Association analysis between a VNTR intron 8 polymorphism of the dopamine transporter gene (SLC6A3) and obsessivecompulsive disorder in a Brazilian sample

Arquivos de Neuro-Psiquiatria

Volumn 65, Issue 4 A, 2007, Pages 936-941

  Miguita, Karen ^a,d   Cordeiro, Quirino ^a   Siqueira Roberto, Jacqueline ^a   Shavitt, Roseli Gedanke ^a,b   Castillo, José Carlos Ramos ^a   Castillo, Ana Regina ^a   Miguel, Euripedes Constantino ^a,c   Vallada, Homero ^a,c  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b HC FMUSP

^c HC FMUSP

^d NONE   (Brazil)

Author keywords

Allele; DAT1; Dopamine; Genetic association; Genotype; Obsessive compulsive disorder

Indexed keywords

DOPAMINE TRANSPORTER;

ARTICLE; BRAZIL; COMORBIDITY; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; FEMALE; GENDER; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HEREDITY; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; OBSESSIVE COMPULSIVE DISORDER; ONSET AGE; PHENOTYPE; PREVALENCE; STATISTICAL ANALYSIS; TIC; VARIABLE NUMBER OF TANDEM REPEAT;

EID: 37649017896     PISSN: 0004282X     EISSN: 16784227     Source Type: Journal    
DOI: 10.1590/S0004-282X2007000600002     Document Type: Article

References (32)

1. Rasmussen SA, Eisen JL. Epidemiology of OCD. J Clin Psychiatry. 1990;51:10-13 discussion 14.
2. Torres AR, Lima MC. Epidemiology of obsessive-compulsive disorder: a review. Rev Bras Psiquiatr 2005; 27:237-242.
3. Pauls DL, Alsobrook JP 2nd, Goodman W, Rasmussen S, Leckman JF. A family study of obsessive-compulsive disorder. Am J Psychiatry 1995;152:76-84.
4. Hounie AG, Brotto SA, Diniz J, Chacon PJ, Miguel EC. Transtorno obsessivo-compulsivo: possíveis subgrupos. Rev Bras Psiquiatr 2001;23(2):13-16.
5. Rasmussen SA, Tsuang MT. Clinical characteristics and family history in DSM-III obsessive compulsive disorder. Am J Psychiatry 1986;143:317-322.
6. Lenane MC, Swedo SE, Leonard H, Pauls DL, Sceery W, Rapoport JL. Psychiatric disorders in first degree relatives of children and adolescents with obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry 1990;29:407-412.
7. Gonzalez CH. Aspectos genéticos do transtorno obsesivo-compulsivo. Rev Bras Psiquiatr 2001;23(2):38-41.
8. Nestadt G, Samuels J, Riddle M, et al. A family study of obsessive-compulsive disorder. Arch Gen Psychiatry 2000;57:358-363.
9. Denys D, van der Wee N, Janssen J, De Geus F, Westenberg HG. Low level of dopaminergic D2 receptor binding in obsessive-compulsive disorder. Biol Psychiatry 2004;55:1041-1045.
10. Van der Wee NJ, Stevens H, Hardeman JA, et al. Enhanced dopamine transporter density in psychotropic-naive patients with obsessive-compulsive disorder shown by [123I]{beta}-CIT SPECT. Am J Psychiatry 2004;161:2201-2206.
11. Jenike MA. Illnesses related to obsessive-compulsive disorder. In Jenike MA, Baer LB, Minichiello WE. Obsessive compulsive disorders: theory and management. 2.Ed. Chicago: Year Book Medical, 1990:38-60.
12. McDougle CJ, Epperson CN, Pelton GH, Wasylink S, Price LH. A double-blind, placebo-controlled study of risperidone addition in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder. Arch Gen Psychiatry. 2000;57:794-801.
13. Billett EA, Richter MA, Sam F, et al. Investigation of dopamine system genes in obsessive-compulsive disorder. Psychiatr Gene 1998;8:163-169.
14. Frisch A, Michaelovsky E, Rockah R, et al. Association between obsessive-compulsive disorder and polymorphisms of genes encoding components of the serotonergic and dopaminergic pathways. Eur Neuropsychopharmacol 2000;10:205-209.
15. Hemmings SM, Kinnear CJ, Niehaus DJ, et al. Investigating the role of dopaminergic and serotonergic candidate genes in obsessive-compulsive disorder. Eur Neuropsychopharmacol. 2003;13(2):93-98.
16. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured clinical interview for DSM-IV axis I disorders-patient edition (SCID-I/P), version 2. New York: New York State Psychiatric Institute: Biometrics Research, 1995.
17. Rosario-Campos MC, Leckman JF, Mercadante MT, et al. Adults with earlyonset obsessive-compulsive disorder. Am J Psychiatry 2001;158:1899-1903
18. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 1988;16:1215.
19. Guindalini C, Howard M, Haddley K, et al. A dopamine transporter gene functional variant associated with cocaine abuse in a Brazilian sample. Proc Natl Acad Sci USA 2006;103:4552-4557.
20. Sham PC, Curtis D. Monte Carlos tests for associations between disease and alleles at highy polymorfh ic loci. Ann Hum Genet 1995;59:97-105.
21. Ott J. Utility programs for analysis of genetic linkage. New York: Columbia University, 1988.
22. Millet B, Chabane N, Delorme R, et al. Association between the dopamine receptor D4 (DRD4) gene and obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet 2003;116:55-59.
23. Denys D, Van Nieuwerburgh F, Deforce D, Westenberg H. Association between the dopamine D2 receptor TaqI A2 allele and low activity COMT allele with obsessive-compulsive disorder in males. Eur Neuropsychopharmacol 2006;16:446-450.
24. Asherson P, Brookes K, Franke B, et al. Confirmation that a specific haplotype of the dopamine transporter gene is associated with combinedtype ADHD. Am J Psychiatry 2007;164:674-677.
25. Miguel EC, Leckman JF, Rauch S, et al. Obsessive-compulsive disorder phenotypes: implications for genetic studies. Molec Psychiatry 2005;10:258-275.
26. Mathis MA, Diniz JB, Rosario MC, et al. What is the optimal way to subdivide obsessive-compulsive disorder? CNS Spectr 2006;11:762-779.
27. Karayiorgou M, Sobin C, Blundell ML, et al. Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder. Biol Psychiatry 1999;45:1178-1189.
28. Alsobrook JP 2nd, Zohar AH, Leboyer M, Chabane N, Ebstein RP, Pauls DL. Association between the COMT locus and obsessive-compulsive disorder in females but not males. Am J Med Gene. 2002;114:116-120
29. Diniz JB, Rosario-Campos MC, Hounie AG, et al. Chronics tics and Tourette syndrome in patients with obsessive-compulsive disorder. J Psych Res 2006;40:487-493.
30. Rosario-Campos MC, Leckman JF, Curi M, et al. A family study of early-onset obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet 2005;12;136:92-97.
31. Weiss ST, Silverman EK, Palmer LJ. Editorial: case-control association studies in pharmacogenetics. Pharmacogenomics J 2001;1:157-158.
32. Guindalini C, O'Gara C, Laranjeira R, et al. A GSTP1 functional variant associated with cocaine dependence in a Brazilian population. Pharmacogenet Genomics 2005;15:891-893.