The Varicella-Zoster Virus Immediate-Early 63 protein affects chromatin controlled gene transcription in a cell-type dependent manner

BMC Molecular Biology

Volumn 8, Issue , 2007, Pages

  Habran, Lionel ^a   El Mjiyad, Nadia ^a   Di Valentin, Emmanuel ^a   Sadzot Delvaux, Catherine ^a   Bontems, Sébastien ^a   Piette, Jacques ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

HEAT SHOCK PROTEIN 70; HISTONE DEACETYLASE 3; HISTONE H3; I KAPPA B KINASE ALPHA; IMMEDIATE EARLY PROTEIN; IMMEDIATE EARLY PROTEIN 63; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 8; RNA POLYMERASE II; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; HYBRID PROTEIN; I KAPPA B; IMMEDIATE EARLY PROTEIN 63, HUMAN HERPESVIRUS 3; INTERLEUKIN DERIVATIVE; NF KAPPAB INHIBITOR ALPHA; NF-KAPPAB INHIBITOR ALPHA; REPRESSOR PROTEIN; VIRUS ENVELOPE PROTEIN;

ACETYLATION; ARTICLE; CONTROLLED STUDY; DNA MICROARRAY; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEAT SHOCK RESPONSE; HUMAN; HUMAN CELL; MOLECULAR CLONING; NONHUMAN; PROMOTER REGION; PROTEIN DNA BINDING; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; RNA BINDING; SIGNAL TRANSDUCTION; TATA BOX; TRANSCRIPTION REGULATION; VARICELLA ZOSTER VIRUS; BIOSYNTHESIS; CELL LINE; CHROMATIN ASSEMBLY AND DISASSEMBLY; COMPARATIVE STUDY; DRUG EFFECT; GENETIC TRANSCRIPTION; GENETIC TRANSDUCTION; GENETICS; HELA CELL; IMMEDIATE EARLY GENE; MELANOMA; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE; VIROLOGY; VIRUS LATENCY;

HUMAN HERPESVIRUS 3;

CELL LINE; CELL LINE, TUMOR; CHROMATIN ASSEMBLY AND DISASSEMBLY; GENE EXPRESSION REGULATION, VIRAL; GENES, IMMEDIATE-EARLY; HELA CELLS; HERPESVIRUS 3, HUMAN; HUMANS; I-KAPPA B PROTEINS; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKINS; MELANOMA; NF-KAPPA B; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; RNA POLYMERASE II; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION, GENETIC; TRANSDUCTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA; VIRAL ENVELOPE PROTEINS; VIRUS LATENCY;

EID: 37849011331     PISSN: None     EISSN: 14712199     Source Type: Journal    
DOI: 10.1186/1471-2199-8-99     Document Type: Article

References (61)

