Proton-decoupled 31P magnetic resonance spectroscopy reveals osmotic and metabolic disturbances in human hepatic encephalopathy

Journal of Neurochemistry

Volumn 71, Issue 4, 1998, Pages 1564-1576

  Bluml, Stefan ^a,b   Zuckerman, Eli ^c,d   Tan, Jeannie ^a,b   Ross, Brian D ^a,b  

^a HUNTINGTON MEDICAL RESEARCH INSTITUTES   (United States)

^b Rudi Schulte Research Institute   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d BNAI ZION MEDICAL CENTER   (Israel)

Author keywords

ATP; Cerebral osmolytes; Ethanolamines; Hepatic encephalopathy; Phosphocholines

Indexed keywords

ADENOSINE TRIPHOSPHATE; CHOLINE; CREATINE PHOSPHATE; GLUTAMIC ACID; GLUTAMINE; GLYCEROPHOSPHOETHANOLAMINE; GLYCEROPHOSPHORYLCHOLINE; INOSITOL; NUCLEOSIDE TRIPHOSPHATE; PHOSPHATE; SODIUM ION; ETHANOLAMINE; PHOSPHORUS; PROTON;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENERGY METABOLISM; HEPATIC ENCEPHALOPATHY; HUMAN; HUMAN TISSUE; HYPONATREMIA; METABOLIC DISORDER; OSMOREGULATION; OSMOTIC STRESS; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; AGED; BRAIN; COMPARATIVE STUDY; ELECTROLYTE BALANCE; FEMALE; MALE; METABOLISM; METHODOLOGY; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; OSMOSIS; PHOSPHORYLATION;

ADENOSINE TRIPHOSPHATE; ADULT; AGED; BRAIN; CHOLINE; ETHANOLAMINE; FEMALE; HEPATIC ENCEPHALOPATHY; HUMANS; HYPONATREMIA; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; OSMOSIS; PHOSPHATES; PHOSPHOCREATINE; PHOSPHORUS ISOTOPES; PHOSPHORYLATION; PROTONS; WATER-ELECTROLYTE BALANCE;

EID: 0031595057     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.71041564.x     Document Type: Article

References (44)

