Bikunin suppresses expression of pro-inflammatory cytokines induced by lipopolysaccharide in neutrophils

Journal of Endotoxin Research

Volumn 13, Issue 6, 2007, Pages 369-376

  Kanayama, Seiji ^a   Yamada, Yoshihiko ^a   Onogi, Akira ^a   Shigetomi, Hiroshi ^a   Ueda, Sachiyo ^a   Tsuji, Yoriko ^a   Haruta, Shoji ^a   Kawaguchi, Ryuji ^a   Yoshida, Shozo ^a   Sakata, Mariko ^a   Sado, Toshiyuki ^a   Kitanaka, Takashi ^a   Oi, Hidekazu ^a   Yagyu, Tatsuo ^b   Kobayashi, Hiroshi ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b NetForce Co Ltd   (Japan)

Author keywords

Bikunin; Lipopolysaccharide; Neutrophils; NF B.; Pro inflammatory cytokines

Indexed keywords

INTERLEUKIN 1; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; ULINASTATIN;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CYTOKINE PRODUCTION; ENZYME REPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; LEUKOCYTE ACTIVATION; MOUSE; NEUTROPHIL; NONHUMAN; PREMATURE LABOR; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT;

ACTIVE TRANSPORT, CELL NUCLEUS; ALPHA-GLOBULINS; ANIMALS; CELLS, CULTURED; CYTOKINES; CYTOPROTECTION; HUMANS; I-KAPPA B PROTEINS; LIPOPOLYSACCHARIDES; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEUTROPHILS; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION;

EID: 37849036761     PISSN: 09680519     EISSN: None     Source Type: Journal    
DOI: 10.1177/0968051907086464     Document Type: Article

References (36)

