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Volumn 63, Issue 3, 2004, Pages 233-245

Motor Recovery and Anatomical Evidence of Axonal Regrowth in Spinal Cord-Repaired Adult Rats

Author keywords

Acidic fibroblast growth factor; Axonal regrowth; Peripheral nerve graft; Spinal cord injury; Tract tracing

Indexed keywords

DEXTRAN; SEROTONIN;

EID: 1542297688     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1093/jnen/63.3.223-a     Document Type: Article
Times cited : (54)

References (50)
  • 1
    • 0022523703 scopus 로고
    • Supraspinal contributions to the initiation and control of locomotion in the cat
    • Armstrong D. Supraspinal contributions to the initiation and control of locomotion in the cat. Prog Neurobiol 1986;26:273-61
    • (1986) Prog Neurobiol , vol.26 , pp. 273-261
    • Armstrong, D.1
  • 2
    • 0023754618 scopus 로고
    • Control of locomotion in vertebrates: Spinal and supraspinal mechanisms
    • Grillner S, Dubuc R. Control of locomotion in vertebrates: Spinal and supraspinal mechanisms. Adv Neurol 1988;47:425-53
    • (1988) Adv Neurol , vol.47 , pp. 425-453
    • Grillner, S.1    Dubuc, R.2
  • 3
    • 0027444931 scopus 로고
    • Myoelectric evoked potentials versus locomotor recovery in chronic spinal cord injured rats
    • Gruner JA, Wade CK, Menna G, Stokes BT. Myoelectric evoked potentials versus locomotor recovery in chronic spinal cord injured rats. J Neurotrauma 1993;10:327-47
    • (1993) J Neurotrauma , vol.10 , pp. 327-347
    • Gruner, J.A.1    Wade, C.K.2    Menna, G.3    Stokes, B.T.4
  • 5
    • 0031936406 scopus 로고    scopus 로고
    • Astrocytes and oligodendrocytes reactions after a total section of the rat spinal cord
    • Morin-Richaud C, Feldblum S, Privat A. Astrocytes and oligodendrocytes reactions after a total section of the rat spinal cord. Brain Res 1998;783:85-110
    • (1998) Brain Res , vol.783 , pp. 85-110
    • Morin-Richaud, C.1    Feldblum, S.2    Privat, A.3
  • 6
    • 0028079637 scopus 로고
    • Restoration of function by replacement of spinal cord segments in the rat
    • Iwashita Y, Kawaguchi S, Murata M. Restoration of function by replacement of spinal cord segments in the rat. Nature 1994;367:167-70
    • (1994) Nature , vol.367 , pp. 167-170
    • Iwashita, Y.1    Kawaguchi, S.2    Murata, M.3
  • 7
    • 0029840835 scopus 로고    scopus 로고
    • Spinal cord repair in adult paraplegic rats: Partial restoration of hind limb function
    • Cheng H, Cao Y, Olson L. Spinal cord repair in adult paraplegic rats: Partial restoration of hind limb function. Science 1996;273:510-13
    • (1996) Science , vol.273 , pp. 510-513
    • Cheng, H.1    Cao, Y.2    Olson, L.3
  • 8
    • 0032759046 scopus 로고    scopus 로고
    • Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord
    • McDonald JW, Liu XZ, Qu Y, et al. Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nature Medicine 1999;5:1410-12
    • (1999) Nature Medicine , vol.5 , pp. 1410-1412
    • McDonald, J.W.1    Liu, X.Z.2    Qu, Y.3
  • 9
    • 0033757632 scopus 로고    scopus 로고
    • Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia
    • Ramon-Cueto A, Cordero MI, Santos-Benito FF, Avila J. Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia. Neuron 2000;25:425-35
    • (2000) Neuron , vol.25 , pp. 425-435
    • Ramon-Cueto, A.1    Cordero, M.I.2    Santos-Benito, F.F.3    Avila, J.4
  • 10
    • 0036797477 scopus 로고    scopus 로고
    • Peripheral nerve graft and aFGF restore partial hindlimb function in adult paraplegic rats
