99mTc-GSA scintigraphy with SPECT for assessment of hepatic function and functional volume during liver regeneration in a rat model of partial hepatectomy

Journal of Nuclear Medicine

Volumn 49, Issue 1, 2008, Pages 122-128

  De Graaf, Wilmar ^a   Veteläinen, Reeta L ^a   De Bruin, Kora ^a   Van Vliet, Arlëne K ^a   Van Gulik, Thomas M ^a   Bennink, Roelof J ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

99mTc GSA scintigraphy; Liver function; Liver functional volume; Liver regeneration

Indexed keywords

PENTETIC ACID GALACTOSYL SERUM ALBUMIN TC 99M; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; MACROSALB TC 99M; PENTETATE TECHNETIUM TC 99M; TECHNETIUM TC 99M DTPA GALACTOSYL HUMAN SERUM ALBUMIN; TECHNETIUM TC 99M DTPA-GALACTOSYL-HUMAN SERUM ALBUMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG UPTAKE; LIVER FUNCTION; LIVER REGENERATION; LIVER RESECTION; LIVER SCINTISCANNING; LIVER WEIGHT; MALE; NONHUMAN; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; RAT; REPRODUCIBILITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; ANIMAL; LIVER; LIVER FUNCTION TEST; METHODOLOGY; PHYSIOLOGY; SCINTISCANNING; WISTAR RAT;

ANIMALS; HEPATECTOMY; LIVER; LIVER FUNCTION TESTS; LIVER REGENERATION; MALE; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; TECHNETIUM TC 99M AGGREGATED ALBUMIN; TECHNETIUM TC 99M PENTETATE; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 37649009511     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.107.044255     Document Type: Article

References (35)

