Transplantation of porous tubes following spinal cord transection improves hindlimb function in the rat

Spinal Cord

Volumn 46, Issue 1, 2008, Pages 58-64

  Reynolds, L F ^a   Bren, M C ^a   Wilson, B C ^a   Gibson, G D ^a   Shoichet, M S ^b   Murphy, R J L ^a  

^a ACADIA UNIVERSITY   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Cytochrome c oxidase; Locomotor function; Spinal cord injury; Transplantation

Indexed keywords

CYTOCHROME C OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY MASS; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GASTROCNEMIUS MUSCLE; HINDLIMB; LOCOMOTION; NONHUMAN; PLANTARIS MUSCLE; PRIORITY JOURNAL; RAT; SCORING SYSTEM; SOLEUS MUSCLE; SPINAL CORD TRANSSECTION; TUBE;

ANIMALS; BIOCOMPATIBLE MATERIALS; BIOLOGICAL MARKERS; ELECTRON TRANSPORT COMPLEX IV; ENERGY METABOLISM; FEMALE; GAIT DISORDERS, NEUROLOGIC; HINDLIMB; HYDROGEL; LOCOMOTION; MUSCLE, SKELETAL; MUSCULAR ATROPHY; NERVE REGENERATION; PARAPLEGIA; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; SPINAL CORD; SPINAL CORD INJURIES; TREATMENT OUTCOME;

EID: 37849014854     PISSN: 13624393     EISSN: 14765624     Source Type: Journal    
DOI: 10.1038/sj.sc.3102063     Document Type: Article

References (32)