1. 1H} double-resonance experiments in a 1.5 T whole-body MR system. Magn. Reson. Med. 15, 165-172.
2. 31P MRS in liver cirrhosis. (Abstr.) Hepatogastroenterology 40, 6/0.
3. Bessman S. and Pal N. (1976) The Krebs cycle depletion theory of hepatic coma, in The Urea Cycle, pp. 83-89. John Wiley & Sons, New York.
4. Cordoba J., Gottstein J., and Blei A. T. (1996) Glutamine, myoinositol, and organic brain osmolytes after portacaval anastomosis in the rat: implications for ammonia-induced brain edema. Hepatology 24, 919-923.
5. Ernst T., Kreis R., and Ross B. D. (1993) Absolute quantitation of water and metabolites in the human brain. Part I: Compartments and water. J. Magn. Reson. 102, 1-8.
6. 31P NMR. J. Neurochem. 52, 741-749.
7. Flögel U., Niendorf T., Serkowa N., Brand A., Henke J., and Leibfritz D. (1995) Changes in organic solutes, volume, energy state, and metabolism associated with osmotic stress in a glial cell line: a multinuclear NMR study. Neurochem. Res. 20, 793-802.
8. Gadian D. G. (1982) Nuclear Magnetic Resonance and Its Applications to Living Systems. Oxford University Press, New York.
9. Geissler A., Lock G., Frund R., Held P., Hollerbach S., Andus T., Scholmerich J., Feuerbach S., and Holstege A. (1997) Cerebral abnormalities in patients with cirrhosis detected by proton magnetic resonance spectroscopy and magnetic resonance imaging. Hepatology 25, 48-54.
10. 31P NMR analyses of phosphocholine metabolism in rat glioma cells. Magn. Reson. Med. 32, 310-318.
11. Gitlin N., Lewis D. C., and Hinkley L. (1986) The diagnosis and prevalence of subclinical hepatic encephalopathy in apparently healthy, ambulent, non-shunted patients with cirrhosis. J. Hepatol. 3, 75-82.
12. 2 adrenoceptor agonist/antagonist activity of formoterol and salmeterol. Thorax 51, 54-58.
13. 31P NMR and optical absorbance spectroscopy. Biochem. Biophys. Res. Commun. 117, 210-216.
14. Haussinger D., Laubenberger J., Dahl S. V., Ernst T., Bayer S., Langer M., Gerok W., and Hennig J. (1994) Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy. Gastroenterology 107, 1475-1480.
15. 1H MRS in the evaluation of Parkinson's and Huntington's disease. Neurology 50, 1033-1040.
16. 31P NMR signals of ATP using the Hahn spin-echo. Magn. Reson. Med. 30, 138.
17. Kanamori K., Ross B. D., Chung J. C., and Kuo E. L. (1996) Severity of hyperammonemic encephalopathy correlates with brain ammonia level and saturation of glutamine synthetase in vivo. J. Neurochem. 67, 1584-1594.
18. Klunk W. E. (1995) Inactivity of PE, an endogenous GABA analog decreased in AD at GABA binding sites. Life Sci. 56, 2377-2383.
19. 1H MRS. Radiology 182, 19-27.
20. Kreis R., Ernst T., and Ross B. D. (1993) Absolute quantitation of water and metabolites in the human brain. Part II: Metabolite concentrations. J. Magn. Reson. 102, 9-19.
21. eq of the creatine kinase reaction and other phosphate hydrolyses and phosphate transfer reactions. J. Biol. Chem. 254, 6528-6537.
22. Lee J. H., Arcinue E., and Ross B. D. (1994) Organic osmolytes in the brain of an infant with hypernatremia. N. Engl. J. Med. 331, 439-442.
23. Lien Y.-H. H., Shapiro J. I., and Chan L. (1990) Effects of hypernatremia on organic brain osmoles. J. Clin. Invest. 85, 1427-1435.
24. 31P NMR spectroscopy. NMR Biomed. 1, 177-183.
25. MacDonnell P., Huff K., Grouse L., and Guroff G. (1980) Brain nucleic acids, in Biochemistry of Brain, pp. 211-233. Pergammon Press, New York.
26. Masuda T., Dobson G. P., and Veech R. L. (1990) The Gibbs-Donnan near-equilibrium system of heart. J. Biol. Chem. 265, 20321-20334.
27. Moats R. A., Lien Y.-H. H., Filippi D., and Ross B. D. (1993) Decrease in cerebral inositols in rats and humans. Biochem. J. 295, 15-18.
28. Morgan M. Y. (1996) Non-invasive neuroinvestigation in liver disease. Semin. Liver Dis. 16, 293-314.
29. Mullen K. D. (1992) Hepatic encephalopathy, in Complications of Chronic Liver Disease, pp. 127-160. Mosby-Year Book, St. Louis.
30. 31P chemical shift imaging of human brain in normal volunteers. NMR Biomed. 6, 173-180.
31. Nitsch R. M., Blusztajn J. K., Pittas A. G., Slack B. E., Growdon J. H., and Wurtman R. J. (1992) Evidence for a membrane defect in Alzheimer disease brain. Proc. Natl. Acad. Sci. USA 89, 1671-1675.
32. 31P MRS. (Abstr.) J. Cereb. Blood Flow Metab. 7, 5396.
33. Ross B. D., Jacobson S., Villamil F., Korula J., Kreis R., Ernst T., Shonk T., and Moats R. A. (1994) Subclinical hepatic encephalopathy: proton MR spectroscopic abnormalities. Radiology 193, 457-463.
34. Schenker S. and Butterworth R. (1997) NMR spectroscopy in portal-systemic encephalopathy: are we there yet? Gastroenterology 112, 1758-1761.
35. Schenker S., McCandless D. W., Brophy E., and Lewis M. S. (1967) Studies on the intracerebral toxicity of ammonia. J. Clin. Invest. 46, 838-848.
36. Seery J. P. and Taylor-Robinson S. D. (1996) The application of magnetic resonance spectroscopy to the study of hepatic encephalopathy. J. Hepatol. 25, 988-998.
37. Smart S. C., Fox G. B., Allen K. L., Swanson A. G., Newman M. J., Swayne G. T. G., Clark J. B., Sales K. D., and Williams S. C. R. (1994) Identification of ethanolamine in rat and gerbil brain tissue extracts by NMR spectroscopy. NMR Biorned. 7, 356-365.
38. Takahashi H., Koehler R. C., Brusilow S. W., and Traystman R. J. (1991) Inhibition of brain glutamine accumulation prevents cerebral edema in hyperammonemic rats. Am. J. Physiol. 261, H825-H829.
39. Takahashi T., Iwanfanti A., Mizuno S., Morishita Y., Nishio H., Kodama S., and Matsuo T. (1984) Endocrine Control of Bone and Calcium Metabolism, pp. 93-94. Excerpta Medica, Amsterdam.
40. Tan J., Bluml S., Hoang T., Dubowitz D., Mevenkamp G., and Ross B. (1998) Lack of effect of oral choline supplement on the concentrations of choline metabolites in human brain. Magn. Reson. Med. 39, 1005-1010.
41. Taylor-Robinson S. D., Sargentoni J., Mallalier R. J., Bell J. D., Bryant D. J., Coutts G. A., and Morgan M. Y. (1994) Cerebral phosphorus-31 magnetic resonance spectroscopy in patients with chronic hepatic encephalopathy. Hepatology 20, 1173-1178.
42. Veech R. L., Lawson J. W. R., Cornell N. W., and Krebs H. A. (1979) Cytosolic phosphorylation potential. J. Biol. Chem. 254, 6538-6547.
43. Videen J. S., Michaelis T., Pinto P., and Ross B. D. (1995) Human cerebral osmolytes during chronic hyponatremia: a proton magnetic resonance spectroscopy study. J. Clin. Invest. 95, 788-793.
44. Whyte M. P. (1989) Hypophosphatasia, in Metabolic Basis of Inherited Disease (Scriver C. R., Beaudet A. Z., Sly W. S., and Valle D., eds), pp. 2581-2604. McGraw-Hill, New York.