Generation of destabilized herpes simplex virus type 1 thymidine kinase as transcription reporter for PET reporter systems in molecular-genetic imaging

Journal of Nuclear Medicine

Volumn 49, Issue 1, 2008, Pages 142-150

  Hsieh, Chia Hung ^a,b   Chen, Fu Du ^c   Wang, Hsin Ell ^b   Hwang, Jeng Jong ^b   Chang, Chi Wei ^b,d   Lee, Yi Jang ^b   Gelovani, Juri G ^e   Liu, Ren Shyan ^b,d  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c CENTRAL TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^d TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^e UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Doxycycline (Dox); Herpes simplex virus type 1 thymidine kinase (HSV1 TK); Mouse ornithine decarboxylase (MODC); Nuclear localization signal (NLS); PET imaging

Indexed keywords

DOXYCYCLINE; ORNITHINE DECARBOXYLASE; THYMIDINE KINASE; TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; GENE EXPRESSION; GENE MUTATION; HERPES SIMPLEX VIRUS 1; MOLECULAR IMAGING; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; POLYMERASE CHAIN REACTION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; CELL LINE; CYCLOHEXIMIDE; DOXYCYCLINE; ENZYME STABILITY; FEMALE; GENES, REPORTER; HERPESVIRUS 1, HUMAN; HUMANS; MICE; MUTATION; NUCLEAR LOCALIZATION SIGNALS; ORNITHINE DECARBOXYLASE; POSITRON-EMISSION TOMOGRAPHY; PROTEASOME ENDOPEPTIDASE COMPLEX; THYMIDINE KINASE; TRANSCRIPTION, GENETIC; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 37649001958     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.106.038943     Document Type: Article

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