Increased blocking activity of combined tachykinin NK1- and NK2-receptor antagonists on hyperventilation-induced bronchoconstriction in the guinea pig

Pulmonary Pharmacology and Therapeutics

Volumn 21, Issue 1, 2008, Pages 67-72

  Corboz, M R ^a   Fernandez, X ^a   Hey, John A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Bronchoconstriction; CP 99994; Guinea pig; Hyperventilation; SB 223412; SR 48968; Tachykinin NK receptor

Indexed keywords

3 (2 METHOXYBENZYLAMINO) 2 PHENYLPIPERIDINE; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; NEUROKININ 2 RECEPTOR; NEUROKININ 2 RECEPTOR ANTAGONIST; NEUROKININ 3 RECEPTOR; NEUROKININ 3 RECEPTOR ANTAGONIST; SAREDUTANT; TACHYKININ RECEPTOR ANTAGONIST; TALNETANT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY PLETHYSMOGRAPHY; BREATHING RATE; BRONCHOSPASM; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG DOSE COMPARISON; GUINEA PIG; HYPERVENTILATION; HYPERVENTILATION INDUCED BRONCHOCONSTRICTION; IN VIVO STUDY; LUNG COMPLIANCE; LUNG RESISTANCE; MALE; MONOTHERAPY; NONHUMAN; PRIORITY JOURNAL; RODENT; STATISTICAL SIGNIFICANCE;

ADMINISTRATION, ORAL; ANIMALS; BENZAMIDES; BRONCHOCONSTRICTION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; GUINEA PIGS; HYPERVENTILATION; INJECTIONS, INTRAVENOUS; MALE; PIPERIDINES; QUINOLINES; RECEPTORS, NEUROKININ-1; RECEPTORS, NEUROKININ-2; RECEPTORS, NEUROKININ-3; RESPIRATORY FUNCTION TESTS;

EID: 38049094237     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2006.11.007     Document Type: Article

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