1. Asehnoune K., Strassheim D., Mitra S., Kim JY, Abraham E. Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B. J Immunol 2004; 172: 2522-2529.
2. Smith JA Neutrophils, host defense, and inflammation: A double-edged sword. J Leukoc Biol 1994; 56: 672-686.
3. Laskin DL, Pendino KJ Macrophages and inflammatory mediators in tissue injury. Annu Rev Pharmacol Toxicol 1995; 35: 655-677.
4. Nick JA, Avdi NJ, Young SK et al. Selective activation and functional significance of p38 mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils. J Clin Invest 1999; 103: 851-858.
5. Parsey MV, Tuder RM, Abraham E. Neutrophils are major contributors to intraparenchymal lung IL-1 expression after hemorrhage and endotoxemia. J Immunol 1998; 160: 1007-1013.
6. Beutler B. Tumor Necrosis Factors: The Molecules and Their Emerging Role in Medicine. New York: Raven, 1992.
7. Kobayashi H., Shinohara H., Gotoh J., Fujie M., Fujishiro S., Terao T. Anti-metastatic therapy by urinary trypsin inhibitor in combination with an anti-cancer agent. Br J Cancer 1995; 72: 1131-1137.
8. Kobayashi H., Suzuki M., Hirashima Y., Terao T. The protease inhibitor bikunin, a novel anti-metastatic agent. Biol Chem 2003; 384: 749-754.
9. Suzuki M., Kobayashi H., Tanaka Y. et al. Bikunin target genes in ovarian cancer cells identified by microarray analysis. J Biol Chem 2003; 278: 14640-14646.
10. Suzuki M., Kobayashi H., Tanaka Y., Hirashima Y., Terao T. Structure and function analysis of urinary trypsin inhibitor (UTI): Identification of binding domains and signaling property of UTI by analysis of truncated proteins. Biochim Biophys Acta 2001; 1547: 26-36.
11. Park JS, Park CW, Lockwood CJ, Norwitz ER Role of cytokines in preterm labor and birth. Minerva Ginecol 2005; 57: 349-366.
12. Kaga N., Katsuki Y., Futamura Y., Obata M., Shibutani Y. Role of urinary trypsin inhibitor in the maintenance of pregnancy in mice. Obstet Gynecol 1996; 88: 872-882.
13. Kaga N., Katsuki Y., Kajikawa S., Shibutani Y. Preventive effect of ritodrine hydrochloride and/or urinary trypsin inhibitor against lipopolysaccharide-induced preterm delivery in mice. Acta Obstet Gynecol Scand 1997; 76: 811-816.
14. Kajikawa S., Kaga N., Futamura Y., Shibutani Y. Tocolytic effect of magnesium sulfate and/or urinary trypsin inhibitor against lipopolysaccharide-induced preterm delivery in mice. Acta Obstet Gynecol Scand 1998; 77: 598-602.
15. Futamura Y., Kajikawa S., Kaga N., Shibutani Y. Protection against preterm delivery in mice by urinary trypsin inhibitor. Obstet Gynecol 1999; 93: 100-108.
16. Kanayama N., el Maradny E., Yamamoto N., Tokunaga N., Maehara K., Terao T. Urinary trypsin inhibitor:AA new drug to treat preterm labor: a comparative study with ritodrine. Eur J Obstet Gynecol Reprod Biol 1996; 67: 133-138.
17. Matsuzaki H., Kobayashi H., Yagyu T. et al. Bikunin inhibits lipopolysaccharide-induced tumor necrosis factor alpha induction in macrophages. Clin Diagn Lab Immunol 2004; 11: 1140-1147.
18. Wakahara K., Kobayashi H., Yagyu T. et al. Bikunin suppresses lipopolysaccharide-induced lethality through down-regulation of tumor necrosis factor- alpha and interleukin-1 beta in macrophages. J Infect Dis 2005; 191: 930-938.
19. Yum H., Arcaroli KJ, Kupfner J. et al. Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury. J Immunol 2001; 167: 6601-6608.
20. Takada Y., Gillenwater A., Ichikawa H., Aggarwal BB Suberoylanilide hydroxamic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing nuclear factor-kappaB activation. J Biol Chem 2006; 281: 5612-5622.
21. Van der Meide PH, Schellekens H. Cytokines and the immune response. Biotherapy 1996; 8: 243-249.
22. Bonner S., Yan SR, Byers DM, Bortolussi R. Activation of extracellular signal-related protein kinases 1 and 2 of the mitogen-activated protein kinase family by lipopolysaccharide requires plasma in neutrophils from adults and newborns. Infect Immun 2001; 69: 3143-3149.
23. Nick JA, Avdi NJ, Gerwins P., Johnson GL, Worthen GS Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide. J Immunol 1996; 156: 4867-4875.
24. Abraham E. Nuclear factor-B and its role in sepsis-associated organ failure. J Infect Dis 2003; 187 (Suppl 2): S364-S369.
25. Gao B., Tsan MF Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor α release by murine macrophages. J Biol Chem 2003; 278: 174-179.
26. Parker LC, Whyte MK, Dower SK, Sabroe I. The expression and roles of Toll-like receptors in the biology of the human neutrophil. J Leukoc Biol 2005; 77: 886-892.
27. Asehnoune K., Strassheim D., Mitra S., Kim JY, Abraham E. Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B. J Immunol 2004; 172: 2522-2529.
28. Yum H-K., Arcaroli J., Kupfner J. et al. Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury. J Immunol 2001; 167: 6601-6608.
29. Romashkova JA, Makarov SS NF-κB is a target of AKT in antiapoptotic PDGF signalling. Nature 1999; 401: 86.
30. Kobayashi H., Suzuki M., Kanayam N., Nishida T., Takigawa M., Terao T. Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade. Eur J Biochem 2002; 269: 3945-3957.
31. Elzi DJ, Bjornsen AJ, MacKenzie T., Wyman TH, Silliman CC Ionomycin causes activation of p38 and p42/44 mitogen-activated protein kinases in human neutrophils. Am J Physiol 2001; 281: C350-C360.
32. 2+ influx. Biochim Biophys Acta 1998; 1381: 139-146.
33. Maehara K., Kanayama N., Halim A. et al. Down-regulation of interleukin-8 gene expression in HL60 cell line by human Kunitz-type trypsin inhibitor. Biochem Biophys Res Commun 1995; 206: 927-934.
34. Jerala R. Structural biology of the LPS recognition. Int J Med Microbiol 2007; 297: 353-363.
35. Pearl-Yafe M., Fabian I., Halperin D., Flatau E., Werber S., Shalit I. Interferon-gamma and bacterial lipopolysaccharide act synergistically on human neutrophils enhancing interleukin-8, interleukin-1beta, tumor necrosis factor-alpha, and interleukin-12 p70 secretion and phagocytosis via upregulation of toll-like receptor 4. Shock 2007; 27: 226-231.
36. Park JS, Park CW, Lockwood CJ, Norwitz ER Role of cytokines in preterm labor and birth. Minerva Ginecol 2005; 57: 349-366.