Mechanism of action of the disease-modifying anti-arthritic thiol agents d-penicillamine and sodium aurothiomalate: Restoration of cellular free thiols and sequestration of reactive aldehydes

European Journal of Pharmacology

Volumn 580, Issue 1-2, 2008, Pages 48-54

  Wood, Paul L ^a   Khan, M Amin ^a   Moskal, Joseph R ^a  

^a Northwestern University   (United States)

Author keywords

Aldehyde sequestration; Cytoprotection; d penicillamine; Rheumatoid arthritis; Thiol

Indexed keywords

ALDEHYDE DERIVATIVE; AUROTHIOMALATE; BUCILLAMINE; CAPTOPRIL; DISEASE MODIFYING ANTIRHEUMATIC DRUG; LEVAMISOLE; PENICILLAMINE; THIOL; THIOMALIC ACID; TIOPRONIN;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL DESTRUCTION; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SAFETY; DRUG STRUCTURE; JOINT DESTRUCTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS;

ALDEHYDES; ANIMALS; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; CELL LINE; GOLD SODIUM THIOMALATE; MICE; OXIDATIVE STRESS; PENICILLAMINE; SULFHYDRYL COMPOUNDS;

EID: 37649019601     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.10.066     Document Type: Article

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