Association between the dopamine D2 receptor TaqI A2 allele and low activity COMT allele with obsessive-compulsive disorder in males

European Neuropsychopharmacology

Volumn 16, Issue 6, 2006, Pages 446-450

  Denys, Damiaan ^a   Van Nieuwerburgh, Filip ^b   Deforce, Dieter ^b   Westenberg, Herman ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

COMT; Dopamine; Dopamine D2 receptor; Genetics; Obsessive compulsive disorder

Indexed keywords

CATECHOL METHYLTRANSFERASE; DOPAMINE 2 RECEPTOR; ENDODEOXYRIBONUCLEASE TAQI; TYPE II SITE SPECIFIC DEOXYRIBONUCLEASE;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; ENZYME ACTIVITY; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; OBSESSIVE COMPULSIVE DISORDER; ONSET AGE; PRIORITY JOURNAL; SEX DIFFERENCE; COMPARATIVE STUDY; GENETIC LINKAGE; GENETICS; METABOLISM; MIDDLE AGED; SEXUAL DEVELOPMENT;

ADULT; ALLELES; CATECHOL O-METHYLTRANSFERASE; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; LINKAGE (GENETICS); MALE; MIDDLE AGED; OBSESSIVE-COMPULSIVE DISORDER; RECEPTORS, DOPAMINE D2; SEX CHARACTERISTICS;

EID: 33745636519     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2005.12.001     Document Type: Article

References (37)

