Elderly patients and high force resistance exercise - A descriptive report: Can an anabolic, muscle growth response occur without muscle damage or inflammation?

Journal of Geriatric Physical Therapy

Volumn 30, Issue 3, 2007, Pages 128-134

  LaStayo, Paul ^a,b   McDonagh, Paul ^b   Lipovic, Dani ^b   Napoles, Phyllis ^c   Bartholomew, Amelia ^c   Esser, Karyn ^d   Lindstedt, Stan ^b,e  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^d UNIVERSITY OF KENTUCKY   (United States)

^e NORTHERN ARIZONA UNIVERSITY   (United States)

Author keywords

Damage; Growth; Inflammation; Mediators; Muscle

Indexed keywords

CREATINE KINASE; SOMATOMEDIN C; TUMOR NECROSIS FACTOR ALPHA;

AGED; ARTICLE; BIOSYNTHESIS; BLOOD ANALYSIS; CLINICAL ARTICLE; CREATINE KINASE BLOOD LEVEL; DUAL ENERGY X RAY ABSORPTIOMETRY; ECCENTRIC MUSCLE CONTRACTION; FEMALE; FUNCTIONAL DISEASE; GERIATRIC PATIENT; HUMAN; KINESIOTHERAPY; MALE; MUSCLE GROWTH; MUSCLE INJURY; MUSCLE MASS; MYOSITIS; TRAINING;

EID: 37849021916     PISSN: 15398412     EISSN: None     Source Type: Journal    
DOI: 10.1519/00139143-200712000-00008     Document Type: Article

References (60)