1. Llovet JM. Updated treatment approach to hepatocellular carcinoma. J Gastroenterol. 2005;40:225-235.
2. Vetelainen R, van Vliet AK, van Gulik TM. Severe steatosis increases hepatocellular injury and impairs liver regeneration in a rat model of partial hepatectomy. Ann Surg. 2007;245:44-50.
3. Yokoyama Y, Nagino M, Nimura Y. Mechanisms of hepatic regeneration following portal vein embolization and partial hepatectomy: a review. World J Surg. 2007;31:367-374.
4. Palmes D, Spiegel HU. Animal models of liver regeneration. Biomaterials. 2004;25:1601-1611.
5. Bennink RJ, Dinant S, Erdogan D, et al. Preoperative assessment of postoperative remnant liver function using hepatobiliary scintigraphy. J Nucl Med. 2004;45:965-971.
6. Kwon AH, Matsui Y, Ha-Kawa SK, Kamiyama Y. Functional hepatic volume measured by technetium-99m-galactosyl-human serum albumin liver scintigraphy: comparison between hepatocyte volume and liver volume by computed tomography. Am J Gastroenterol. 2001;96:541-546.
7. Kwon AH, Matsui Y, Kaibori M, Kamiyama Y. Functional hepatic regeneration following hepatectomy using galactosyl-human serum albumin liver scintigraphy. Transplant Proc. 2004;36:2257-2260.
8. Daniel GB, DeNovo RC, Schultze AE, Schmidt D, Smith GT. Hepatic extraction efficiency of technetium-99m-mebrofenin in the dog with toxic-induced acute liver disease. J Nucl Med. 1998;39:1286-1292.
9. 99mTc-Mebrofenin scintigraphy for evaluating liver disease in a rat model of Wilson's disease. J Nucl Med. 2002;43:246-252.
10. Bennink RJ, Vetelainen R, de Bruin K, van Vliet AK, van Gulik TM. Imaging of liver function with dedicated animal dynamic pinhole scintigraphy in rats. Nucl Med Commun. 2005;26:1005-1012.
11. 99mTc-mebrofenin cholescintigraphy in the evaluation of severity of steatosis in a rat model. Eur J Nucl Med Mol Imaging. 2006;33:1107-1114.
12. Kokudo N, Vera DR, Makuuchi M. Clinical application of TcGSA. Nucl Med Biol. 2003;30:845-849.
13. Akaki S, Mitsumori A, Kanazawa S, et al. Technetium-99m-DTPA-galactosyl human serum albumin liver scintigraphy evaluation of regional CT/MRI attenuation/signal intensity differences. J Nucl Med. 1998;39:529-532.
14. Marshall JS, Green AM, Pensky J, Williams S, Zinn A, Carlson DM. Measurement of circulating desialylated glycoproteins and correlation with hepatocellular damage. J Clin Invest. 1974;54:555-562.
15. Matsuzaki S, Onda M, Tajiri T, Kim DY. Hepatic lobar differences in progression of chronic liver disease: correlation of asialoglycoprotein scintigraphy and hepatic functional reserve. Hepatology. 1997;25:828-832.
16. Sawamura T, Kawasato S, Shiozaki Y, Sameshima Y, Nakada H, Tashiro Y. Decrease of a hepatic binding protein specific for asialoglycoproteins with accumulation of serum asialoglycoproteins in galactosamine-treated rats. Gastroenterology. 1981;81:527-533.
17. Kudo M, Washino K, Yamamichi Y, Ikekubo K. Synthesis and radiolabeling of galactosyl human serum albumin. Methods Enzymol. 1994;247:383-394.
18. Habraken JB, de Bruin K, Shehata M, et al. Evaluation of high-resolution pinhole SPECT using a small rotating animal. J Nucl Med. 2001;42:1863-1869.
19. Kwon AH, Ha-Kawa SK, Uetsuji S, Kamiyama Y, Tanaka Y. Use of technetium 99m diethylenetriamine-pentaacetic acid-galactosyl-human serum albumin liver scintigraphy in the evaluation of preoperative and postoperative hepatic functional reserve for hepatectomy. Surgery. 1995;117:429-434.
20. Ekman M, Fjalling M, Holmberg S, Person H. IODIDA clearance rate: a method for measuring hepatocyte uptake function. Transplant Proc. 1992;24:387-388.
21. Kudo M, Vera DR, Stadalnik RC. In vivo quantification of asialoglycoprotein receptor. Methods Enzymol. 1994;247:373-382.
22. Jansen PL, Chamuleau RA, van Leeuwen DJ, Schipper HG, Busemann-Sokole E, van der Heyde MN. Liver regeneration and restoration of liver function after partial hepatectomy in patients with liver tumors. Scand J Gastroenterol. 1990;25:112-118.
23. Chan SC, Liu CL, Lo CM, et al. Estimating liver weight of adults by body weight and gender. World J Gastroenterol. 2006;12:2217-2222.
24. 99mTc-galactosyl-human serum albumin for prognosis of cirrhosis of the liver. J Nucl Med. 1999;40:1652-1656.
25. Vera DR, Stadalnik RC, Metz CE, Pimstone NR. Diagnostic performance of a receptor-binding radiopharmacokinetic model. J Nucl Med. 1996;37:160-164.
26. Ha-Kawa SK, Tanaka Y. A quantitative model of technetium-99m-DTPA- galactosyl-HSA for the assessment of hepatic blood flow and hepatic binding receptor. J Nucl Med. 1991;32:2233-2240.
27. Miki K, Kubota K, Kokudo N, Inoue Y, Bandai Y, Makuuchi M. Asialoglycoprotein receptor and hepatic blood flow using technetium-99m-DTPA- galactosyl human serum albumin. J Nucl Med. 1997;38:1798-1807.
28. Tanaka A, Shinohara H, Hatano E, et al. Perioperative changes in hepatic function as assessed by asialoglycoprotein receptor indices by technetium 99m galactosyl human serum albumin. Hepatogastroenterology. 1999;46:369-375.
29. Mitsumori A, Nagaya I, Kimoto S, et al. Preoperative evaluation of hepatic functional reserve following hepatectomy by technetium-99m galactosyl human serum albumin liver scintigraphy and computed tomography. Eur J Nucl Med. 1998;25:1377-1382.
30. Jochum C, Beste M, Penndorf V, et al. Quantitative liver function tests in donors and recipients of living donor liver transplantation. Liver Transpl. 2006;12:544-549.
31. Kobayashi T, Imamura H, Aoki T, Sugawara Y, Kokudo N, Makuuchi M. Morphological regeneration and hepatic functional mass after right hemihepatectomy. Dig Surg. 2006;23:44-50.
32. Yildirim SI, Poulsen HE. Quantitative liver functions after 70% hepatectomy. Eur J Clin Invest. 1981;11:469-472.
33. Sato Y, Koyama S, Tsukada K, Hatakeyama K. Acute portal hypertension reflecting shear stress as a trigger of liver regeneration following partial hepatectomy. Surg Today. 1997;27:518-526.
34. Hirose S, Ise H, Uchiyama M, Cho CS, Akaike T. Regulation of asialoglycoprotein receptor expression in the proliferative state of hepatocytes. Biochem Biophys Res Commun. 2001;287:675-681.
35. Howard DJ, Stockert RJ, Morell AG. Asialoglycoprotein receptors in hepatic regeneration. J Biol Chem. 1982;257:2856-2858.