Effects of cAMP-phosphodiesterase isozyme inhibitor on cytokine production by lipopolysaccharide-stimulated human peripheral blood mononuclear cells

General Pharmacology

Volumn 29, Issue 4, 1997, Pages 633-638

  Yoshimura, Tomoaki ^a   Kurita, Chikako ^a   Nagao, Tomomi ^a   Usami, Eiseki ^a   Nakao, Toshiya ^a   Watanabe, Shino ^a   Kobayashi, Joji ^a   Yamazaki, Futoshi ^a   Tanaka, Hiroyuki ^b   Nagai, Hiroichi ^b  

^a OGAKI MUNICIPAL HOSPITAL   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

cAMP; Interleukin 1 ; Interleukin 8; Mononuclear cells; Phosphodiesterase isozyme inhibitor; Tumor necrosis factor

Indexed keywords

4 (3 BUTOXY 4 METHOXYBENZYL) 2 IMIDAZOLIDINONE; 6 (4 ACETAMIDOPHENYL) 1,2,3,4,4A,10B HEXAHYDRO 8,9 DIMETHOXY 2 METHYLBENZO[C][1,6]NAPHTHYRIDINE; 8 [[1 (3,4 DIMETHOXYPHENYL) 2 HYDROXYETHYL]AMINO] 3,7 DIHYDRO 7 (2 METHOXYETHYL) 1,3 DIMETHYL 1H PURINE 2,6 DIONE; AMINOPHYLLINE; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BUCLADESINE; CYCLIC AMP PHOSPHODIESTERASE; CYTOKINE; ENZYME INHIBITOR; INTERLEUKIN 1BETA; INTERLEUKIN 8; ISOENZYME; LIPOPOLYSACCHARIDE; MILRINONE; ROLIPRAM; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; NEUTROPHIL; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0030751452     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(96)00580-0     Document Type: Article

References (30)

