Isolation and characterization of process related impurities and degradation products of bicalutamide and development of RP-HPLC method for impurity profile study

Journal of Pharmaceutical and Biomedical Analysis

Volumn 46, Issue 3, 2008, Pages 505-519

  Nageswara Rao, R ^a   Narasa Raju, A ^a   Narsimha, R ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Bicalutamide; Forced degradation; Isolation and characterization; Kinetics of degradation; Process impurities

Indexed keywords

ACETONITRILE; AMINE; BICALUTAMIDE; PEROXIDE;

ACIDITY; ALKALINITY; ARTICLE; DRUG DEGRADATION; DRUG ISOLATION; ELECTROSPRAY MASS SPECTROMETRY; INFRARED SPECTROSCOPY; KINETICS; PARTICLE SIZE; PHOTODEGRADATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUALITY CONTROL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; THERMAL ANALYSIS; VALIDATION PROCESS;

ANILIDES; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CONTAMINATION; DRUG STABILITY; HYDROGEN-ION CONCENTRATION; NITRILES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TOSYL COMPOUNDS;

EID: 37749013343     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2007.11.015     Document Type: Article

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