1. Fiatarone MA, Marcs EC, Ryan ND, et al. High-intensity strength training in nonagenarians. Effects on skeletal muscle. JAMA. 1990;263:3029-3034.
2. Frontera WR, Meredith CN, O'Reilly KP, Evans WJ. Strength training and determinants of VO2max in older men. J Appl Physiol. 1990;68:329-333.
3. Campbell WW, Crim MC, Young VR, et al. Effects of resistance training and dietary protein intake on protein metabolism in older adults. Am J Physiol. 1995;268:E1143-1153.
4. Fiatarone MA, O'Neill EF, Ryan ND, et al. Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med. 1994;330:1769-1775.
5. Hakkinen K, Alen M, Lakkinen M, et al. Neuromuscular adaptation during prolonged strength training, detraining and re-strength-training in middle-aged and elderly people. Eur J Appl Physiol. 2000;83:51-62.
6. Frontera WR, Meredith CN, O'Reilly KP, Knugttgen HG, Evans WJ. Strength conditioning in older men: skeletal muscle hypertrophy and improved function. J Appl Physiol. 1988;64:1038-1044.
7. Bamman MM, Ragan RC, Kim JS, et al. Myogenic protein expression before and after resistance loading in 26- and 64-yr-old men and women. J Appl Physiol. 2004;97:1329-1337.
8. Hunter GR, McCarthy JP, Bamman MM. Effects of resistance training on older adults. Sports Med. 2004;34:329-348.
9. Welle S, Totterman S, Thornton C. Effect of age on muscle hypertrophy induced by resistance training. J Gerontol A Biol Sci Med Sci.1996;51:M270-275.
10. Goldspink G. Gene expression in muscle in response to exercise. J Muscle Res Cell Motil, 2003;24:121-126.
11. Evans WJ, Cannon JG. The metabolic effects of exercise-induced muscle damage. Exerc Sport Sci Rev. 1991;19:99-125.
12. Folland JP, Irish CS, Roberts JC, et al. Fatigue is not a necessary stimulus for strength gains during resistance training. Br J Sports Med. 2002;36:370-373; discussion 374.
13. Hawke TJ, Garry DJ. Myogenic satellite cells: physiology to molecular biology. J Appl Physiol. 2001;91:534-551.
14. Smith HK, Plyley MJ, Rodgers CD, McKee NH. Expression of developmental myosin and morphological characteristics in adult rat skeletal muscle following exercise-induced injury. Eur J Appl Physiol Occup Physiol. 1999;80:84-91.
15. Hortobagyi T, Hill JP, Houmard JA, et al. Adaptive responses to muscle lengthening and shortening in humans. J Appl Physiol, 1996;80:765-772.
16. Hortobagyi T, Barrier J, Beard D, et al. Greater initial adaptations to submaximal muscle lengthening than maximal shortening. J Appl Physiol. 1996;81:1677-1682.
17. LaStayo PC, Pierotti DJ. Eccentric ergometry: increases in locomotor muscle size and strength at low training intensities. Am J Physiol Regul Integr Comp Physiol. 2000;278:1282-1288.
18. LaStayo PC, Ewy GA, Pierotti DD, et al. The positive effects of negative work: increased muscle strength and decreased fall risk in a frail elderly population. J Gerontol A Biol Sci Med Sci. 2003;58:M419-424.
19. Colliander EB, Tesch PA. Effects of eccentric and concentric muscle actions in resistance training. Acta Physiol Scand. 1990;140:31-39.
20. Clarkson PM, Byrnes WC, McCormick KM, et al.Muscle soreness and serum creatine kinase activity following isometric, eccentric, and concentric exercise. Int J Sports Med, 1986;7:152-155.
21. Ebbeling CB, Clarkson PM. Exercise-induced muscle damage and adaptation. Sports Med, 1989;7:207-234.
22. Newham DJ. The consequences of eccentric contractions and their relationship to delayed onset muscle pain. Eur J Appl Physiol Occup Physiol. 1988;57:353-359.
23. Newham DJ, McPhail G, Mills KR, Edwards RH. Ultrastructural changes after concentric and eccentric contractions of human muscle. J Neurol Sci. 1983;61:109-122.
24. Brooks SV,Faulkner JA. Severity of contraction-induced injury is affected by velocity only during stretches of large strain. J Appl Physiol. 2001;91:661-666.
25. Faulkner JA, Brooks SV, Opiteck JA. Injury to skeletal muscle fibers during contractions: conditions of occurrence and prevention. Phys Ther. 1993;73:911-921.
26. Vierck J, O'Reilly B, Hossner K, et al. Satellite cell regulation following myotrauma caused by resistance exercise. Cell Biol Int. 2000;24:263-272.
27. Adams GR. Invited Review: Autocrine/paracrine IGF-I and skeletal muscle adaptation. J Appl Physiol. 2002;93:159-167.
28. Barber M, Braid V, Glimore D, et al. IGF-1 levels, leg extensor power and physical performance after proximal femoral fracture. Age Ageing, 2003;32:678-680.
29. Jennische E, Hansson HA. Regenerating skeletal muscle cells express insulin-like growth factor I. Acta Physiol Scand. 1987;130:327-332.
30. Grounds MD. Reasons for the degeneration of ageing skeletal muscle: a central role for IGF-1 signalling. Biogerontology. 2002;3:19-24.
31. Clarkson PM. Eccentric exercise and muscle damage. Int J Sports Med. 1997;18 Suppl 4:S314-317.