    • Lee YS, Ian H, Lin V. Peripheral nerve graft and aFGF restore partial hindlimb function in adult paraplegic rats. J Neurotrauma 2002;19:1203-16
    • (2002) J Neurotrauma , vol.19 , pp. 1203-1216
    • Lee, Y.S.1    Ian, H.2    Lin, V.3
  • 11
    • 0028919411 scopus 로고
    • A sensitive and reliable locomotor rating scale for open field testing in rats
    • Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995;12:1-21
    • (1995) J Neurotrauma , vol.12 , pp. 1-21
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3
  • 12
    • 0019760388 scopus 로고
    • Influence of the glial environment on the elongation of axons after injury: Transplantation studies in adult rodents
    • Aguayo A, David S, Bary G. Influence of the glial environment on the elongation of axons after injury: Transplantation studies in adult rodents. J Exp Biol 1981;95:231-40
    • (1981) J Exp Biol , vol.95 , pp. 231-240
    • Aguayo, A.1    David, S.2    Bary, G.3
  • 13
    • 0028867947 scopus 로고
    • Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors
    • Bregman BS, Kunkel-Bagden E, Schnell L, Dai HN, Gao D, Schwab ME. Recovery from spinal cord injury mediated by antibodies to neurite growth inhibitors. Nature 1995;378:498-501
    • (1995) Nature , vol.378 , pp. 498-501
    • Bregman, B.S.1    Kunkel-Bagden, E.2    Schnell, L.3    Dai, H.N.4    Gao, D.5    Schwab, M.E.6
  • 14
    • 0031417671 scopus 로고    scopus 로고
    • The ability of human Schwann cell grafts to promote regeneration in the transected nude rat spinal cord
    • Guest JD, Rao A, Olson L, Bunge MB, Bunge RP. The ability of human Schwann cell grafts to promote regeneration in the transected nude rat spinal cord. Exp Neurol 1997;148:502-22
    • (1997) Exp Neurol , vol.148 , pp. 502-522
    • Guest, J.D.1    Rao, A.2    Olson, L.3    Bunge, M.B.4    Bunge, R.P.5
  • 15
    • 0019856865 scopus 로고
    • Axonal elongation into peripheral nerve system "bridges" after central nervous system injury in adult rats
    • David S, Aguayo A. Axonal elongation into peripheral nerve system "bridges" after central nervous system injury in adult rats. Science 1981;214:931-33
    • (1981) Science , vol.214 , pp. 931-933
    • David, S.1    Aguayo, A.2
  • 16
    • 0025666502 scopus 로고
    • Predegenerated peripheral nerve grafts facilitate neurite outgrowth from the hippocampus
    • Lewin-Kowalik J, Sieron AL, Krause M, Kwiek S. Predegenerated peripheral nerve grafts facilitate neurite outgrowth from the hippocampus. Brain Res Bull 1990;25:669-73
    • (1990) Brain Res Bull , vol.25 , pp. 669-673
    • Lewin-Kowalik, J.1    Sieron, A.L.2    Krause, M.3    Kwiek, S.4
  • 17
    • 0033942954 scopus 로고    scopus 로고
    • Intercostal nerve implants transduced with an adenoviral vector encoding neurotrophin-3 promote regrowth of injured rat corticospinal tract fibers and improve hindlimb function
    • Blits B, Dijkhuizen PA, Boer GJ, Verhaagen J. Intercostal nerve implants transduced with an adenoviral vector encoding neurotrophin-3 promote regrowth of injured rat corticospinal tract fibers and improve hindlimb function. Exp Neurol 2000;164:25-37
    • (2000) Exp Neurol , vol.164 , pp. 25-37
    • Blits, B.1    Dijkhuizen, P.A.2    Boer, G.J.3    Verhaagen, J.4
  • 18
    • 0035576371 scopus 로고    scopus 로고
    • Axonal regeneration and functional recovery after complete spinal cord transection in rats by delayed treatment with transplants and neurotrophins
