Varicella-zoster virus IE63 protein represses the basal transcription machinery by disorganizing the pre-initiation complex

Biological Chemistry

Volumn 386, Issue 3, 2005, Pages 255-267

  Di Valentin, Emmanuel ^a   Bontems, Sébastien ^a   Habran, Lionel ^a   Jolois, Olivier ^a   Markine Goriaynoff, Nicolas ^a   Vanderplasschen, Alain ^a   Sadzot Delvaux, Catherine ^a   Piette, Jacques ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Down regulation; General transcription factors; Repression; Transcription; Varicella zoster

Indexed keywords

AMINO ACID; IE63 PROTEIN; INTERLEUKIN 8; REPRESSOR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; COMPLEX FORMATION; CONTROLLED STUDY; GENE CONSTRUCT; GENE DELETION; GENE MUTATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NERVE CELL CULTURE; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS; TATA BOX; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; VARICELLA ZOSTER VIRUS; VERO CELL; WILD TYPE;

ANIMALS; CELL NUCLEUS; CERCOPITHECUS AETHIOPS; IMMEDIATE-EARLY PROTEINS; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; TATA BOX; TRANSCRIPTION FACTORS, TFII; TRANSCRIPTION, GENETIC; VERO CELLS; VIRAL ENVELOPE PROTEINS;

HUMAN HERPESVIRUS 3;

EID: 16844384137     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2005.031     Document Type: Article

References (51)

