve. J Commun Disord 33 (2000) 321-331
151. Deary I., Whiteman M., Starr J., Whalley L., and Fox H. The impact of childhood intelligence on later life: following up the Scottish mental surveys of 1932 and 1947. J Pers Soc Psychol 86 (2004) 130-147
152. Whalley L., Starr J., Athawes R., Hunter D., Pattie A., and Deary I. Childhood mental ability and dementia. Neurology 55 (2000) 1455-1459
153. Whalley L., Deary I., Appleton C., and Starr J. Cognitive reserve and the neurobiology of cognitive aging. Ageing Res Rev 3 (2004) 369-382