Pretreatment with olprinone hydrochloride, a phosphodiesterase III inhibitor, attenuates lipopolysaccharide-induced lung injury via an anti-inflammatory effect

Pulmonary Pharmacology and Therapeutics

Volumn 21, Issue 1, 2008, Pages 166-171

  Koike, Terumoto ^a   Nadeen Qutab, Muhammad ^a   Tsuchida, Masanori ^a   Takekubo, Masaru ^a   Saito, Masayuki ^a   Hayashi, Jun ichi ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

Author keywords

Cytokine; Interleukin 10; LPS induced lung injury; Phosphodiesterase III inhibitor

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; DEXAMETHASONE; INTERLEUKIN 10; INTERLEUKIN 6; LOPRINONE; PHOSPHODIESTERASE III INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLOOD SAMPLING; CELL CULTURE; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG EFFECT; DRUG EFFICACY; INFLAMMATORY DISEASE; LUNG ALVEOLUS MACROPHAGE; LUNG FLUID; LUNG INJURY; LUNG LAVAGE; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BRONCHOALVEOLAR LAVAGE FLUID; CELL CULTURE TECHNIQUES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 3; DEXAMETHASONE; IMIDAZOLES; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; LUNG; MALE; PYRIDONES; RATS; RATS, WISTAR; RESPIRATORY DISTRESS SYNDROME, ADULT;

EID: 38049053987     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2007.01.007     Document Type: Article

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