Palladium bis(2,2,6,6-tetramethyl-3,5-heptanedionate): an efficient catalyst for regioselective C-2 arylation of heterocycles

Tetrahedron Letters

Volumn 49, Issue 6, 2008, Pages 1045-1048

  Nandurkar, Nitin S ^a   Bhanushali, Mayur J ^a   Bhor, Malhari D ^a   Bhanage, Bhalchandra M ^a  

^a UNIVERSITY OF MUMBAI   (India)

Author keywords

Aryl halides; C Arylation; Heterocycles; Palladium complex; Regioselectivity

Indexed keywords

HALIDE; METAL COMPLEX; PALLADIUM; PALLADIUM BIS 2,2,6,6 TETRAMETHYL 3,5 HEPTADIONATE; UNCLASSIFIED DRUG;

ARTICLE; ARYLATION; CATALYST; CHEMICAL REACTION; CHEMICAL STRUCTURE; SYNTHESIS;

EID: 38049001149     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2007.11.209     Document Type: Article

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20. 2: Palladium chloride (1.8 g, 10 mmol) and sodium chloride (0.59 g, 10 mmol) were dissolved in methanol (50 mL) and stirred at room temperature overnight. The solution was filtered into a 100 mL volumetric flask and diluted with methanol to give a solution of 0.1 M palladium(II) concentration. A mixture of this solution (100 mL), the ligand 2,2,6,6-tetramethyl-3,5-heptanedione (4.6 g), and sodium carbonate (1.06 g, 10 mmol) was stirred overnight. The resulting yellow precipitate was filtered and dried, mp 238-240 °C.
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