1. Alsobrook J.P., Zohar A.H., Leboyer M., Chabane N., Ebstein R.P., and Pauls D.L. Association between the COMT locus and obsessive-compulsive disorder in females but not males. Am. J. Med. Genet. 114 1 (2002) 116-120
2. Azzam A., Mathews C., and Reus V. A meta-analysis of the association between the catecholamine-O-methyl-transferase gene and obsessive-compulsive disorder. Am. J. Med. Genet. 114 7 (2002) 834-835
3. Billett E.A., Richter M.A., Sam F., Swinson R.P., Dai X.Y., King N., Badri F., Sasaki T., Buchanan J.A., and Kennedy J.L. Investigation of dopamine system genes in obsessive-compulsive disorder. Psychiatr.Genet. 8 3 (1998) 163-169
4. Castle D.J., Deale A., and Marks I.M. Gender differences in obsessive compulsive disorder. Aust. N.Z. J. Psychiatry 29 1 (1995) 114-117
5. Comings D.E., and Blum K. Reward deficiency syndrome: genetic aspects of behavioral disorders. Prog. Brain Res. 126 (2000) 325-341
6. Crum R.M., and Anthony J.C. Cocaine use and other suspected risk factors for obsessive-compulsive disorder: a prospective study with data from the Epidemiologic Catchment Area surveys. Drug Alcohol Depend. 31 3 (1993) 281-295
7. Denys D., van Megen H., and Westenberg H. Quetiapine addition to serotonin reuptake inhibitor treatment in patients with treatment-refractory obsessive-compulsive disorder: an open-label study. J. Clin. Psychiatry 63 8 (2002) 700-703
8. 2 receptor binding in obsessive-compulsive disorder. Der Nervenartz 74 2 (2003) S290
9. Erdal M.E., Tot S., Yazici K., Yazici A., Herken H., Erdem P., Derici E., and Camdeviren H. Lack of association of catechol-O-methyltransferase gene polymorphism in obsessive-compulsive disorder. Depress. Anxiety 18 1 (2003) 41-45
10. Goodman W.K., Price L.H., Rasmussen S.A., Mazure C., Fleischmann R.L., Hill C.L., Heninger G.R., and Charney D.S. The Yale-Brown Obsessive Compulsive Scale: I. Development, use, and reliability. Arch. Gen. Psychiatry 46 11 (1989) 1006-1011
11. Grandy D.K., Zhang Y., and Civelli O. PCR detection of the TaqA Rflp at the Drd2 Locus. Hum. Mol. Genet. 2 12 (1993) 2197
12. 2 TaqI A A2 allele in Japanese males: a confirmatory study. J. Epidemiol. 12 4 (2002) 297-304
13. Hamilton M. The assessment of anxiety states by rating. Br. J. Med. Psychol. 32 (1959) 50-55
14. Hamilton M. A rating scale for depression. J. Neurol. Neurosurg. Psychiatry 23 (1960) 56-62
15. 2 dopamine receptor expression. Mol. Psychiatry 3 3 (1998) 198-203
16. Jenike M.A., Baer L., Summergrad P., Minichiello W.E., Holland A., and Seymour R. Sertraline in obsessive-compulsive disorder: a double-blind comparison with placebo [published erratum appears in Am J Psychiatry 1990 Oct; 147(10): 1393]. Am. J. Psychiatry 147 7 (1990) 923-928
17. 2 receptor gene and their relationships to striatal dopamine receptor density of healthy volunteers. Mol. Psychiatry 4 3 (1999) 290-296
18. Kaasinen V., Nagren K., Hietala J., Farde L., and Rinne J.O. Sex differences in extrastriatal dopamine d(2)-like receptors in the human brain. Am. J. Psychiatry 158 2 (2001) 308-311
19. Karayiorgou M., Altemus M., Galke B.L., Goldman D., Murphy D.L., Ott J., and Gogos J.A. Genotype determining low catechol-O-methyltransferase activity as a risk factor for obsessive-compulsive disorder. Proc. Natl. Acad. Sci. U. S. A. 94 9 (1997) 4572-4575
20. Karayiorgou M., Sobin C., Blundell M.L., Galke B.L., Malinova L., Goldberg P., Ott J., and Gogos J.A. Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder [In Process Citation]. Biol. Psychiatry 45 9 (1999) 1178-1189
21. Kim C.H., Koo M.S., Cheon K.A., Ryu Y.H., Lee J.D., and Lee H.S. Dopamine transporter density of basal ganglia assessed with [(123)I]IPT SPET in obsessive-compulsive disorder. Eur. J. Nucl. Med. Mol. Imaging (2003)
22. 2 receptor gene. Mol. Psychiatry 3 3 (1998) 261-265
23. Lensi P., Cassano G.B., Correddu G., Ravagli S., Kunovac J.L., and Akiskal H.S. Obsessive-compulsive disorder. Familial-developmental history, symptomatology, comorbidity and course with special reference to gender-related differences. Br. J. Psychiatry 169 1 (1996) 101-107
24. Lotta T., Vidgren J., Tilgmann C., Ulmanen I., Melen K., Julkunen I., and Taskinen J. Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 34 13 (1995) 4202-4210
25. McDougle C.J., Goodman W.K., Leckman J.F., Lee N.C., Heninger G.R., and Price L.H. Haloperidol addition in fluvoxamine-refractory obsessive-compulsive disorder. A double-blind, placebo-controlled study in patients with and without tics. Arch. Gen. Psychiatry 51 4 (1994) 302-308
26. McDougle C.J., Epperson C.N., Pelton G.H., Wasylink S., and Price L.H. A double-blind, placebo-controlled study of risperidone addition in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder. Arch. Gen. Psychiatry 57 8 (2000) 794-801
27. Nestadt G., Lan T., Samuels J., Riddle M., Bienvenu III O.J., Liang K.Y., Hoehn-Saric R., Cullen B., Grados M., Beaty T.H., and Shugart Y.Y. Complex segregation analysis provides compelling evidence for a major gene underlying obsessive-compulsive disorder and for heterogeneity by sex. Am. J. Hum. Genet. 67 6 (2000) 1611-1616
28. 2A receptor genes polymorphisms in obsessive-compulsive disorder. Mol. Psychiatry 1 6 (1996) 461-465
29. Niehaus D.J., Kinnear C.J., Corfield V.A., Du Toit P.L., van Kradenburg J., Moolman-Smook J.C., Weyers J.B., Potgieter A., Seedat S., Emsley R.A., Knowles J.A., Brink P.A., and Stein D.J. Association between a catechol-o-methyltransferase polymorphism and obsessive-compulsive disorder in the Afrikaner population. J. Affect. Disord. 65 1 (2001) 61-65
30. Ohara K., Nagai M., Suzuki Y., Ochiai M., and Ohara K. No association between anxiety disorders and catechol-O-methyltransferase polymorphism. Psychiatry Res. 80 2 (1998) 145-148
31. Pauls D.L., Alsobrook J.P., Goodman W., Rasmussen S., and Leckman J.F. A family study of obsessive-compulsive disorder. Am. J. Psychiatry 152 1 (1995) 76-84
32. Pohjalainen T., Rinne J.O., Nagren K., Lehikoinen P., Anttila K., Syvalahti E.K., and Hietala J. The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers. Mol. Psychiatry 3 3 (1998) 256-260
33. Rowe D.C., Van den Oord E.J., Stever C., Giedinghagen L.N., Gard J.M., Cleveland H.H., Gilson M., Terris S.T., Mohr J.H., Sherman S., Abramowitz A., and Waldman I.D. The DRD2 TaqI polymorphism and symptoms of attention deficit hyperactivity disorder. Mol. Psychiatry 4 6 (1999) 580-586
34. Satel S.L., and McDougle C.J. Obsessions and compulsions associated with cocaine abuse. [letter]. Am. J. Psychiatry 148 7 (1991) 947
35. Schindler K.M., Richter M.A., Kennedy J.L., Pato M.T., and Pato C.N. Association between homozygosity at the COMT gene locus and obsessive compulsive disorder. Am. J. Med. Genet. 96 6 (2000) 721-724
36. Sheehan D.V., Lecrubier Y., Sheehan K.H., Amorim P., Janavs J., Weiller E., Hergueta T., Baker R., and Dunbar G.C. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin. Psychiatry 59 Suppl. 20 (1998) 22-33
37. van der Wee N., Stevens H., Hardeman H., Denys D., van Megen H.J., Kahn R.S., and Westenberg H.G. Enhanced densities of dopamine but not of serotonin transporters in psychotropic-naïve patients with obsessive-compulsive disorder. J. Nucl. Med. 42 5 (2001) 238P