    • Coumans JV, Lin TT, Dai HN, et al. Axonal regeneration and functional recovery after complete spinal cord transection in rats by delayed treatment with transplants and neurotrophins. J Neurosci 2001;21:9334-44
    • (2001) J Neurosci , vol.21 , pp. 9334-9344
    • Coumans, J.V.1    Lin, T.T.2    Dai, H.N.3
  • 19
    • 0036703612 scopus 로고    scopus 로고
    • Schwann cell but not olfactory ensheathing glia transplants improve hindlimb locomotor performance in the moderately contused adult rat thoracic spinal cord
    • Takami T, Oudega M, Bates ML, Wood PM, Kleitman N, Bunge MB. Schwann cell but not olfactory ensheathing glia transplants improve hindlimb locomotor performance in the moderately contused adult rat thoracic spinal cord. J Neurosci 2002;22:6670-81
    • (2002) J Neurosci , vol.22 , pp. 6670-6681
    • Takami, T.1    Oudega, M.2    Bates, M.L.3    Wood, P.M.4    Kleitman, N.5    Bunge, M.B.6
  • 20
    • 0036119686 scopus 로고    scopus 로고
    • Peripheral nerve grafts promoting central nervous system regeneration after spinal cord injury in the primate
    • Levi AD, Dancausse H, Li X, Duncan S, Horkey L, Oliviera M. Peripheral nerve grafts promoting central nervous system regeneration after spinal cord injury in the primate. J Neurosurg 2002;96:197-205
    • (2002) J Neurosurg , vol.96 , pp. 197-205
    • Levi, A.D.1    Dancausse, H.2    Li, X.3    Duncan, S.4    Horkey, L.5    Oliviera, M.6
  • 21
    • 0036457423 scopus 로고    scopus 로고
    • Spinal cord repair in neonatal rats: A correlation between axonal regeneration and functional recovery
    • Hase T, Kawaguchi S, Hayashi H, Nishio T, Mizoguchi A, Nakamura T. Spinal cord repair in neonatal rats: A correlation between axonal regeneration and functional recovery. Eur J Neurosci 2002;15:969-74
    • (2002) Eur J Neurosci , vol.15 , pp. 969-974
    • Hase, T.1    Kawaguchi, S.2    Hayashi, H.3    Nishio, T.4    Mizoguchi, A.5    Nakamura, T.6
  • 22
    • 0033180342 scopus 로고    scopus 로고
    • The glial scar and central nervous system repair
    • Fawcett JW, Asher RA. The glial scar and central nervous system repair. Brain Res Bull 1999;49:377-91
    • (1999) Brain Res Bull , vol.49 , pp. 377-391
    • Fawcett, J.W.1    Asher, R.A.2
  • 23
    • 0031026709 scopus 로고    scopus 로고
    • Nerve fibre regeneration across the peripheral-central transitional zone
    • Carlstedt T. Nerve fibre regeneration across the peripheral-central transitional zone. J Anat 1997;190:51-56
    • (1997) J Anat , vol.190 , pp. 51-56
    • Carlstedt, T.1
  • 24
    • 0030780075 scopus 로고    scopus 로고
    • Glial cell extracellular matrix: Boundaries for axon growth in development and regeneration
    • Fitch MT, Silver J. Glial cell extracellular matrix: Boundaries for axon growth in development and regeneration. Cell Tissue Res 1997;290:379-84
    • (1997) Cell Tissue Res , vol.290 , pp. 379-384
    • Fitch, M.T.1    Silver, J.2
  • 25
    • 0037061426 scopus 로고    scopus 로고
    • Chondroitinase ABC promotes functional recovery after spinal cord injury
    • Bradbury EJ, Moon LD, Popat RJ, et al. Chondroitinase ABC promotes functional recovery after spinal cord injury. Nature 2002;416:636-40
    • (2002) Nature , vol.416 , pp. 636-640
    • Bradbury, E.J.1    Moon, L.D.2    Popat, R.J.3
  • 26
    • 0034815198 scopus 로고    scopus 로고
    • Nogo: A molecular determinant of axonal growth and regeneration
    • 200
    • Grandpre T, Strittmatter SM. Nogo: A molecular determinant of axonal growth and regeneration. Neuroscientist 200;7:377-86