1. Bailly S., Ferrua B., Fay M., Gougerot-Pocidalo M. A. Differential regulation of IL 6, IL 1a, IL 1β and TNFα production in LPS-stimulated human monocytes. role of cyclic AMP Cytokine. 2:1990;205-210.
2. Beavo J. A. Multiple isozymes of cyclic nucleotide phosphodiesterase. Adv. Second Messenger Phosphoprotein Res. 22:1988;1-38.
3. Boer J., Philpott A. J., Amsterdam R. G. M., Shahid M., Zaagsma J., Nicholson C. D. Human bronchial cyclic nucleotide phosphodiesterase isoenzymes. biochemical and pharmacological analysis using selective inhibitors Br. J. Pharmac. 106:1992;1028-1034.
4. Dent G., Giembycz M. A., Rabe K. F., Barnes P. J. Inhibition of eosinophil cyclic nucleotide PDE activity and opsonized zymosan-stimulated respiratory burst by "type IV"-selective PDE inhibitors. Br. J. Pharmac. 103:1991;1339-1346.
5. Dinarello C. A. Interleukin-1 and its biologically related cytokines. Adv. Immunol. 44:1989;153-205.
6. Endress S., Fulle H. J., Sinha B., Stoll D., Dinarello C. A., Gerzer R., Weber P. C. Cyclic nucleotides differentially regulate the synthesis of tumor necrosis factor-α and interleukin-1β by human mononuclear cells. Immunology. 72:1991;56-60.
7. Kunkel S. L., Standiford T., Kasahara K., Strieter R. M. Interleukin-8 (IL-8). the major neutrophil chemotactic factor in the lung Exp. Lung Res. 17:1991;17-23.
8. Matsushima K., Morishita K., Yoshimura T., Lavu S., Kobayashi Y., Lew W., Appella E., Kung H. F., Leonard E. J., Oppenheim J. J. Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor. J. Exp. Med. 167:1988;1883-1893.
9. Murray K. J., Eden R. J., England P. J., Dolan J., Grimsditch D. C., Stutchbury C. A., Patel B., Reeves M. L., Worby A., Torphy T. J., Wood L. M., Warrington B. H., Coates W. J. Potential use of selective phosphodiesterase inhibitors in the treatment of asthma. Agents Actions. 34:1991;S27-S46.
10. Newsholme S. J., Schwartz L. cAMP-specific phosphodiesterase inhibitor, rolipram, reduces eosinophil infiltration evoked by leukotrienes or by histamine in guinea pig conjunctiva. Inflammation. 17:1993;25-31.
11. Nicholson C. D., Challiss R. A. J., Shahid M. Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. Trends Pharmac. Sci. 12:1991;19-27.
12. Nielson C. P. Beta-adrenergic modulation of the polymorphonuclear leukocyte respiratory burst is dependent upon the mechanism of cell activation. J. Immunol. 139:1987;2392-2397.
13. Nielson C. P., Vestal R. E., Sturm R. J., Heaslip R. J. Effects of a selective phosphodiesterase inhibitor on the polymorphonuclear leukocyte respiratory burst. J. Allergy Clin. Immunol. 86:1990;801-808.
14. Old L. J. Tumor necrosis factor. Bonavida B., Granger G. Tumor Necrosis Factor. Structure, Mechanism of Action, Role in Disease and Therapy:1990;1-30 Karger, Basel.
15. Pang D. C., Cantor E., Hagedorn A., Erhardt P., Wiggins J. Tissue specificity of cAMP-phosphodiesterase inhibitors. rolipram, amrinone, milrinone, enoximone, piroximone, and imazodan Drug Develop. Res. 14:1988;141-149.
16. 2 and cyclic nucleotides J. Immunol. 141:1988;2388-2393.
17. Rot A. Endothelial cell binding of NAP-1/IL-8. role in neutrophil emigration Immunol. Today. 13:1992;291-294.
18. 2 suppresses tumor necrosis factor but not interleukin-1a or β-mRNA and cell-associated bioactivity J. Leukocyte Biol. 45:1989;416-421.
19. Semmler J., Gebert U., Eisenhut T., Moeller J., Scharting M. M., Allera A., Endres S. Xanthine derivatives. comparison between suppression of tumour necrosis factor-α production and inhibition of cAMP phosphodiesterase activity Immunology. 78:1993;520-525.
20. Spatafora M., Chiappara G., Merendino A. M., D'Amico D., Bellia V., Bonsignore G. Theophylline suppresses the release of tumour necrosis factor-α by blood monocytes and alveolar macrophages. Eur. Respir. J. 7:1994;223-228.
21. Strieter R. M., Chensue S. W., Basha M. A., Standiford T. J., Lynch J. P., Baggiolini M., Kunkel S. L. Human alveolar macrophage gene expression of interleukin-8 by tumor necrosis factor-alpha, lipopolysaccharide, and interleukin-1 beta. Am. J. Respir. Cell. Mol. Biol. 2:1990;3221-3226.
22. 2, forskolin, and dibutyryl cAMP on arachidonic acid release and inositol phospholipid metabolism in guinea pig neutrophils. J. Biol. Chem. 261:1986;1092-1098.
23. Teixeira M. M., Rossi A. G., Williams T. J., Hellewell P. G. Effects of phosphodiesterase isoenzyme inhibitors on cutaneous inflammation in the guinea-pig. Br. J. Pharmac. 112:1994;332-340.
24. Torphy T. J., Undem B. J. Phosphodiesterase inhibitors. new opportunities for the treatment of asthma Thorax. 46:1991;512-523.
25. Torphy T. J., Livi G. P., Balcarek J. M., White J. R., Chilton F. H., Undem B. J. Therapeutic potential of isozyme-selective phosphodiesterase inhibitors in the treatment of asthma. Adv. Second. Messenger Phosphoprotein Res. 25:1992;289-305.
26. Underwood D. C., Osborn R. R., Novak L. B., Matthews J. K., Newsholme S. J., Undem B. J., Hand J. M., Torphy T. J. Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram. J. Pharmac. Exp. Ther. 266:1993;306-313.
27. Verghese M. W., Mcconnell R. T., Strickland A. B., Gooding R. C., Stimpson S. A., Yarnall D. P., Taylor J. D., Furdon P. J. Differential regulation of human monocyte-derived TNF-α and IL-1β by type IV cAMP-phosphodiesterase (cAMP-PDE) inhibitors. J. Pharmac. Exp. Ther. 272:1995;1313-1320.
28. Viherluoto J., Palkam T. O. S., Hurme M. Cyclic adenosine monophosphate decreases secretion, but not the cell-associated levels of interleukin-1β, in lipopolysaccharide-activated monocytes. Scand. J. Immunol. 34:1991;121-125.
29. Yoshimura T., Matsushima K., Tanaka S., Robinson E. A., Appella E., Oppenheim J. J., Leonard E. J. Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. Proc. Natl. Acad. Sci. USA. 84:1987;9233-9237.
30. Yoshimura T., Usami E., Kurita C., Watanabe S., Nakao T., Kobayashi J., Yamazaki F., Nagai H. Effect of theophylline on the production of interleukin-1β, tumor necrosis factor-α, and interleukin-8 by human peripheral blood mononuclear cells. Biol. Pharm. Bull. 18:1995;1405-1408.