1. Flisser A Tapia-Conyer R Epidemiology of varicella infections Contrib Microbiol 1999, 3:76-85 10599522
2. Croen KD Ostrove JM Dragovic LJ Straus SE Patterns of gene expression and sites of latency in human nerve ganglia are different for varicella-zoster and herpes simplex viruses Proc Natl Acad Sci U S A 1988, 85(24):9773-9777 282863 2849116 10.1073/pnas.85.24.9773
3. Kennedy PG Grinfeld E Bell JE Varicella-zoster virus gene expression in latently infected and explanted human ganglia JVirol 2000, 74(24):11893-11898 10.1128/JVI.74.24.11893-11898.2000
4. Cohrs RJ Barbour M Gilden DH Varicella-zoster virus (VZV) transcription during latency in human ganglia: Detection of transcripts mapping to genes 21, 29, 62, and 63 in a cDNA library enriched for VZV RNA J Virol 1996, 70(5):2789-2796 190136 8627753
5. Baiker A Bagowski C Ito H Sommer M Zerboni L Fabel K Hay J Ruyechan W Arvin AM The immediate-early 63 protein of Varicella-Zoster virus: analysis of functional domains required for replication in vitro and for T-cell and skin tropism in the SCIDhu model in vivo J Virol 2004, 78(3):1181-1194 321405 14722273 10.1128/JVI.78.3.1181-1194.2004
6. Hay J Ruyechan W varicella zoster virus-a different kind of herpesvirus latency? seminars in virology 1994, 5:241-247 10.1006/smvy.1994.1026
7. Everett RD The regulation of transcription of viral and cellular genes by herpesvirus immediate-early gene products (review) Anticancer Res 1987, 7(4A):589-604 3310848
8. Lungu O Panagiotidis CA Annunziato PW Gershon AA Silverstein SJ Aberrant intracellular localization of Varicella-Zoster virus regulatory proteins during latency Proc Natl Acad Sci U S A 1998, 95(12):7080-7085 22745 9618542 10.1073/pnas.95.12.7080
9. Debrus S Sadzot-Delvaux C Nikkels AF Piette J Rentier B Varicella-zoster virus gene 63 encodes an immediate-early protein that is abundantly expressed during latency J Virol 1995, 69 (5):3240-3245 189034 7707559
10. Mahalingam R Wellish M Cohrs R Debrus S Piette J Rentier B Gilden DH Expression of protein encoded by varicella-zoster virus open reading frame 63 in latently infected human ganglionic neurons Proc Natl Acad Sci U S A 1996, 93(5):2122-2124 39920 8700895 10.1073/pnas.93.5.2122
11. Kennedy PG Grinfeld E Bontems S Sadzot-Delvaux C Varicella-Zoster virus gene expression in latently infected rat dorsal root ganglia Virology 2001, 289(2):218-223 10.1006/viro.2001.1173 11689044
12. Sato H Pesnicak L Cohen JI Varicella-zoster virus ORF47 protein kinase, which is required for replication in human T cells, and ORF66 protein kinase, which is expressed during latency, are dispensable for establishment of latency J Virol 2003, 77(20):11180-11185 225004 14512565 10.1128/JVI.77.20.11180-11185.2003
13. Gary L Gilden DH Cohrs RJ Epigenetic regulation of varicella-zoster virus open reading frames 62 and 63 in latently infected human trigeminal Ganglia J Virol 2006, 80(10):4921-4926 1472082 16641283 10.1128/JVI.80.10.4921-4926.2006
14. Mitchell BM Bloom DC Cohrs RJ Gilden DH Kennedy PG Herpes simplex virus-1 and varicella-zoster virus latency in ganglia J Neurovirol 2003, 9(2):194-204 10.1080/713831492 12707850
15. Grinfeld E Kennedy PG Translation of varicella-zoster virus genes during human ganglionic latency Virus Genes 2004, 29(3):317-319 10.1007/ s11262-004-7434-z 15550771
16. Spengler M Niesen N Grose C Ruyechan WT Hay J Interactions among structural proteins of varicella zoster virus Arch Virol Suppl 2001, 71-79 11339553
17. Lynch JM Kenyon TK Grose C Hay J Ruyechan WT Physical and functional interaction between the varicella zoster virus IE63 and IE62 proteins Virology 2002, 302(1):71-82 10.1006/viro.2002.1555 12429517
18. Sommer MH Zagha E Serrano OK Ku CC Zerboni L Baiker A Santos R Spengler M Lynch J Grose C Ruyechan W Hay J Arvin AM Mutational analysis of the repeated open reading frames, ORFs 63 and 70 and ORFs 64 and 69, of varicella-zoster virus JVirol 2001, 75(17):8224-8239 10.1128/ JVI.75.17.8224-8239.2001
19. Cohen JI Cox E Pesnicak L Srinivas S Krogmann T The varicella-zoster virus open reading frame 63 latency-associated protein is critical for establishment of latency J Virol 2004, 78(21):11833-11840 523280 15479825 10.1128/JVI.78.21.11833-11840.2004
