Occipital proton magnetic resonance spectroscopy (1H-MRS) reveals normal metabolite concentrations in retinal visual field defects

PLoS ONE

Volumn 2, Issue 2, 2007, Pages

  Boucard, Christine C ^a   Hoogduin, Johannes M ^a   van der Grond, Jeroen ^b   Cornelissen, Frans W ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLINE; CREATINE; N ACETYLASPARTIC ACID; ASPARTIC ACID; BIOLOGICAL MARKER; DRUG DERIVATIVE; N-ACETYLASPARTATE; PROTON;

ADULT; AGED; ARTICLE; BRAIN RADIOGRAPHY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GLAUCOMA; HEMISPHERE; HUMAN; IMAGE ANALYSIS; IMAGE ENHANCEMENT; MALE; OCCIPITAL CORTEX; PROTEIN BLOOD LEVEL; PROTON NUCLEAR MAGNETIC RESONANCE; RETINA MACULA AGE RELATED DEGENERATION; VISUAL CORTEX; VISUAL FIELD DEFECT; VISUAL NERVOUS SYSTEM; CHEMISTRY; COMPARATIVE STUDY; METABOLISM; METHODOLOGY; MIDDLE AGED; NERVE DEGENERATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OCCIPITAL LOBE; PATHOLOGY; RETINA MACULA DEGENERATION; SCOTOMA; VISUAL FIELD;

AGED; AGED, 80 AND OVER; ASPARTIC ACID; BIOLOGICAL MARKERS; CHOLINE; CREATINE; FEMALE; GLAUCOMA; HUMANS; MACULAR DEGENERATION; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; NERVE DEGENERATION; OCCIPITAL LOBE; PROTONS; SCOTOMA; VISUAL FIELDS;

EID: 38049074744     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0000222     Document Type: Article

References (25)

1. Resnikoff S, Pascolini D, Etya'ale D, Kocur I, Pararajasegaram R, et al. (2004) Global data on visual impairment in the year 2002. Bull World Health Organ 82: 844-851.
2. Johansson BB (2004) Brain plasticity in health and disease. Keio J Med 53: 231-246.
3. Merzenich MM, Nelson RJ, Stryker MP, Cynader MS, Schoppmann A, et al. (1984) Somatosensory cortical map changes following digit amputation in adult monkeys. J Comp Neurol 224: 591-605.
4. Gujar SK, Maheshwari S, Bjorkman-Burtscher I, Sundgren PC (2005) Magnetic resonance spectroscopy. J Neuroophthalmol 25: 217-226.
5. Passe TJ, Charles HC, Rajagopalan P, Krishnan KR (1995) Nuclear magnetic resonance spectroscopy: a review of neuropsychiatric applications. Prog Neuropsychopharmacol Biol Psychiatry 19: 541-563.
6. Simmons ML, Frondoza CG, Coyle JT (1991) Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience 45: 37-45.
7. Block W, Traber F, Flacke S, Jessen F, Pohl C, et al. (2002) In-vivo proton MR-spectroscopy of the human brain: assessment of N-acetylaspartate (NAA) reduction as a marker for neurodegeneration. Amino Acids 23: 317-323.
8. Demougeot C, Garnier P, Mossiat C, Bertrand N, Giroud M, et al. (2001) N-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury. J Neurochem 77: 408-415.
9. Block W, Karitzky J, Traber F, Pohl C, Keller E, et al. (1998) Proton magnetic resonance spectroscopy of the primary motor cortex in patients with motor neuron disease: subgroup analysis and follow-up measurements. Arch Neurol 55: 931-936.
10. Karitzky J, Block W, Mellies JK, Traber F, Sperfeld A, et al. (1999) Proton magnetic resonance spectroscopy in Kennedy syndrome. Arch Neurol 56: 1465-1471.
11. Kuzniecky R (2004) Clinical applications of MR spectroscopy in epilepsy. Neuroimaging Clin N Am 14: 507-516.
12. Sijens PE, Mostert JP, Oudkerk M, De Keyser J (2006) (1)H MR spectroscopy of the brain in multiple sclerosis subtypes with analysis of the metabolite concentrations in gray and white matter: initial findings. Eur Radiol 16: 489-495
13. Tedeschi G, Litvan I, Bonavita S, Bertolino A, Lundbom N, et al. (1997) Proton magnetic resonance spectroscopic imaging in progressive supranuclear palsy, Parkinson's disease and corticobasal degeneration. Brain 120(Pt 9): 1541-1552.
14. Ettl A, Fischer-Klein C, Chemelli A, Daxer A, Felber S (1994) Nuclear magnetic resonance spectroscopy. Principles and applications in neuroophthalmology. Int Ophthalmol 18: 171-181.
15. Chan YL, Yeung DK, Leung SF, Cao G (1999) Proton magnetic resonance spectroscopy of late delayed radiation-induced injury of the brain. J Magn Reson Imaging 10: 130-137.
16. Schuff N, Amend D, Ezekiel F, Steinman SK, Tanabe J, et al. (1997) Changes of hippocampal N-acetyl aspartate and volume in Alzheimer's disease. A proton MR spectroscopic imaging and MRI study. Neurology 49: 1513-1521.
17. Holz FG, Pauleikhoff D, Klein R, Bird AC (2004) Pathogenesis of lesions in late age-related macular disease. Am J Ophthalmol 137: 504-510.
18. Zarbin MA (2004) Current concepts in the pathogenesis of age-related macular degeneration. Arch Ophthalmol 122: 598-614.
19. Fechtner RD, Weinreb RN (1994) Mechanisms of optic nerve damage in primary open angle glaucoma. Surv Ophthalmol 39: 23-42.
20. Nickells RW (1996) Retinal ganglion cell death in glaucoma: the how, the why, and the maybe. J Glaucoma 5: 345-356.
21. De Stefano N, Matthews PM, Arnold DL (1995) Reversible decreases in Nacetylaspartate after acute brain injury. Magn Reson Med 34: 721-727.
22. Jansonius NM (2005) Bayes' theorem applied to perimetric progression detection in glaucoma: from specificity to positive predictive value. Graefes Arch Clin Exp Ophthalmol 243: 433-437.
23. De Stefano N, Narayanan S, Mortilla M, Guidi L, Bartolozzi ML, et al. (2000) Imaging axonal damage in multiple sclerosis by means of MR spectroscopy. Neurol Sci 21: S883-887.
24. Bjartmar C, Battistuta J, Terada N, Dupree E, Trapp BD (2002) Nacetylaspartate is an axon-specific marker of mature white matter in vivo: a biochemical and immunohistochemical study on the rat optic nerve. Ann Neurol 51: 51-58.
25. Hashimoto M, Ohtsuka K, Harada K (2004) N-acetylaspartate concentration in the chiasm measured by in vivo proton magnetic resonance spectroscopy. Jpn J Ophthalmol 48: 353-357.