Pneumocyte apoptosis induction during cardiopulmonary bypass: Effective prevention by radical scavenging using N-acetylcysteine

Journal of Investigative Surgery

Volumn 20, Issue 6, 2007, Pages 349-356

  Klass, Oliver ^a   Fischer, Uwe M ^b   Antonyan, Albert ^c   Bosse, Mafalda ^c   Fischer, Juergen H ^c   Bloch, Wilhelm ^b   Mehlhorn, Uwe ^d  

^a UNIVERSITY OF ULM   (Germany)

^b GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

^c UNIVERSITY OF COLOGNE   (Germany)

^d JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Apoptosis; Cardiopulmonary bypass; Oxidative stress; Pneumocytes

Indexed keywords

3 NITROTYROSINE; 8 HYDROXYDEOXYGUANOSINE; 8 ISOPROSTAGLANDIN F2 ALPHA; ACETYLCYSTEINE; BIOLOGICAL MARKER; CASPASE 3; PLACEBO; REACTIVE OXYGEN METABOLITE; SCAVENGER; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARDIOPLEGIA; CARDIOPULMONARY BYPASS; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HEART ARREST; IMMUNOCYTOCHEMISTRY; LUNG ALVEOLUS CELL; LUNG BIOPSY; LUNG INJURY; MALE; NONHUMAN; PRIORITY JOURNAL; RANDOMIZATION; SIGNAL TRANSDUCTION; STAINING; SWINE;

ACETYLCYSTEINE; ANIMALS; APOPTOSIS; CARDIOPULMONARY BYPASS; CASPASE 3; FEMALE; FREE RADICAL SCAVENGERS; LUNG; MALE; REACTIVE OXYGEN SPECIES; SWINE; TYROSINE;

EID: 37549065148     PISSN: 08941939     EISSN: 15210553     Source Type: Journal    
DOI: 10.1080/08941930701772165     Document Type: Article

References (20)

1. Asimakopoulos, G., Smith, P. L., Ratnatunga, C. P. and Taylor, K. M. (1999) Lung injury and acute respiratory distress syndrome after cardiopulmonary bypass. Ann Thorac Surg, 68, pp. 1107-1115.
2. Fowler, A. A., Hamman, R. F., Good, J. T., Benson, K. N., Baird, M., Eberle, D. J., Petty, T. L. and Hyers, T. M. (1983) Adult respiratory distress syndrome: Risk with common predispositions. Ann Intern Med, 98, pp. 593-597.
3. Messent, M., Sullivan, K., Keogh, B. F., Morgan, C. J. and Evans, T. W. (1992) Adult respiratory distress syndrome following cardiopulmonary bypass: Incidence and prediction. Anaesthesia, 47, pp. 267-268.
4. Ng, C. S., Wan, S., Yim, A. P. and Arifi, A. A. (2002) Pulmonary dysfunction after cardiac surgery. Chest, 121, pp. 1269-1277.
5. Dhalla, N. S., Elmoselhi, A. B., Hata, T. and Makino, N. (2000) Status of myocardial antioxidants in ischemia-reperfusion injury. Cardiovasc Res, 47, pp. 446-456.
6. Mehlhorn, U., Krahwinkel, A., Geissler, H. J., La Rosee, K., Fischer, U. M., Klass, O., Suedkamp, M., Hekmat, K., Tossios, P. and Bloch, W. (2003) Nitrotyrosine and 8-isoprostane formation indicate free radical-mediated injury in hearts of patients subjected to cardioplegia. J Thorac Cardiovasc Surg, 125, pp. 178-183.
7. Tossios, P., Bloch, W., Huebner, A., Raji, M. R., Dodos, F., Klass, O., Suedkamp, M., Kasper, S. M., Hellmich, M. and Mehlhorn, U. (2003) N-Acetylcysteine prevents reactive oxygen species-mediated myocardial stress in patients undergoing cardiac surgery: Results of a randomized, double-blind, placebo-controlled clinical trial. J Thorac Cardiovasc Surg, 126, pp. 1513-1520.
8. Fischer, U. M., Tossios, P., Huebner, A., Geissler, H. J., Bloch, W. and Mehlhorn, U. (2004) Myocardial apoptosis prevention by radical scavenging in patients undergoing cardiac surgery. J Thorac Cardiovasc Surg, 128, pp. 103-108.
9. Ferdinandy, P., Danial, H., Ambrus, I., Rothery, R. A. and Schulz, R. (2000) Peroxynitrite is a major contributor to cytokine-induced myocardial contractile failure. Circ Res, 87, pp. 241-247.
10. Gupte, S. A. and Okada, T. (2001) Prostaglandins and nitric oxide mediate superoxide-induced myocardial contractile dysfunction in isolated rat hearts. J Mol Cell Cardiol., 33, pp. 1107-1117.
11. Mihm, M. J., Coyle, C. M., Schanbacher, B. L., Weinstein, D. M. and Bauer, J. A. (2001) Peroxynitrite induced nitration and inactivation of myofibrillar creatine kinase in experimental heart failure. Cardiovasc Res, 49, pp. 798-807.
12. Basu, S., Nozari, A., Liu, X. L., Rubertsson, S. and Wiklund, L. (2000) Development of a novel biomarker of free radical damage in reperfusion injury after cardiac arrest. FEBS Lett, 470, pp. 1-6.
13. Reilly, M. P., Delanty, N., Roy, L., Rokach, J., Callaghan, P. O., Crean, P., Lawson, J. A. and Gerald, G A Fitz (1997) Increased formation of the isoprostanes IPF2alpha-I and 8-epi-prostaglandin F2alpha in acute coronary angioplasty: Evidence for oxidant stress during coronary reperfusion in humans. Circulation, 96, pp. 3314-3320.
14. Shigenaga, M. K. and Ames, B. N. (1991) Assays for 8-hydroxy-2′-deoxyguanosine: A biomarker of in vivo oxidative DNA damage. Free Radical Biol Med, 10, pp. 211-216.
15. Leeuwenburgh, C., Hansen, P., Shaish, A., Holloszy, J. O. and Heinecke, J. W. (1998) Markers of protein oxidation by hydroxyl radical and reactive nitrogen species in tissues of aging rats. Am J Physiol, 274, pp. R453-R461.
16. Schwartz, J. D., Shamamian, P., Schwartz, D. S., Grossi, E. A., Jacobs, C. E., Steiner, F., Minneci, P. C., Baumann, F. G., Colvin, S. B. and Galloway, A. C. (1998) Cardiopulmonary bypass primes polymorphonuclear leukocytes. J Surg Res., 75, pp. 177-182.
17. Giomarelli, P., Scolletta, S., Borrelli, E. and Biagioli, B. (2003) Myocardial and lung injury after cardiopulmonary bypass: Role of interleukin (IL)-10. Ann Thorac Surg, 76, pp. 117-123.
18. Nakazawa, H., Fukuyama, N., Takizawa, S., Tsuji, C., Yoshitake, M. and Ishida, H. (2000) Nitrotyrosine formation and its role in various pathological conditions. Free Radical Res, 33, pp. 771-784.
19. Nagai, A. (2003) [Apoptosis in chronic obstructive pulmonary disease]. Nippon Rinsho, 61, pp. 2126-2132.
20. Matute-Bello, G. and Martin, T. R. (2003) Science review: Apoptosis in acute lung injury. Crit Care, 7, pp. 355-358.