20. Hood C Cunningham AL Slobedman B Arvin AM Sommer MH Kinchington PR Abendroth A Varicella-zoster virus ORF63 inhibits apoptosis of primary human neurons J Virol 2006, 80(2):1025-1031 1346839 16379003 10.1128/ JVI.80.2.1025-1031.2006
21. Ambagala AP Cohen JI Varicella-Zoster virus IE63, a major viral latency protein, is required to inhibit the alpha interferon-induced antiviral response J Virol 2007, 81(15):7844-7851 10.1128/JVI.00325-07 17507475
22. Kost RG Kupinsky H Straus SE Varicella-zoster virus gene 63: Transcript mapping and regulatory activity Virology 1995, 209(1):218-224 10.1006/ viro.1995.1246 7747473
23. Di Valentin E Bontems S Habran L Jolois O Markine-Goriaynoff N Vanderplasschen A Sadzot-Delvaux C Piette J Varicella-zoster virus IE63 protein represses the basal transcription machinery by disorganizing the pre-initiation complex Biol Chem 2005, 386(3):255-267 10.1515/ BC.2005.031 15843171
24. Habran L Bontems S Di Valentin E Sadzot-Delvaux C Piette J Varicella-zoster virus IE63 protein phosphorylation by roscovitine-sensitive cyclin-dependent kinases modulates its cellular localization and activity J Biol Chem 2005, 280(32);29135-29143 10.1074/ jbc.M503312200 15955820
25. Bontems S Di Valentin E Baudoux L Rentier B Sadzot-Delvaux C Piette J Phosphorylation of varicella-zoster virus IE63 protein by casein kinases influences its cellular localization and gene regulation activity J Biol Chem 2002, 277(23):21050-21060 10.1074/jbc.M111872200 11912195
26. Zuranski T Nawar H Czechowski D Lynch JM Arvin A Hay J Ruyechan WT Cell-type-dependent activation of the cellular EF-1alpha promoter by the varicella-zoster virus IE63 protein Virology 2005, 338(1):35-42 10.1016/ j.virol.2005.05.005 15936796
27. Desloges N Rahaus M Wolff MH The varicella-zoster virus-mediated delayed host shutoff: Open reading frame 17 has no major function, whereas immediate-early 63 protein represses heterologous gene expression Microbes Infect 2005. 16039898
28. Hoover SE Cohrs RJ Rangel ZG Gilden DH Munson P Cohen JI Downregulation of varicella-zoster virus (VZV) immediate-early ORF62 transcription by VZV ORF63 correlates with virus replication in vitro and with latency J Virol 2006, 80(7):3459-3468 1440367 16537613 10.1128/ JVI.80.7.3459-3468.2006
29. Hoberg JE Yeung F Mayo MW SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival Mol Cell 2004, 16(2):245-255 10.1016/j.molcel.2004.10.010 15494311
30. Jones JO Arvin AM Microarray Analysis of Host Cell Gene Transcription in Response to Varicella-Zoster Virus Infection of Human T Cells and Fibroblasts In Vitro and SCIDhu Skin Xenografts In Vivo JVirol 2003, 77(2):1268-1280 10.1128/JVI.77.2.1268-1280.2003
31. Jones JO Arvin AM Viral and cellular gene transcription in fibroblasts infected with small plaque mutants of varicella-zoster virus Antiviral Res 2005, 68(2):56-65 10.1016/j.antiviral.2005.06.011 16118026
32. Stevenson D Xue M Hay J Ruyechan WT Phosphorylation and nuclear localization of the varicella-zoster virus gene 63 protein J Virol 1996, 70(1):658-662 189862 8523589
33. Ohgitani E Kobayashi K Takeshita K Imanishi J Induced expression and localization to nuclear-inclusion bodies of hsp70 in varicella-zoster virus-infected human diploid fibroblasts Microbiol Immunol 1998, 42(11):755-760 9886148
34. Phillips B Abravaya K Morimoto RI Analysis of the specificity and mechanism of transcriptional activation of the human hsp70 gene during infection by DNA viruses J Virol 1991, 65(11):5680-5692 250228 1656064
35. Santoro MG Heat shock proteins and virus replication: Hsp70s as mediators of the antiviral effects of prostaglandins Experientia 1994, 50 (11-12):1039-1047 10.1007/BF01923459 7988663
36. White E Spector D Welch W Differential distribution of the adenovirus E1A proteins and colocalization of E1A with the 70-kilodalton cellular heat shock protein in infected cells J Virol 1988, 62(11):4153-4166 253847 2971821
37. Gasque P Complement: A unique innate immune sensor for danger signals Mol Immunol 2004, 41(11):1089-1098 10.1016/j.molimm.2004.06.011 15476920
38. Blom AM Strategies developed by bacteria and virus for protection from the human complement system Scand J Clin Lab Invest 2004, 64(5):479-496 10.1080/00365510410002904 15276914
39. Mold C Bradt BM Nemerow GR Cooper NR Epstein-Barr virus regulates activation and processing of the third component of complement J Exp Med 1988, 168(3):949-969 10.1084/jem.168.3.949 2844953