1. Baiker, A., Bagowski, C., Ito, H., Sommer, M., Zerboni, L., Fabel, K., Hay, J., Ruyechan, W., and Arvin, A.M. (2004). The immediate-early 63 protein of varicella-zoster virus: analysis of functional domains required for replication in vitro and for T-cell and skin tropism in the SCIDhu model in vivo. J. Virol. 78, 1181-1194.
2. Baudoux, L., Defechereux, P., Schoonbroodt, S., Merville, M.P., Rentier, B., and Piette, J. (1995). Mutational analysis of varicella-zoster virus major immediate-early protein IE62. Nucleic Acids Res. 23, 1341-1349.
3. Bontems, S., Di Valentin, E., Baudoux, L., Rentier, B., Sadzot-Delvaux, C., and Piette, J. (2002). Phosphorylation of varicella-zoster virus IE63 protein by casein kinases influences its cellular localization and gene regulation activity. J. Biol. Chem. 277 21050-21060.
4. Buratowski, S. (1994). The basics of basal transcription by RNA polymerase II. Cell 77, 1-3.
5. Carrozza, M.J. and DeLuca, N.A. (1996). Interaction of the viral activator protein ICP4 with TFIID through TAF250. Mol. Cell. Biol. 16, 3085-3093.
6. Choy, B. and Green, M.R. (1993). Eukaryotic activators function during multiple steps of preinitiation complex assembly. Nature 366, 531-536.
7. Cohen, J.I., Cox, E., Pesnicak, L., Srinivas, S., and Krogmann, T. (2004). The varicella-zoster virus open reading frame 63 latency-associated protein is critical for establishment of latency. J. Virol. 78, 11833-11840.
8. Cohrs, R.J., Barbour, M., and Gilden, D.H. (1996). Varicella-zoster virus (VZV) transcription during latency in human ganglia: detection of transcripts mapping to genes 21, 29, 62, and 63 in a cDNA library enriched for VZV RNA. J. Virol. 70, 2789-2796.
9. Cohrs, R.J., Gilden, D.H., Kinchington, P.R., Grinfeld, E., and Kennedy, P.G. (2003). Varicella-zoster virus gene 66 transcription and translation in latently infected human ganglia. J. Virol. 77, 6660-6665.
10. Davison, A.J., and McGeoch, D.J. (1986). Evolutionary comparisons of the S segments in the genomes of herpes simplex virus type 1 and varicella-zoster virus. J. Gen. Virol. 67, 597-611.
11. Davison, A.J. and Scott, J.E. (1986). The complete DNA sequence of varicella-zoster virus. J. Gen. Virol. 67, 1759-1816.
12. Debrus, S., Sadzot-Delvaux, C., Nikkels, A.F., Piette, J., and Rentier, B. (1995). Varicella-zoster virus gene 63 encodes an immediate-early protein that is abundantly expressed during latency. J. Virol. 69, 3240-3245.
13. Defechereux, P., Melen, L., Baudoux, L., Merville-Louis, M.P., Rentier, B., and Piette, J. (1993). Characterization of the regulatory functions of varicella-zoster virus open reading frame 4 gene product. J. Virol. 67, 4379-4385.
14. Derbigny, W.A., Kim, S.K., Caughman, G.B., and O'Callaghan, D.J. (2000). The EICP22 protein of equine herpes virus 1 physically interacts with the immediate-early protein and with itself to form dimers and higher-order complexes. J. Virol. 74, 1425-1435.
15. Foecking, M.K. and Hofstetter, H. (1986). Powerful and versatile enhancer-promoter unit for mammalian expression vectors. Gene 45, 101-105.
16. Gaston, K. and Jayaraman, P.S. (2003). Transcriptional repression in eukaryotes: repressors and repression mechanisms: Cell Mol. Life Sci. 60, 721-741.
17. Grinfeld, E. and Kennedy, P. (2004). Translation of varicella-zoster virus genes during human ganglionic latency. Virus Genes 29, 317-319.
18. Grondin, B. and DeLuca, N. (2000). Herpes simplex virus type 1 ICP4 promotes transcription preinitiation complex formation by enhancing the binding of TFIID to DNA. J. Virol. 74, 11504-11510.
19. Gu, B., Kuddus, R., and DeLuca, N.A. (1995). Repression of activator-mediated transcription by herpes simplex virus ICP4 via a mechanism involving interactions with the basal transcription factors TATA-binding protein and TFIIB. Mol. Cell. Biol. 15, 3618-3626.
20. Hahn, S. (2004). Structure and mechanism of the RNA polymerase II transcription machinery. Nat. Struct. Mol. Biol. 11, 394-403.
21. Hampsey, M. (1998). Molecular genetics of the RNA polymerase II general transcriptional machinery. Microbiol. Mol. Biol. Rev. 62 465-503.
22. Heinemeyer, T., Wingender, E., Reuter, I., Hermjakob, H., Kel, A.E., Kel, O.V., Ignatieva, E.V., Ananko, E.A., Podkolodnaya, O.A., Kolpakov, F.A., Podkolodny, N.L., and Kolchanov, N.A. (1998). Databases on transcriptional regulation: TRANSFAC, TRRD and COMPEL. Nucleic Acids Res. 26, 362-367.
23. Heinemeyer, T., Chen, X., Karas, H., Kel, A.E., Kel, O.V., Liebich, I., Meinhardt, T., Reuter, I., Schacherer, F., and Wingender, E. (1999). Expanding the TRANSFAC database towards an expert system of regulatory molecular mechanisms. Nucleic Acids Res. 27, 318-322.
24. Huang, S.M. and McCance, D.J. (2002). Downregulation of the interleukin-8 promoter by human papilloma virus type 16 E6 and E7 through effects on CREB binding protein/p300 and P/CAF J. Virol. 76, 8710-8721.
25. Jackers, P., Defechereux, P., Baudoux, L., Lambert, C., Massaer, M., Merville-Louis, M.P., Rentier, B., and Piette, J. (1992). Characterization of regulatory functions of the varicella-zoster virus gene 63-encoded protein. J. Virol. 66, 3899-3903.
26. Jang, H.K., Albrecht, R.A., Buczynski, K.A., Kim, S.K., Derbigny, W.A., and O'Callaghan, D.J. (2001). Mapping the sequences that mediate interaction of the equine herpes virus 1 immediate-early protein and human TFIIB. J. Virol. 75, 10219-10230.
27. Kawaguchi, Y., Bruni, R., and Roizman, B. (1997). Interaction of herpes simplex virus 1 α regulatory protein ICP0 with elongation factor 1δ: ICP0 affects translational machinery. J. Virol. 71, 1019-1024.