    • Neuroscientist , vol.7 , pp. 377-386
    • Grandpre, T.1    Strittmatter, S.M.2
  • 27
    • 0029988793 scopus 로고    scopus 로고
    • Axonal regeneration in the mammalian CNS
    • Brosmale C, Schwab M. Axonal regeneration in the mammalian CNS. Sem Neurosci 1996;8:107-13
    • (1996) Sem Neurosci , vol.8 , pp. 107-113
    • Brosmale, C.1    Schwab, M.2
  • 28
    • 0036458516 scopus 로고    scopus 로고
    • Increasing plasticity and functional recovery of the lesioned spinal cord
    • Schwab ME. Increasing plasticity and functional recovery of the lesioned spinal cord. Prog Brain Res 2002;137:351-59
    • (2002) Prog Brain Res , vol.137 , pp. 351-359
    • Schwab, M.E.1
  • 29
    • 0038076000 scopus 로고    scopus 로고
    • Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury
    • Simonen M, Pedersen V, Weinmann O, et al. Systemic deletion of the myelin-associated outgrowth inhibitor Nogo-A improves regenerative and plastic responses after spinal cord injury. Neuron 2003;38:201-11
    • (2003) Neuron , vol.38 , pp. 201-211
    • Simonen, M.1    Pedersen, V.2    Weinmann, O.3
  • 31
    • 0029987296 scopus 로고    scopus 로고
    • Proteoglycans and other repulsive molecules in glial boundaries during development and regeneration of the nervous system
    • Höke A, Silver J. Proteoglycans and other repulsive molecules in glial boundaries during development and regeneration of the nervous system. Progress in Brain Res 1996;108:149-63
    • (1996) Progress in Brain Res , vol.108 , pp. 149-163
    • Höke, A.1    Silver, J.2
  • 32
    • 0026408781 scopus 로고
    • Boundaries and wounds, glia and glycoconjugates. Cellular and molecular analyses of developmental partitions and adult brain lesions
    • Laywell ED, Steindler DA. Boundaries and wounds, glia and glycoconjugates. Cellular and molecular analyses of developmental partitions and adult brain lesions. Ann NY Acad Sci 1991;633:122-41
    • (1991) Ann NY Acad Sci , vol.633 , pp. 122-141
    • Laywell, E.D.1    Steindler, D.A.2
  • 33
    • 0026345228 scopus 로고
    • Reactive astrocytes are substrates for the growth of adult CNS axons in the presence of elevated levels of nerve growth factor
    • Kawaja MD, Gage FH. Reactive astrocytes are substrates for the growth of adult CNS axons in the presence of elevated levels of nerve growth factor. Neuron 1991;7:1019-30
    • (1991) Neuron , vol.7 , pp. 1019-1030
    • Kawaja, M.D.1    Gage, F.H.2
  • 34
    • 0030222129 scopus 로고    scopus 로고
    • Hagg T Nerve growth factor promotes regeneration of sensory axons into adult rat spinal cord
    • Oudega M, Hagg T Nerve growth factor promotes regeneration of sensory axons into adult rat spinal cord. Exp Neurol 1996;140:218-29
    • (1996) Exp Neurol , vol.140 , pp. 218-229
    • Oudega, M.1
  • 35
    • 0030973478 scopus 로고    scopus 로고
    • Functional characterization of NGF-secreting cell grafts to the acutely injured spinal cord
    • Tuszynski MH, Murai K, Blesch A, Grill R, Miller I. Functional characterization of NGF-secreting cell grafts to the acutely injured spinal cord. Cell Transplantation 1997;6:361-68
    • (1997) Cell Transplantation , vol.6 , pp. 361-368
    • Tuszynski, M.H.1    Murai, K.2    Blesch, A.3    Grill, R.4    Miller, I.5
  • 36
    • 0037104763 scopus 로고    scopus 로고
    • Ensheathing cells and methylprednisolone promote axonal regeneration and functional recovery in the lesioned adult rat spinal cord
