Conditional knockout of mouse insulin-like growth factor-1 gene using the Cre/loxP system (44500)

Experimental Biology and Medicine

Volumn 223, Issue 4, 2000, Pages 344-351

  Liu, Jun Li ^a   Yakar, Shoshana ^a   LeRoith, Derek ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; SOMATOMEDIN C;

ANIMAL EXPERIMENT; ANIMAL TISSUE; BODY GROWTH; CONTROLLED STUDY; GENE FUNCTION; GROWTH RETARDATION; HORMONE DEFICIENCY; INFERTILITY; KNOCKOUT GENE; LIVER; MOUSE; NONHUMAN; ORGANOGENESIS; POSTNATAL GROWTH; PRENATAL DEVELOPMENT; SHORT SURVEY;

ANIMALS; FEMALE; GENE TARGETING; INFERTILITY; INSULIN-LIKE GROWTH FACTOR I; INTEGRASES; LIVER; MALE; MICE; MICE, KNOCKOUT; VIRAL PROTEINS;

ANIMALIA; RODENTIA;

EID: 0034082772     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1373.2000.22349.x     Document Type: Article

References (9)

1. Thomas KR, Capecchi MR. Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51:503-512, 1987.
2. Bradley A, Hasty P, Davis A, Ramirez-Solis R. Modifying the mouse: Design and desire. Biotechnol (N Y) 10:534-539, 1992.
3. Capecchi MR. Targeted gene replacement. Sci Am 270:52-59, 1994.
4. Galli-Taliadoros LA, Sedgwick JD, Wood SA, Korner H. Gene knockout technology: A methodological overview for the interested novice. J Immunol Meth 181:1-15, 1995.
5. Fassler R, Martin K, Forsberg E, Litzenburger T, Iglesias A. Knockout mice: How to make them and why. The immunological approach. Int Arch Allergy Immunol 6:323-334, 1995.
6. Moreadith RW, Radford NB. Gene targeting in embryonic stem cells: The new physiology and metabolism. J Mol Med 75:208-216, 1997.
7. van der Neut R. Targeted gene disruption: Applications in neurobiology. J Neurosci Meth 71:19-27, 1997.
8. Liu JP, Baker J, Perkins AS, Robertson EJ. Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (IGF-1) and type 1 IGF receptor (IGF-1r). Cell 75:59-72, 1993.
9. Powell-Braxton L, Hollingshead P, Warburton C, Dowd M, Pitts-Meek S, Dalton D, Gillett N, Stewart TA. IGF-1 is required for normal embryonic growth in mice. Genes Dev 7:2609-2617, 1993.