Chromen-based TNF-α converting enzyme (TACE) inhibitors: Design, synthesis, and biological evaluation

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 1, 2008, Pages 530-535

  Chun, Kwangwoo ^a,d   Park, Song Kyu ^b   Kim, Hwan Mook ^b   Choi, Yongseok ^c   Kim, Myung Hwa ^d   Park, Chun Ho ^d   Joe, Bo Young ^d   Chun, Tae Gyu ^a,e   Choi, Hyun Moo ^e   Lee, Hee Yoon ^e   Hong, Sung Hee ^a   Kim, Myung Sook ^a   Nam, Ky Youb ^f   Han, Gyoonhee ^a  

^a Yonsei University   (South Korea)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^c Korea University   (South Korea)

^d Jeil Pharmaceutical Company   (South Korea)

^e Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^f Bioinformatics and Molecular Design Research Center (BMDRC)   (South Korea)

Author keywords

Coumarin derivatives; Gelastatin hydroxamates; Metalloproteinase 2 (MMP 2); Metalloproteinase 9 (MMP 9); Rheumatoid arthritis (RA); TNF converting enzyme (TACE)

Indexed keywords

CHROMENE DERIVATIVE; COUMARIN DERIVATIVE; GELATINASE A; GELATINASE B; HYDROXAMIC ACID DERIVATIVE; MATRIX METALLOPROTEINASE INHIBITOR; N HYDROXY 2 METHYL 3 (6 METHYL 2 OXO 2H CHROMEN 3 YL)PROPIONAMIDE; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; MOUSE; NONHUMAN;

ADAM PROTEINS; COUMARINS; HYDROXAMIC ACIDS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; METALLOENDOPEPTIDASES; NITRIC OXIDE; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 38049028622     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.09.014     Document Type: Article

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