The differentially mutational spectra of the APC, K-ras, and p53 genes in sporadic colorectal cancers from Taiwanese patients

Hepato-Gastroenterology

Volumn 54, Issue 80, 2007, Pages 2259-2265

  Wang, Jaw Yuan ^b   Hsieh, Jan Sing ^b   Lu, Chien Yu ^a   Yu, Fang Jung ^a   Wu, Jeng Yih ^a   Chen, Fang Ming ^b   Huang, Che Jen ^b   Lin, Shiu Ru ^b,c  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

APC; Colorectal cancer; K ras; p53; Somatic mutations

Indexed keywords

K RAS PROTEIN; PROTEIN P53;

ADULT; AGED; ARTICLE; CANCER INCIDENCE; CANCER STAGING; CLINICAL FEATURE; COLORECTAL CANCER; CONTROLLED STUDY; DNA EXTRACTION; DNA POLYMORPHISM; ELECTROPHORESIS; FEMALE; GENE MUTATION; GENE SEQUENCE; HUMAN; MAJOR CLINICAL STUDY; MALE; MISSENSE MUTATION; NONSENSE MUTATION; ONCOGENE K RAS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SURGICAL TECHNIQUE; TAIWAN;

AGED; AGED, 80 AND OVER; ASIAN CONTINENTAL ANCESTRY GROUP; COLORECTAL NEOPLASMS; FEMALE; GENES, APC; GENES, P53; GENES, RAS; GENETICS, POPULATION; HUMANS; MALE; MIDDLE AGED; MUTATION, MISSENSE; POLYMORPHISM, SINGLE-STRANDED CONFORMATIONAL; TAIWAN;

EID: 37749054079     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Fearon ER, Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 1990; 61:759-767.
2. Kinzler KW, Vogelstein B: Lessons from hereditary colorectal cancer. Cell 1996; 87:159-170.
3. Laurent-Puig P, Blons H, Cugnenc PH: Sequence of molecular genetic events in colorectal tumorigenesis. Eur J Cancer Pre 1999; 8(Suppl 1):S39-47.
4. Astler VB, Coller FA: The prognostic significance of direct extension of carcinoma of the colon and rectum. Ann Surg 1954; 139: 846-851.
5. Sambrook J, Fritsch EF, Maniatis T: Molecular cloning: a laboratory manual (Eds.). New York: Cold Spring Harbor Laboratory Press, 1989; 6.22-6.34.
6. Wang JY, Hsieh JS, Chang MY, et al: Molecular Detection of the APC, K-ras, and p53 Mutations in the Serum of Colorectal Cancer Patients as Circulating Biomarkers. World J Surg 2004; 28:721-726.
7. Nakamura Y: The role of the adenomatous polyposis coli (APC) gene in human cancers. Adv Cancer Res 1993; 62:65-87.
8. Fahy B, Bold RJ: Epidemiology and molecular genetics of colorectal cancer. Surg Oncol 1998; 7:115-123.
9. Leslie A, Carey FA, Pratt NR, et al:The colorectal adenoma-carcinoma sequence. Br J Surg 2002; 89:845-860.
10. Smith G, Carey FA, Beattie J, et al: Mutations in APC, Kirsten-ras, and p53 - alternative genetic pathways to colorectal cancer. Proc Natl Acad Sci USA 2002; 99:9433-9438.
11. Tang R, Wang PF, Wang HC, et al: Mutations of p53 gene in human colorectal cancer: distinct frameshifts among populations. Int J Cancer 2001; 91:863-868.
12. Yuen ST, Chung LP, Leung SY, et al: Colorectal carcinoma in Hong Kong: epidemiology and genetic mutations. Br J Cancer 1997; 76:1610-1616.
13. Borresen-Dale AL, Lothe RA, Meling GI, et al: TP53 and long-term prognosis in colorectal cancer: mutations in the L3 zinc-binding domain predict poor survival. Clin Cancer Res 1998; 4:203-210.
14. Neibergs HL, Hein DW, Spratt JS: Genetic profiling of colon cancer. J Surg Oncol 2002; 80:204-213.
15. Bos JL: Ras oncogenes in human cancer: A review. Cancer Res 1989; 49:4682-4689.
16. Capellá G, Cronauer-Mitra S, Pienado MA, et al: Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors. Environ Health Perspect 1991; 93:25-131.
17. Shibata D, Schaeffer J, Li ZH, et al: Genetic heterogeneity of the c-K-ras locus in colorectal adenomas but not in adenocarcinomas. J Natl Cancer Inst 1993; 85:1058-1063.
18. Wang JY, Hsieh JS, Chen FM, et al: High frequency of Activated K-ras Codon 15 Mutants in colorectal carcinomas from Taiwanese patients. Int J Cancer 2003; 107:387-393.
19. Hayashi N, Sugai S, Ito I, Nakamori S, et al: Ethnic difference in the pattern of K-ras oncogene mutations in human colorectal cancers. Hum Mutat 1996; 8:258-261.