1. Bresnahan JC, Beattie MS, Todd III FD, Noyes DH. A behavioral and anatomical analysis of spinal cord injury produced by a feedback-controlled impaction device. Exp Neurol 1987; 95: 548-570.
2. Dupont-Versteegden EE, Houle JD, Gurley CM, Peterson CA. Early changes in muscle fiber size and gene expression in response to spinal cord transection and exercise. Am J Physiol 1998; 275: C1124-C1133.
3. Lieber RL. Skeletal muscle adaptability. II: Muscle properties following spinal cord injury. Dev Med Child Neurol 1986; 28: 533-542.
4. Murphy RJL, Dupont-Versteegden EE, Peterson CA, Houle JD. Two experimental strategies to restore muscle mass in adult rats following spinal cord injury. Neurorehabil Neural Repair 1998; 13: 125-134.
5. Otis JS, Roy RR, Edgerton VR, Talmadge RJ. Adaptations in metabolic capacity of rat soleus after paralysis. J Appl Physiol 2004; 96: 584-596.
6. Talmadge RJ, Roy RR, Caiozzo VJ, Edgerton VR. Mechanical properties of rat soleus after long-term spinal cord transection. J Appl Physiol 2002; 93: 1487-1497.
7. Tsai EC, Dalton PD, Shoichet MS, Tator CH. Matrix inclusion within synthetic hydrogel guidance channels improves specific supraspinal and local axonal regeneration after complete spinal cord transection. Biomaterials 2006; 27: 519-533.
8. Katayama Y, Montenegro R, Freier T, Midha R, Belkas JS, Shoichet MS. Coil-reinforced hydrogel tubes promote nerve regeneration equivalent to that of nerve autografts. Biomaterials 2006; 27: 505-518.
9. Tsai EC, Dalton PD, Shoichet MS, Tator CH. Synthetic hydrogel guidance channels facilitate regeneration of adult rat brainstem motor axons after complete spinal cord transection. J Neurotrauma 2004; 21: 789-804.
10. Fawcett JW, Asher RA. The glial scar and central nervous system repair. Brain Res Bull 1999; 49: 377-391.
11. Hermanns S, Reiprich P, Muller HW. A reliable method to reduce collagen scar formation in the lesioned rat spinal cord. J Neurosci Methods 2001; 110: 141-146.
12. Lee YS, Lin CY, Robertson RT, Hsiao I, Lin VW. Motor recovery and anatomical evidence of axonal regrowth in spinal cord repaired adult rats. J Neuropathol Exp Neurol 2004; 63: 233-245.
13. Teng YD, Lavik EB, Qu X, Park KI, Ourednik J, Zurakowski D et al. Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc Natl Acad Sci USA 2002; 99: 3024-3029.
14. Noble LJ, Wrathall JR. Spinal cord contusion in the rat: morphometric analyses of alterations in the spinal cord. Exp Neurol 1985; 88: 135-149.
15. Schucht P, Raineteau O, Schwab ME, Fouad K. Anatomical correlates of locomotor recovery following dorsal and ventral lesions of the rat spinal cord. Exp Neurol 2002; 176: 143-153.
16. You SW, Chen BY, Liu HL, Lang B, Xia JL, Jiao XY et al. Spontaneous recovery of locomotion induced by remaining fibers after spinal cord transection in adult rats. Restor Neurol Neurosci 2003; 21: 39-45.
17. Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995; 12: 1-21.
18. Roy RR, Talmadge RJ, Hodgson JA, Zhong H, Baldwin KM, Edgerton VR. Training effects on soleus of cats spinal cord transected (T12-13) as adults. Muscle Nerve 1998; 21: 63-71.
19. Talmadge RJ, Roy RR, Edgerton VR. Persistence of hybrid fibers in rat soleus after spinal cord transection. Anat Rec 1999; 255: 188-201.
20. Yu D. A crash course in spinal cord injury. Postgrad Med 1998; 104: 109-110, 113-116, 119-122.
21. Kelley MD, Nim S, Rousseau G, Fowles JR, Murphy RL. Early effects of spinal cord transection on skeletal muscle properties. Appl Physiol Nutr Metab 2006; 31: 398-406.
22. Canadian Council on Animal Care. Guide to the Care and Use of Experimental Animals, 2nd edn, Ottawa, ON, Canada, 1993.
23. Thomas AJ, Nockels RP, Pan HQ, Shaffrey CI, Chopp M. Progesterone is neuroprotective after acute experimental spinal cord trauma in rats. Spine 1999; 24: 2134-2138.
24. Dalton PD, Shoichet MS. Creating porous tubes by centrifugal forces for soft tissue application. Biomaterials 2001; 22: 2661-2669.
25. Dalton PD, Flynn L, Shoichet MS. Manufacture of poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) hydrogel tubes for use as nerve guidance channels. Biomaterials 2002; 23: 3843-3851.
26. Smith L. Spectrophotometric assay of cytochrome c oxidase. Methods Biochem Anal 1955; 2: 427-434.
27. Basso DM, Beattie MS, Bresnahan JC, Anderson DK, Faden AI, Gruner JA et al. MASCIS evaluation of open field locomotor scores: effects of experience and teamwork on reliability. Multicenter Animal Spinal Cord Injury Study. J Neurotrauma 1996; 13: 343-359.
28. Hase T, Kawaguchi S, Hayashi H, Nishio T, Mizoguchi A, Nakamura T. Spinal cord repair in neonatal rats: a correlation between axonal regeneration and functional recovery. Eur J Neurosci 2002; 15: 969-974.
29. Brown KM, Wolfe BB, Wrathall JR. Rapid functional recovery after spinal cord injury in young rats. J Neurotrauma 2005; 22: 559-574.
30. Eng LF, Yu AC, Lee YL. Astrocytic response to injury. Prog Brain Res 1992; 94: 353-365.
31. Wicks KL, Hood DA. Mitochondrial adaptations in denervated muscle: relationship to muscle performance. Am J Physiol 1991; 260: C841-C850.
32. Talmadge RJ, Roy RR, Edgerton VR. Prominence of myosin heavy chain hybrid fibers in soleus muscle of spinal cord transected rats. J Appl Physiol 1995; 78: 1256-1265.