Maspin and mutant p53 expression in malignant melanoma and carcinoma: Use of tissue microarray

Applied Immunohistochemistry and Molecular Morphology

Volumn 16, Issue 1, 2008, Pages 19-23

  Webber, Brian A ^a,b   Lawson, Diane ^a   Cohen, Cynthia ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY HOSPITAL   (United States)

Author keywords

Immunohistochemistry; Maspin; Melanoma; p53; Tissue microarray

Indexed keywords

MASPIN; MUTANT PROTEIN; PROTEIN P53;

ARTICLE; BREAST CARCINOMA; CANCER LOCALIZATION; CARCINOMA; COLON CARCINOMA; CORRELATION ANALYSIS; CORRELATION COEFFICIENT; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LUNG CARCINOMA; MAJOR CLINICAL STUDY; MALE; MELANOMA; MUTATION; OVARY CARCINOMA; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN EXPRESSION; REGULATORY MECHANISM; STATISTICAL SIGNIFICANCE; TISSUE MICROARRAY;

FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MELANOMA; NEOPLASMS; SERPINS; TISSUE ARRAY ANALYSIS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 37549068850     PISSN: 15412016     EISSN: 15334058     Source Type: Journal    
DOI: 10.1097/PAI.0b013e31815d0fca     Document Type: Article

References (15)

1. Zou Z, Anisowicz A, Hendrix MJ, et al. Maspin, a serpin with tumor-suppressing activity in human mammary epithelial cells. Science. 1994;263:526-529.
2. Sager R, Sheng S, Anisowicz A, et al. RNA genetics of breast cancer: maspin as a paradigm. Cold Spring Harb Symp Quant Biol. 1994;59:537-546.
3. Pemberton PA, Tipton AR, Pavloff N, et al. Maspin is an intracellular serpin that partitions into secretory vesicles and is present at the cell surface. J Histochem Cytochem. 1997;45:1697-1706.
4. Hendrix MJ. De-mystifying the mechanism(s) of maspin. Nat Med. 2000;6:374-376.
5. Domann FE, Rice JC, Hendrix MJ, et al. Epigenetic silencing of maspin gene expression in human breast cancers. Int J Cancer 2000;85:805-810.
6. Jiang WG, Hiscox S, Horrobin DF, et al. Gamma linolenic acid regulates expression of maspin and the motility of cancer cells. Biochem Biophys Res Commun. 1997;237:639-644.
7. Zhang M, Magit D, Sager R. Expression of maspin in prostate cells is regulated by a positive ETS element and a negative hormonal responsive element site recognized by androgen receptor. Proc Natl Acad Sci USA. 1997;94:5673-5678.
8. Zou Z, Gao C, Nagaich AK, et al. p53 regulates the expression of the tumor suppressor gene maspin. J Biol Chem. 2000;275:6051-6054.
9. Rhadi JM. Malignant melanoma arising from nevi, p53, p16, and bcl-2: expression in benign versus malignant components. J Cutan Med Surg. 1999;3:293-297.
10. Loggini B, Rinaldi I, Pingitore R, et al. Immunohistochemical study of 49 cutaneous melanomas: p53, PCNA, Bcl-2 expression and multidrug resistance. Tumori. 2001;87:179-186.
11. Machtens S, Serth J, Bokemeyer C, et al. Expression of the p53 and maspin protein in primary prostate cancer: correlation with clinical features. Int J Cancer. 2001;95:337-342.
12. Kononen J, Bubendorf L, Kallioniemi A, et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat Med. 1998;4:844-847.
13. Manual Tissue Arrayer II. Available at: www.beacherinstruments.com [Beecher Instruments web site]. Accessed October 28, 2003.
14. Sager R, Sheng S, Pemberton P, et al. Maspin: a tumor suppressing serpin. Curr Top Microbiol Immunol. 1996;213:51-64.
15. Fernebro E, Dictor M, Bendahl PO, et al. Evaluation of the tissue microarray technique for immunohistochemical analysis in rectal cancer. Arch Pathol Lab Med. 2002;126:702-705.