    • Nash HH, Borke RC, Anders JJ. Ensheathing cells and methylprednisolone promote axonal regeneration and functional recovery in the lesioned adult rat spinal cord. J Neurosci 2002;22:7111-20
    • (2002) J Neurosci , vol.22 , pp. 7111-7120
    • Nash, H.H.1    Borke, R.C.2    Anders, J.J.3
  • 37
    • 0037022618 scopus 로고    scopus 로고
    • Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells
    • Teng YD, Lavik EB, Qu X, et al. Functional recovery following traumatic spinal cord injury mediated by a unique polymer scaffold seeded with neural stem cells. Proc Natl Acad Sci U S A 2002;99:3024-29
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 3024-3029
    • Teng, Y.D.1    Lavik, E.B.2    Qu, X.3
  • 38
    • 0037104719 scopus 로고    scopus 로고
    • Long-lasting sprouting and gene expression changes induced by the monoclonal antibody IN-1 in the adult spinal cord
    • Bareyre FM, Haudenschild B, Schwab ME. Long-lasting sprouting and gene expression changes induced by the monoclonal antibody IN-1 in the adult spinal cord. J Neurosci 2002;22:7097-10
    • (2002) J Neurosci , vol.22 , pp. 7097-7010
    • Bareyre, F.M.1    Haudenschild, B.2    Schwab, M.E.3
  • 39
    • 0034331170 scopus 로고    scopus 로고
    • Regeneration of lesioned corticospinal tract fibers in the adult rat induced by a recombinant, humanized IN-1 antibody fragment
    • Brosamle C, Huber AB, Fiedler M, Skerra A, Schwab ME. Regeneration of lesioned corticospinal tract fibers in the adult rat induced by a recombinant, humanized IN-1 antibody fragment. J Neurosci 2000;20:8061-68
    • (2000) J Neurosci , vol.20 , pp. 8061-8068
    • Brosamle, C.1    Huber, A.B.2    Fiedler, M.3    Skerra, A.4    Schwab, M.E.5
  • 40
    • 0036294747 scopus 로고    scopus 로고
    • Promotion of regeneration of corticospinal tract axons in rats with recombinant vascular endothelial growth factor alone and combined with adenovirus coding for this factor
    • Facchiano F, Fernandez E, Mancarella S, et al. Promotion of regeneration of corticospinal tract axons in rats with recombinant vascular endothelial growth factor alone and combined with adenovirus coding for this factor. J Neurosurg 2002;97:161-68
    • (2002) J Neurosurg , vol.97 , pp. 161-168
    • Facchiano, F.1    Fernandez, E.2    Mancarella, S.3
  • 41
    • 0035106203 scopus 로고    scopus 로고
    • Stimulation of corticospinal tract regeneration in the chronically injured spinal cord
    • Ferguson IA, Koide T, Rush RA. Stimulation of corticospinal tract regeneration in the chronically injured spinal cord. Eur J Neurosci 2001;13:1059-64
    • (2001) Eur J Neurosci , vol.13 , pp. 1059-1064
    • Ferguson, I.A.1    Koide, T.2    Rush, R.A.3
  • 42
    • 0032535687 scopus 로고    scopus 로고
    • Regeneration of adult rat corticospinal axons induced by transplanted olfactory ensheathing cells
    • Li Y, Field PM, Raisman G. Regeneration of adult rat corticospinal axons induced by transplanted olfactory ensheathing cells. J Neurosci 1998;18:10514-24
    • (1998) J Neurosci , vol.18 , pp. 10514-10524
    • Li, Y.1    Field, P.M.2    Raisman, G.3
  • 43
    • 0032428520 scopus 로고    scopus 로고
    • Regeneration and sprouting of chronically injured corticospinal tract fibers in adult rats promoted by NT-3 and the mAb IN-I, which neutralizes myelin-associated neurite growth inhibitors
    • von Meyenburg J, Brosamle C, Metz GA, Schwab ME. Regeneration and sprouting of chronically injured corticospinal tract fibers in adult rats promoted by NT-3 and the mAb IN-I, which neutralizes myelin-associated neurite growth inhibitors. Exp Neurol 1998;154:583-94
