Thiourea to dithiazolopyrimidines: Highly regio- and stereoselective synthetic routes via mercaptoacetylative cyclization

Synthesis

Volumn , Issue 24, 2007, Pages 3831-3838

  Yadav, Lal Dhar S ^a   Yadav, Seema ^a   Rai, Vijai K ^a  

^a UNIVERSITY OF ALLAHABAD   (India)

Author keywords

Diastereoselective synthesis; Mercaptodithiazolopyrimidines; Michael addition; Microwaves; Thiourea

Indexed keywords

DIASTEREOSELECTIVE SYNTHESIS; HETEROCYCLIZATION; MERCAPTOACETYLATIVE ANNULATION; MICHAEL ADDITION; THIOUREA;

ADDITION REACTIONS; CYCLIZATION; MICROWAVE IRRADIATION; ORGANIC SOLVENTS; STEREOSELECTIVITY; SYNTHESIS (CHEMICAL);

ALCOHOLS;

1 [(2 METHYL 5 OXO 2 PHENYL 1,3 OXATHIOLAN 4 YL)(PHENYL)METHYL] 2 [(METHYLSULFINYL)METHYL]ISOTHIOUREA; 1 [(4 METHOXYPHENYL)(2 METHYL 5 OXO 2 PHENYL 1,3 OXATHIOLAN 4 YL)METHYL)] 2 [(METHYLSULFINYL)METHYL]ISOTHIOUREA; 2 [(BENZYLSULFINYL)(PHENYL)METHYL] 1 [[4 (DIMETHYLAMINO)PHENYL](2 METHYL 5 OXO 2 PHENYL 1,3 OXATHIOLAN 4 YL)METHYL]ISOTHIOUREA; 2 [(BENZYLSULFINYL)PHENYLMETHYLTHIO] 5,6 DIHYDRO 5 MERCAPTO 6 PHENYLPYRIMIDIN 4(1H) ONE; 2 [[(BENZYLSULFINYL)(PHENYL)METHYL]THIO] 5,6 DIHYDRO 5 MERCAPTO 6 (4 METHOXYPHENYL)PYRIMIDIN 4(1H) ONE; 2 [[(BENZYLSULFINYL)(PHENYL)METHYL]THIO] 6 (4 CHLOROPHENYL) 5,6 DIHYDRO 5 MERCAPTOPYRIMIDIN 4(1H) ONE; 2 [[(BENZYLSULFINYL)(PHENYL)METHYL]THIO] 6 [4 (DIMETHYLAMINO)PHENYL] 5,6 DIHYDRO 5 MERCAPTOPYRIMIDIN 4(1H) ONE; 4 [(3 IMINO 1,4,2 DITHIAZOLIDIN 2 YL)(4 METHOXYPHENYL)METHYL] 2 METHYL 2 PHENYL 1,3 OXATHIOLAN 5 ONE; 4 [(3 IMINO 1,4,2 DITHIAZOLIDIN 2 YL)PHENYLMETHYL] 2 METHYL 2 PHENYL 1,3 OXATHIOLAN 5 ONE; 4 [[4 (DIMETHYLAMINO)PHENYL](3 IMINO 5 PHENYL 1,4,2 DITHIAZOLIDIN 2 YL)METHYL] 2 METHYL 2 PHENYL 1,3 OXATHIOLAN 5 ONE; 5,6 DIHYDRO 5 MERCAPTO 2 [[(METHYLSULFINYL)METHYL]THIO] 6 PHENYLPYRIMIDIN 4(1H) ONE; 5,6 DIHYDRO 5 MERCAPTO 6 (4 METHOXYPHENYL) 2 [[(METHYLSULFINYL)METHYL]THIO]PYRIMIDIN 4(1H) ONE; 6 (4 CHLOROPHENYL) 5,6 DIHYDRO 5 MERCAPTO 2[[(METHYLSULFINYL)METHYL]THIO]PYRIMIDIN 4(1H) ONE; 6 [4 (DIMETHYLAMINO)PHENYL] 5,6 DIHYDRO 5 MERCAPTO 2 [[(METHYLSULFINYL)METHYL]THIO]PYRIMIDIN 4(1H) ONE; 6 MERCAPTODITHIAZOLOPYRIMIDINE DERIVATIVE; 6,7 DIHYDRO 6 MERCAPTO 2,7 DIPHENYL 5H [1,4,2]DITHIAZOLO[2,3,A]PYRIMIDIN 5 ONE; 6,7 DIHYDRO 6 MERCAPTO 7 (4 METHOXYPHENYL) 2 PHENYL 5H [1,4,2]DITHIAZOLO[2,3 A]PYRIMIDIN 5 ONE; 6,7 DIHYDRO 6 MERCAPTO 7 (4 METHOXYPHENYL) 5H [1,4,2]DITHIAZOLO[2,3 A]PYRIMIDIN 5 ONE; 6,7 DIHYDRO 6 MERCAPTO 7 PHENYL 5H [1,4,2]DITHIAZOLO[2,3 A]PYRIMIDIN 5 ONE; 7 (4 CHLOROPHENYL) 6,7 DIHYDRO 6 MERCAPTO 2 PHENYL 5H [1,4,2]DITHIAZOLO[2,3 A]PYRIMIDIN 5 ONE; 7 (4 CHLOROPHENYL) 6,7 DIHYDRO 6 MERCAPTO 5H [1,4,2]DITHIAZO[2,3A]PYRIMIDIN 5 ONE; 7 [4 (DIMETHYLAMINO)PHENYL] 6,7 DIHYDRO 6 MERCAPTO 2 PHENYL 5H [1,4,2]DITHIAZOLO[2,3 A]PYRIMIDIN 5 ONE; 7 [4 (DIMETHYLAMINO)PHENYL] 6,7 DIHYDRO 6 MERCAPTO 5H [1,4,2]DITHIAZOLO[2,3 A]PYRIMIDIN 5 ONE; DITHIAZOLOPYRIMIDINE DERIVATIVE; PYRIMIDINE DERIVATIVE; THIOUREA; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CYCLIZATION; DRUG STRUCTURE; DRUG SYNTHESIS; MICHAEL ADDITION; MICROWAVE IRRADIATION; STEREOCHEMISTRY;

EID: 37549066906     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-990892     Document Type: Article

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