32. Nosaka K, Clarkson PM. Muscle damage following repeated bouts of high force eccentric exercise. Med Sci Sports Exerc. 1995;27:1263-1269.
33. Shumway-Cook A, Brauer S, Woollacott M. Predicting the probability for falls in community-dwelling older adults using the Timed Up & Go Test. Phys Ther. 2000;80:896-903.
34. Nosaka K, Clarkson PM, Changes in indicators of inflammation after eccentric exercise of the elbow flexors. Med Sci Sports Exerc. 1996;28:953-961.
35. Manfredi TG, Fielding RA, O'Reilly KP, et al. Plasma creatine kinase activity and exercise-induced muscle damage in older men. Med Sci Sports Exerc. 1991;23:1028-1034.
36. Paddon-Jones D, Abernethy PJ. Acute adaptation to low volume eccentric exercise. Med Sci Sports Exerc. 2001;33:1213-1219.
37. Evans WJ, Meridith CN, Cannon JG, et al. Metabolic changes following eccentric exercise in trained and untrained men. J Appl Physiol. 1986;61:1864-1868.
38. Toft AD, Jensen LB, Bruungaard H, et al. Cytokine response to eccentric exercise in young and elderly humans. Am J Physiol Cell Physiol, 2002;283:C289-295.
39. Smith LL, Anwar A, Fragen M, et al. Cytokines and cell adhesion molecules associated with high-intensity eccentric exercise. Eur J Appl Physiol. 2000;82:61-67.
40. Pedersen BK, Ostrowki K, Rohde T, Bruunsgaard H. The cytokine response to strenuous exercise. Can J Physiol Pharmacol. 1998;76:505-511.
41. Kraemer WJ, Hakkinen K, Newton RU, et al. Effects of heavy-resistance training on hormonal response patterns in younger vs. older men. J Appl Physiol. 1999;87:982-992.
42. Tidball JG. Inflammatory cell response to acute muscle injury. Med Sci Sports Exerc. 1995;27:1022-1032.
43. LaStayo PC, Woolf JM, Lewek MD, et al. Eccentric muscle contractions: their contribution to injury, prevention, rehabilitation, and sport. J Orthop Sports Phys Ther, 2003;33:557-571.
44. Lindstedt SL, LaStayo PC, Reich TE. When active muscles lengthen: properties and consequences of eccentric contractions. News Physiol Sci. 2001;16:256-261.
45. Dibble LE, Hale T, Marcus RL, et al. The safety and feasibility of high-force eccentric resistance exercise in persons with Parkinson's disease. Arch Phys Med Rehabil. 2006;87:1280-1282.
46. Dibble LE, Hale TF, Marcus RL et al. High-intensity resistance training amplifies muscle hypertrophy and functional gains in persons with Parkinson's disease. Mov Disord. 2006;21:1444-1452.
47. Hortobagyi T. The positives of negatives: clinical implications of eccentric resistance exercise in old adults. J Gerontol A Biol Sci Med Sci. 2003;58:417-418.
48. Hortobagyi T, DeVita P. Favorable neuromuscular and cardiovascular responses to 7 days of exercise with an eccentric overload in elderly women. J Gerontol A Biol Sci Med Sci. 2000; 55:B401-410.
49. Singh MA, Ding W, Manfredi TJ, et al. Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders. Am J Physiol. 1999;277:E135-143.
50. Parkhouse WS, Coupland DC, Li C, Vanderhoek KJ. IGF-1 bioavailability is increased by resistance training in older women with low bone mineral density. Mech Ageing Dev. 2000;113:75-83.
51. Bermon S, Ferrari P, Bernard P, et al. Responses of total and free insulin-like growth factor-I and insulin-like growth factor binding protein-3 after resistance exercise and training in elderly subjects. Acta Physiol Scand. 1999;165:51-56.
52. Borst SE, Vincent KR, Lowentha DT, Braith RW. Effects of resistance training on insulin-like growth factor and its binding proteins in men and women aged 60 to 85. J Am Geriatr Soc. 2002;50:884-888.
53. Nicklas BJ, Ryan AJ, Treuth MM, et al. Testosterone, growth hormone and IGF-I responses to acute and chronic resistive exercise in men aged 55-70 years. Int J Sports Med. 1995;16:45-50.
54. Yan Z, Biggs RB, Booth FW. Insulin-like growth factor immunoreactivity increases in muscle after acute eccentric contractions. J Appl Physiol. 1993;74:410-414.
55. Hameed M, Orrell RW, Cobbold M, et al. Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise. J Physiol. 2003;547:247-254.
56. Rudman D, Feller AG, Nagraj HS, et al. Effects of human growth hormone in men over 60 years old. N Engl J Med. 1990;323:1-6.
57. Teale JD, Marks V. The measurement of insulin-like growth factor I: clinical applications and significance. Ann Clin Biochem. 1986;23:413-424.
58. Liu JL, Yakar S, LeRoith D. Conditional knockout of mouse insulin-like growth factor-1 gene using the Cre/IoxP system. Proc Soc Exp Biol Med. 2000;223:344-351.
59. Adams GR, Haddad F. The relationships among IGF-1, DNA content, and protein accumulation during skeletal muscle hypertrophy. J Appl Physiol. 1996;81:2509-2516.
60. Adams GR, McCue SA, Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats. J Appl Physiol, 1998;84:1716-1722.