40. Harris SL Frank I Yee A Cohen GH Eisenberg RJ Friedman HM Glycoprotein C of herpes simplex virus type 1 prevents complement-mediated cell lysis and virus neutralization J Infect Dis 1990, 162(2):331-3372 165106
41. Friedman HM Wang L Fishman NO Lambris JD Eisenberg RJ Cohen GH Lubinski J Immune evasion properties of herpes simplex virus type 1 glycoprotein gC J Virol 1996, 70(7):4253-4260 190356 8676446
42. Karin M How NF-kappaB is activated: The role of the IkappaB kinase (IKK) complex Oncogene 1999, 18(49):6867-6874 10.1038/sj.onc.1203219 10602462
43. Karin M Ben-Neriah Y Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity Annu Rev Immunol 2000, 18:621-663 10.1146/ annurev.immunol.18.1.621 10837071
44. Beinke S Ley SC Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology Biochem J 2004, 382(Pt 2):393-409 1133795 15214841
45. Gregory D Hargett D Holmes D Money E Bachenheimer SL Efficient replication by herpes simplex virus type 1 involves activation of the IkappaB kinase-IkappaB-p65 pathway J Virol 2004, 78(24):13582-13590 533927 15564469 10.1128/JVI.78.24.13582-13590.2004
46. DeMeritt IB Milford LE Yurochko AD Activation of the NF-kappaB pathway in human cytomegalovirus-infected cells is necessary for efficient transactivation of the major immediate-early promoter J Virol 2004, 78(9):4498-4507 387686 15078930 10.1128/JVI.78.9.4498-4507.2004
47. Montag C Wagner J Gruska I Hagemeier C Human Cytomegalovirus blocks TNF{alpha} and IL-1{beta}-mediated NF-{kappa}B signaling J Virol 2006. 1642604 17005669
48. Taylor RT Bresnahan WA Human cytomegalovirus immediate-early 2 protein IE86 blocks virus-induced chemokine expression J Virol 2006, 80(2):920-928 1346867 16378994 10.1128/JVI.80.2.920-928.2006
49. Wang JP Kurt-Jones EA Shin OS Manchak MD Levin MJ Finberg RW Varicella-zoster virus activates inflammatory cytokines in human monocytes and macrophages via Toll-like receptor 2 J Virol 2005, 79(20):12658-12666 1235827 16188968 10.1128/JVI.79.20.12658-12666.2005
50. Rahaus M Desloges N Wolff MH Replication of varicella-zoster virus is influenced by the levels of JNK/SAPK and p38/MAPK activation J Gen Virol 2004, 85(Pt 12):3529-3540 10.1099/vir.0.80347-0 15557226
51. Kent JR Zeng PY Atanasiu D Gardner J Fraser NW Berger SL During lytic infection herpes simplex virus type 1 is associated with histones bearing modifications that correlate with active transcription J Virol 2004, 78(18):10178-10186 514973 15331750 10.1128/ JVI.78.18.10178-10186.2004
52. Gu H Liang Y Mandel G Roizman B Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells Proc Natl Acad Sci U S A 2005, 102(21):7571-7576 1140450 15897453 10.1073/pnas.0502658102
53. Poon AP Gu H Roizman B ICP0 and the US3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression Proc Natl Acad Sci U S A 2006, 103(26):9993-9998 1502567 16785443 10.1073/pnas.0604142103
54. Zhang Y Jones C The bovine herpesvirus 1 immediate-early protein (bICP0) associates with histone deacetylase 1 to activate transcription J Virol 2001, 75(20):9571-9578 114527 11559788 10.1128/JVI.75.20.9571-9578.2001
55. Zhang Y Jiang Y Geiser V Zhou J Jones C Bovine herpesvirus 1 immediate-early protein (bICP0) interacts with the histone acetyltransferase p300, which stimulates productive infection and gC promoter activity J Gen Virol 2006, 87(Pt 7):1843-1851 10.1099/ vir.0.81766-0 16760386
56. Sirven A Pflumio F Zennou V Titeux M Vainchenker W Coulombel L Dubart-Kupperschmitt A Charneau P The human immunodeficiency virus type-1 central DNA flap is a crucial determinant for lentiviral vector nuclear import and gene transduction of human hematopoietic stem cells Blood 2000, 96(13):4103-4110 11110680
57. Naldini L Blomer U Gage FH Trono D Verma IM Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector Proc Natl Acad Sci U S A 1996, 93(21):11382-11388 38066 8876144 10.1073/pnas.93.21.11382
58. Emi N Friedmann T Yee JK Pseudotype formation of murine leukemia virus with the G protein of vesicular stomatitis virus J Virol 1991, 65(3):1202-1207 239887 1847450
59. http://www.graphpad.com
60. http://abs.cit.nih.gov/geneexpression.html
61. Livak KJ Schmittgen TD Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method Methods 2001, 25(4):402-408 10.1006/meth.2001.1262 11846609