    • (1998) Exp Neurol , vol.154 , pp. 583-594
    • Von Meyenburg, J.1    Brosamle, C.2    Metz, G.A.3    Schwab, M.E.4
  • 44
    • 0037100178 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor applied to the motor cortex promotes sprouting of corticospinal fibers but not regeneration into a peripheral nerve transplant
    • Hiebert GW, Khodarahmi K, McGraw J, Steeves JD, Tetzlaff W. Brain-derived neurotrophic factor applied to the motor cortex promotes sprouting of corticospinal fibers but not regeneration into a peripheral nerve transplant. J Neurosci Res 2002;69:160-68
    • (2002) J Neurosci Res , vol.69 , pp. 160-168
    • Hiebert, G.W.1    Khodarahmi, K.2    McGraw, J.3    Steeves, J.D.4    Tetzlaff, W.5
  • 45
    • 0031013730 scopus 로고    scopus 로고
    • Treatment of the chronically injured spinal cord with neurotrophic factors can promote axonal regeneration from supraspinal neurons
    • Ye JH, Houle JD. Treatment of the chronically injured spinal cord with neurotrophic factors can promote axonal regeneration from supraspinal neurons. Exp Neurol 1997;143:70-81
    • (1997) Exp Neurol , vol.143 , pp. 70-81
    • Ye, J.H.1    Houle, J.D.2
  • 46
    • 0030969909 scopus 로고    scopus 로고
    • Purkinje cell survival and axonal regeneration are age dependent: An in vitro study
    • Dusart I, Airaksinen MS, Solelo C. Purkinje cell survival and axonal regeneration are age dependent: An in vitro study. J Neurosci 1997;17:3710-26
    • (1997) J Neurosci , vol.17 , pp. 3710-3726
    • Dusart, I.1    Airaksinen, M.S.2    Solelo, C.3
  • 47
    • 0035834633 scopus 로고    scopus 로고
    • Membrane heparan sulfate proteoglycan-supported FGF2-FGFR1 signaling: Evidence in support of the "cooperative end structures" model
    • Zhang Z, Coomans C, David G. Membrane heparan sulfate proteoglycan-supported FGF2-FGFR1 signaling: Evidence in support of the "cooperative end structures" model. J Biol Chem 2001;276: 41921-29
    • (2001) J Biol Chem , vol.276 , pp. 41921-41929
    • Zhang, Z.1    Coomans, C.2    David, G.3
  • 48
    • 0028835748 scopus 로고
    • Acidic fibroblast growth factor stimulates motor and sensory axon regeneration after sciatic nerve crush in the rat
    • Laird JM, Mason GS, Thomas KA, Hargreaves RJ, Hill RG. Acidic fibroblast growth factor stimulates motor and sensory axon regeneration after sciatic nerve crush in the rat. Neuroscience 1995;65:209-16
    • (1995) Neuroscience , vol.65 , pp. 209-216
    • Laird, J.M.1    Mason, G.S.2    Thomas, K.A.3    Hargreaves, R.J.4    Hill, R.G.5
  • 49
    • 0033553324 scopus 로고    scopus 로고
    • Grafts of meningeal fibroblasts in adult rat spinal cord lesion promote axonal regrowth
    • Franzen R, Martin D, Daloze A, Moonen G, Schoenen J. Grafts of meningeal fibroblasts in adult rat spinal cord lesion promote axonal regrowth. Neuroreport 1999;10:1551-56
    • (1999) Neuroreport , vol.10 , pp. 1551-1556
    • Franzen, R.1    Martin, D.2    Daloze, A.3    Moonen, G.4    Schoenen, J.5
  • 50
    • 0036128693 scopus 로고    scopus 로고
    • AFGF promotes axonal growth in rat spinal cord organotypic slice co-cultures
    • Lee YS, Baratta J, Yu J, Lin VW, Robertson RT. AFGF promotes axonal growth in rat spinal cord organotypic slice co-cultures. J Neurotrauma 2002;19:357-67
    • (2002) J Neurotrauma , vol.19 , pp. 357-367
    • Lee, Y.S.1    Baratta, J.2    Yu, J.3    Lin, V.W.4    Robertson, R.T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.