28. Kennedy, P.G., Grinfeld, E., and Bell, J.E. (2000). Varicella-zoster virus gene expression in latently infected and explanted human ganglia. J. Virol. 74, 11893-11898.
29. Kennedy, P.G., Grinfeld, E., Bontems, S., and Sadzot-Delvaux, C. (2001). Varicella-zoster virus gene expression in latently infected rat dorsal root ganglia. Virology 289, 218-223.
30. Kim, S.K., Jang, H.K., Albrecht, R.A., Derbigny, W.A., Zhang, Y., and O'Callaghan, D.J. (2003). Interaction of the equine herpes virus 1 EICP0 protein with the immediate-early (IE) protein, TFIIB, and TBP may mediate the antagonism between the IE and EICP0 proteins. J. Virol. 77 2675-2685.
31. Kinchington, P.R., Vergnes, J.P., Defechereux, P., Piette, J., and Turse, S.E. (1994). Transcriptional mapping of the varicella-zoster virus regulatory genes encoding open reading frames 4 and 63. J. Virol. 68, 3570-3581.
32. Kinchington, P.R., Vergnes, J.P., and Turse, S.E. (1995). Transcriptional mapping of varicella-zoster virus regulatory proteins. Neurology 45, S33-35.
33. Kost, R.G., Kupinsky, H., and Straus, S.E. (1995). Varicella-zoster virus gene 63: transcript mapping and regulatory activity. Virology 209, 218-224.
34. Ling, P., Kinchington, P.R., Sadeghi-Zadeh, M., Ruyechan, W.T., and Hay, J. (1992). Transcription from varicella-zoster virus gene 67 (glycoprotein IV). J. Virol. 66, 3690-3698.
35. Lium, E.K. and Silverstein, S. (1997). Mutational analysis of the herpes simplex virus type 1 ICP0 C3HC4 zinc ring finger reveals a requirement for ICP0 in the expression of the essential alpha27 gene. J. Virol. 71, 8602-8614.
36. Long, M.C., Leong, V., Schaffer, P.A., Spencer, C.A., and Rice, S.A. (1999). ICP22 and the UL13 protein kinase are both required for herpes simplex virus-induced modification of the large subunit of RNA polymerase II. J. Virol. 73, 5593-5604.
37. Lungu, O., Panagiotidis, C.A., Annunziato, P.W., Gershon, A.A., and Silverstein, S.J. (1998). Aberrant intracellular localization of varicella-zoster virus regulatory proteins during latency. Proc. Natl. Acad. Sci. USA 95, 7080-7085.
38. Lynch, J.M., Kenyon, T.K., Grose, C., Hay, J., and Ruyechan, W.T. (2002). Physical and functional interaction between the varicella zoster virus IE63 and IE62 proteins. Virology 302, 71-82.
39. Mahalingam, R., Wellish, M., Cohrs, R., Debrus, S., Piette, J., Rentier, B., and Gilden, D.H. (1996). Expression of protein encoded by varicella-zoster virus open reading frame 63 in latently infected human ganglionic neurons. Proc. Natl. Acad. Sci. USA 93, 2122-2124.
40. Manet, E., Allera, C., Gruffat, H., Mikaelian, I., Rigolet, A., and Sergeant, A. (1993). The acidic activation domain of the Epstein-Barr virus transcription factor R interacts in vitro with both TBP and TFIIB and is cell-specifically potentiated by a proline-rich region. Gene Expr. 3, 49-59.
41. Meier, J.L., Holman, R.P., Croen, K.D., Smialek, J.E., and Straus, S.E. (1993). Varicella-zoster virus transcription in human trigeminal ganglia. Virology 193, 193-200.
42. Meier, J.L., Luo, X., Sawadogo, M., and Straus, S.E. (1994). The cellular transcription factor USF cooperates with varicella-zoster virus immediate-early protein 62 to symmetrically activate a bidirectional viral promoter. Mol. Cell. Biol. 14, 6896-6906.
43. Moon, N.S., Premdas, P., Truscott, M., Leduy, L., Berube, G., and Nepveu, A. (2001). S phase-specific proteolytic cleavage is required to activate stable DNA binding by the CDP/Cut homeodomain protein. Mol. Cell. Biol. 21, 6332-6345.
44. Reese, M.G., Harris, N.L., and Eeckman, F.H. (1996). Large-scale sequencing specific neural networks for promoter and splice site recognition. In: Biocomputing. Proceedings of the 1996 Pacific Symposium, L. Hunter and T.E. Klein, eds. (Singapore: World Scientific Publishing Co).
45. Roebuck, K.A. (1999). Regulation of interleukin-8 gene expression. J. Interferon Cytokine Res. 19, 429-438.
46. Sommer, M.H., Zagha, E., Serrano, O.K., Ku, C.C., Zerboni, L., Baiker, A., Santos, R., Spengler, M., Lynch, J., Grose, C., et al. (2001). Mutational analysis of the repeated open reading frames, ORFs 63 and 70 and ORFs 64 and 69, of varicella-zoster virus. J. Virol. 75, 8224-8239.
47. Song, C.Z., Loewenstein, P.M., Toth, K., Tang, Q., Nishikawa, A., and Green, M. (1997). The adenovirus E1A repression domain disrupts the interaction between the TATA binding protein and the TATA box in a manner reversible by TFIIB. Mol. Cell. Biol. 17, 2186-2193.
48. Truscott, M., Raynal, L., Premdas, P., Goulet, B., Leduy, L., Berube, G., and Nepveu, A. (2003). CDP/Cux stimulates transcription from the DNA polymerase α gene promoter. Mol. Cell. Biol. 23, 3013-3028.
49. Vanderplasschen, A., Markine-Goriaynoff, N., Lomonte, P., Suzuki, M., Hiraoka, N., Yeh, J.C., Bureau, F., Willems, L., Thiry, E., Fukuda, M., and Pastoret, P.P. (2000). A multipotential β-1,6-N acetylglucosaminyl-transferase is encoded by bovine herpes virus type 4. Proc. Natl. Acad. Sci. USA 97, 5756-5761.
50. Wood, J.N., Bevan, S.J., Coote, P.R., Dunn, P.M., Harmar, A., Hogan, P., Latchman, D.S., Morrison, C., Rougon, G., Theveniau, M., et al. (1990). Novel cell lines display properties of nociceptive sensory neurons. Proc. R. Soc. Lond. B Biol. Sci. 241, 187-194.
51. Yamamoto, S., Watanabe, Y., van der Spek, P.J., Watanabe, T., Fujimoto, H., Hanaoka, F., and Ohkuma, Y. (2001). Studies of nematode TFIIE function reveal a link between Ser-5 phosphorylation of RNA polymerase II and the transition from transcription initiation to elongation. Mol. Cell. Biol. 21, 1-15.